LOCUS       NM_001372381            2478 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus methenyltetrahydrofolate synthetase domain containing
            (Mthfsd), transcript variant 3, mRNA.
ACCESSION   NM_001372381
VERSION     NM_001372381.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2478)
  AUTHORS   MacNair,L., Xiao,S., Miletic,D., Ghani,M., Julien,J.P., Keith,J.,
            Zinman,L., Rogaeva,E. and Robertson,J.
  TITLE     MTHFSD and DDX58 are novel RNA-binding proteins abnormally
            regulated in amyotrophic lateral sclerosis
  JOURNAL   Brain 139 (Pt 1), 86-100 (2016)
   PUBMED   26525917
  REMARK    GeneRIF: identifies DDX58 and MTHFSD as two TDP-43 targets that are
            misregulated in amyotrophic lateral sclerosis. 1
REFERENCE   2  (bases 1 to 2478)
  AUTHORS   Grote,P., Wittler,L., Hendrix,D., Koch,F., Wahrisch,S., Beisaw,A.,
            Macura,K., Blass,G., Kellis,M., Werber,M. and Herrmann,B.G.
  TITLE     The tissue-specific lncRNA Fendrr is an essential regulator of
            heart and body wall development in the mouse
  JOURNAL   Dev Cell 24 (2), 206-214 (2013)
   PUBMED   23369715
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127554.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.302532.1,
                                           SRR7345562.974425.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC127554.4         31871-31920         c
            51-154              AC127554.4         30453-30556         c
            155-268             AC127554.4         29157-29270         c
            269-382             AC127554.4         27975-28088         c
            383-473             AC127554.4         26497-26587         c
            474-586             AC127554.4         25007-25119         c
            587-712             AC127554.4         24702-24827         c
            713-1157            AC127554.4         22291-22735         c
            1158-2478           AC127554.4         20188-21508         c
FEATURES             Location/Qualifiers
     source          1..2478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 70.31 cM"
     gene            1..2478
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /note="methenyltetrahydrofolate synthetase domain
                     containing"
                     /db_xref="GeneID:234814"
                     /db_xref="MGI:MGI:2679252"
     exon            1..50
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1153
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /note="isoform 3 is encoded by transcript variant 3;
                     methenyltetrahydrofolate synthetase domain-containing
                     protein; methenyltetrahydrofolate synthase
                     domain-containing protein"
                     /codon_start=1
                     /product="methenyltetrahydrofolate synthase
                     domain-containing protein isoform 3"
                     /protein_id="NP_001359310.1"
                     /db_xref="GeneID:234814"
                     /db_xref="MGI:MGI:2679252"
                     /translation="METQEGVSKQSIRERIWDYMESHDIADFPRPVHHRIPNFKGSYL
                     AGQSIRDLEVFAGTQEVKVDPDKPLEGVRFLALQSKKTLLVPTPRLRTGLFNKITPPP
                     GATKDILRKCATSQGVRNFSVPVGLDSSVLVDLVVVGSVAVSEKGWRIGKGEGYADLE
                     YAMMVSMGAVHKGTPVVTIVHDCQVVDIPEALVEDHDLTVDYILTPTRVITTGCARPK
                     PTGIMWSKVSCEMLTKIPVLRNLREREKQAGKDVTLRDEPGSQQPAPGPIRRPQDRPQ
                     TGSRGGSRSPLQGADTQLAATVCVGNLPFTTRVRELKRVLQELGVVPLRLTWQGPQHR
                     AVLHYTDSAAAQQAASLLQGLRLGANALRVSLGQQRDM"
     exon            51..154
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /inference="alignment:Splign:2.1.0"
     exon            155..268
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /inference="alignment:Splign:2.1.0"
     exon            269..382
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /inference="alignment:Splign:2.1.0"
     exon            383..473
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /inference="alignment:Splign:2.1.0"
