LOCUS       NM_001362185            2276 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus myotubularin related protein 14 (Mtmr14), transcript
            variant 4, mRNA.
ACCESSION   NM_001362185
VERSION     NM_001362185.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2276)
  AUTHORS   Feng,Q., Li,X., Liu,R., Liu,G., He,Y. and Li,T.
  TITLE     Overexpression of MTMR14 induced learning and memory impairments in
            2-month-old C57 mice
  JOURNAL   Neurosci Lett 825, 137700 (2024)
   PUBMED   38401642
  REMARK    GeneRIF: Overexpression of MTMR14 induced learning and memory
            impairments in 2-month-old C57 mice.
REFERENCE   2  (bases 1 to 2276)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2276)
  AUTHORS   Kong,L.Y., Liang,C., Li,P.C., Zhang,Y.W., Feng,S.D., Zhang,D.H.,
            Yao,R., Yang,L.L., Hao,Z.Y., Zhang,H., Tian,X.X., Guo,C.R.,
            Du,B.B., Dong,J.Z. and Zhang,Y.Z.
  TITLE     Myotubularin-Related Protein14 Prevents Neointima Formation and
            Vascular Smooth Muscle Cell Proliferation by Inhibiting Polo-Like
            Kinase1
  JOURNAL   J Am Heart Assoc 11 (21), e026174 (2022)
   PUBMED   36314496
  REMARK    GeneRIF: Myotubularin-Related Protein14 Prevents Neointima
            Formation and Vascular Smooth Muscle Cell Proliferation by
            Inhibiting Polo-Like Kinase1.
REFERENCE   4  (bases 1 to 2276)
  AUTHORS   Pan,Q., Liu,Y., Wang,G., Wen,Z. and Wang,Y.
  TITLE     MTMR14 protects against cerebral stroke through suppressing
            PTEN-regulated autophagy
  JOURNAL   Biochem Biophys Res Commun 529 (4), 1045-1052 (2020)
   PUBMED   32819563
  REMARK    GeneRIF: MTMR14 protects against cerebral stroke through
            suppressing PTEN-regulated autophagy.
REFERENCE   5  (bases 1 to 2276)
  AUTHORS   Li,S., Zhang,M. and Zhang,B.
  TITLE     MTMR14 protects against hepatic ischemia-reperfusion injury through
            interacting with AKT signaling in vivo and in vitro
  JOURNAL   Biomed Pharmacother 129, 110455 (2020)
   PUBMED   32768948
  REMARK    GeneRIF: MTMR14 protects against hepatic ischemia-reperfusion
            injury through interacting with AKT signaling in vivo and in vitro.
REFERENCE   6  (bases 1 to 2276)
  AUTHORS   Romero-Suarez,S., Shen,J., Brotto,L., Hall,T., Mo,C.,
            Valdivia,H.H., Andresen,J., Wacker,M., Nosek,T.M., Qu,C.K. and
            Brotto,M.
  TITLE     Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with
            age and its loss accelerates skeletal muscle aging process by
            altering calcium homeostasis
  JOURNAL   Aging (Albany NY) 2 (8), 504-513 (2010)
   PUBMED   20817957
  REMARK    GeneRIF: a knockout mice were more susceptible to exercise-induced
            muscle damage, a trademark of muscle functional changes in older
            subjects
REFERENCE   7  (bases 1 to 2276)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   8  (bases 1 to 2276)
  AUTHORS   Shen,J., Yu,W.M., Brotto,M., Scherman,J.A., Guo,C., Stoddard,C.,
            Nosek,T.M., Valdivia,H.H. and Qu,C.K.
  TITLE     Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by
            disrupting Ca(2+) homeostasis
  JOURNAL   Nat Cell Biol 11 (6), 769-776 (2009)
   PUBMED   19465920
  REMARK    GeneRIF: Data report that mice deficient in the newly identified
            phosphatidylinositol phosphate phosphatase MIP/MTMR14
            (muscle-specific inositol phosphatase) show muscle weakness and
            fatigue.
