LOCUS       NM_199301               1595 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial ribosome-associated GTPase 1 (Mtg1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_199301 XM_133931
VERSION     NM_199301.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1595)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1595)
  AUTHORS   Xu,D., Zhao,Y., Weng,X., Lu,Y., Li,W., Tang,K., Chen,W., Liu,Z.,
            Qi,X., Zheng,J., Fassett,J., Zhang,Y. and Xu,Y.
  TITLE     Novel role of mitochondrial GTPases 1 in pathological cardiac
            hypertrophy
  JOURNAL   J Mol Cell Cardiol 128, 105-116 (2019)
   PUBMED   30707992
  REMARK    GeneRIF: dampening oxidative stress with N-acetylcysteine (NAC)
            lowered hypertrophy in MTG1 KO to WT levels. Collectively, our data
            indicate that MTG1 protects against pressure overload-induced
            cardiac hypertrophy and dysfunction by preserving mitochondrial
            function and reducing oxidative stress and downstream TAK1 stress
            signaling.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY240360.1, AK140018.1, AK144453.1 and AK144625.1.
            
            On May 17, 2008 this sequence version replaced NM_199301.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144625.1, AK144453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                BY240360.1         1-89
            90-380              AK140018.1         6-296
            381-1415            AK144453.1         306-1340
            1416-1595           AK144625.1         1378-1557
FEATURES             Location/Qualifiers
     source          1..1595
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 85.16 cM"
     gene            1..1595
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /note="mitochondrial ribosome-associated GTPase 1"
                     /db_xref="GeneID:212508"
                     /db_xref="MGI:MGI:2685015"
     exon            1..210
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1082
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /note="GTP binding protein 7 (putative); GTP-binding
                     protein 7; mitochondrial GTPase 1 homolog"
                     /codon_start=1
                     /product="mitochondrial ribosome-associated GTPase 1"
                     /protein_id="NP_955005.2"
                     /db_xref="CCDS:CCDS52432.1"
                     /db_xref="GeneID:212508"
                     /db_xref="MGI:MGI:2685015"
                     /translation="MRLWPQAWGAVRGAWRECFPLQGHDVARWFPGHMAKGLKKMQSS
                     LKSVDCVIEVHDARIPFSGRNPLFQELLGLKPHLLVLNKMDLADLTEQQKIVQRLEEK
                     GLSNVLFTNCVKDENIKQIVPKVMELIRCSYRYHRAETPEYCIMVVGVPNVGKSSLIN
                     SLRRQHLRTGKAARVGGEPGITRAVTSRIQVCERPLVFLLDTPGVLAPRIESVETGLK
                     LALCGTVLDHLVGEETMADYLLYTLNRHGLFGYVQHYALASACDQIEWVLKNVAIKLR
                     KTRKVKVLTGTGNVNVIQPDYAMAARDFLRTFRSGLLGQVMLDRDIIPAC"
     exon            211..275
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            276..380
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            381..461
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            462..518
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            519..609
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            610..671
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            672..768
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            769..850
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            851..963
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1595
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1389..1394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /note="putative"
     polyA_site      1415
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /note="putative"
     regulatory      1576..1581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /note="putative"
     polyA_site      1595
                     /gene="Mtg1"
                     /gene_synonym="Gm169; Gtpbp7"
                     /note="putative"
ORIGIN      
        1 atgcgcagtc gcgcacggaa cccaggcgcg ccggaaccct gtgagcagat ccaggccctg
       61 gcggaggcgg tccgactgcg aactcttccg acaccagtga catgaggctg tggccgcagg
      121 catggggtgc cgtccggggc gcttggcgcg agtgcttccc tctgcaaggt cacgatgtag
      181 cacgctggtt ccccggccac atggccaagg gactaaagaa gatgcagagc agtctgaagt
      241 cggtggattg tgttatcgag gttcatgacg ccaggatccc attttcaggt cgaaaccctc
      301 tgttccaaga gctgcttggt ctgaaaccgc atctgcttgt cctcaacaaa atggacttgg
      361 cagatcttac agagcagcag aaaattgtcc agcgcttaga agaaaaaggc ctgagcaacg
      421 ttctcttcac gaactgtgtg aaagatgaaa acatcaagca gattgtccca aaagtcatgg
      481 aactgatcag gtgcagctac cgctaccatc gagccgagac cccagaatac tgcatcatgg
      541 tggtcggtgt ccccaatgta ggcaaatcct ccctcatcaa ctccctgagg cggcagcacc
      601 tcaggacagg aaaagctgcc agagtgggag gtgagccagg aatcacaaga gctgtgacat
      661 ccagaatcca ggtatgtgag cgtccactgg tattcttgct ggatactcct ggggtgctgg
      721 ctcctcggat tgaaagcgtg gagacaggcc tgaagctggc cctgtgtgga actgtgttgg
      781 accaccttgt tggggaagag accatggccg attatctcct ttacaccctc aacaggcatg
      841 ggctctttgg gtatgtgcag cactatgccc tggccagcgc ctgtgaccaa atagagtggg
      901 tgctgaagaa cgtggctatc aagctgagga agacgcggaa agtgaaggtt ctcacaggca
      961 caggtaatgt caatgttatc cagcctgatt atgccatggc agcccgagac ttcctccgga
     1021 ccttccgcag tgggctgttg ggccaggtga tgctggaccg tgacattata cctgcttgct
     1081 gatgacgtta acccctggac tggctggctg gagtatggtc tcctgcatag tccatgtgac
     1141 tgcagctgga gtgtttaatg cttaggactg ttcctccagt tcagaagctc tctgtgctgg
     1201 taactgaggc tcaggcccca gctccaaagg gcgctatgtt ctcttgtcta tcagagcctg
     1261 gtcagtcctg gttactacca tgagacccca ggagtgctgt gtatgtggct tggtcaggag
     1321 gttttctcca tctcaagtaa gagacaaatg ctatctcaga ggagtctaag ttataatctg
     1381 taatttaaaa taaaatgggt taaaaggccc actttaaaaa aaaatctctc tctggcttct
     1441 cttattttac tttatttatt tttttgtcat tttcagacaa agtttcatca tgtggcttgg
     1501 gctggtctca aacacattcc ttctgcctta gcctcttgag tgctggaatt atacaggtgt
     1561 gtgccatgac aaccgattaa aagacctatt ttctg
//
