LOCUS       NM_001384135             806 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus mitoregulin (Mtln), mRNA.
ACCESSION   NM_001384135
VERSION     NM_001384135.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 806)
  AUTHORS   Chen,H.X., Ma,Y.Z., Xie,P.P., Huang,J.Y., Li,L.Q., Zhang,W.,
            Zhu,Y., Zhuang,S.M. and Lin,Y.F.
  TITLE     Micropeptide MPM regulates cardiomyocyte proliferation and heart
            growth via the AKT pathway
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119820 (2024)
   PUBMED   39163918
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 806)
  AUTHORS   Zhang,S., Guo,Y., Fidelito,G., Robinson,D.R.L., Liang,C., Lim,R.,
            Bichler,Z., Guo,R., Wu,G., Xu,H., Zhou,Q.D., Singh,B.K., Yen,P.,
            Kappei,D., Stroud,D.A. and Ho,L.
  TITLE     LINC00116-encoded microprotein mitoregulin regulates fatty acid
            metabolism at the mitochondrial outer membrane
  JOURNAL   iScience 26 (9), 107558 (2023)
   PUBMED   37664623
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 806)
  AUTHORS   Averina,O.A., Permyakov,O.A., Emelianova,M.A., Guseva,E.A.,
            Grigoryeva,O.O., Lovat,M.L., Egorova,A.E., Grinchenko,A.V.,
            Kumeiko,V.V., Marey,M.V., Manskikh,V.N., Dontsova,O.A.,
            Vyssokikh,M.Y. and Sergiev,P.V.
  TITLE     Kidney-Related Function of Mitochondrial Protein Mitoregulin
  JOURNAL   Int J Mol Sci 24 (10), 9106 (2023)
   PUBMED   37240452
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 806)
  AUTHORS   Averina,O.A., Permyakov,O.A., Emelianova,M.A., Grigoryeva,O.O.,
            Lovat,M.L., Egorova,A.E., Grinchenko,A.V., Kumeiko,V.V.,
            Marey,M.V., Manskikh,V.N., Dontsova,O.A., Vysokikh,M.Y. and
            Sergiev,P.V.
  TITLE     Mitoregulin Contributes to Creatine Shuttling and Cardiolipin
            Protection in Mice Muscle
  JOURNAL   Int J Mol Sci 24 (8), 7589 (2023)
   PUBMED   37108753
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 806)
  AUTHORS   Averina,O.A., Permyakov,O.A., Emelianova,M.A., Grigoryeva,O.O.,
            Gulyaev,M.V., Pavlova,O.S., Mariasina,S.S., Frolova,O.Y.,
            Kurkina,M.V., Baydakova,G.V., Zakharova,E.Y., Marey,M.V.,
            Tsarev,D.A., Tashlitsky,V.N., Popov,V.S., Lovat,M.L.,
            Polshakov,V.I., Vyssokikh,M.Y. and Sergiev,P.V.
  TITLE     Mitochondrial peptide Mtln contributes to oxidative metabolism in
            mice
  JOURNAL   Biochimie 204, 136-139 (2023)
   PUBMED   36174793
REFERENCE   6  (bases 1 to 806)
  AUTHORS   Stein,C.S., Jadiya,P., Zhang,X., McLendon,J.M., Abouassaly,G.M.,
            Witmer,N.H., Anderson,E.J., Elrod,J.W. and Boudreau,R.L.
  TITLE     Mitoregulin: A lncRNA-Encoded Microprotein that Supports
            Mitochondrial Supercomplexes and Respiratory Efficiency
  JOURNAL   Cell Rep 23 (13), 3710-3720 (2018)
   PUBMED   29949756
  REMARK    GeneRIF: Mtln overexpression increases mitochondrial membrane
            potential, respiration rates, and Ca(2+) retention capacity while
            decreasing mitochondrial ROS and matrix-free Ca(2+). Mtln-knockout
            mice display perturbations in mitochondrial respiratory
            (super)complex formation and activity, fatty acid oxidation,
            tricarboxylic acid (TCA) cycle enzymes, and Ca(2+) retention
            capacity.
