LOCUS       NM_026849               2676 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus myotubularin related protein 14 (Mtmr14), transcript
            variant 1, mRNA.
ACCESSION   NM_026849 XM_132749
VERSION     NM_026849.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2676)
  AUTHORS   Feng,Q., Li,X., Liu,R., Liu,G., He,Y. and Li,T.
  TITLE     Overexpression of MTMR14 induced learning and memory impairments in
            2-month-old C57 mice
  JOURNAL   Neurosci Lett 825, 137700 (2024)
   PUBMED   38401642
  REMARK    GeneRIF: Overexpression of MTMR14 induced learning and memory
            impairments in 2-month-old C57 mice.
REFERENCE   2  (bases 1 to 2676)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2676)
  AUTHORS   Kong,L.Y., Liang,C., Li,P.C., Zhang,Y.W., Feng,S.D., Zhang,D.H.,
            Yao,R., Yang,L.L., Hao,Z.Y., Zhang,H., Tian,X.X., Guo,C.R.,
            Du,B.B., Dong,J.Z. and Zhang,Y.Z.
  TITLE     Myotubularin-Related Protein14 Prevents Neointima Formation and
            Vascular Smooth Muscle Cell Proliferation by Inhibiting Polo-Like
            Kinase1
  JOURNAL   J Am Heart Assoc 11 (21), e026174 (2022)
   PUBMED   36314496
  REMARK    GeneRIF: Myotubularin-Related Protein14 Prevents Neointima
            Formation and Vascular Smooth Muscle Cell Proliferation by
            Inhibiting Polo-Like Kinase1.
REFERENCE   4  (bases 1 to 2676)
  AUTHORS   Pan,Q., Liu,Y., Wang,G., Wen,Z. and Wang,Y.
  TITLE     MTMR14 protects against cerebral stroke through suppressing
            PTEN-regulated autophagy
  JOURNAL   Biochem Biophys Res Commun 529 (4), 1045-1052 (2020)
   PUBMED   32819563
  REMARK    GeneRIF: MTMR14 protects against cerebral stroke through
            suppressing PTEN-regulated autophagy.
REFERENCE   5  (bases 1 to 2676)
  AUTHORS   Li,S., Zhang,M. and Zhang,B.
  TITLE     MTMR14 protects against hepatic ischemia-reperfusion injury through
            interacting with AKT signaling in vivo and in vitro
  JOURNAL   Biomed Pharmacother 129, 110455 (2020)
   PUBMED   32768948
  REMARK    GeneRIF: MTMR14 protects against hepatic ischemia-reperfusion
            injury through interacting with AKT signaling in vivo and in vitro.
REFERENCE   6  (bases 1 to 2676)
  AUTHORS   Romero-Suarez,S., Shen,J., Brotto,L., Hall,T., Mo,C.,
            Valdivia,H.H., Andresen,J., Wacker,M., Nosek,T.M., Qu,C.K. and
            Brotto,M.
  TITLE     Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with
            age and its loss accelerates skeletal muscle aging process by
            altering calcium homeostasis
  JOURNAL   Aging (Albany NY) 2 (8), 504-513 (2010)
   PUBMED   20817957
  REMARK    GeneRIF: a knockout mice were more susceptible to exercise-induced
            muscle damage, a trademark of muscle functional changes in older
            subjects
REFERENCE   7  (bases 1 to 2676)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   8  (bases 1 to 2676)
  AUTHORS   Shen,J., Yu,W.M., Brotto,M., Scherman,J.A., Guo,C., Stoddard,C.,
            Nosek,T.M., Valdivia,H.H. and Qu,C.K.
  TITLE     Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by
            disrupting Ca(2+) homeostasis
  JOURNAL   Nat Cell Biol 11 (6), 769-776 (2009)
   PUBMED   19465920
  REMARK    GeneRIF: Data report that mice deficient in the newly identified
            phosphatidylinositol phosphate phosphatase MIP/MTMR14
            (muscle-specific inositol phosphatase) show muscle weakness and
            fatigue.
