LOCUS       NM_001313702            4754 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus myotubularin related protein 1 (Mtmr1), transcript
            variant 4, mRNA.
ACCESSION   NM_001313702 XM_006528129
VERSION     NM_001313702.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4754)
  AUTHORS   Gendrel AV, Tang YA, Suzuki M, Godwin J, Nesterova TB, Greally JM,
            Heard E and Brockdorff N.
  TITLE     Epigenetic functions of smchd1 repress gene clusters on the
            inactive X chromosome and on autosomes
  JOURNAL   Mol Cell Biol 33 (16), 3150-3165 (2013)
   PUBMED   23754746
REFERENCE   2  (bases 1 to 4754)
  AUTHORS   Licatalosi DD, Yano M, Fak JJ, Mele A, Grabinski SE, Zhang C and
            Darnell RB.
  TITLE     Ptbp2 represses adult-specific splicing to regulate the generation
            of neuronal precursors in the embryonic brain
  JOURNAL   Genes Dev 26 (14), 1626-1642 (2012)
   PUBMED   22802532
REFERENCE   3  (bases 1 to 4754)
  AUTHORS   Kalsotra A, Xiao X, Ward AJ, Castle JC, Johnson JM, Burge CB and
            Cooper TA.
  TITLE     A postnatal switch of CELF and MBNL proteins reprograms alternative
            splicing in the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 105 (51), 20333-20338 (2008)
   PUBMED   19075228
REFERENCE   4  (bases 1 to 4754)
  AUTHORS   Blewitt ME, Gendrel AV, Pang Z, Sparrow DB, Whitelaw N, Craig JM,
            Apedaile A, Hilton DJ, Dunwoodie SL, Brockdorff N, Kay GF and
            Whitelaw E.
  TITLE     SmcHD1, containing a structural-maintenance-of-chromosomes hinge
            domain, has a critical role in X inactivation
  JOURNAL   Nat Genet 40 (5), 663-669 (2008)
   PUBMED   18425126
REFERENCE   5  (bases 1 to 4754)
  AUTHORS   Buj-Bello A, Furling D, Tronchere H, Laporte J, Lerouge T,
            Butler-Browne GS and Mandel JL.
  TITLE     Muscle-specific alternative splicing of myotubularin-related 1 gene
            is impaired in DM1 muscle cells
  JOURNAL   Hum Mol Genet 11 (19), 2297-2307 (2002)
   PUBMED   12217958
REFERENCE   6  (bases 1 to 4754)
  AUTHORS   Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N and
            Mandel JL.
  TITLE     Characterization of the myotubularin dual specificity phosphatase
            gene family from yeast to human
  JOURNAL   Hum Mol Genet 7 (11), 1703-1712 (1998)
   PUBMED   9736772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC056376.1, CJ135661.1, AL772294.6 and BE956969.1.
            
            [WARNING] On Dec 6, 2023 this sequence was replaced by
            NM_001313702.2.
            
            On Aug 27, 2015 this sequence version replaced XM_006528129.2.
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest isoform (D).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849390,
                              SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: PMID: 12217958
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BC056376.1         1-39
            40-443              CJ135661.1         42-445
            444-470             AL772294.6         77544-77570
            471-735             BE956969.1         243-507
            736-4754            BC056376.1         634-4652
FEATURES             Location/Qualifiers
     source          1..4754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 36.75 cM"
     gene            1..4754
                     /gene="Mtmr1"
                     /note="myotubularin related protein 1"
                     /db_xref="GeneID:53332"
                     /db_xref="MGI:MGI:1858271"
     exon            1..313
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2267
                     /gene="Mtmr1"
                     /EC_number="3.1.3.64"
                     /EC_number="3.1.3.95"
                     /note="isoform D is encoded by transcript variant 4;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase"
                     /codon_start=1
                     /product="myotubularin-related protein 1 isoform D"
                     /protein_id="NP_001300631.1"
                     /db_xref="GeneID:53332"
