LOCUS       NM_026182               2963 bp    mRNA    linear   ROD 08-FEB-2024
DEFINITION  Mus musculus mitochondrial fission regulator 1 (Mtfr1), transcript
            variant 3, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_026182
VERSION     NM_026182.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2963)
  AUTHORS   Wang,K., Zhang,D.L., Long,B., An,T., Zhang,J., Zhou,L.Y., Liu,C.Y.
            and Li,P.F.
  TITLE     NFAT4-dependent miR-324-5p regulates mitochondrial morphology and
            cardiomyocyte cell death by targeting Mtfr1
  JOURNAL   Cell Death Dis 6 (12), e2007 (2015)
   PUBMED   26633713
  REMARK    GeneRIF: Study defines the NFAT4/ miR-324-5p/Mtfr1 axis, which
            participates in the regulation of mitochondrial fission and
            cardiomyocyte apoptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2963)
  AUTHORS   Monticone,M., Panfoli,I., Ravera,S., Puglisi,R., Jiang,M.M.,
            Morello,R., Candiani,S., Tonachini,L., Biticchi,R., Fabiano,A.,
            Cancedda,R., Boitani,C. and Castagnola,P.
  TITLE     The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic
            and cellular respiration
  JOURNAL   J Cell Physiol 225 (3), 767-776 (2010)
   PUBMED   20568109
  REMARK    GeneRIF: The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial
            dynamic and cellular respiration and may affect male fertility.
REFERENCE   3  (bases 1 to 2963)
  AUTHORS   Monticone,M., Tonachini,L., Tavella,S., Degan,P., Biticchi,R.,
            Palombi,F., Puglisi,R., Boitani,C., Cancedda,R. and Castagnola,P.
  TITLE     Impaired expression of genes coding for reactive oxygen species
            scavenging enzymes in testes of Mtfr1/Chppr-deficient mice
  JOURNAL   Reproduction 134 (3), 483-492 (2007)
   PUBMED   17709566
REFERENCE   4  (bases 1 to 2963)
  AUTHORS   Tonachini,L., Monticone,M., Puri,C., Tacchetti,C., Pinton,P.,
            Rizzuto,R., Cancedda,R., Tavella,S. and Castagnola,P.
  TITLE     Chondrocyte protein with a poly-proline region (CHPPR) is a novel
            mitochondrial protein and promotes mitochondrial fission
  JOURNAL   J Cell Physiol 201 (3), 470-482 (2004)
   PUBMED   15389597
  REMARK    GeneRIF: CHPPR is able to promote mitochondrial fission with a
            sequence specific mechanism suggesting that this event may be
            relevant to late stage of chondrocyte differentiation [CHPPR]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127283.2, BY143181.1, AK004846.1 and BY429681.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by NM_026182.7.
            
            On Sep 28, 2017 this sequence version replaced NM_026182.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004846.1, DQ369744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC127283.2         101397-101507
            112-134             BY143181.1         3-25
            135-2941            AK004846.1         2-2808
            2942-2963           BY429681.1         391-412
FEATURES             Location/Qualifiers
     source          1..2963
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 5.36 cM"
     gene            1..2963
                     /gene="Mtfr1"
                     /gene_synonym="1300002C08Rik; 1700080D04Rik;
                     2810026O10Rik; 4930579E05Rik; Chppr; Fam54a2"
                     /note="mitochondrial fission regulator 1"
