LOCUS       NM_026443               1396 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus mitochondrial fission process 1 (Mtfp1), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_026443
VERSION     NM_026443.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1396)
  AUTHORS   Cui,H., Hu,D., Liu,Y. and Zhao,J.
  TITLE     Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising
            biomarkers of sarcopenia in various models
  JOURNAL   Gene 896, 148053 (2024)
   PUBMED   38042218
  REMARK    GeneRIF: Identifying Acss1, Mtfp1 and Oxct1 as key regulators and
            promising biomarkers of sarcopenia in various models.
REFERENCE   2  (bases 1 to 1396)
  AUTHORS   Patitucci,C., Hernandez-Camacho,J.D., Vimont,E., Yde,S.,
            Cokelaer,T., Chaze,T., Giai Gianetto,Q., Matondo,M., Gazi,A.,
            Nemazanyy,I., Stroud,D.A., Hock,D.H., Donnarumma,E. and Wai,T.
  TITLE     Mtfp1 ablation enhances mitochondrial respiration and protects
            against hepatic steatosis
  JOURNAL   Nat Commun 14 (1), 8474 (2023)
   PUBMED   38123539
  REMARK    GeneRIF: Mtfp1 ablation enhances mitochondrial respiration and
            protects against hepatic steatosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1396)
  AUTHORS   Donnarumma,E., Kohlhaas,M., Vimont,E., Kornobis,E., Chaze,T.,
            Gianetto,Q.G., Matondo,M., Moya-Nilges,M., Maack,C. and Wai,T.
  TITLE     Mitochondrial Fission Process 1 controls inner membrane integrity
            and protects against heart failure
  JOURNAL   Nat Commun 13 (1), 6634 (2022)
   PUBMED   36333300
  REMARK    GeneRIF: Mitochondrial Fission Process 1 controls inner membrane
            integrity and protects against heart failure.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1396)
  AUTHORS   Wu,D., Schieren,I., Qian,Y., Zhang,C., Jessell,T.M. and de
            Nooij,J.C.
  TITLE     A Role for Sensory end Organ-Derived Signals in Regulating Muscle
            Spindle Proprioceptor Phenotype
  JOURNAL   J Neurosci 39 (22), 4252-4267 (2019)
   PUBMED   30926747
REFERENCE   5  (bases 1 to 1396)
  AUTHORS   Wei,Q., Sun,H., Song,S., Liu,Y., Liu,P., Livingston,M.J., Wang,J.,
            Liang,M., Mi,Q.S., Huo,Y., Nahman,N.S., Mei,C. and Dong,Z.
  TITLE     MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in
            ischemic acute kidney injury
  JOURNAL   J Clin Invest 128 (12), 5448-5464 (2018)
   PUBMED   30325740
  REMARK    GeneRIF: the results suggest that miR-668 is induced via HIF-1 in
            ischemic AKI and that, upon induction, miR-668 represses MTP18 to
            preserve mitochondrial dynamics for renal tubular cell survival and
            kidney protection.
REFERENCE   6  (bases 1 to 1396)
  AUTHORS   Aung,L.H.H., Li,R., Prabhakar,B.S. and Li,P.
  TITLE     Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by
            inhibiting Dnm1l-mediated mitochondrial fission
  JOURNAL   J Cell Mol Med 21 (12), 3394-3404 (2017)
   PUBMED   28643438
  REMARK    GeneRIF: Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity
            by inhibiting Dnm1l-mediated mitochondrial fission.
REFERENCE   7  (bases 1 to 1396)
  AUTHORS   Morita,M., Prudent,J., Basu,K., Goyon,V., Katsumura,S., Hulea,L.,
            Pearl,D., Siddiqui,N., Strack,S., McGuirk,S., St-Pierre,J.,
            Larsson,O., Topisirovic,I., Vali,H., McBride,H.M., Bergeron,J.J.
            and Sonenberg,N.
  TITLE     mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1
  JOURNAL   Mol Cell 67 (6), 922-935 (2017)
   PUBMED   28918902
  REMARK    GeneRIF: Data provide direct evidence for cell survival upon mTOR
            inhibition through mitochondrial hyperfusion employing MTFP1 as a
            critical effector of mTORC1 to govern cell fate decisions.
REFERENCE   8  (bases 1 to 1396)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   9  (bases 1 to 1396)
  AUTHORS   Tondera,D., Santel,A., Schwarzer,R., Dames,S., Giese,K., Klippel,A.
            and Kaufmann,J.
  TITLE     Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent
            protein, affects mitochondrial morphology and induces apoptosis
  JOURNAL   J Biol Chem 279 (30), 31544-31555 (2004)
   PUBMED   15155745
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK078381.1.
