LOCUS       NM_027930               2307 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus mitochondrial fission regulator 2 (Mtfr2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_027930 XM_908397 XM_920840
VERSION     NM_027930.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2307)
  AUTHORS   Wei,L., Feng,Z., Dou,Q., Tan,L., Zhao,X. and Hao,B.
  TITLE     Dysregulation of MTFR2, ATP5IF1 and BAK1 in Sertoli cells relates
            to idiopathic non-obstructive azoospermia via inhibiting
            mitochondrial fission and inducing mitochondrial dysfunctiondagger
  JOURNAL   Biol Reprod 110 (2), 408-418 (2024)
   PUBMED   37903059
  REMARK    GeneRIF: Dysregulation of MTFR2, ATP5IF1 and BAK1 in Sertoli cells
            relates to idiopathic non-obstructive azoospermia via inhibiting
            mitochondrial fission and inducing mitochondrial dysfunctiondagger.
REFERENCE   2  (bases 1 to 2307)
  AUTHORS   Monticone,M., Panfoli,I., Ravera,S., Puglisi,R., Jiang,M.M.,
            Morello,R., Candiani,S., Tonachini,L., Biticchi,R., Fabiano,A.,
            Cancedda,R., Boitani,C. and Castagnola,P.
  TITLE     The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic
            and cellular respiration
  JOURNAL   J Cell Physiol 225 (3), 767-776 (2010)
   PUBMED   20568109
  REMARK    GeneRIF: The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial
            dynamic and cellular respiration and may affect male fertility.
REFERENCE   3  (bases 1 to 2307)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153845.10 and AK011410.1.
            
            On Jun 17, 2008 this sequence version replaced NM_027930.2.
            
            Sequence Note: The RefSeq record was created from transcript and
            genomic sequence data because transcript sequence  from the
            reference strain that is consistent with the reference genome
            assembly was not available for all regions of the RefSeq
            transcript. The extent of this transcript is supported by
            transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011410.1, BC019132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC153845.10        138292-138297
            7-773               AK011410.1         2-768
            774-774             AC153845.10        147841-147841
            775-1836            AK011410.1         770-1831
            1837-2307           AC153845.10        151672-152142
FEATURES             Location/Qualifiers
     source          1..2307
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 9.75 cM"
     gene            1..2307
                     /gene="Mtfr2"
                     /gene_synonym="2610016C23Rik; 4933412C16Rik; Dufd1;
                     Fam54a"
                     /note="mitochondrial fission regulator 2"
                     /db_xref="GeneID:71804"
                     /db_xref="MGI:MGI:1919054"
     exon            1..105
                     /gene="Mtfr2"
                     /gene_synonym="2610016C23Rik; 4933412C16Rik; Dufd1;
                     Fam54a"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1178
                     /gene="Mtfr2"
                     /gene_synonym="2610016C23Rik; 4933412C16Rik; Dufd1;
                     Fam54a"
                     /note="DUF729 domain containing 1; DUF729
                     domain-containing protein 1; protein FAM54A; family with
                     sequence similarity 54, member A"
                     /codon_start=1
                     /product="mitochondrial fission regulator 2"
                     /protein_id="NP_082206.2"
                     /db_xref="CCDS:CCDS48511.1"
                     /db_xref="GeneID:71804"
                     /db_xref="MGI:MGI:1919054"
                     /translation="MPRDGTNEQRFLELPSPMSFILNILRNVLEYFGVPVDQDLLICQ
                     NKNCGSARSIVRIIGRRLPLKPCRRPHFELIPHVNSTESDDYELRVPSFADVLCVAND
                     EEASCLRFRHSLWQKKEERKIAPFYPSKLTWDPSSPGLRQNKTETDDLPVNEAAIKKI
                     AALEDELTFLRSQIAAIVAMQDLRESRETGFIDLSDEQVPPSSATTGLSVEPDHAPSV
                     VLPPPPPPPPPPQFSLQPPSSLPMQPGSANTHDIDSLATEMERQLSGVKKTDDSHHSK
                     SQRLRDVPNMLDVLKDVNKVRLRPVERSPGGRPVQKRKRRSSEWDPVSLISNALKQKF
                     AFQDDSFDRENSSWECSPFSSPETSRF"
     exon            106..206
                     /gene="Mtfr2"
                     /gene_synonym="2610016C23Rik; 4933412C16Rik; Dufd1;
                     Fam54a"
                     /inference="alignment:Splign:2.1.0"
     exon            207..311
                     /gene="Mtfr2"
                     /gene_synonym="2610016C23Rik; 4933412C16Rik; Dufd1;
                     Fam54a"