REFERENCE   7  (bases 1 to 806)
  AUTHORS   Makarewich,C.A., Baskin,K.K., Munir,A.Z., Bezprozvannaya,S.,
            Sharma,G., Khemtong,C., Shah,A.M., McAnally,J.R., Malloy,C.R.,
            Szweda,L.I., Bassel-Duby,R. and Olson,E.N.
  TITLE     MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid
            beta-Oxidation
  JOURNAL   Cell Rep 23 (13), 3701-3709 (2018)
   PUBMED   29949755
  REMARK    GeneRIF: MOXI overexpression leads to enhanced beta-oxidation.
            Hearts from MOXI knockout mice preferentially oxidize carbohydrates
            over fatty acids in an isolated perfused heart system compared to
            wild-type.
REFERENCE   8  (bases 1 to 806)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   9  (bases 1 to 806)
  AUTHORS   Crappe,J., Van Criekinge,W., Trooskens,G., Hayakawa,E., Luyten,W.,
            Baggerman,G. and Menschaert,G.
  TITLE     Combining in silico prediction and ribosome profiling in a
            genome-wide search for novel putatively coding sORFs
  JOURNAL   BMC Genomics 14, 648 (2013)
   PUBMED   24059539
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 806)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844204.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KY467426.1, AK027942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               AL844204.3         141558-141912       c
            356-806             AL844204.3         140806-141256       c
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.1 cM"
     gene            1..806
                     /gene="Mtln"
                     /gene_synonym="1500011K16Rik; Moxi; Mpm"
                     /note="mitoregulin"
                     /db_xref="GeneID:67885"
                     /db_xref="MGI:MGI:1915135"
     exon            1..355
                     /gene="Mtln"
                     /gene_synonym="1500011K16Rik; Moxi; Mpm"
                     /inference="alignment:Splign:2.1.0"
     exon            356..806
                     /gene="Mtln"
                     /gene_synonym="1500011K16Rik; Moxi; Mpm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      425..430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtln"
                     /gene_synonym="1500011K16Rik; Moxi; Mpm"
                     /note="hexamer: AATAAA"
     polyA_site      442
                     /gene="Mtln"
                     /gene_synonym="1500011K16Rik; Moxi; Mpm"
                     /note="major polyA site"
     regulatory      782..787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtln"
                     /gene_synonym="1500011K16Rik; Moxi; Mpm"
                     /note="hexamer: GATAAA"
     polyA_site      806
                     /gene="Mtln"
                     /gene_synonym="1500011K16Rik; Moxi; Mpm"
                     /note="major polyA site"
ORIGIN      
        1 actttgtgct gagtggttgc aatggcggac gtgtctgaga ggacgctgca ggtgtccgtg
       61 ctagtggctt tcgcctctgg agtggtcctg ggctggcaag cgaatcggct gcggaggcgt
      121 tacctagact ggaggaagcg gaggctgcag gacaagctgg caacgactca gaaaaagctg
      181 gacctggcct gagcacgcgc tgcagcccga gtccgccggg ttctcactcc ctaagcccaa
      241 cgcagcccgg atcgtgggag ccgcgcgacc caggagtcgt ccttgcacgg cttgcaagaa
      301 catggcttgc ttcagaaaga aaatagtttt gtcttctcta acaacttact ttcagcttgt
      361 cgaagatgaa aataaaaagc actggagaga aataatttct tgcactttat gaatctattt
      421 ttaaaataaa aaattaaaca tctttgaatc tttttcctcc tcacaaaaga aagcagtatt
      481 tttgcctacc attcagtttg ctgcagtaag agatttggag cctgaaagca gagactttct
      541 gatggaatct caccttggta cagcctggag gcagatctga tcaacggacc attatgagtc
      601 atttttctag acatattcag aaaacctagg agctgtgtca aatgcctgaa ttaagcatta
      661 caaatgcaag atatttgcac tttgaagaat gtagagagta aaaaaactaa aattaaaaaa
      721 aataatgcat gtgatataac ggaatatata tgtgaaagag aaactgttga gtaagcttaa
      781 agataaatgc cagtcctatc aagtga
//
