LOCUS       NP_081125                648 aa            linear   ROD 20-OCT-2024
DEFINITION  phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 isoform
            1 [Mus musculus].
ACCESSION   NP_081125 XP_132749
VERSION     NP_081125.2
DBSOURCE    REFSEQ: accession NM_026849.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 648)
  AUTHORS   Feng,Q., Li,X., Liu,R., Liu,G., He,Y. and Li,T.
  TITLE     Overexpression of MTMR14 induced learning and memory impairments in
            2-month-old C57 mice
  JOURNAL   Neurosci Lett 825, 137700 (2024)
   PUBMED   38401642
  REMARK    GeneRIF: Overexpression of MTMR14 induced learning and memory
            impairments in 2-month-old C57 mice.
REFERENCE   2  (residues 1 to 648)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 648)
  AUTHORS   Kong,L.Y., Liang,C., Li,P.C., Zhang,Y.W., Feng,S.D., Zhang,D.H.,
            Yao,R., Yang,L.L., Hao,Z.Y., Zhang,H., Tian,X.X., Guo,C.R.,
            Du,B.B., Dong,J.Z. and Zhang,Y.Z.
  TITLE     Myotubularin-Related Protein14 Prevents Neointima Formation and
            Vascular Smooth Muscle Cell Proliferation by Inhibiting Polo-Like
            Kinase1
  JOURNAL   J Am Heart Assoc 11 (21), e026174 (2022)
   PUBMED   36314496
  REMARK    GeneRIF: Myotubularin-Related Protein14 Prevents Neointima
            Formation and Vascular Smooth Muscle Cell Proliferation by
            Inhibiting Polo-Like Kinase1.
REFERENCE   4  (residues 1 to 648)
  AUTHORS   Pan,Q., Liu,Y., Wang,G., Wen,Z. and Wang,Y.
  TITLE     MTMR14 protects against cerebral stroke through suppressing
            PTEN-regulated autophagy
  JOURNAL   Biochem Biophys Res Commun 529 (4), 1045-1052 (2020)
   PUBMED   32819563
  REMARK    GeneRIF: MTMR14 protects against cerebral stroke through
            suppressing PTEN-regulated autophagy.
REFERENCE   5  (residues 1 to 648)
  AUTHORS   Li,S., Zhang,M. and Zhang,B.
  TITLE     MTMR14 protects against hepatic ischemia-reperfusion injury through
            interacting with AKT signaling in vivo and in vitro
  JOURNAL   Biomed Pharmacother 129, 110455 (2020)
   PUBMED   32768948
  REMARK    GeneRIF: MTMR14 protects against hepatic ischemia-reperfusion
            injury through interacting with AKT signaling in vivo and in vitro.
REFERENCE   6  (residues 1 to 648)
  AUTHORS   Romero-Suarez,S., Shen,J., Brotto,L., Hall,T., Mo,C.,
            Valdivia,H.H., Andresen,J., Wacker,M., Nosek,T.M., Qu,C.K. and
            Brotto,M.
  TITLE     Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with
            age and its loss accelerates skeletal muscle aging process by
            altering calcium homeostasis
  JOURNAL   Aging (Albany NY) 2 (8), 504-513 (2010)
   PUBMED   20817957
  REMARK    GeneRIF: a knockout mice were more susceptible to exercise-induced
            muscle damage, a trademark of muscle functional changes in older
            subjects
REFERENCE   7  (residues 1 to 648)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   8  (residues 1 to 648)
  AUTHORS   Shen,J., Yu,W.M., Brotto,M., Scherman,J.A., Guo,C., Stoddard,C.,
            Nosek,T.M., Valdivia,H.H. and Qu,C.K.
  TITLE     Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by
            disrupting Ca(2+) homeostasis
  JOURNAL   Nat Cell Biol 11 (6), 769-776 (2009)
   PUBMED   19465920
  REMARK    GeneRIF: Data report that mice deficient in the newly identified
            phosphatidylinositol phosphate phosphatase MIP/MTMR14
            (muscle-specific inositol phosphatase) show muscle weakness and
            fatigue.
REFERENCE   9  (residues 1 to 648)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   10 (residues 1 to 648)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX207820.1, CD805346.1, DV648379.1, DV653632.1, DV653288.1 and
            BB256623.2.
            
            On Dec 27, 2007 this sequence version replaced NP_081125.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.295062.1, BC018294.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.74 cM"
     Protein         1..648
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR14 isoform 1"
                     /EC_number="3.1.3.95"
                     /note="mJumpy; phosphatidylinositol-3-phosphate
                     phosphatase; phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR14"
                     /calculated_mol_wt=72312
     Region          1..27
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VEL2.2)"
     Region          127..243
                     /region_name="PH-GRAM_MTMR14"
                     /note="Myotubularian (MTM) related 14 protein (MTMR14)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; cd13213"
                     /db_xref="CDD:275400"
     Site            193
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q8NCE2; propagated from
                     UniProtKB/Swiss-Prot (Q8VEL2.2)"
     Site            225
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VEL2.2)"
     Site            240
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VEL2.2)"
     Region          <293..386
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     Region          471..544
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VEL2.2)"
     Site            516
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NCE2; propagated from
                     UniProtKB/Swiss-Prot (Q8VEL2.2)"
     Site            517
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VEL2.2)"
     Site            528
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VEL2.2)"
     Site            578
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NCE2; propagated from
                     UniProtKB/Swiss-Prot (Q8VEL2.2)"
     Site            622
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NCE2; propagated from
                     UniProtKB/Swiss-Prot (Q8VEL2.2)"
     Site            636
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q8NCE2; propagated from
                     UniProtKB/Swiss-Prot (Q8VEL2.2)"
     CDS             1..648
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /coded_by="NM_026849.2:124..2070"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS20412.2"
                     /db_xref="GeneID:97287"
                     /db_xref="MGI:MGI:1916075"
ORIGIN      
        1 magaraaaaa sagstassgs pppqepglwe lleefsrtqy rakdsggksg skveriekrc
       61 lelfgrdycf svipnvngdi cghyprhivf leyessekek dtfqstvqvn klqdlihrsk
      121 marcrgrfvc pvilfkgkhi crsatlagwg elygrsgyny lfsggaddtw astedvteed
      181 fvlrsgdthl fdkvrgydik llqylsvkyi cdlmvenkkv kfgmnvtsse kvdkaqryan
      241 ftllsipypg ceffkeykdr dymaeglifn wkqdyvdapl nipnfltqsl nidwsqyqsw
      301 dlvqqtqnyl klllfimnrd ddsgllvhci sgwdrtplfi sllrlslwad glihtslkpa
      361 eilyltvayd wflfghmlvd rlskgeeiff fcfnflkhit seefclktqr rkslptrdag
      421 ftvedicmlr hkdrgsttsl gsdfslvleh spgavgsfsy etvelapaga ptqaawrksh
      481 ssspqsmlws rpqpseerlp shhglteaks ssssssnhsd nffrmgsspl evpkprsvdh
      541 plpgsslstd fgswqlvsgc gsiqdrpvlh tdsslpfsfq delpnscllt alsdretrlq
      601 evrsaflaay sstvglraat pspsgaiggl leqfargvgl rgtststl
//