                     /db_xref="MGI:MGI:1858271"
                     /translation="MDRPVAAAAAASAASCEGAGGPGPGPGASWRPSRVAGGASASSR
                     HPSIETLDSPTGSHVEWCKQLIAATISSQISGSVTSENVSRDYKVFRRPDTRNIHKAR
                     QRLELEEEHNGYPSEAEADQALRDGNKLAQMEEAPLFPGESIKAIVKDVIYICPFMGA
                     VSGTLTVTDFKMYFKNVERDPHFVLDVPLGVISRVEKIGAQSHGDNSCGIEIVCKDMR
                     NLRLAYKQEEQRKLGIFENLNKHAFPLSNGQVLFAFNYKEKFPVNGWKVYDPVSEYKR
                     QGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFRAKGRVPVLSWIHP
                     ESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLTIFDARQNSVADTNKAK
                     GGGYENESAYPNAELIFLEIHNIHVMRESLRKLKEIVYPSIDESHWLSNVDGTHWLEY
                     IRVLLAGAVRIADKIESGKTSVVIHCSDGWDRTSQLTSLAMLMLDSYYRTIKGFEALI
                     EKEWISFGHRFALRVGHGDDNHADADRSPIFLQFIDCVWQMTRQFPSAFEFNELFLIT
                     ILDHLYSCLFGTFLCNCEQQRIKEDVYTNTISLWSYINSQLDEFSNPFFVNYENHVLY
                     PVASMSHLELWVNYYVRWNPRMRPQMPIHQNLKELLAIKAELQKRVEDLQREMATRTI
                     SSSSERGSSPTHSATPVHTSV"
     exon            314..419
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..443
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..470
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..521
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..597
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..692
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..800
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..902
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..986
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1136
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1325
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1511
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1718
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1811
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1925
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2102
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..4736
                     /gene="Mtmr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtaacgcg gggccgccag gtgacagcta atggcggcgg ccgcttgacg cgagcggtca
       61 agcagcgaag cagggcggca gggggcgcgt cggggagcct ggctgccgct gcactccgga
      121 ctgtggctca ccggaggcgc cgggcttgac gcgtcatgga caggccagtg gcggcggcgg
      181 ccgccgcatc tgcggcgagc tgcgagggcg ctgggggccc ggggccaggg ccgggcgcta
      241 gctggagacc ctctcgggtt gcggggggcg cctcggccag ctcccggcac cccagcattg
      301 agacccttga cagtcctaca gggtcacatg ttgaatggtg taaacagctt atagctgcta
      361 caatttctag tcagatttca ggttcagtga catcagaaaa tgtgtcaaga gattacaagg
      421 ttttcaggag gcctgatacc aggaatattc ataaagcaag acaaagattg gagctagagg
      481 aagaacacaa tggctaccct tctgaagctg aagctgatca ggctctaagg gatggaaata
      541 aactggcaca gatggaagaa gctccacttt tcccaggaga atcaattaag gccattgtga
      601 aagacgtcat ttatatctgt ccatttatgg gagcagtgag tgggaccctg acagtgacgg
      661 actttaaaat gtacttcaaa aatgtagaaa gggacccaca tttcgtcctt gatgttcctc
      721 ttggagtgat cagcagagtg gagaagattg gtgcacagag ccatggggat aattcttgtg
      781 gtatagagat tgtgtgcaag gatatgagga acctgagact tgcatataag caggaagaac
      841 agcgaaaact tgggatattt gaaaacctca acaagcatgc ttttcctctt tccaatgggc
      901 aggtgctatt tgcattcaac tataaagaaa agtttccagt taatggctgg aaagtttatg
      961 atccagtgtc tgaatataag agacagggct tgccaaatga gagttggaaa atatcaaaaa
     1021 taaacagtaa ttatgagttc tgtgatacct atcctgccat cattgttgtg ccaactagtg
     1081 tgaaagatga tgacctttca aaagtggcag cctttcgagc gaaaggcaga gtccctgtgt
     1141 tgtcatggat tcacccagaa agtcaggcaa caattacacg ttgcagccag ccattagtgg
     1201 gtcccaatga taaacgctgc aaagaagatg agaaatacct gcagacaata atggatgcta
     1261 atgcacagtc acataaactt actatctttg atgccagaca aaacagcgtt gctgatacca
     1321 acaaggcaaa gggtggtgga tatgaaaatg aaagtgctta ccctaatgcc gaactcatat
     1381 tcttggagat ccacaatatt catgtgatga gggagtcact tcgtaaatta aaggagattg
     1441 tgtatccttc aattgatgag tcacattggc tatccaatgt ggatgggaca cattggctgg
     1501 aatatatacg ggttctcctt gctggggcag tgagaattgc tgataaaata gaatctggga
