LOCUS       NM_001256100            5139 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial translational initiation factor 3
            (Mtif3), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001256100
VERSION     NM_001256100.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5139)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5139)
  AUTHORS   Richman,T.R., Ermer,J.A., Baker,J., Siira,S.J., Kile,B.T.,
            Linden,M.D., Rackham,O. and Filipovska,A.
  TITLE     Mitochondrial gene expression is required for platelet function and
            blood clotting
  JOURNAL   Cell Rep 42 (11), 113312 (2023)
   PUBMED   37889747
REFERENCE   3  (bases 1 to 5139)
  AUTHORS   Rudler,D.L., Hughes,L.A., Perks,K.L., Richman,T.R., Kuznetsova,I.,
            Ermer,J.A., Abudulai,L.N., Shearwood,A.J., Viola,H.M., Hool,L.C.,
            Siira,S.J., Rackham,O. and Filipovska,A.
  TITLE     Fidelity of translation initiation is required for coordinated
            respiratory complex assembly
  JOURNAL   Sci Adv 5 (12), eaay2118 (2019)
   PUBMED   31903419
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5139)
  AUTHORS   Koc,E.C. and Spremulli,L.L.
  TITLE     Identification of mammalian mitochondrial translational initiation
            factor 3 and examination of its role in initiation complex
            formation with natural mRNAs
  JOURNAL   J Biol Chem 277 (38), 35541-35549 (2002)
   PUBMED   12095986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY284518.1, BC115685.1, AK012733.1, BC052439.1 and BM944410.1.
            
            Transcript Variant: This variant (1) is the longest transcript. All
            five variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC115685.1, SRR5189682.103160.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BY284518.1         1-48
            49-168              BC115685.1         1-120
            169-1743            AK012733.1         136-1710
            1744-2596           BC052439.1         1538-2390
            2597-2837           BM944410.1         479-719
            2838-5139           BC052439.1         2631-4932
FEATURES             Location/Qualifiers
     source          1..5139
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 86.57 cM"
     gene            1..5139
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /note="mitochondrial translational initiation factor 3"
                     /db_xref="GeneID:76366"
                     /db_xref="MGI:MGI:1923616"
     exon            1..86
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            87..246
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            247..698
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1078
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /note="IF3mt; IF-3Mt; IF3(mt); IF-3(Mt)"
                     /codon_start=1
                     /product="translation initiation factor IF-3,
                     mitochondrial"
                     /protein_id="NP_001243029.1"
                     /db_xref="CCDS:CCDS19874.1"
                     /db_xref="GeneID:76366"
                     /db_xref="MGI:MGI:1923616"
                     /translation="MAVLLMRLMLQTTKLDHNLIGRCLQRHAVKPDPAQLSLSASTPK
                     LLYLTSAKGFSTAGDPQGERKQKRRDAFSNTGRKISERIIRVLDEKGMDLGMMHRADV
                     IRLMNKQDLRLVQRNTSSEPPEYQLMTGEQIHQERLKLREQEKAKPKTGPTMTKELVF
                     SSNIGQHDLDTKSKQIQQWIEKKYHVQVTIKRRKDAEQSEEETEEIFNQILQTMPDIA
                     TFSSRPKAIRGGTASMCVFRHLSKKEEKAYRESQESQRRDTLSKDDDGNSKESDVVCQ