REFERENCE   9  (bases 1 to 2676)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   10 (bases 1 to 2676)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX207820.1, CD805346.1, DV648379.1, DV653632.1, DV653288.1 and
            BB256623.2.
            
            On Dec 27, 2007 this sequence version replaced NM_026849.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.295062.1, BC018294.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               CX207820.1         1-462
            463-1037            CD805346.1         9-583
            1038-1685           DV648379.1         97-744
            1686-1922           DV653632.1         430-666
            1923-2480           DV653288.1         64-621
            2481-2676           BB256623.2         552-747
FEATURES             Location/Qualifiers
     source          1..2676
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.74 cM"
     gene            1..2676
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /note="myotubularin related protein 14"
                     /db_xref="GeneID:97287"
                     /db_xref="MGI:MGI:1916075"
     exon            1..279
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2070
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /EC_number="3.1.3.95"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mJumpy; phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase
                     MTMR14"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR14 isoform 1"
                     /protein_id="NP_081125.2"
                     /db_xref="CCDS:CCDS20412.2"
                     /db_xref="GeneID:97287"
                     /db_xref="MGI:MGI:1916075"
                     /translation="MAGARAAAAASAGSTASSGSPPPQEPGLWELLEEFSRTQYRAKD
                     SGGKSGSKVERIEKRCLELFGRDYCFSVIPNVNGDICGHYPRHIVFLEYESSEKEKDT
                     FQSTVQVNKLQDLIHRSKMARCRGRFVCPVILFKGKHICRSATLAGWGELYGRSGYNY
                     LFSGGADDTWASTEDVTEEDFVLRSGDTHLFDKVRGYDIKLLQYLSVKYICDLMVENK
                     KVKFGMNVTSSEKVDKAQRYANFTLLSIPYPGCEFFKEYKDRDYMAEGLIFNWKQDYV
                     DAPLNIPNFLTQSLNIDWSQYQSWDLVQQTQNYLKLLLFIMNRDDDSGLLVHCISGWD
                     RTPLFISLLRLSLWADGLIHTSLKPAEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFC
                     FNFLKHITSEEFCLKTQRRKSLPTRDAGFTVEDICMLRHKDRGSTTSLGSDFSLVLEH
                     SPGAVGSFSYETVELAPAGAPTQAAWRKSHSSSPQSMLWSRPQPSEERLPSHHGLTEA
                     KSSSSSSSNHSDNFFRMGSSPLEVPKPRSVDHPLPGSSLSTDFGSWQLVSGCGSIQDR
                     PVLHTDSSLPFSFQDELPNSCLLTALSDRETRLQEVRSAFLAAYSSTVGLRAATPSPS
                     GAIGGLLEQFARGVGLRGTSTSTL"
     exon            280..428
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            429..537
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            538..613
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            614..674
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            675..797
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            798..871
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            872..942
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1017
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1084
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1170
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1247
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1284
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1352
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1411
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1550
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1730
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1886
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2676