REFERENCE   9  (bases 1 to 2276)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   10 (bases 1 to 2276)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153592.3 and AC155287.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.11934.1,
                                           SRR7345562.2908513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AC153592.3         17245-17523         c
            280-388             AC153592.3         5387-5495           c
            389-464             AC153592.3         1560-1635           c
            465-525             AC153592.3         1216-1276           c
            526-553             AC155287.6         88891-88918
            554-627             AC155287.6         90098-90171
            628-698             AC155287.6         93663-93733
            699-773             AC155287.6         94281-94355
            774-840             AC155287.6         98519-98585
            841-926             AC155287.6         99045-99130
            927-1003            AC155287.6         99335-99411
            1004-1040           AC155287.6         99634-99670
            1041-1108           AC155287.6         101703-101770
            1109-1167           AC155287.6         102576-102634
            1168-1306           AC155287.6         102807-102945
            1307-1486           AC155287.6         103597-103776
            1487-2276           AC155287.6         113678-114467
FEATURES             Location/Qualifiers
     source          1..2276
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.74 cM"
     gene            1..2276
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /note="myotubularin related protein 14"
                     /db_xref="GeneID:97287"
                     /db_xref="MGI:MGI:1916075"
     exon            1..279
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            280..388
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            389..464
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             432..1670
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /EC_number="3.1.3.95"
                     /note="isoform 4 is encoded by transcript variant 4;
                     mJumpy; phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase
                     MTMR14"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR14 isoform 4"
                     /protein_id="NP_001349114.1"
                     /db_xref="GeneID:97287"
                     /db_xref="MGI:MGI:1916075"
                     /translation="MDARDTTIYSQGEQMIPGQVQKMSQKRTLFFGVVTRTFLISVTS
                     SEKVDKAQRYANFTLLSIPYPGCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLNIPNFL
                     TQSLNIDWSQYQSWDLVQQTQNYLKLLLFIMNRDDDSGLLVHCISGWDRTPLFISLLR
                     LSLWADGLIHTSLKPAEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSE
                     EFCLKTQRRKSLPTRDAGFTVEDICMLRHKDRGSTTSLGSDFSLVLEHSPGAVGSFSY
                     ETVELAPAGAPTQAAWRKSHSSSPQSMLWSRPQPSEERLPSHHGLTEAKSSSSSSSNH
                     SDNFFRMGSSPLEVPKPRLTALSDRETRLQEVRSAFLAAYSSTVGLRAATPSPSGAIG
                     GLLEQFARGVGLRGTSTSTL"
     exon            465..525
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            526..553
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            554..627
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            628..698
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            699..773
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            774..840
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            841..926
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1003
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1040
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1108
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1167
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1306
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1486
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..2276
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2062..2067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2086
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /note="major polyA site"
     regulatory      2254..2259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2273
                     /gene="Mtmr14"
                     /gene_synonym="1110061O04Rik"
ORIGIN      
        1 gcggggccgg aagtggaaga agaaggcggc ggctgagtcg gttcaggagg ttttagagcc
       61 ggagtccgag cttcaggtgc catgggctgg gggaaggcgc cctgagggga ctcgaggctg
      121 tgcatggcgg gtgctcgggc cgccgccgcc gcctcggcgg gttccaccgc ctcgtcgggc
      181 agcccgccgc ctcaggagcc cgggctctgg gagctgctgg aggagttctc ccggactcag
      241 taccgtgcca aggacagcgg cgggaagagc ggctctaaga tttcagagca ctgtgcaggt
      301 gaacaagttg caagacctca ttcaccgaag caagatggcc aggtgcagag gtcggtttgt
      361 ctgcccagtg atcctgttca aaggcaagca tatttgcagg tcggccacac tggctggatg
      421 gggagagcta tatggacgct cgggatacaa ctatttattc tcagggggag cagatgatac
      481 ctgggcaagt acagaagatg tcacagaaga ggactttgtt cttcggagtg gtgacacgca
      541 cctttttgat aagtgtaacc tcctctgaga aggtggacaa agcccagcgc tatgcaaact
      601 tcactctcct ctctattcca tatccaggtt gtgaattctt caaggaatat aaagatcggg
      661 attacatggc tgaagggctc atatttaact ggaagcagga ctacgtcgat gccccattga
      721 acatccccaa cttcctgact caatctctga acattgactg gagccagtat cagagttggg
      781 acctggtgca acaaacacag aactacctga aactgctgct tttcatcatg aacagagatg
      841 atgacagcgg gctgctggta cactgtatct caggctggga ccggaccccc ctcttcatct
      901 ctcttctgcg cctttccttg tgggctgatg ggctaattca cacatccctg aagcctgctg
      961 agatcctcta cctgactgtg gcctatgact ggttcctctt tggacacatg ttggtagatc
     1021 ggctcagcaa aggggaggag attttcttct tttgcttcaa ttttttgaag catatcacct
     1081 ccgaagagtt ctgcctgaag acccagagga ggaagagttt gccaactcgg gatgcaggct
     1141 tcactgtgga agatatctgc atgttgagac acaaagatcg aggcagcaca accagcctag
     1201 gcagcgactt ctccctggtc ttggagcact caccgggagc tgtggggagc ttcagctatg
     1261 agactgtgga acttgccccg gcaggagcac caactcaggc agcttggagg aagagtcact
     1321 catcctcccc acagagtatg ctctggagcc ggccacagcc ctctgaggag cgcctacctt
     1381 cacaccatgg gctcactgaa gccaagtctt ctagctcttc atcctcaaac cattctgaca
     1441 actttttcag gatgggcagc agtcctcttg aggtccccaa acccagactt acagctctga
     1501 gtgaccggga gacaaggctg caggaggtgc ggtctgcctt cttggctgca tacagcagca
     1561 cagtgggact tcgagcagca acccccagtc cctctggtgc catcgggggc ctgctagaac
     1621 agtttgcccg tggtgttggg ctccggggca caagcaccag caccttgtga agctgacagc
     1681 ccacagccat ttcccgcccc tgtctcagct gagccctgtg gaatcaggcc aggcctggca
     1741 aaaggggccc tggagagcag gggaaatttc ccatccccct tctctgttgc acacatggca
     1801 gccccaaacc tgagcaggcc tgaggatggg actttctacc tcccaacctc ctgactggtg
     1861 accactctcg ccactcactg ccttccactg accctggtgt tcagattact gtcaactctc
     1921 agaattgtgt tggagggtac aggggcgttc ccagggcctc atggagatta taatgtcagc
     1981 aaaaccccat tctgcaattt ttgtttcctg ggaaggagaa tcacctgcac tgaaaatgag
     2041 gcaatttcac actaatcaca aaataaaagc aagttttttg aatggctttt cattagcatt
     2101 tcatccggtt gtgaccgtcg ttgagctgct cggaatcttc actgcctggc ctcgtgctga
     2161 atgaagggtt ggagtttggg ggagttacga agtaggattt atctctgttc cttctttgct
     2221 ggggaaagaa acccgggctt gtgtttataa gcaaataaat gctctaccac caagtc
//