                     "
     exon            699..856
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            857..5099
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1722..1727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1743
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /note="major polyA site"
     polyA_site      2152
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
     regulatory      5078..5083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5099
                     /gene="Mtif3"
                     /gene_synonym="2810012L14Rik"
ORIGIN      
        1 ggaagccgac gcggtgctcc ggcggagtcc aggtacggac ctgctagttc ttcctgctcg
       61 cctaccccgg cccaggtaac gctgagggtc tcactattta tctctggctg tcctgaaacg
      121 cactcggtag accagtctga cctcaaacct atagaaatcc tcctgcctct acctccgaag
      181 tgctgggatt aaaggcgtgc accgctcgcc gtgtcaggac ttttgaaatt ccttccggaa
      241 ttgaaggatg gctgttcttc tgatgaggtt gatgctacaa actacaaagc ttgaccataa
      301 cttaattgga agatgtttgc aaagacacgc tgtgaagcca gatccagcac agctgtccct
      361 gtctgcgtcc accccaaagc tgttgtacct gacttctgca aaaggtttta gtactgctgg
      421 agacccacag ggtgagagga aacagaaaag aagggatgct ttctctaaca ccggccggaa
      481 gattagtgag cggattatcc gcgtcctgga tgagaagggc atggacctgg ggatgatgca
      541 tcgagcagat gtgatcagac tcatgaacaa gcaggacctg aggctggtgc agaggaacac
      601 cagctcagag ccaccggagt accagcttat gaccggagag cagatccacc aggagcggct
      661 aaagctccgg gaacaggaaa aggccaaacc caaaactgga ccaactatga cgaaagagct
      721 cgttttctct tcaaatattg gacagcacga tttagacacc aagagtaaac agatccagca
      781 gtggatagag aagaaatacc acgttcaagt cacgataaag aggaggaaag atgcggagca
      841 gtcagaggag gaaacggagg agatatttaa ccagattctc cagactatgc ctgacatagc
      901 aaccttctca agcagaccaa aagccatcag aggagggact gcttccatgt gtgtttttcg
      961 tcacttgagc aagaaagaag aaaaggcgta cagagaatcc caggagagcc agagaagaga
     1021 cactttgagc aaagacgacg acggaaacag caaagagtcg gatgttgtgt gtcagtgact
     1081 ttaataggaa aagtgcaggc caggagcctc tgctggccgc cctgaagtct tcccgcctag
     1141 cagacagtga gtaaggcggc tggcgggggc agctgggcct ctgggctgct gctggactct
     1201 gcgctggcgt taggcaagga gtagtcgggc tcttgtttcc tcttaggagg gaagtaccca
     1261 ctgaggcgag aggccaagct gcgtctctcc cgaggggctc ttaccttcag gagtgaggaa
     1321 gacagacaac tgagttgccc attacacaac ggggatccac tccaacagat gagcccctga
     1381 tgggagtcac accctcagca ggcacagaca cgcaggatgg ggtatgcgga tggacagacg
     1441 ccaagcaggc ctcacagccg agtgctggcc ccagcagctg ccacttactt tgagcttcat
     1501 cctcttcttg tcgggatcgt gcacgacact gtgcctcatg agactctgct gcagtgcaag
     1561 ggaaagaagg acgcttgacc tgggcctgca gacgtggctc agtgcttaca gcattcgctg
     1621 ctcgaggagg acacgggttt ggttcccagc acccgtactc cagttccagt aaaaactctt
     1681 ggtgtctgct aaccttaaga tgcagtggtc cagtgtgcaa taataaacta ccagctgcct
     1741 ttctgttgtg tagtgaatct gaccttcacc tgactcccta accagagcca actccttggc
     1801 agagcgagcg actgtcagcc tgctgacacg catgggattt acttcttccc ggtcctcctg
     1861 agaagggaaa gccggctatg cttgaacatc caggctcatg ctggggtaac tgaatctacc
     1921 tcagctgcgt ccctaagtgc cagggggaaa tctgacctct gccctgctgg ctatgctgac
     1981 agtgctgacc acgggacctt tgctgtgggc tggtctgggt tatgttcagt gactttgtaa
     2041 tccacagtaa gagctcttta gaaaccagct aggcttaggc aaactgttca gttccctact
     2101 aggaaccatg ttcccacgcg atccatgaat catgccaaga ttccagagtc tagaggctgt
     2161 gcatttgtgc tacccacctc ctctcccaga ccctaggcga cggtcagaag ctcctaatca
     2221 cctcagaaca tcctctaagt aggaatacag gccccgggct ctcccactca gcatggctag
     2281 aatcccccag gagtggttct caacctgcta ctcatgactc ctctggggtc atataccaga
