LOCUS       NM_029581               4979 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial translational initiation factor 3
            (Mtif3), transcript variant 3, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_029581
VERSION     NM_029581.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4979)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4979)
  AUTHORS   Richman,T.R., Ermer,J.A., Baker,J., Siira,S.J., Kile,B.T.,
            Linden,M.D., Rackham,O. and Filipovska,A.
  TITLE     Mitochondrial gene expression is required for platelet function and
            blood clotting
  JOURNAL   Cell Rep 42 (11), 113312 (2023)
   PUBMED   37889747
REFERENCE   3  (bases 1 to 4979)
  AUTHORS   Rudler,D.L., Hughes,L.A., Perks,K.L., Richman,T.R., Kuznetsova,I.,
            Ermer,J.A., Abudulai,L.N., Shearwood,A.J., Viola,H.M., Hool,L.C.,
            Siira,S.J., Rackham,O. and Filipovska,A.
  TITLE     Fidelity of translation initiation is required for coordinated
            respiratory complex assembly
  JOURNAL   Sci Adv 5 (12), eaay2118 (2019)
   PUBMED   31903419
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4979)
  AUTHORS   Koc,E.C. and Spremulli,L.L.
  TITLE     Identification of mammalian mitochondrial translational initiation
            factor 3 and examination of its role in initiation complex
            formation with natural mRNAs
  JOURNAL   J Biol Chem 277 (38), 35541-35549 (2002)
   PUBMED   12095986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY284518.1, AK147090.1, BC052439.1 and BM944410.1.
            
            On Jan 5, 2012 this sequence version replaced NM_029581.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052439.1, SRR1660811.249661.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY284518.1         1-23
            24-1990             AK147090.1         2-1968
            1991-2436           BC052439.1         1945-2390
            2437-2677           BM944410.1         479-719
            2678-4979           BC052439.1         2631-4932
FEATURES             Location/Qualifiers
     source          1..4979
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 86.57 cM"
     gene            1..4979
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /note="mitochondrial translational initiation factor 3"
                     /db_xref="GeneID:76366"
                     /db_xref="MGI:MGI:1923616"
     exon            1..86
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            87..538
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..918
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /note="IF3mt; IF-3Mt; IF3(mt); IF-3(Mt)"
                     /codon_start=1
                     /product="translation initiation factor IF-3,
                     mitochondrial"
                     /protein_id="NP_083857.1"
                     /db_xref="CCDS:CCDS19874.1"
                     /db_xref="GeneID:76366"
                     /db_xref="MGI:MGI:1923616"
                     /translation="MAVLLMRLMLQTTKLDHNLIGRCLQRHAVKPDPAQLSLSASTPK
                     LLYLTSAKGFSTAGDPQGERKQKRRDAFSNTGRKISERIIRVLDEKGMDLGMMHRADV
                     IRLMNKQDLRLVQRNTSSEPPEYQLMTGEQIHQERLKLREQEKAKPKTGPTMTKELVF
                     SSNIGQHDLDTKSKQIQQWIEKKYHVQVTIKRRKDAEQSEEETEEIFNQILQTMPDIA
                     TFSSRPKAIRGGTASMCVFRHLSKKEEKAYRESQESQRRDTLSKDDDGNSKESDVVCQ
                     "
