LOCUS       NM_172958               4584 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus myotubularin related protein 12 (Mtmr12), transcript
            variant 1, mRNA.
ACCESSION   NM_172958
VERSION     NM_172958.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4584)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4584)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 4584)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   4  (bases 1 to 4584)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   5  (bases 1 to 4584)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150560.5.
            
            On Oct 6, 2017 this sequence version replaced NM_172958.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054352.1, AK030139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               AC150560.5         94224-94475         c
            253-313             AC150560.5         69169-69229         c
            314-459             AC150560.5         66602-66747         c
            460-532             AC150560.5         65577-65649         c
            533-663             AC150560.5         63355-63485         c
            664-754             AC150560.5         61484-61574         c
            755-884             AC150560.5         54390-54519         c
            885-960             AC150560.5         48075-48150         c
            961-1067            AC150560.5         41770-41876         c
            1068-1192           AC150560.5         40961-41085         c
            1193-1271           AC150560.5         39857-39935         c
            1272-1342           AC150560.5         37592-37662         c
            1343-1515           AC150560.5         35606-35778         c
            1516-1683           AC150560.5         33792-33959         c
            1684-1845           AC150560.5         32735-32896         c
            1846-4584           AC150560.5         27263-30001         c
FEATURES             Location/Qualifiers
     source          1..4584
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.9 cM"
     gene            1..4584
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /note="myotubularin related protein 12"
                     /db_xref="GeneID:268783"
                     /db_xref="MGI:MGI:2443034"
     exon            1..252
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2415
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol-3-phosphatase associated protein;
                     phosphatidylinositol-3 phosphate 3-phosphatase adaptor
                     subunit; inactive phosphatidylinositol 3-phosphatase 12"
                     /codon_start=1
                     /product="myotubularin-related protein 12 isoform 1"
                     /protein_id="NP_766546.1"
                     /db_xref="CCDS:CCDS27388.1"
                     /db_xref="GeneID:268783"
                     /db_xref="MGI:MGI:2443034"
                     /translation="MLGKGGVGGGGGTKAPKPSFVSYVRPEEIHTDEKEVTEKEVTLH
                     LLPGEQLLCEASTVLKYVQEDSCQRGVYGRLVCTDFKISFLGDEDSALDNGGEAQFKN
                     KIIGVNDVPLHCVDQIYGVFDEKKKPLFGQLKKYPEKLVIHCKDLRVLHFCLRYTKEE
                     EVKRIVSGIIHHTQSPKLLKRLFLFSYAAAVHGTATDSRNCTVMFDTPKDWCWELERT
                     KGSVKYRTVSVNEGYRVSDRLPAYFVVPTPLPEDDVRRFQGHGIPIWCWSCHNGSALL
                     KMSALPKEQDDGALQVQKSFLDGIYKTIHRPPYEMVKTEDLSSNFLSLQEIQSAYCKF
                     KQLFLIDNSSEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECLEAQNVNVLLLEE
                     NASDLCCLLSSLVQVMMDAHCRTRTGFQSLIQKEWVMGGHSFLDRCNHLHQSDKEEVP
                     IFLLFLDCVWQLVHQYPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREN
                     LDAQSKPLTLLTVWDWSVQFEPKAQTLLRNPLYVEKPKLDRGQQKGSRFKHQRQLSLP
                     LTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDDLQDSSREFYDSWHSKPTDYH