     2341 tcgcctgaat atcattattt acaatccata ccagtagcaa aattatagtt atgaagtagc
     2401 aactaaataa tattatggtt gggggtcccc acaacatgag gaactgttat tgggtcccag
     2461 tattaggaag gttgagaacc actgctctag aggtcctaaa taggcctgtt tagcctccca
     2521 accccagggc tcctgcattt ccaagttctg caggctggac atgaacacac cagcctggag
     2581 cgggagacac tcactttcat tgcgaatgtc ttgccacagc cagcgtgctc acacacaaat
     2641 gggcgctttt cctcgtggaa ggagagaatg tggctctgca ggttgaacac ggttgtgtag
     2701 gttcttccgc agccttgccg cggacagcgg tacacatccc tttccggggc gtgagtcttc
     2761 atgtgctgct taaggtaatc tctgcgcttg aacatcctct gacatacatt gcaggttatg
     2821 tcctctggga ggagaaacac acacgtgtaa ccagcgtccc atgagtaacc cgtctggtcc
     2881 tatgactaca cacaatctgg ggacttcaca tgggaaatgt cagcttgtct cactgctatg
     2941 ctggtttcaa attcctcaag ttcactcatg gctcccaaca tcctgagtcc tcgcctgtca
     3001 aggagcaggc gtcctcggtg tgataactga gcacgaggaa gtatgccctc atagcatcta
     3061 cctttaccct ctgacacagt agcatctgct aagtcctgca gggcctcacg aacacccggg
     3121 cacagccgca ccagctctga ggcctgcagg gctccctcga ctgtcacagc ccaggaagcc
     3181 agcactaccc tgaactcgat gcagagcccc cttcctttac agcgcaagtg ggtatctcac
     3241 tctctcagag tacaccatgc actccccaga gctcagagca cacacaccat gggctccccg
     3301 gggttcagag cacaccgggc tctccccagg gccgatgcgc ttccacagct cctgcctacc
     3361 ttacctttat gggcttctct catgtgtttc aggagctctg tccacgtttt tcccatgaaa
     3421 gaacatccct tttgacacag gtagcctgtt caaaacaaaa acaaaacaag ttacccacag
     3481 cctgttgaat gcccagggca atccctaatg acagccaaga aagcccgtgc caagtgcact
     3541 cccctctctg aagtgtgctg ctctgctggg tgcaatgcag cgggctccag tggcccctgc
     3601 tctgaaagct cccatcagcc agacttttgc acacttgagt ggcacataac caggtagcgt
     3661 aggaacagta tagcaccagt ggacgtggca aagaggatag cggcaaaaca cacagcacag
     3721 tgtctcttgg cataagaggc aaacactcaa ataacacaac aggcgcttgc ttgtcacaga
     3781 actttgtcta ctcagcgtga ctacagaata gacccagcct accctgccgg tggcatgttc
     3841 ctcgcggccg gcacagtccc catctacgta ccctcgtgaa ctttcccatg ccgtttcagc
     3901 ctgctgggcg aggcaaagtg cttcccgcat ccctcgtggg tacacctagg acaatagcag
     3961 gcaaagcatc agccaggccc tttccatgga caattctaag attccctctt ctcccacacc
     4021 aaagcccatg tcttcccaca ccacacctgt catccaaaac aaagagtaag tacagtcccg
     4081 aatatggaca tagtggcttg gccagcttgg gagcaaaaca agccatcctg agaaaaagtc
     4141 acatcttttg tttgtgttat caaactaaaa gttctctgaa ttctggaaat gtggctacag
     4201 aagcgacatc aagaggctgt ctgactcggt ttgcactgga ccagacacag agctgttgtc
     4261 tggggtctgc ccaatatgct gcatacggtc agatgagaac acagcacaga ggctggggac
     4321 cagcaccaga aacacacgag aatgtacagc agtcggtgca gagctccagg cactggcagc
     4381 acaaacaggc cacagggctg ctggtaagac ctcggtcact gtagctgcac cagtgcaaag
     4441 agcagcctat gggagccagg ggcaaggccc catcacccgg actgtgcagg gagacactgc
     4501 cctaggaggg aggcaggcag gtaacctggc acccctgccc acctcctctt tgtccctctt
     4561 gagtactcag gaatccctca aaacaagcag ggcctcatta ctcctgttct atagtaagaa
     4621 aaaaaaaagc cctcatgaca cagagccttc ctcgggatcc tgatcttagc gttctactct
     4681 gaatcccaga gcgctggcaa agcaccaacc tgaagagcgg ctcgctggtg tgctggcact
     4741 gatgggttct cagctgctgg tgcttcttaa aggccttctt gcaaccctca taactgcact
     4801 gtttaaaaaa aataaatgca cggtttagta caggcagggg atcatcagtt gctgaagtcc
     4861 tttaaaaggc aggagagatt gctcaatggt tagggacact tgcttctctg gtcccaggtt
     4921 tggactgcag cacccacgtg gtgcctcaca accatctgac tccagttcca caggacctca
     4981 caccctcttc tgacctccac aggcaccgag cacgcatatg gtatatagat acatatgcag
     5041 gcaaaacgct tgcacataaa acctttttta actaaacaat aaagtctctc tggatctgaa
     5101 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