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2462..2467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2486
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /note="major polyA site"
     regulatory      2654..2659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2673
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
ORIGIN      
        1 gcggggccgg aagtggaaga agaaggcggc ggctgagtcg gttcaggagg ttttagagcc
       61 ggagtccgag cttcaggtgc catgggctgg gggaaggcgc cctgagggga ctcgaggctg
      121 tgcatggcgg gtgctcgggc cgccgccgcc gcctcggcgg gttccaccgc ctcgtcgggc
      181 agcccgccgc ctcaggagcc cgggctctgg gagctgctgg aggagttctc ccggactcag
      241 taccgtgcca aggacagcgg cgggaagagc ggctctaagg ttgaacgcat tgagaagaga
      301 tgtctggagc tatttggccg tgactactgt ttcagcgtga ttccaaatgt gaatggtgat
      361 atctgcggcc actacccccg ccacatcgta ttcctggagt atgagagttc tgagaaagag
      421 aaagacacat ttcagagcac tgtgcaggtg aacaagttgc aagacctcat tcaccgaagc
      481 aagatggcca ggtgcagagg tcggtttgtc tgcccagtga tcctgttcaa aggcaagcat
      541 atttgcaggt cggccacact ggctggatgg ggagagctat atggacgctc gggatacaac
      601 tatttattct cagggggagc agatgatacc tgggcaagta cagaagatgt cacagaagag
      661 gactttgttc ttcggagtgg tgacacgcac ctttttgata aggtgagagg ctatgatatc
      721 aagctgcttc aatacctgtc agtcaagtac atctgtgacc tgatggtgga gaacaagaag
      781 gtgaagtttg gcatgaatgt aacctcctct gagaaggtgg acaaagccca gcgctatgca
      841 aacttcactc tcctctctat tccatatcca ggttgtgaat tcttcaagga atataaagat
      901 cgggattaca tggctgaagg gctcatattt aactggaagc aggactacgt cgatgcccca
      961 ttgaacatcc ccaacttcct gactcaatct ctgaacattg actggagcca gtatcagagt
     1021 tgggacctgg tgcaacaaac acagaactac ctgaaactgc tgcttttcat catgaacaga
     1081 gatgatgaca gcgggctgct ggtacactgt atctcaggct gggaccggac ccccctcttc
     1141 atctctcttc tgcgcctttc cttgtgggct gatgggctaa ttcacacatc cctgaagcct
     1201 gctgagatcc tctacctgac tgtggcctat gactggttcc tctttggaca catgttggta
     1261 gatcggctca gcaaagggga ggagattttc ttcttttgct tcaatttttt gaagcatatc
     1321 acctccgaag agttctgcct gaagacccag aggaggaaga gtttgccaac tcgggatgca
     1381 ggcttcactg tggaagatat ctgcatgttg agacacaaag atcgaggcag cacaaccagc
     1441 ctaggcagcg acttctccct ggtcttggag cactcaccgg gagctgtggg gagcttcagc
     1501 tatgagactg tggaacttgc cccggcagga gcaccaactc aggcagcttg gaggaagagt
     1561 cactcatcct ccccacagag tatgctctgg agccggccac agccctctga ggagcgccta
     1621 ccttcacacc atgggctcac tgaagccaag tcttctagct cttcatcctc aaaccattct
     1681 gacaactttt tcaggatggg cagcagtcct cttgaggtcc ccaaacccag atcagtggac
     1741 catcccctgc ccggatcctc tctctccaca gactttggca gctggcagct ggtatcgggc
     1801 tgtggcagta ttcaggaccg gcctgtcctg cacacagact cctctctccc tttcagcttc
     1861 caggatgagc tccctaacag ttgtctactt acagctctga gtgaccggga gacaaggctg
     1921 caggaggtgc ggtctgcctt cttggctgca tacagcagca cagtgggact tcgagcagca
     1981 acccccagtc cctctggtgc catcgggggc ctgctagaac agtttgcccg tggtgttggg
     2041 ctccggggca caagcaccag caccttgtga agctgacagc ccacagccat ttcccgcccc
     2101 tgtctcagct gagccctgtg gaatcaggcc aggcctggca aaaggggccc tggagagcag
     2161 gggaaatttc ccatccccct tctctgttgc acacatggca gccccaaacc tgagcaggcc
     2221 tgaggatggg actttctacc tcccaacctc ctgactggtg accactctcg ccactcactg
     2281 ccttccactg accctggtgt tcagattact gtcaactctc agaattgtgt tggagggtac
     2341 aggggcgttc ccagggcctc atggagatta taatgtcagc aaaaccccat tctgcaattt
     2401 ttgtttcctg ggaaggagaa tcacctgcac tgaaaatgag gcaatttcac actaatcaca
     2461 aaataaaagc aagttttttg aatggctttt cattagcatt tcatccggtt gtgaccgtcg
     2521 ttgagctgct cggaatcttc actgcctggc ctcgtgctga atgaagggtt ggagtttggg
     2581 ggagttacga agtaggattt atctctgttc cttctttgct ggggaaagaa acccgggctt
     2641 gtgtttataa gcaaataaat gctctaccac caagtc
//