     1561 aaacttccgt ggtcatccac tgcagtgatg ggtgggatcg aacatcccag ctcacatctc
     1621 tggcaatgct gatgttagac agttattacc ggaccattaa aggatttgag gctctcatag
     1681 aaaaggagtg gataagcttt ggacacaggt ttgccctgag agtgggccat ggtgatgaca
     1741 accatgcaga tgctgaccga tcacctatat ttcttcagtt tattgattgt gtttggcaga
     1801 tgacaagaca gttcccttca gcatttgagt ttaatgaatt attcttgatt acaattttgg
     1861 atcacctcta tagttgtctt tttgggacct ttttgtgcaa ctgtgaacaa cagcgaatca
     1921 aagaggatgt atatacaaat actatatctt tatggtctta tatcaatagc caactagatg
     1981 aattctcaaa tcccttcttt gtgaattatg agaaccatgt gttatatcct gttgctagta
     2041 tgagtcactt ggaattgtgg gtaaattatt atgtacggtg gaatccacgg atgagaccac
     2101 agatgccaat tcatcagaat ctcaaggaac tgctggctat caaggctgag ctgcagaagc
     2161 gtgtggagga cttgcagcgg gagatggcca cccggaccat ctcatcttcc tctgagaggg
     2221 gctcctcacc tacccactca gctactcctg tacacacctc agtctgatga acaaagccag
     2281 taccccgggc catccggctg ctctattgtc ttccagcagc tcggggacct ggccattgat
     2341 attatggttc tagcttgtca tcttagctct taggactcag cccagggacc atttgtgggt
     2401 ggtgaaagct cctattatta acaagtactt cttttgtgtg aacagcctgt gccccttttg
     2461 cgagcagcct caccctgtga accacctgtg tcttgtacag gtagcttggg agaaaccaga
     2521 ttgaatgcag tgcggtattt taacttaaga gaatcttaca ccacttcttt ccaagttaca
     2581 tcctttgtta cgaacaactc gtttacttat agaacacatc accagccatg tggctcctct
     2641 cagccttttg gcacaattta aaaactgttt taaatgaaat gttagtgtgg caaatgaacc
     2701 attgccacct gttctacagt tatcagttat cttcatacaa gaagtcctgt tcaactggta
     2761 caatatgtac tgctgtgtac atataaggta ttttttaaag agaaacatgc ctttattttc
     2821 ctatgtcctt ttttatgttt agaatagcct gagaaatcat ctgctaaact gtgctgtagg
     2881 agaaattctt tcccaacgga gtccatgctg ccttttgcgc agcacatttg aattaagatt
     2941 cgagatgtgt cagctcagtg gcaatggagt gttgtcctct aactctggta cttgtctttt
     3001 gagatggcac agcccattca ttcattggtg gtagcagcag gttccctcag gatgcagcaa
     3061 actatgaatg ctcagtcctc tggccttgtc gcaggtaaac tgagggctca ggcagcaact
     3121 ctgcatttgt tggcctccct ctatgacagc tctctaaagg agcaagtctt gaaaattgct
     3181 ttggcatcct accacctgtt aagatgccca gcatctatgt caaatcaagt cgtctctcac
     3241 ctgttagaca cctggacagc ttgctttcat ttaccacgat ctcttctcag ttgatttaca
     3301 tgactgcctg gccatacttt aaggcaacca gtggctaaaa tactcatgaa attaaatatc
     3361 agtgattgca ctgaactgta tacttcagat gagctaattt tactacgtta atttagcatt
     3421 tatttaagtg gagaattaat tagttttgta ttccctattt tacaaaaatt gataaagata
     3481 tagttcatgg attttattct gctgttatgg gtttatttct atgggtctga aagcataaca
     3541 tgctcttcca tggttttccc ctctcggacc cagccctggc ttggcaggcc tctttccaca
     3601 gttaacagtg ttgatctctg ctactcaacc agtccttcta ggaatgaatc tcccatcagc
     3661 ttcgacgtgt gcaatgccag catagccacc accaccacca tgtccacttc tgtgtgtcac
     3721 caggcccttc agagttggag atgtgtttga ggctgaccaa gtgagcccct gaggacagat
     3781 ggctcacatc ttcctcttgt cagtgtcaaa tcactggatg ctgtgcagtc ctacacatta
     3841 acctcggttt tcaaaagtgt tcttaaaaga atttttacag ccaaatacat agaaactaga
     3901 tgatttttca acttacagaa aactacccaa ctataagata accagagaca tttattcaag
     3961 gaagtttcat aagttatgat caattctcca tttttaatca tctgggggat ttgtttctaa
     4021 actacagttt aagtgatttt agcttttgat ttgtgttcat catagatata aaaccttatt
     4081 tgtagatgga taaactgcca tatctgaggt aggagaagct gtgagttcag ggacagcttt
     4141 ggctacatat cgagttctgg gacagctggc ctatattgtg gagccctgtc tcaaaatcaa
     4201 taccaaaaag aaaataacat gaactataat attttttttc ttcatatact ttttaaaagt
     4261 ggggacattt accaattttt ccctagaaat actgtgtaat ttcccagcga cacttgaact
     4321 attgaagata gagtggactg gataatgttt tgacagaacc agagaagcca tggggatggc
     4381 tgcttgttga ggtcagctag cctggtacag atggctggta aactgtggct ctggctcctg
     4441 ctcaagccat ggcctcccag ctgccatgcc tgcagcaccc ctaaaaatgt ccactggatt
     4501 ttaaagaagc acaacagagt ctttcccttt gtatgtttct agcacagaac tgtttctaaa
     4561 acaacttgaa gtatagtttt cttatctaaa caattctttc atgtatgttt tatttaagta
     4621 ctataatgta aaccctttaa ggttcaggtt tttaaacaag tacaatactg tatttgcctc
     4681 atctgaagca ctgtattcca acatgtaact aaaatgataa tatgtttgct ccctggaaaa
     4741 aaaaaaaaaa aaaa
//