     exon            474..586
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /inference="alignment:Splign:2.1.0"
     exon            587..712
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /inference="alignment:Splign:2.1.0"
     exon            713..1157
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..2478
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1498..1503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /note="hexamer: AATAAT"
     polyA_site      1522
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /note="major polyA site"
     polyA_site      1566
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
     regulatory      2460..2465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
                     /note="hexamer: CATAAA"
     polyA_site      2478
                     /gene="Mthfsd"
                     /gene_synonym="C920004D05"
ORIGIN      
        1 atgctacggg gcgtcgctcg gtgacgtgtt agccatggag acccaggagg gtgtctccaa
       61 acaaagcata cgtgaacgga tttgggacta catggaatcc catgatatag ctgactttcc
      121 ccgacccgtt catcacagga tccccaactt caaggggtcc tacctggctg gccagagcat
      181 cagagacctg gaagtctttg ctgggacaca ggaagtgaaa gtggaccctg ataagcccct
      241 ggaaggtgtc cgattcctgg cactgcagag caaaaaaaca ctgctggtcc caacaccacg
      301 actgcgaaca gggctgttta acaagatcac gccaccccct ggagccacca aagacattct
      361 gaggaaatgt gccacctccc agggtgtgcg gaatttcagc gtcccagtgg gcttggattc
      421 cagtgttctt gtggatctag ttgtggtggg atctgttgct gtgtctgaga aaggctggcg
      481 aattgggaaa ggggaaggct atgctgatct tgaatacgcc atgatggtgt caatgggagc
      541 cgtccacaag gggacaccgg ttgtcacaat tgtccacgac tgccaggtcg tagacatccc
      601 cgaggctctt gtggaggacc acgacctcac agttgactac atcctcactc ccaccagggt
      661 catcactaca ggctgtgcac gcccaaagcc aacgggcatc atgtggtcca aggtcagctg
      721 tgagatgctt acgaaaatcc cagtgctcag gaacctccgg gagagagaga aacaggctgg
      781 gaaggatgtc actctccggg acgagcctgg cagccagcag ccagctccag gccccatcag
      841 gagaccccag gatagaccac aaacaggttc tcgaggaggg tcccgtagtc ccctgcaggg
      901 ggcggacacc caactagctg ccactgtgtg tgtgggaaac ctgcccttca ctactcgtgt
      961 gcgtgagctg aagagagtcc tccaggagct gggggtggtg cccctgaggc ttacctggca
     1021 ggggccacag cacagggcag ttctacacta tacagactca gctgctgccc agcaggccgc
     1081 ctctctccta cagggcctac gtctgggtgc caacgccttg agggtgtcac tggggcagca
     1141 gagggatatg tgacctggac tcagccttgg aaaacggcta attcagtaac cagcgcttcc
     1201 aagctgtcag aggtgccatg aggagtgact gagggacgca ggctcaggct gtgctggcct
     1261 ctgtcctggc ctgcgccccc tcccactcct gcccaccaga cactgtccac cccactctca
     1321 cctgctcagc tttcctcggg ggttccgcct gcatttgcac ccttgccttc ttatcttctt
     1381 accattgatg tcccagtggg acagcgcctg cagtttagca ggatggagct gtctgttctt
     1441 cctgctgcag accagcgggg catgagcaac tcaggaaatc catgttacgt gagccagaat
     1501 aatccagatg cattgacaca cagtctaagc tgcttgtatg tttgtgtaaa gtgtgtaagt
     1561 gctgaagcct gggtgccctc aatctaagcc ctggtacagg gtgaaccctg tctcaggata
     1621 cctttgaggt ctggttctcc aggtgacgtg acccacaagt gacaaaagtc actgtgtcct
     1681 ttgtcactac agttgtatag cacacataat caaaatggat agaaagctac tgtcagatgg
     1741 caaagtgtca ctgcagggtt ctgggctctt ccacacttcc tctcatggtt ttctgctttg
     1801 ccaatgtggg gacctgagca agacctattt ggaagagttc gttctcaggg ctgcagtcac
     1861 cctgactggc taactttggg taactgtcgc tgtgatgcac caccaagacc aaagcaactt
     1921 gggaggaaag ggtttatttc attcacaatt ccatataaca gtttgtcatc aaaatcagtg
     1981 aggctgggca gtgggagcat gcctttaatc ccagcactcg ggaggcagag gcaggcggat
     2041 ttctgagttc aaggccaacc ttgtctacag agtgagttcc aggacagcca gggctacaca
     2101 gagaaaccct gtctcaaaaa acaaaaacaa aacaaaacaa aacaaaaaac caaacaaaca
     2161 aacaaaacag tgaggcgagg aactcaagca gagcaggaac ctggaacagg agctgatgca
     2221 gaggccatgg agggatgctg cttactggct tgctcctcat ggcttactca gcctgctttc
     2281 tcataggacc caaaatcagc agcagccggg gatgacacca cctacaatgt ggtctgggcc
     2341 ctcccacatc agtcaatcat aaggaaatat tttacaggct tctctgcagc ctgatcttac
     2401 ggaggcattt tcccaattga ggttccttcc tcagatggtt ctactttgcg tcagtttggc
     2461 ataaaaatcc ccaacata
//