     exon            539..696
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            697..4939
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1562..1567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1583
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /note="major polyA site"
     polyA_site      1992
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
     regulatory      4918..4923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4939
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
ORIGIN      
        1 ggaagccgac gcggtgctcc ggcggagtcc aggtacggac ctgctagttc ttcctgctcg
       61 cctaccccgg cccaggtaac gctgaggatg gctgttcttc tgatgaggtt gatgctacaa
      121 actacaaagc ttgaccataa cttaattgga agatgtttgc aaagacacgc tgtgaagcca
      181 gatccagcac agctgtccct gtctgcgtcc accccaaagc tgttgtacct gacttctgca
      241 aaaggtttta gtactgctgg agacccacag ggtgagagga aacagaaaag aagggatgct
      301 ttctctaaca ccggccggaa gattagtgag cggattatcc gcgtcctgga tgagaagggc
      361 atggacctgg ggatgatgca tcgagcagat gtgatcagac tcatgaacaa gcaggacctg
      421 aggctggtgc agaggaacac cagctcagag ccaccggagt accagcttat gaccggagag
      481 cagatccacc aggagcggct aaagctccgg gaacaggaaa aggccaaacc caaaactgga
      541 ccaactatga cgaaagagct cgttttctct tcaaatattg gacagcacga tttagacacc
      601 aagagtaaac agatccagca gtggatagag aagaaatacc acgttcaagt cacgataaag
      661 aggaggaaag atgcggagca gtcagaggag gaaacggagg agatatttaa ccagattctc
      721 cagactatgc ctgacatagc aaccttctca agcagaccaa aagccatcag aggagggact
      781 gcttccatgt gtgtttttcg tcacttgagc aagaaagaag aaaaggcgta cagagaatcc
      841 caggagagcc agagaagaga cactttgagc aaagacgacg acggaaacag caaagagtcg
      901 gatgttgtgt gtcagtgact ttaataggaa aagtgcaggc caggagcctc tgctggccgc
      961 cctgaagtct tcccgcctag cagacagtga gtaaggcggc tggcgggggc agctgggcct
     1021 ctgggctgct gctggactct gcgctggcgt taggcaagga gtagtcgggc tcttgtttcc
     1081 tcttaggagg gaagtaccca ctgaggcgag aggccaagct gcgtctctcc cgaggggctc
     1141 ttaccttcag gagtgaggaa gacagacaac tgagttgccc attacacaac ggggatccac
     1201 tccaacagat gagcccctga tgggagtcac accctcagca ggcacagaca cgcaggatgg
     1261 ggtatgcgga tggacagacg ccaagcaggc ctcacagccg agtgctggcc ccagcagctg
     1321 ccacttactt tgagcttcat cctcttcttg tcgggatcgt gcacgacact gtgcctcatg
     1381 agactctgct gcagtgcaag ggaaagaagg acgcttgacc tgggcctgca gacgtggctc
     1441 agtgcttaca gcattcgctg ctcgaggagg acacgggttt ggttcccagc acccgtactc
     1501 cagttccagt aaaaactctt ggtgtctgct aaccttaaga tgcagtggtc cagtgtgcaa
     1561 taataaacta ccagctgcct ttctgttgtg tagtgaatct gaccttcacc tgactcccta
     1621 accagagcca actccttggc agagcgagcg actgtcagcc tgctgacacg catgggattt
     1681 acttcttccc ggtcctcctg agaagggaaa gccggctatg cttgaacatc caggctcatg
     1741 ctggggtaac tgaatctacc tcagctgcgt ccctaagtgc cagggggaaa tctgacctct
     1801 gccctgctgg ctatgctgac agtgctgacc acgggacctt tgctgtgggc tggtctgggt
     1861 tatgttcagt gactttgtaa tccacagtaa gagctcttta gaaaccagct aggcttaggc
     1921 aaactgttca gttccctact aggaaccatg ttcccacgcg atccatgaat catgccaaga
     1981 ttccagagtc tagaggctgt gcatttgtgc tacccacctc ctctcccaga ccctaggcga
     2041 cggtcagaag ctcctaatca cctcagaaca tcctctaagt aggaatacag gccccgggct
     2101 ctcccactca gcatggctag aatcccccag gagtggttct caacctgcta ctcatgactc
     2161 ctctggggtc atataccaga tcgcctgaat atcattattt acaatccata ccagtagcaa
     2221 aattatagtt atgaagtagc aactaaataa tattatggtt gggggtcccc acaacatgag