                     /inference="alignment:Splign:2.1.0"
     exon            312..424
                     /gene="Mtfr2"
                     /gene_synonym="2610016C23Rik; 4933412C16Rik; Dufd1;
                     Fam54a"
                     /inference="alignment:Splign:2.1.0"
     exon            425..660
                     /gene="Mtfr2"
                     /gene_synonym="2610016C23Rik; 4933412C16Rik; Dufd1;
                     Fam54a"
                     /inference="alignment:Splign:2.1.0"
     exon            661..1172
                     /gene="Mtfr2"
                     /gene_synonym="2610016C23Rik; 4933412C16Rik; Dufd1;
                     Fam54a"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..2307
                     /gene="Mtfr2"
                     /gene_synonym="2610016C23Rik; 4933412C16Rik; Dufd1;
                     Fam54a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1924..1929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtfr2"
                     /gene_synonym="2610016C23Rik; 4933412C16Rik; Dufd1;
                     Fam54a"
                     /note="hexamer: AATAAA"
     polyA_site      1942
                     /gene="Mtfr2"
                     /gene_synonym="2610016C23Rik; 4933412C16Rik; Dufd1;
                     Fam54a"
                     /note="major polyA site"
     regulatory      1968..1973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtfr2"
                     /gene_synonym="2610016C23Rik; 4933412C16Rik; Dufd1;
                     Fam54a"
                     /note="hexamer: ATTATA"
     polyA_site      1992
                     /gene="Mtfr2"
                     /gene_synonym="2610016C23Rik; 4933412C16Rik; Dufd1;
                     Fam54a"
ORIGIN      
        1 cgagtcggaa gcggcgagcg attccgggaa gaagctactc tgcggctgta ggtcgcgtcc
       61 ggagagtttc cccggccgcc tggcgccgtg caatgccgcg ggatggtacc aacgaacagc
      121 gttttcttga acttccttca ccaatgtctt tcattctaaa tatattaaga aacgtgctgg
      181 aatattttgg tgttcccgta gaccaggatt tgctgatttg tcaaaataaa aactgtgggt
      241 cagctcggag tattgttcgt attattggga gaaggcttcc tttaaaacct tgcagaagac
      301 ctcattttga gttgatcccg catgtgaact ctacggagtc tgatgattat gaacttaggg
      361 ttccatcttt tgctgacgtt ttatgtgtgg caaatgatga agaagccagt tgtctcagat
      421 ttcgacatag tctatggcaa aagaaggaag aaagaaaaat tgctcctttt tatccttcaa
      481 aactaacttg ggatccatca tcacctggtc taagacagaa caaaacagag acagacgatc
      541 tgcctgtaaa tgaagctgca attaaaaaga tagctgccct tgaagatgag ctgacttttc
      601 tccggtctca gattgctgcg attgtggcaa tgcaggacct gagagagagc agagagactg
      661 gtttcatcga cttgagtgat gaacaagtgc cgccatcatc agcgaccact gggctgagtg
      721 tggaaccaga ccatgctcca agtgtggtgc ttcctcctcc tcctccccca cctcctcctc
      781 ctcagttttc tctgcagcct ccaagttctc ttcccatgca gcctggatct gccaatacac
      841 atgacataga tagtctggct actgaaatgg aaaggcagct ctcaggtgtt aagaagaccg
      901 atgacagcca tcattcaaaa agccagagac ttcgtgatgt cccaaacatg ctggatgttc
      961 tgaaggacgt gaacaaggtc agacttcggc ctgtggaaag gtcaccaggt ggcagacccg
     1021 ttcagaagag gaagagacgg agttcagaat gggatccagt gtctttaata tctaatgcac
     1081 tgaagcagaa gtttgcattt caagatgatt cctttgacag agaaaatagt tcctgggagt
     1141 gttctccgtt ttctagtcct gaaacttcaa ggttttgaca tcacattctc caacagaaag
     1201 ttgatgacct aagggaagga ctgataatat aaaagcagtt atccaggcta tcagaagcaa
     1261 aagctgtgct cacacttgga cagacagacc cagatgtgcc acgtggcatc cttcactgcc
     1321 tgtcagagaa tcacctcctc tgttagggtg atcaagctgt accccaggac ccatctccac
     1381 ccagcctgag gaatgaggaa gacacttaag aatactgtcc ctgcttttgg aagatgtggc
     1441 atttaactgg ctactgaaga gagttggggg tatagattcc ctgctttatg agactgctac
     1501 tgaaaatgga atacatggtt cagtgagctg cctaaaatta tggcttccta ctgaggctcc
     1561 tttcagtctt gtgagttgct gtgatacggt ttgtttggcc ttcagcagct tgtggatttt
     1621 tagtgagcag aagatgatat tgttttttat taagttagtc atagttgtga aaacacagga
     1681 acacctgaga aactgaaggg aaaaaaaaga tagtcacaat tttagtcatg tagggttgaa
     1741 ctttctactg caagtagaag tagacccttg ataagttcca tccacactgg ctttgcacac
     1801 acagatggct ggtttgttcc ctttgttctc tattatgttt gtatcccata tgtatgtgtg
     1861 tgtgtgtgtg tgtgtgtgtg tatatatata tatatatata tatatatata atgtagattt
     1921 tataataaat ggatcttttg aatttggttg agtatttaac atttcaaatt atattcttac
     1981 tgttttatga aatctggtta ttttgtgaga agtggttata tttctgttag aatttcttgg
     2041 ggggtggtac aagtgaaccc tagtttattt gcagtaggct gtctcctcat tggtgctaat
     2101 gtgatacatt tgcatgcttc cctgcttggc ttcgcctgtg ttgcagcagg gagcaggggg
     2161 gcggggccgt gtccgtgggg tcagcaccca cccattcccc caggtgctct cctatcagag
     2221 gaccctaact tgtctgtcac tcatcaacag tttattgtaa agaacttaga aataaaaccc
     2281 gttgtgtatc agggcctcca ttttgaa
//
