LOCUS       NM_013827               4343 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus metal response element binding transcription factor 2
            (Mtf2), transcript variant 1, mRNA.
ACCESSION   NM_013827
VERSION     NM_013827.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4343)
  AUTHORS   Sun,F., Cheng,Y., Riordan,J.D., Dupuy,A., Dubois,W., Pisano,M.,
            Dong,J., Mock,B., Zhan,F., Hari,P. and Janz,S.
  TITLE     WDR26 and MTF2 are therapeutic targets in multiple myeloma
  JOURNAL   J Hematol Oncol 14 (1), 203 (2021)
   PUBMED   34876184
  REMARK    GeneRIF: WDR26 and MTF2 are therapeutic targets in multiple
            myeloma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4343)
  AUTHORS   Loh,C.H., van Genesen,S., Perino,M., Bark,M.R. and Veenstra,G.J.C.
  TITLE     Loss of PRC2 subunits primes lineage choice during exit of
            pluripotency
  JOURNAL   Nat Commun 12 (1), 6985 (2021)
   PUBMED   34848733
  REMARK    GeneRIF: Loss of PRC2 subunits primes lineage choice during exit of
            pluripotency.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4343)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4343)
  AUTHORS   Petracovici,A. and Bonasio,R.
  TITLE     Distinct PRC2 subunits regulate maintenance and establishment of
            Polycomb repression during differentiation
  JOURNAL   Mol Cell 81 (12), 2625-2639 (2021)
   PUBMED   33887196
  REMARK    GeneRIF: Distinct PRC2 subunits regulate maintenance and
            establishment of Polycomb repression during differentiation.
REFERENCE   5  (bases 1 to 4343)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4343)
  AUTHORS   Yoshikawa,T., Piao,Y., Zhong,J., Matoba,R., Carter,M.G., Wang,Y.,
            Goldberg,I. and Ko,M.S.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   7  (bases 1 to 4343)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4343)
  AUTHORS   Kitaguchi,T., Nakata,K., Nagai,T., Aruga,J. and Mikoshiba,K.
  TITLE     Xenopus Polycomblike 2 (XPcl2) controls anterior to posterior
            patterning of the neural tissue
  JOURNAL   Dev Genes Evol 211 (6), 309-314 (2001)
   PUBMED   11466526
REFERENCE   9  (bases 1 to 4343)
  AUTHORS   Remondelli,P. and Leone,A.
  TITLE     Interactions of the zinc-regulated factor (ZiRF1) with the mouse
            metallothionein Ia promoter
  JOURNAL   Biochem J 323 (Pt 1) (Pt 1), 79-85 (1997)
   PUBMED   9173905
REFERENCE   10 (bases 1 to 4343)
  AUTHORS   Inouye,C., Remondelli,P., Karin,M. and Elledge,S.
  TITLE     Isolation of a cDNA encoding a metal response element binding
            protein using a novel expression cloning procedure: the one hybrid
            system
  JOURNAL   DNA Cell Biol 13 (7), 731-742 (1994)
   PUBMED   7772254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031409.1, BC092237.1, AK137539.1 and CJ311871.1.
            
            On Dec 9, 2011 this sequence version replaced NM_013827.2.
            
            Transcript Variant: This variant (1) lacks an alternate exon in the
            5' end compared to variant 7. The resulting isoform (1) has a
            shorter and distinct N-terminus compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AK031409.1         2-69
            69-2294             BC092237.1         1-2226
            2295-3393           AK137539.1         2635-3733
            3394-4128           BC092237.1         3326-4060
            4129-4343           CJ311871.1         233-447
FEATURES             Location/Qualifiers
     source          1..4343
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 52.41 cM"
     gene            1..4343
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /note="metal response element binding transcription factor
                     2"
                     /db_xref="GeneID:17765"
                     /db_xref="MGI:MGI:105050"
     exon            1..292
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..2069
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /note="isoform 1 is encoded by transcript variant 1; metal
                     response element DNA-binding protein M96; mPCl2; ziRF1;
                     polycomb-like protein 2; zinc-regulated factor 1; metal
                     regulatory transcription factor 2"
                     /codon_start=1
                     /product="metal-response element-binding transcription
                     factor 2 isoform 1"
                     /protein_id="NP_038855.2"
                     /db_xref="CCDS:CCDS39201.1"
                     /db_xref="GeneID:17765"
                     /db_xref="MGI:MGI:105050"
                     /translation="MRDSTGAGNSLVHKRSPLRRNQKTSASLNKLSLQDGHKAKKPAC
                     KFEEGQDVLARWSDGLFYLGTIKKINILKQSCFIIFEDSSKSWVLWKDIQTGATGSGE
                     MVCTICQEEYSEAPNEMVICDKCGQGYHQLCHTPHIDSSVIDSDEKWLCRQCVFATTT
                     KRGGALKKGPNAKALQVMKQTLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQ
                     CCKCKQWFHEACVQCLQKPMLFGDRFYTFICSVCSSGPEYLKRLPLQWVDIAHLCLYN
                     LSVIHKKKYFDSELELMTYINENWDRLHPGELADTPKSERYEHVLEALNDYKTMFMSG
                     KEIKKKKHLFGLRIRVPPVPPNVAFKAEKEPEGTSHEFKIKGRKASKPTSDSREVSNG
