LOCUS       NM_001359992             742 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus 5, 10-methenyltetrahydrofolate synthetase-like
            (Mthfsl), transcript variant 2, mRNA.
ACCESSION   NM_001359992 XM_006510729
VERSION     NM_001359992.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 742)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 742)
  AUTHORS   Shimizu,R., Ishihara,K., Kawashita,E., Sago,H., Yamakawa,K.,
            Mizutani,K.I. and Akiba,S.
  TITLE     Decrease in the T-box1 gene expression in embryonic brain and adult
            hippocampus of down syndrome mouse models
  JOURNAL   Biochem Biophys Res Commun 535, 87-92 (2021)
   PUBMED   33348080
REFERENCE   3  (bases 1 to 742)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   4  (bases 1 to 742)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 742)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030710.7 and AC163666.2.
            
            On Jan 24, 2018 this sequence version replaced XM_006510729.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024567.1, CK787897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                CT030710.7         151771-151869       c
            100-361             CT030710.7         147770-148031       c
            362-742             AC163666.2         1396-1776
FEATURES             Location/Qualifiers
     source          1..742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.24 cM"
     gene            1..742
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /note="5, 10-methenyltetrahydrofolate synthetase-like"
                     /db_xref="GeneID:100039707"
                     /db_xref="MGI:MGI:3780550"
     exon            1..99
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /inference="alignment:Splign:2.1.0"
     exon            100..361
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..594
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="5, 10-methenyltetrahydrofolate synthetase-like
                     isoform 2"
                     /protein_id="NP_001346921.1"
                     /db_xref="CCDS:CCDS90638.1"
                     /db_xref="GeneID:100039707"
                     /db_xref="MGI:MGI:3780550"
                     /translation="MQDEVETEVIIKDIFKQGKICFIPQYQFQSNHMDMVRLTSPEEI
                     ALLPKTSWNIHQPGEGDVREEALSTGGLDLIFLPGLGFDKDGNRLGRGKGYYDTYLKR
                     CVQHQEVKPYTMALAFKEQICPQIPVDEHDMKVDEVLYEDSPAS"
     exon            362..742
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /inference="alignment:Splign:2.1.0"
     regulatory      685..690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /note="hexamer: ATTAAA"
     polyA_site      707
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /note="major polyA site"
     regulatory      721..726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /note="hexamer: AATAAA"
     polyA_site      742
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /note="major polyA site"
ORIGIN      
        1 gggggcgcgt gcgcgtcgtc cggggagcgc gctccgcagg caagggcggc tctcgctggt
       61 cctggagctt gtgagggagc gagctgagct tccgggcagg tgattgccca caatcagtat
      121 cagaattcca aaagaatttc catctttctg agcatgcaag atgaagttga gacggaagta
      181 atcatcaagg acattttcaa acaaggcaaa atctgcttca tccctcagta ccaattccag
      241 agcaatcaca tggacatggt gaggttaacg tcacctgaag aaattgcttt acttcccaag
      301 acatcttgga atattcatca gcctggtgag ggagatgttc gggaggaggc cttatccact
      361 ggtggacttg acctcatctt ccttcctggc ctcgggtttg acaaagatgg caaccggctg
      421 gggcggggta aggggtacta tgacacctac ctgaagcgct gtgtacagca tcaggaagtg
      481 aagccctaca ccatggcttt ggcttttaaa gagcagatct gtccccagat cccagtggat
      541 gagcatgaca tgaaggtaga tgaagtcctt tatgaagatt ccccagcatc ctaagttaca
      601 caacgacggc tacacttact gctctgtccc ggtgtaaaga acatatgtat atttttctct
      661 tgtcaaaatg aatcaaaatg gcacattaaa gtgaatatgg gttgtgattt taagtgtaaa
      721 aataaaataa tataaaatcc ta
//
