LOCUS       NM_023858               5434 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus myotubularin related protein 2 (Mtmr2), transcript
            variant 1, mRNA.
ACCESSION   NM_023858
VERSION     NM_023858.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5434)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5434)
  AUTHORS   Sawade,L., Grandi,F., Mignanelli,M., Patino-Lopez,G., Klinkert,K.,
            Langa-Vives,F., Di Guardo,R., Echard,A., Bolino,A. and Haucke,V.
  TITLE     Rab35-regulated lipid turnover by myotubularins represses mTORC1
            activity and controls myelin growth
  JOURNAL   Nat Commun 11 (1), 2835 (2020)
   PUBMED   32503983
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5434)
  AUTHORS   Narayanan,P., Hutte,M., Kudryasheva,G., Taberner,F.J.,
            Lechner,S.G., Rehfeldt,F., Gomez-Varela,D. and Schmidt,M.
  TITLE     Myotubularin related protein-2 and its phospholipid substrate PIP2
            control Piezo2-mediated mechanotransduction in peripheral sensory
            neurons
  JOURNAL   Elife 7, e32346 (2018)
   PUBMED   29521261
  REMARK    GeneRIF: we identified a PI(3,5)P2 binding region in Piezo2, but
            not Piezo1, that confers sensitivity to Mtmr2 as indicated by
            functional analysis of a domain-swapped Piezo2 mutant. Altogether,
            our results propose local PI(3,5)P2 modulation via Mtmr2 in the
            vicinity of Piezo2 as a novel mechanism to dynamically control
            Piezo2-dependent mechanotransduction in peripheral sensory neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5434)
  AUTHORS   Raess,M.A., Cowling,B.S., Bertazzi,D.L., Kretz,C., Rinaldi,B.,
            Xuereb,J.M., Kessler,P., Romero,N.B., Payrastre,B., Friant,S. and
            Laporte,J.
  TITLE     Expression of the neuropathy-associated MTMR2 gene rescues
            MTM1-associated myopathy
  JOURNAL   Hum Mol Genet 26 (19), 3736-3748 (2017)
   PUBMED   28934386
  REMARK    GeneRIF: Expression of several MTMR2 isoforms ameliorates the
            myopathic phenotype owing to MTM1 loss, with increased muscle
            force, reduced myofiber atrophy, and reduction of the intracellular
            disorganization hallmarks associated with myotubular myopathy.
REFERENCE   5  (bases 1 to 5434)
  AUTHORS   Tasfaout,H., Buono,S., Guo,S., Kretz,C., Messaddeq,N., Booten,S.,
            Greenlee,S., Monia,B.P., Cowling,B.S. and Laporte,J.
  TITLE     Antisense oligonucleotide-mediated Dnm2 knockdown prevents and
            reverts myotubular myopathy in mice
  JOURNAL   Nat Commun 8, 15661 (2017)
   PUBMED   28589938
  REMARK    GeneRIF: analysis of epistasis between Mtm1 and Dnm2 reveal
            possibilities for DNM2 knockdown as a therapeutic approach for
            X-linked centronuclear myopathy (XLCNM), or myotubular myopathy
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5434)
  AUTHORS   Berger,P., Schaffitzel,C., Berger,I., Ban,N. and Suter,U.
  TITLE     Membrane association of myotubularin-related protein 2 is mediated
            by a pleckstrin homology-GRAM domain and a coiled-coil dimerization
            module
  JOURNAL   Proc Natl Acad Sci U S A 100 (21), 12177-12182 (2003)
   PUBMED   14530412
  REMARK    GeneRIF: Mtmr2 forms a dimer and the C-terminal coiled-coil is
            responsible for homodimerization, in addition to membrane
            association
REFERENCE   7  (bases 1 to 5434)
  AUTHORS   Previtali,S.C., Zerega,B., Sherman,D.L., Brophy,P.J., Dina,G.,
            King,R.H., Salih,M.M., Feltri,L., Quattrini,A., Ravazzolo,R.,
            Wrabetz,L., Monaco,A.P. and Bolino,A.
  TITLE     Myotubularin-related 2 protein phosphatase and neurofilament light
            chain protein, both mutated in CMT neuropathies, interact in
            peripheral nerve
  JOURNAL   Hum Mol Genet 12 (14), 1713-1723 (2003)
   PUBMED   12837694
REFERENCE   8  (bases 1 to 5434)
  AUTHORS   Berger,P., Bonneick,S., Willi,S., Wymann,M. and Suter,U.
