LOCUS       NP_598528                727 aa            linear   ROD 27-APR-2025
DEFINITION  translation initiation factor IF-2, mitochondrial isoform 1
            precursor [Mus musculus].
ACCESSION   NP_598528
VERSION     NP_598528.2
DBSOURCE    REFSEQ: accession NM_133767.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 727)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 727)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   3  (residues 1 to 727)
  AUTHORS   Jin,W.H., Dai,J., Zhou,H., Xia,Q.C., Zou,H.F. and Zeng,R.
  TITLE     Phosphoproteome analysis of mouse liver using immobilized metal
            affinity purification and linear ion trap mass spectrometry
  JOURNAL   Rapid Commun Mass Spectrom 18 (18), 2169-2176 (2004)
   PUBMED   15378723
REFERENCE   4  (residues 1 to 727)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (residues 1 to 727)
  AUTHORS   Koc,E.C. and Spremulli,L.L.
  TITLE     Identification of mammalian mitochondrial translational initiation
            factor 3 and examination of its role in initiation complex
            formation with natural mRNAs
  JOURNAL   J Biol Chem 277 (38), 35541-35549 (2002)
   PUBMED   12095986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX284634.8, CK620846.1, AK146961.1 and CF737093.1.
            
            On Jul 23, 2006 this sequence version replaced NP_598528.1.
            
            Transcript Variant: This variant (1) encodes isoform (1). Both
            variants 1 and 2 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146961.1, SRR7652917.988793.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 16.77 cM"
     Protein         1..727
                     /product="translation initiation factor IF-2,
                     mitochondrial isoform 1 precursor"
                     /note="translation initiation factor IF-2, mitochondrial"
                     /calculated_mol_wt=77747
     transit_peptide 1..29
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q91YJ5.2)"
                     /calculated_mol_wt=3560
     mat_peptide     30..727
                     /product="Translation initiation factor IF-2,
                     mitochondrial. /id=PRO_0000014481"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YJ5.2)"
                     /calculated_mol_wt=77747
     Region          177..718
                     /region_name="InfB"
                     /note="Translation initiation factor IF-2, a GTPase
                     [Translation, ribosomal structure and biogenesis];
                     COG0532"
                     /db_xref="CDD:440298"
     Region          187..194
                     /region_name="G1. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YJ5.2)"
     Region          212..216
                     /region_name="G2. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YJ5.2)"
     Region          234..237
                     /region_name="G3. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YJ5.2)"
     Region          288..291
                     /region_name="G4. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YJ5.2)"
     Region          324..326
                     /region_name="G5. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91YJ5.2)"
     Site            688
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:15378723; propagated from
                     UniProtKB/Swiss-Prot (Q91YJ5.2)"
     CDS             1..727
                     /gene="Mtif2"
                     /gene_synonym="2310038D14Rik; 2410112O06Rik; IF-2(Mt);
                     IF-2mt; IF2(mt)"
                     /coded_by="NM_133767.3:455..2638"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS24496.1"
                     /db_xref="GeneID:76784"
                     /db_xref="MGI:MGI:1924034"
ORIGIN      
        1 mnqkllklen llrfhticrq vhspsqrrll awcrhgfapa ssvwrdllga rswqtdmlig
       61 salhqhrllv tkkekrpprs qlspvktkke vevwvgmtve dlasamakdi dcvyeallnt
      121 aidvdslean shldevwike vikkagmklk wsklkqerir enkdavrrpg tdpallkprs
      181 pvvtvmghvd hgkttlldkl retqvaamev ggitqhigaf lvslpsgeki tfldtpghaa
      241 fsamrargaq vtdivvlvva addgvmkqtv esiqhakdae vpiilainkc dktdadpekv
      301 kkellaydvv ceeyggdvqa vhvsaltgdn lmalaeatia laeilelkad ptgpvegtvi
      361 esftdkgrgp vttaiiqrgt lrkgsilvag kswakvrlif dengkilnea ypsmpvgiig
      421 wrdlpsagde ilevesepra reviewrkse qkeekgkddl kimeekrreh qeahrkarek
      481 ygslhwkers yikflerkqq rplkpkekve rqsnvlpiii kgdvdgsvea ilnlldtyda
      541 shecelelvh fglgdisend vtfaetfdgv iygfnveags aiqqsaaqkg vkiklhkiiy
      601 hliedlqeel ssrlphtlee ypigeasila tftvtegkkk ipvagcrvqk gqlerhkkfk
      661 lirngqviwk gsltslkhhk ddisviktgm dcglsldeek vefkpgdqvi cyeenkvptk
      721 tswdpgf
//
