LOCUS       NM_001128601             783 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus 5, 10-methenyltetrahydrofolate synthetase-like
            (Mthfsl), transcript variant 1, mRNA.
ACCESSION   NM_001128601 XM_001473273
VERSION     NM_001128601.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 783)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 783)
  AUTHORS   Shimizu,R., Ishihara,K., Kawashita,E., Sago,H., Yamakawa,K.,
            Mizutani,K.I. and Akiba,S.
  TITLE     Decrease in the T-box1 gene expression in embryonic brain and adult
            hippocampus of down syndrome mouse models
  JOURNAL   Biochem Biophys Res Commun 535, 87-92 (2021)
   PUBMED   33348080
REFERENCE   3  (bases 1 to 783)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   4  (bases 1 to 783)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 783)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030710.7 and AC163666.2.
            
            On Jun 19, 2008 this sequence version replaced XM_001473273.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI098777.1, BE689416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               CT030710.7         151941-152080       c
            141-402             CT030710.7         147770-148031       c
            403-783             AC163666.2         1396-1776
FEATURES             Location/Qualifiers
     source          1..783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.24 cM"
     gene            1..783
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /note="5, 10-methenyltetrahydrofolate synthetase-like"
                     /db_xref="GeneID:100039707"
                     /db_xref="MGI:MGI:3780550"
     exon            1..140
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..635
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="5, 10-methenyltetrahydrofolate synthetase-like
                     isoform 1"
                     /protein_id="NP_001122073.1"
                     /db_xref="CCDS:CCDS52881.1"
                     /db_xref="GeneID:100039707"
                     /db_xref="MGI:MGI:3780550"
                     /translation="MAAVTVNSAKRGLRAELKQRLRALSAEERLRQSLLLTQKVIAHN
                     QYQNSKRISIFLSMQDEVETEVIIKDIFKQGKICFIPQYQFQSNHMDMVRLTSPEEIA
                     LLPKTSWNIHQPGEGDVREEALSTGGLDLIFLPGLGFDKDGNRLGRGKGYYDTYLKRC
                     VQHQEVKPYTMALAFKEQICPQIPVDEHDMKVDEVLYEDSPAS"
     exon            141..402
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /inference="alignment:Splign:2.1.0"
     exon            403..783
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /inference="alignment:Splign:2.1.0"
     regulatory      726..731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /note="hexamer: ATTAAA"
     polyA_site      748
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /note="major polyA site"
     regulatory      762..767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /note="hexamer: AATAAA"
     polyA_site      783
                     /gene="Mthfsl"
                     /gene_synonym="100039707; Gm2382"
                     /note="major polyA site"
ORIGIN      
        1 ggccggggcg gtgcttgcca ggaatggcgg cggtcacggt aaacagtgcc aagcggggcc
       61 tgcgggccga gctgaagcag cgcttgaggg ccttgagcgc ggaggaacgg ctgcgccagt
      121 ctctcctcct cacgcagaag gtgattgccc acaatcagta tcagaattcc aaaagaattt
      181 ccatctttct gagcatgcaa gatgaagttg agacggaagt aatcatcaag gacattttca
      241 aacaaggcaa aatctgcttc atccctcagt accaattcca gagcaatcac atggacatgg
      301 tgaggttaac gtcacctgaa gaaattgctt tacttcccaa gacatcttgg aatattcatc
      361 agcctggtga gggagatgtt cgggaggagg ccttatccac tggtggactt gacctcatct
      421 tccttcctgg cctcgggttt gacaaagatg gcaaccggct ggggcggggt aaggggtact
      481 atgacaccta cctgaagcgc tgtgtacagc atcaggaagt gaagccctac accatggctt
      541 tggcttttaa agagcagatc tgtccccaga tcccagtgga tgagcatgac atgaaggtag
      601 atgaagtcct ttatgaagat tccccagcat cctaagttac acaacgacgg ctacacttac
      661 tgctctgtcc cggtgtaaag aacatatgta tatttttctc ttgtcaaaat gaatcaaaat
      721 ggcacattaa agtgaatatg ggttgtgatt ttaagtgtaa aaataaaata atataaaatc
      781 cta
//