                     /db_xref="GeneID:67472"
                     /db_xref="MGI:MGI:1914722"
     exon            1..179
                     /gene="Mtfr1"
                     /gene_synonym="1300002C08Rik; 1700080D04Rik;
                     2810026O10Rik; 4930579E05Rik; Chppr; Fam54a2"
                     /inference="alignment:Splign:2.1.0"
     exon            180..321
                     /gene="Mtfr1"
                     /gene_synonym="1300002C08Rik; 1700080D04Rik;
                     2810026O10Rik; 4930579E05Rik; Chppr; Fam54a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1242
                     /gene="Mtfr1"
                     /gene_synonym="1300002C08Rik; 1700080D04Rik;
                     2810026O10Rik; 4930579E05Rik; Chppr; Fam54a2"
                     /note="chondrocyte protein with a poly-proline region"
                     /codon_start=1
                     /product="mitochondrial fission regulator 1"
                     /protein_id="NP_080458.1"
                     /db_xref="CCDS:CCDS17256.1"
                     /db_xref="GeneID:67472"
                     /db_xref="MGI:MGI:1914722"
                     /translation="MLGWIKCLMRMWFQRVGVSMQSVLWSGKPYGSSRSIVRKIGTNL
                     SLIQCPRVQFQLTSHATEWSPAHSGEDAVASFADVGLVATEEGECSIRLRAEVSSKPP
                     HEDDPPCFEKPPSRHTSFPSLSQDKPSPERTLASEEALQKISALENELAALRAQIAKI
                     VTLQEQQSPSAGCLDSSTSVTVAPPPPPPPPPPPLPLVLHQSTSALDLIKERREQRLS
                     AGKTLATGHPKKPDMPNMLEILKDMNSVKLRSVKRSEKDVKPRPADTDHAAFIAEALK
                     KKFAYRHNSQGETERGIPKPESEATSEPALFGPHILKSTGKMKALIENVPDS"
     exon            322..420
                     /gene="Mtfr1"
                     /gene_synonym="1300002C08Rik; 1700080D04Rik;
                     2810026O10Rik; 4930579E05Rik; Chppr; Fam54a2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..536
                     /gene="Mtfr1"
                     /gene_synonym="1300002C08Rik; 1700080D04Rik;
                     2810026O10Rik; 4930579E05Rik; Chppr; Fam54a2"
                     /inference="alignment:Splign:2.1.0"
     exon            537..769
                     /gene="Mtfr1"
                     /gene_synonym="1300002C08Rik; 1700080D04Rik;
                     2810026O10Rik; 4930579E05Rik; Chppr; Fam54a2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1013
                     /gene="Mtfr1"
                     /gene_synonym="1300002C08Rik; 1700080D04Rik;
                     2810026O10Rik; 4930579E05Rik; Chppr; Fam54a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1173
                     /gene="Mtfr1"
                     /gene_synonym="1300002C08Rik; 1700080D04Rik;
                     2810026O10Rik; 4930579E05Rik; Chppr; Fam54a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..2953
                     /gene="Mtfr1"
                     /gene_synonym="1300002C08Rik; 1700080D04Rik;
                     2810026O10Rik; 4930579E05Rik; Chppr; Fam54a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgagcaga cacgccttcc gccggcctct cctgagcccg cccccgggcc tcagcgagcc
       61 gttcactggt cagcctaggc cgggccaggg gcggggattg gctgattggc ataaggtcct
      121 gggacagcca atctggaagg ctgagcagct gcgaaggtga gggctgctgc gcagccgagt
      181 gtgctctatg gaccatgtgc tgctatggat gcctgaagtt gttgacctgc aggttgggaa
      241 gactcagcca tctccatgct gggctggatt aagtgcctga tgaggatgtg gtttcagcga