                     GLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGRVATMGKLLEMMEEVQSLQEKIEARH
                     HRQEAVHAEAPGLLRNSVRLSSLFPFALLQRHSAKPVLPTSGWKALGGEDDLAKREDE
                     FVDLGDV"
     exon            253..313
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            314..459
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            460..532
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            533..663
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            664..754
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            755..884
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            885..960
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1067
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1192
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1271
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1342
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1515
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1683
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1845
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..4584
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4315..4320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /note="hexamer: AATAAG"
     polyA_site      4339
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /note="major polyA site"
     regulatory      4438..4443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /note="hexamer: ATTAAA"
     polyA_site      4461
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /note="major polyA site"
     regulatory      4560..4565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /note="hexamer: ATTAAA"
     polyA_site      4583
                     /gene="Mtmr12"
                     /gene_synonym="3Pap; 4932703C11; C730015A02Rik; mKIAA1682;
                     Pip3ap"
                     /note="major polyA site"
ORIGIN      
        1 gtcagcggcg gagccggatg cgggcggtac tgctgccgcc gccgcggccc tagggatggg
       61 cggagccccg gccgctggtg ctggtggccg ccgccgctgc cggaacctga gccggagccg
      121 ccgcctctgc tgtcgccgcg cttcggcttc gttgcttcgc aaggcggcgg gatgctgggg
      181 aaagggggag tcggcggtgg cggcggcacc aaggcgccca agccctcctt cgtgtcgtac
      241 gtacgccctg aggaaattca cacagatgaa aaggaagtaa cagagaagga agtcactctt
      301 cacttgttgc caggtgaaca gctgctttgt gaagccagca cagtcctgaa gtatgtgcag
      361 gaagattcgt gtcagcgcgg cgtctatggg agactcgtgt gcactgactt caagatttcc
      421 ttcctggggg acgaggactc ggccctggat aatggcgggg aagctcagtt taagaataag
      481 atcataggag taaatgacgt gccactgcac tgtgtggatc agatttatgg agtgtttgat
      541 gagaaaaaga aacctctgtt tggacaactg aagaagtacc ccgagaagct cgttatccat
      601 tgcaaagacc tgcgggtgct ccacttctgt ctgaggtaca caaaggagga ggaagtcaaa
      661 aggatcgtca gtggcataat ccatcatacc cagagcccca aactgctgaa aagactgttt
      721 ctgttctcct acgccgctgc tgtgcacggc actgccactg attccaggaa ctgtactgta
      781 atgtttgaca ctccgaaaga ctggtgttgg gagctggagc ggaccaaggg tagtgtgaag
      841 tacagaacag tgagtgtgaa tgaaggctac cgagtctctg acaggttgcc agcatacttc
      901 gttgtcccca ctccccttcc ggaagacgat gtgaggcgtt ttcagggcca tggtatacca
      961 atctggtgtt ggtcctgtca caatggaagt gcccttttga aaatgtcagc actgcccaaa
     1021 gaacaggatg acggtgcttt gcaagttcag aagagcttct tggatggaat ttacaagact
     1081 atccacaggc caccctacga gatggttaaa actgaagact tatcaagcaa cttcctgtcc
     1141 ctgcaggaga tccagagtgc atactgtaaa tttaagcaac tgtttctgat agataacagt
     1201 tcggaatttt gggacacaga cataaaatgg ttttctctct tagaaagcag cagctggctt
     1261 gatataatca gacgctgcct gaagaaagca atcgagatta cggaatgcct ggaagcgcag
     1321 aacgtgaacg tcctcctgtt ggaagagaat gcttctgatc tctgctgcct cctctcctct
     1381 ctggtgcaag tgatgatgga cgcccactgt cgaaccagga ctggattcca gagcctcatc
     1441 caaaaggaat gggtcatggg tggccactct ttcttggacc gctgtaacca tctccaccag