     2281 gaactgttat tgggtcccag tattaggaag gttgagaacc actgctctag aggtcctaaa
     2341 taggcctgtt tagcctccca accccagggc tcctgcattt ccaagttctg caggctggac
     2401 atgaacacac cagcctggag cgggagacac tcactttcat tgcgaatgtc ttgccacagc
     2461 cagcgtgctc acacacaaat gggcgctttt cctcgtggaa ggagagaatg tggctctgca
     2521 ggttgaacac ggttgtgtag gttcttccgc agccttgccg cggacagcgg tacacatccc
     2581 tttccggggc gtgagtcttc atgtgctgct taaggtaatc tctgcgcttg aacatcctct
     2641 gacatacatt gcaggttatg tcctctggga ggagaaacac acacgtgtaa ccagcgtccc
     2701 atgagtaacc cgtctggtcc tatgactaca cacaatctgg ggacttcaca tgggaaatgt
     2761 cagcttgtct cactgctatg ctggtttcaa attcctcaag ttcactcatg gctcccaaca
     2821 tcctgagtcc tcgcctgtca aggagcaggc gtcctcggtg tgataactga gcacgaggaa
     2881 gtatgccctc atagcatcta cctttaccct ctgacacagt agcatctgct aagtcctgca
     2941 gggcctcacg aacacccggg cacagccgca ccagctctga ggcctgcagg gctccctcga
     3001 ctgtcacagc ccaggaagcc agcactaccc tgaactcgat gcagagcccc cttcctttac
     3061 agcgcaagtg ggtatctcac tctctcagag tacaccatgc actccccaga gctcagagca
     3121 cacacaccat gggctccccg gggttcagag cacaccgggc tctccccagg gccgatgcgc
     3181 ttccacagct cctgcctacc ttacctttat gggcttctct catgtgtttc aggagctctg
     3241 tccacgtttt tcccatgaaa gaacatccct tttgacacag gtagcctgtt caaaacaaaa
     3301 acaaaacaag ttacccacag cctgttgaat gcccagggca atccctaatg acagccaaga
     3361 aagcccgtgc caagtgcact cccctctctg aagtgtgctg ctctgctggg tgcaatgcag
     3421 cgggctccag tggcccctgc tctgaaagct cccatcagcc agacttttgc acacttgagt
     3481 ggcacataac caggtagcgt aggaacagta tagcaccagt ggacgtggca aagaggatag
     3541 cggcaaaaca cacagcacag tgtctcttgg cataagaggc aaacactcaa ataacacaac
     3601 aggcgcttgc ttgtcacaga actttgtcta ctcagcgtga ctacagaata gacccagcct
     3661 accctgccgg tggcatgttc ctcgcggccg gcacagtccc catctacgta ccctcgtgaa
     3721 ctttcccatg ccgtttcagc ctgctgggcg aggcaaagtg cttcccgcat ccctcgtggg
     3781 tacacctagg acaatagcag gcaaagcatc agccaggccc tttccatgga caattctaag
     3841 attccctctt ctcccacacc aaagcccatg tcttcccaca ccacacctgt catccaaaac
     3901 aaagagtaag tacagtcccg aatatggaca tagtggcttg gccagcttgg gagcaaaaca
     3961 agccatcctg agaaaaagtc acatcttttg tttgtgttat caaactaaaa gttctctgaa
     4021 ttctggaaat gtggctacag aagcgacatc aagaggctgt ctgactcggt ttgcactgga
     4081 ccagacacag agctgttgtc tggggtctgc ccaatatgct gcatacggtc agatgagaac
     4141 acagcacaga ggctggggac cagcaccaga aacacacgag aatgtacagc agtcggtgca
     4201 gagctccagg cactggcagc acaaacaggc cacagggctg ctggtaagac ctcggtcact
     4261 gtagctgcac cagtgcaaag agcagcctat gggagccagg ggcaaggccc catcacccgg
     4321 actgtgcagg gagacactgc cctaggaggg aggcaggcag gtaacctggc acccctgccc
     4381 acctcctctt tgtccctctt gagtactcag gaatccctca aaacaagcag ggcctcatta
     4441 ctcctgttct atagtaagaa aaaaaaaagc cctcatgaca cagagccttc ctcgggatcc
     4501 tgatcttagc gttctactct gaatcccaga gcgctggcaa agcaccaacc tgaagagcgg
     4561 ctcgctggtg tgctggcact gatgggttct cagctgctgg tgcttcttaa aggccttctt
     4621 gcaaccctca taactgcact gtttaaaaaa aataaatgca cggtttagta caggcagggg
     4681 atcatcagtt gctgaagtcc tttaaaaggc aggagagatt gctcaatggt tagggacact
     4741 tgcttctctg gtcccaggtt tggactgcag cacccacgtg gtgcctcaca accatctgac
     4801 tccagttcca caggacctca caccctcttc tgacctccac aggcaccgag cacgcatatg
     4861 gtatatagat acatatgcag gcaaaacgct tgcacataaa acctttttta actaaacaat
     4921 aaagtctctc tggatctgaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