      301 gttggggtca gcatgcagtc ggtactatgg tctggaaaac catatggttc atctcgaagt
      361 atcgtaagga aaattggtac caacttatct ctgattcagt gtccaagagt tcaatttcag
      421 cttaccagcc atgcaacaga atggagtccc gcacactcag gagaggatgc ggtggcatct
      481 tttgctgatg ttggattggt agccactgaa gaaggagagt gctcaataag actcagggca
      541 gaagtcagtt ccaagcctcc tcatgaggat gaccctcctt gctttgagaa gcccccaagc
      601 aggcacactt ccttcccaag cctgtctcaa gacaagcctt ctccagagag gacgctggcc
      661 agcgaggagg ccctgcagaa gatctctgcc cttgagaatg agcttgctgc ccttagagct
      721 cagattgcca agattgtgac cctgcaggag caacagagtc caagtgcagg ttgcttagat
      781 tcttccacat ctgttactgt agcaccacca ccaccacctc ctcctcctcc ccctcccctt
      841 ccgttggtac tccaccaaag tacgtctgct cttgatctga ttaaagaaag aagagagcag
      901 agactcagtg ctggaaagac tttggctacg ggccacccaa agaagcctga catgccaaat
      961 atgcttgaga tccttaaaga catgaacagt gtgaagctac ggtcagtcaa gaggtcagag
     1021 aaagatgtaa aacccaggcc agcggatact gaccatgctg ccttcatagc agaggctctg
     1081 aaaaagaagt ttgcatatcg acacaatagc caaggagaaa ctgaaagagg aattccaaag
     1141 ccagagtcag aggccacctc agagccagcc ctgtttggcc cacatatatt gaagtctaca
     1201 gggaaaatga aggctttaat tgaaaatgtt cccgactcct aatggacaat gaattcagaa
     1261 agactcctgg ttcaccagtt ggcttgcaga gctgagtttg tctaggagaa atcaccagta
     1321 tttagtaaat tccttgctgt agtgttcatt ggtctccttc cttctgagcc caactagagg
     1381 agtaagaagc agtgaaagca gcaggaggtc tggcttctga gaggtcagct ctggagctct
     1441 ccctaacaca catgtactat gtgcatgttc tgttcttaac actaaaatct gtgcacacat
     1501 ttcaccatga atggcatcag agaggacact gttatcttcc tcttcactga gagttcacta
     1561 gtcagtgatg gagagctggt atactgttat tatagcacac tattggagct gggaatgcct
     1621 cggacaggac ttgagtatgt tctcactttc tgttttctgg agctgagttt acataaacag
     1681 cagaagatgt ttactgctga gtctctgtgt tgctttctgt tagagggaag tgaggaccag
     1741 gaaggccatt tacacctcat taccacccac tactgggaag caaatgaact tctcaagtag
     1801 taacaaatca aactattgaa ttaaatcatt tcttaaataa aagccagaat gtatcatctt
     1861 tctcatcagt ttaataagtg gccctataaa gatggatgat ttgttgctaa gttaaaaatt
     1921 gtcttagtta aggttaccat cactgtgatg aaacaccatg gccagaagca ccttggggga
     1981 ggaaatggtt tatgtcactc acagtgccat atagcagttc ttcatcacaa gcattgaggg
     2041 cagggactaa gcagggcagg gccctggagc caggagctga tgcagaggcc atggaggctg
     2101 ctgcttactg gcttgcttcc tatggcctgc tcagcctgct ttcttataga acccaggacc
     2161 accaacccag ggttggcact accttcccca tcaatcacta attaagagaa ggccttgcag
     2221 ccagatctta tggaggcatt ttctcaattg aggttcactt ccttttagat gactctagct
     2281 gtgtcaagct gacaaactag ccaccacaat acttctagaa atgtcagcgt aattgaattt
     2341 ataattttaa tatactggtc aaaatatcct ttataatgaa acattactga atagatgaat
     2401 aagttccctt taagctattt attattggtc agccaatgaa ttacattatg cagataaacc
     2461 ttcggtgtta ttagaaagta gaaaactacc tttgttatct agggcttgga aggacttatc
     2521 taaagtactt agtagtttac catgattttt gtgtttctga taagactctt taatgtcaga
     2581 atctcttacc atgagtaaat atttggatta tttaaatcta gactattggt tcttcccaga
     2641 gtttagagat gggaagtgta gataatattg taagttattg aagataggtg ttctaaatca
     2701 tacaaagact gggctatttt ttcatagcat atttagttta aattgtggta tgtttttgct
     2761 gtatattgtt tctaaatatt ttttatggtt tgaaaactgt cttttatgaa attcagaaaa
     2821 tttgtgtgac cacatatttt gacctaagag tttatattta tatcagtatt gaatttggct
     2881 agcagtctac tatataaaag ttaatatttt aaaataaagt aagctgttga attttctttt
     2941 gacaatacta ttaaaaaaaa aaa
//