            
            On Apr 6, 2007 this sequence version replaced NM_026443.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078381.1, AK012058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1396              AK078381.1         2-1397
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.87 cM"
     gene            1..1396
                     /gene="Mtfp1"
                     /gene_synonym="1700020C11Rik; 2610507A21Rik; Mtp18"
                     /note="mitochondrial fission process 1"
                     /db_xref="GeneID:67900"
                     /db_xref="MGI:MGI:1916686"
     exon            1..216
                     /gene="Mtfp1"
                     /gene_synonym="1700020C11Rik; 2610507A21Rik; Mtp18"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..650
                     /gene="Mtfp1"
                     /gene_synonym="1700020C11Rik; 2610507A21Rik; Mtp18"
                     /note="mitochondrial 18 kDa protein; mitochondrial fission
                     protein MTP18"
                     /codon_start=1
                     /product="mitochondrial fission process protein 1"
                     /protein_id="NP_080719.2"
                     /db_xref="CCDS:CCDS24376.1"
                     /db_xref="GeneID:67900"
                     /db_xref="MGI:MGI:1916686"
                     /translation="MSEQQRQGAERDLYRDTWVRYLGYANEVGEAFRSLVPAAVVWLS
                     YGVSSSYVLADAIDKGKKAGEVPSPEAGRNTRMALAVVDTFVWQSLASVAIPGFTINR
                     LCAASLYVLGTMTHWPPTVRKWTTTTLGLLAIPVIIHPIDRSVDFLLDSSLRKLYPSV
                     EKPSTP"
     exon            217..344
                     /gene="Mtfp1"
                     /gene_synonym="1700020C11Rik; 2610507A21Rik; Mtp18"
                     /inference="alignment:Splign:2.1.0"
     exon            345..577
                     /gene="Mtfp1"
                     /gene_synonym="1700020C11Rik; 2610507A21Rik; Mtp18"
                     /inference="alignment:Splign:2.1.0"
     exon            578..1396
                     /gene="Mtfp1"
                     /gene_synonym="1700020C11Rik; 2610507A21Rik; Mtp18"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1396
                     /gene="Mtfp1"
                     /gene_synonym="1700020C11Rik; 2610507A21Rik; Mtp18"
                     /note="putative"
ORIGIN      
        1 actccctgca gtggcgttag cgatagcggg acccgtcctt cagcctcgga ctactggcgg
       61 gttcttgcct ggtgttagcc aagtgctagt ggagacacag ttgtggtgag actctaatct
      121 gcagcgactc caaccttgcc ggggaagtca tgtcggagca gcagcggcag ggcgccgagc
      181 gcgacctcta ccgggacacg tgggtgcgct acctgggcta cgccaatgag gtgggggagg
      241 ctttccgctc gctggttcct gcagctgtgg tgtggttgag ctatggtgtg tccagctcct
      301 atgtcctggc cgatgccata gacaaaggca agaaggcagg agaggtgcca agccctgaag
      361 caggccgcaa caccagaatg gccctggctg tggtcgacac ctttgtgtgg cagtctctgg
      421 cctctgtggc tatcccaggc ttcaccatca accgtctgtg tgctgcctct ctctatgtct
      481 tgggtactat gacccactgg cccccgactg tccgcaaatg gaccaccacc acacttggac
      541 tgctggccat ccccgtcata atccacccca tcgacaggtc agtggacttc ctcctggact
      601 ctagcctgcg caagctgtac ccgtcagtgg agaagcccag caccccctga ccctgccctg
      661 tgccttgcct ggggtcggcc cactcacatc aaagaatgtg gatacgtggc tgtttggggt
      721 ccatggcact gccatctggg tgggttcaca ttgatgggag cttagagatg aaggccccga
      781 ggagtagtgg cagtgagttc tgaggtggga cccaattctg tctgcctcag tggccacggt
      841 tgtgctgagt gggaacgaac tctggctggg cctgtctttt gaaatctttt tttaaaagta
      901 tttattttat gtgtataagt gttttacttg catgtctgta tgtatgtgca gaacccttag
      961 aggttaaaag aggtgattag acccctctgg gactggagtt agggatgctt gtgaaccccc
     1021 atgcgggtgc tgagaactga atctggttct tctgcaagag cagcaagtgc tctgttcact
     1081 aaagttcctc ttagccccgg gcccaccttc tgatggaaaa gttagttcct cccatggaag
     1141 agaagaatac taaggcccag agagggcagg gaatactgag atcatgtgac aagtgagagc
     1201 cagtcttctg gctattctaa gtcactttgt ggtagtgtgg ctgagcgact tagggaaaga
     1261 tacagaggta cagtatttgg gacactcagg gcagagtctc tggccagcct gttcctgttg
     1321 caggagctgc tgggcctggt gagaggcagg acaatcacaa cccaagtgct aacctaataa
     1381 aactttcaaa aatggc
//