  TITLE     Loss of phosphatase activity in myotubularin-related protein 2 is
            associated with Charcot-Marie-Tooth disease type 4B1
  JOURNAL   Hum Mol Genet 11 (13), 1569-1579 (2002)
   PUBMED   12045210
  REMARK    GeneRIF: Loss of phosphatase activity in myotubularin-related
            protein 2 is associated with Charcot-Marie-Tooth disease type 4B1
REFERENCE   9  (bases 1 to 5434)
  AUTHORS   Bolino,A., Marigo,V., Ferrera,F., Loader,J., Romio,L., Leoni,A., Di
            Duca,M., Cinti,R., Cecchi,C., Feltri,M.L., Wrabetz,L., Ravazzolo,R.
            and Monaco,A.P.
  TITLE     Molecular characterization and expression analysis of Mtmr2, mouse
            homologue of MTMR2, the Myotubularin-related 2 gene, mutated in
            CMT4B
  JOURNAL   Gene 283 (1-2), 17-26 (2002)
   PUBMED   11867209
REFERENCE   10 (bases 1 to 5434)
  AUTHORS   Laporte,J., Blondeau,F., Buj-Bello,A., Tentler,D., Kretz,C.,
            Dahl,N. and Mandel,J.L.
  TITLE     Characterization of the myotubularin dual specificity phosphatase
            gene family from yeast to human
  JOURNAL   Hum Mol Genet 7 (11), 1703-1712 (1998)
   PUBMED   9736772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010488.9.
            
            On Sep 4, 2019 this sequence version replaced NM_023858.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY055832.1, AK133476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               CT010488.9         188464-188685       c
            223-328             CT010488.9         155482-155587       c
            329-404             CT010488.9         151937-152012       c
            405-499             CT010488.9         149189-149283       c
            500-610             CT010488.9         148714-148824       c
            611-712             CT010488.9         145784-145885       c
            713-796             CT010488.9         144632-144715       c
            797-946             CT010488.9         142478-142627       c
            947-1135            CT010488.9         141718-141906       c
            1136-1321           CT010488.9         138529-138714       c
            1322-1528           CT010488.9         137782-137988       c
            1529-1621           CT010488.9         135857-135949       c
            1622-1735           CT010488.9         134326-134439       c
            1736-1912           CT010488.9         132882-133058       c
            1913-5434           CT010488.9         128968-132489       c
FEATURES             Location/Qualifiers
     source          1..5434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 3.44 cM"
     gene            1..5434
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /note="myotubularin related protein 2"
                     /db_xref="GeneID:77116"
                     /db_xref="MGI:MGI:1924366"
     exon            1..222
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2074
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /EC_number="3.1.3.95"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR2 isoform 1"
                     /protein_id="NP_076347.3"
                     /db_xref="CCDS:CCDS22818.3"
                     /db_xref="GeneID:77116"
                     /db_xref="MGI:MGI:1924366"
                     /translation="MEKSSSCESLGAQLPAARLPSEDSLSSASTSHSENSVHTKSASA
                     ISSDSISTSADNFSPDLRVLREANKLAEMEEPALLPGENIKDMAKDVTYICPFTGAVR
                     GTLTVTSYRLYFKSMERDPPFVLDASLGVISRVEKIGGASSRGENSYGLETVCKDIRN
                     LRFAHKPEGRTRRSIFENLMKYAFPVSNGLPLFAFEYKEVFPENGWKLYDPLLEYRRQ
                     GIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPE
                     SQATVTRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKG
                     GGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPTIEETHWLSNLESTHWLEHI
                     KLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVE
                     KEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITI
                     LDHLYSCLFGTFLCNSEQQRGKENLPKKTVSLWSYINSQLEDFTNPLYGSYSNHVLYP