     1501 agtgacaaag aggaggtccc tatcttcctg cttttcttgg actgcgtctg gcagctggtg
     1561 caccagtatc ccccagcatt tgagttcaca gagacatacc tgactgtttt gtcagatagc
     1621 ctgtatatac ctatttttag caccttcttc ttcaattcac ctcatcaaaa agatactaac
     1681 atgggtaggg aaaacctgga tgcacaaagc aagcctttga ctctgctcac cgtgtgggac
     1741 tggtcagtac agtttgaacc caaagcacag acgttactta gaaaccctct ctatgtggaa
     1801 aagccaaaac tggacagagg ccagcagaaa ggatcacgtt tcaaacatca acgacaactt
     1861 tctttgccac ttacccagtc taagtcatct cccaaaagag gatttttcag ggaagaaaca
     1921 gatcatttaa tcaagaacct cctaggcaag agaattagta aacttattaa ctcttccgat
     1981 gacctccagg acagctcaag ggagttctac gacagctggc atagcaagcc cacagactac
     2041 cacggcctgt tgttgcctca cattgagggg ccggaaatca aggtgtgggc tcagcgctat
     2101 ttacgttgga ttccagaagc ccaaatcctg ggtggtggca gagtggccac catgggcaaa
     2161 ctcttagaga tgatggagga agtgcagagc ttgcaggaga agatagaggc aagacaccac
     2221 aggcaggagg ctgtccatgc agaggcaccc ggcctgctca ggaactcagt ccgcctgtct
     2281 tccttgttcc cctttgcact gctccagcga cattcggcca agcctgtctt acccaccagt
     2341 ggctggaaag ctttaggagg cgaagatgac ctggccaaac gagaagatga gtttgtggac
     2401 ctaggggacg tgtgacctgt ctcctcaggg actgtgaaag aggcacactg tatggtggga
     2461 cagttgttcc ctggactggt gtcacggtgt tagcccagtg gtgtgaagga aagagcagag
     2521 gcttttggga agagagcttg ttctcctttt cttccacagt tctggaagac attcaatgaa
     2581 agccatgcct ctagtatgca taggacggag ttcctccttg acctgtcata ggatggggtc
     2641 gtctcctgac atctgtatta tatgtataca gaatggctca cggccaggct gctgtgagag
     2701 ctccctcctg ttgtttctgt gccaagataa ttatgtagcc attccgaaca agaggtattc
     2761 agggatgtgc ttagaccata gcatattcct tgacttaaac catagcatat tccaatgcgt
     2821 gcgtgtacac acacacacac acacacacac acacacacac acacacacgc agcccataga
     2881 gaacttggac agttctgctg gtgtcatcca tcctaatgtt cagcccctcc ttcctgggct
     2941 gtaacaacac aggatgcggg cagcctcctt cccttttcct ttgctgtcac tcccaccttc
     3001 ccttttcctg ctctatgcat accatcctat gagtctacct tggtgtgcat cgtcccaggg
     3061 tcctgctgct gtgacctgtt gattaaactg ggggcagtcc tctgtcttcc acaggggagc
     3121 tcattcctgg agccctcagt tttgaccaca catttggccc tctgctcacc acacctggac
     3181 tgtgcctctc tgcagcccct cagctggtcc ccttgccttc cccgttaccc tcacagatgc
     3241 tggggtgggc aggccaattc gaatgtggct ttcacaggaa agcggtcgtg tcagaagcag
     3301 ttatcactca tatatgcctc agcgatgtca aaagccatag aagaaaccca gctctgccta
     3361 gtcaccttgg atctgctgtc ttaaagatat atattttttt aatgtttgaa agaatccttt
     3421 gtaaggctca gtcctatcat tctcaacaga gccctgttca gtcccacaaa cggtgtgaag
     3481 agtgggagtg ggcgagggac ctcattgagt ctgcctcaag tgtttgcctt ttatctatat
     3541 ttgctggtca ggagaggtcc tgttgagggc gtctctgttg ctcatgggca ataagacatt
     3601 ttgaaacttc acaaagaatc ctttctgatt gcactgaatc atctttcata cataatgata
     3661 atttttcctc gtctccctcc ataataatgc acaatccggg ttggtgtgtt gacccagcaa
     3721 gttgagggga ggtcaggatt tgtgtttctg gggacaaatg cactcagtct cggttgcctt
     3781 aagagtcttt caggccaggt tcgtgctagg cttgcgctag gaacttagaa cacaccagtc
     3841 cttagctccc tctccctggg ctccttgggc ttctctaaac tagcactaac cgccacgccc
     3901 tgagcctctg ccacaccctc agcctctgcc tcccaagtcc tcagcggaga gaactatttt
     3961 tgttaccata ttataacgtg aatgtttata tggtagactc tacagtctta gtgattttct
     4021 ttccaaaaaa tgcctcttgt gatgttttgt acttcacaac gtatggttta aaggcacatg
     4081 gtcatgaccc ttggtatagc agttgaatgt gcattaaaat atttttctat ttttttaaat
     4141 cacaatagaa aaagtaaata agctgttatg acctgtgtgg ttatgactta tgtatttata
     4201 tttgaagcca gatttctata acttggattt gtgtacagaa cttcccgtgg gtttatatat
     4261 tgtgtatttt tattcaagat tgagatgtgg attatgctta acattaaaag atacaataag
     4321 accatttgtt taaaacacac tgtgcaagtt tggaagtgtc tgttaataat ttactgtgta
     4381 taacacttgc atttgtttat acctctatgt ttttacactg aagataaact agctttaatt
     4441 aaattttaaa aatttaaggg attaagctat tagactgagt cagcttcact gtgcagttta
     4501 ttttctgggt gttaatgaaa gtttatacat gtctcactgc attggagctg actgcagaga
     4561 ttaaagcaca actttgaaac agcg
//