                     VASMRHLELWVGYYIRWNPRMKPQEPIHSRYKELLAKRAELQRKVEELQREISNRSTS
                     SSERASSPAQCVTPVQTVV"
     exon            223..328
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            329..404
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            405..499
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            500..610
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            611..712
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            713..796
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            797..946
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1135
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1321
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1528
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1621
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1735
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1912
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..5434
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2999..3004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3018
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /note="major polyA site"
     regulatory      5415..5420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5434
                     /gene="Mtmr2"
                     /gene_synonym="6030445P13Rik"
ORIGIN      
        1 gcaggctggg ggaacatggc cgcttccggt ctcggagcct gcctggcgcg gggctgaccg
       61 cggctgcggc cccgtgcgct cctccctctg catctcgcgc cggcggccgc ggagggcgca
      121 gcggcctcca gtttctcgcg ccatggagaa gagctccagc tgcgagagtc tcggcgcgca
      181 gctcccggcg gcaaggctgc ccagcgagga ctcactgtcc agtgcttcta cttctcattc
      241 agagaactcg gtgcatacca aatcagcttc tgctatatca tcagattcca tttcaacctc
      301 tgcagacaac ttttctcctg acttgagggt cctgagggag gcaaacaagt tagcagaaat
      361 ggaggaacca gccctgcttc caggagagaa cattaaagat atggccaaag atgtgactta
      421 catatgtcca ttcactggtg ctgtgcgagg aacgctgact gtcacaagtt acaggttata
      481 tttcaagagc atggagcggg accccccatt tgttctagat gcttctcttg gagtgataag
      541 tagagtagaa aaaattggtg gtgcatctag ccgaggtgaa aactcctatg gcctggaaac
      601 tgtgtgcaag gatatcagga acttgcgatt tgctcataaa ccggaggggc gaacaagaag
      661 atccatattt gagaatctaa tgaaatatgc atttcctgtg tctaatggct tgcctctttt
      721 tgcttttgag tataaagaag tattccccga aaatgggtgg aaactgtatg acccccttct
      781 agagtacaga aggcagggaa ttccaaatga aagctggaga ataacaaaga taaatgaacg
      841 ctatgaactc tgtgacacat atcctgccct cttggttgtg ccagcaaaca ttcctgatga
      901 ggagctaaag agagtggcat cctttaggtc acggggccgg atcccagttt tatcctggat
      961 tcatcctgaa agtcaagcca cagtcactcg ctgcagccag cccatggttg gagtgagtgg
     1021 gaagcgcagc aaagaagatg agaagtacct tcaggccatc atggactcca atgcccagtc
     1081 tcacaaaata tttatctttg atgctcggcc aagtgtcaat gcggttgcca ataaggcaaa
     1141 ggggggaggt tatgaaagtg aagatgccta tcaaaatgca gaactcgttt ttctggatat
     1201 tcataatatc catgttatga gagaatcatt acggaagctt aaggagattg tgtaccccac
     1261 cattgaagaa actcactggt tgtctaactt agaatctaca cactggctgg aacacattaa
     1321 gctcattctt gcaggggctc ttaggattgc tgacaaggtc gagtctggga agacgtctgt
     1381 ggtggtacac tgcagtgatg gatgggatcg cacagctcag ctcacttccc tggccatgct
     1441 catgttggat ggatactacc gaaccatacg aggatttgaa gtccttgtgg agaaagaatg
     1501 gctgagcttt ggacatagat tccaactaag agttggccat ggagataaga accatgctga
     1561 cgcagacagg tcacctgttt tccttcagtt tattgactgt gtctggcaaa tgacaagaca
     1621 gttccctacc gcatttgaat tcaatgagta ttttctcatt accatcctgg accacttgta
     1681 cagctgttta tttggaacat tcctttgtaa cagcgaacag cagaggggga aagagaatct
     1741 tcctaagaag acagtgtcac tgtggtccta tataaacagc cagctggaag actttactaa
     1801 tcctctttat ggaagctact ccaatcatgt cctttaccca gtagccagca tgcgccacct
     1861 agagctctgg gtgggatatt atataaggtg gaacccccgg atgaaacctc aggaacctat
     1921 ccacagcaga tacaaagaac ttcttgccaa aagagcagag cttcaaagaa aagtagagga
     1981 acttcagaga gaaatttcca accgctcaac ctcctcttca gagagagcca gctctcctgc
     2041 acagtgtgtg actcctgtcc aaactgttgt atgaaaggac taggcccagg gcctcattgc
     2101 caggaacctg acattccagc accttatggg tagaaaacct tccgtgttta aaacccatct
     2161 actggagaat ccttcggatg ctgtatttat ttcaaatctc tcttagatga gtttagaaac
     2221 atagcagtgc aagtgacaat gaagatgatc tcattcataa ttaaagtatg acactaatct
     2281 taagtcaccc aaagaatact aaagtactgc agtcctgtat tcacactggg agcaagtttt
     2341 tcatttaaaa atgtcttaaa accctgagca cctggtcaga tctccaggag gggagaaaag
     2401 caaggccacc tgctgttgca cctgagagca cacgcattga ggcttgtgtc agatccaaat
     2461 attcctttct cagtttcccc aagttttgtg atatttaata tagtaaaaag cattgtcttg
     2521 agattattat ggcatagtag gttttttttt tttttttttt tttgctgctg acattgtaat
     2581 tagcatattc tcaacagcaa ttaggaaaca atgccttata tatgtgcttt ggggggttga
     2641 agggacaaag tagtagctgt catctactcc atttgtgtat tgatcacaaa catcacagaa
     2701 gacatcttaa aaccttactg ttactctact ttatctaaat gctatttggc aagttttaag
     2761 acagtatttt aaaaacttag aagtctgact ttatgtgctg tgtaaatctc acatggacac
     2821 tttaccaaag agcactctgc atgagttagt ctcagtgcca gcaagtaaag ccttgcttct
     2881 ctgctcaccc gagtccggtg ctggtgggga cagttgactc ctggggtctg ttttactctg
     2941 tacaagagcc atatgtaatg tactgtaaca aacgagcttc ttaccacttg gtcttttaat
     3001 taaatgactt caaactttgt ccttgtccac agttgtctaa agtaccctcc ccaccccacc
     3061 cccaaaatgt taacctggaa ttatccaatc caatttaagc ccacctgtct ttgacaccta
     3121 aaatcaaact gtaaaaagca ttgttccgta actcattgtt tgaactgtag tcctggtgtt
     3181 gattttggaa ttagtacatc acagatctcc tctttcctac tttttttttt tttttgctta
     3241 tatattttac ctggatattg agcccagagc ctcacacttg ccaggcaaat gctatactat
     3301 tgaatatacc ccagcatacc cagtatttac aagaattggt accaaataat ttggttggtg
     3361 taaacttagc tataaaaatt tttttgagga ggtatttatg ttcccagcat tcaagtaaga
     3421 tttctgtaac agttcacttt cctcactagt ctgctttctt ccctgaaacc tttgaccatc
     3481 ttggtatgac atcagaggga tgctgatcat acggtcaccc aaacggcaga gaaatatgtc
     3541 actccaaaac cttgcaatgt tttctgtgac ctccaaggaa tcttgagtgt ggaatgtgca
     3601 cactaaaagt gcttatgtgg agttcaactg cattcctggt gttcacacac accccagtat
     3661 gacatcaagg aaagcactcc tttcttacga agcgtgggat ccgcgctggc gtcttgtaca
     3721 ggatacaagg gagctctgct gcaagtgaac aagaaactga agcagaatca aaacccaaag
     3781 cctacagttg gaatccagct ggagacaggt aggagttact atcctccaat tactattcta
     3841 actaggagtt ggagccatca tcattcagat gacagttata cagtttactg tcctgaaatc
     3901 caaggaatta acacaagtgg aacagttgga agtggtggtt gagccatgtc accagagcag
     3961 tttcttacct tcctggggac tatggactca cggttgtcag gtcattgttc ctgcaaacct
     4021 catcagaaaa ctgcacacac aaatttatat acaatttcag gtgactcatg aagcttaaaa
     4081 atctatgttt ctaactagaa aattcaccaa gtgatagggc cttctggtgc ccaagtaaca
     4141 aacaattcat gctattcaac ttagtagatg gctagtatgt tccccagcct gtctgaacca
     4201 ttcaggaaca ctgagcttgg tctctgtaag cacaaggatg acaagcatgc ctcagatatt
     4261 ctcgttcctc aatcacgata ctaacatgca ctttttgagt ttgtatgaca aataaagcct
     4321 ttgttagctg gctgttaagc aaagtttaaa aactgcttta ttgatttgaa gtaccaaatt
     4381 tataaagatt ataacatgtc gatctactca aagttaaata atttacattg gcatgataga
     4441 tgtgtgtatt caattcacat actgtatgct aaaagcatga gcttctctta agtcaagatt
     4501 aaacagtgct taacatgatt acaaatagat actgtctaaa aactgtaaac gtgtacattt
     4561 tacaataccc acgttctcat tctttattcc aaaatttcat ttacttcagt aacaactgtt
     4621 tatatagttt ttctgaagac attgtgacat atttcatgga taactgactt aagtgaattt
     4681 atgattgatc aatgtctaaa ataccaaagc aaaacaaagt cttcttgaaa acagtacatt
     4741 taatggtcat ctggagaagg gagagtagtg gtcacttcat gctgtgggaa gatttaaaaa
     4801 acaagacttc aagcactgac tatggggact atctcatatt ctgaattttc aaacccaatt
     4861 tacatatata cctagtttaa aaaacacacc catgagtaaa aaactggtca tttgtttaca
     4921 aagtgcagtg aatgagtaca gcaaattcaa agacagtgag gcttctctgc cgcagaactc
     4981 catctccatc agttgtgcta catagcacaa tagactgtaa tgaagcttgg cccctaacac
     5041 ctgccagtaa tggcagctta gcaagcatga gacctggaaa gtctgctcat gtccagtacg
     5101 tacatcgttt atgaccagtg aggtacatca tttatgacct ggtgtcagta atcccaacac
     5161 agattactgc tctgcagtga attctgtatg gtctgcatgt ccttcagtaa ctgaagattt
     5221 ttcctgcttt tttctccagg tctctgtttg gccagatcct tcttacttgc ggtccttggg
     5281 actccagatg aacgaccgct gctgttccct tcttcatcaa gagtcttttt gttagctttt
     5341 aattccttct tctgcttatc tatgttttgt ttctccagct gaccaaataa tcaaaacagg
     5401 gaaaaaatga attcaataaa aacattttct ttta
//