                     IEKKGKKKSVGRPPGPYTRKMIQKTAELPLDKESVSENPTLDLPCSIGRTEGIAHSSN
                     TSDVDLTGASSANETTSASISRHCGLSDSRKRTRTGRSWPAAIPHLRRRRGRLPRRAL
                     QTQNSEVVKDDEGKEDYQFEELNTEILNNLADQELQLNHLKNSITSYFGAAGRIACGE
                     KYRVLARRVTLDGKVQYLVEWEGATAS"
     exon            293..491
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            492..573
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            574..669
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..770
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            771..919
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1015
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1084
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1208
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1276
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1447
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1553
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1606
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1711
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..4343
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3442..3447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /note="hexamer: ACTAAA"
     polyA_site      3478
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /note="major polyA site"
     regulatory      4090..4095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /note="hexamer: ATTAAA"
     regulatory      4106..4111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /note="hexamer: ATTAAA"
     polyA_site      4111
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /note="major polyA site"
     polyA_site      4130
                     /gene="Mtf2"
                     /gene_synonym="9230112N11Rik; M96; Pcl2"
                     /note="major polyA site"
ORIGIN      
        1 attcggcccc ggagtagctc cgcgctccca gaatgcaccg ctagtccgcg ggaaaccaaa
       61 atggcgaagg gctgttgcga agtggtctgt gtttgaggcc ggtgtgagca cgcacattct
      121 ccttcctaac cctcgtcccc aaggaactcg gtgtgtgtgt gcgtgtgcgc agggctcccg
      181 ctggggcggg tgcccaggga gtgcccggac tcgcggggga gcgcccacgg gaacgagatt
      241 gcttctattt tcctgtatga agcggttggc accacttaag tgaccgaatg agagactcta
      301 caggagcagg taattcactg gtccacaagc ggtctccttt acgtcgaaac caaaagacct
      361 cagcatcctt gaacaagctg tctttacagg atggacataa agccaaaaaa ccagcatgta
      421 aatttgaaga gggtcaagat gtcttagcta gatggtcaga tggcttgttt tatcttggaa
      481 ctatcaaaaa gataaacata ttgaaacaga gctgcttcat catatttgag gacagttcca
      541 aatcctgggt tctctggaag gacatccaaa caggagccac tgggagtggg gaaatggtct
      601 gtacaatatg tcaagaagag tattcagaag ctcccaatga aatggttata tgtgataagt
      661 gtggtcaagg atatcatcag ctgtgtcaca cacctcatat tgactcgagt gtgattgatt
      721 cagatgaaaa gtggctttgt cgacagtgcg tttttgcaac aactacaaag aggggtggtg
      781 cgcttaagaa aggaccaaat gccaaagcat tgcaagtcat gaagcagaca ttaccctata
      841 gtgtggctga ccttgaatgg gatgcaggcc ataaaaccaa tgtccagcag tgctactgct
      901 attgtggagg ccctggagac tggtatttaa agatgctgca gtgctgcaaa tgtaagcagt
      961 ggtttcatga agcttgtgtc caatgccttc agaagccaat gctgtttgga gataggtttt
     1021 atacatttat ttgctctgtc tgcagttctg gaccagaata cctcaaacgt ctaccgttac
     1081 agtgggtaga tatagcacac ctatgccttt acaacctaag tgttattcac aagaagaaat
     1141 actttgattc tgaacttgag cttatgacat acattaatga aaactgggat agattgcacc
     1201 ctggagagct ggcagacaca cccaaatctg aaagatatga gcatgttctg gaggcattaa
     1261 atgattacaa gaccatgttt atgtctggga aagaaataaa gaagaagaag catttgtttg
     1321 ggttgcgaat tcgtgttcct cctgtgccac caaatgtggc tttcaaagca gagaaagaac
     1381 cagaaggaac atcccatgaa tttaaaatta aaggcagaaa ggcatccaaa cctacatctg
     1441 actcaaggga agtaagcaat gggatagaaa aaaaaggaaa gaaaaaatct gtaggtcgtc
     1501 ctcctggccc atatacaaga aaaatgattc aaaaaactgc tgagctacct ttggataagg
     1561 aatcagtttc agagaatcct acgttggatt taccttgttc tatagggaga actgagggaa
     1621 ttgcacattc atccaatacc tcagatgtgg acctcacggg tgcttccagt gcaaacgaaa
     1681 ctacctcggc tagcatttcc aggcattgtg gattatcaga ctctagaaaa agaactcgca
     1741 caggaagatc atggcctgct gcaataccac atttgcggag aagaagaggt cgccttccac
     1801 gaagagcact ccagactcag aactcagaag ttgtgaaaga tgatgaaggc aaagaagatt
     1861 atcagtttga agaacttaac acagaaattc tgaataactt agcagatcag gagttgcagc
     1921 tcaatcacct gaaaaactcc atcactagtt attttggtgc cgcaggtaga atagcatgtg
     1981 gcgaaaaata cagagttttg gctcgtcggg tgacgcttga tgggaaggtg cagtatcttg
     2041 tggaatggga aggagcgact gcatcctgac tgtaggactg aacgtaatgt tcactgcact
     2101 cgttttctgt tggtacagtt aaaaaaaaaa aaaacaaaaa acagagtgtg ggttttatta
     2161 tctttcttag aaaaacaaac aaagagaaaa cacaaaaata ttcacaaaag gagatgatac
     2221 tggccttaaa acatgttctt gtcaatgtta tggatattgt cataaaaaaa gatatctttt
     2281 aaaaatcaga ggagagactt aattttttta aatcttaaga tttgtagact gtttctagga
     2341 taggctatta aacatgattc atacccatgc atggtgttag atacttttta taattattcc
     2401 attgagtcaa tttttgtgat tagtggttat cagagcaaac agatcatgta gatagcacaa
     2461 gtatttggag aaacattgtg tgttttgtta acaaaatgtt ggaaagattt atttcaatac
     2521 cctttagatt tcataaagtg cagtgtatat aatgtctact gaaagactgt aaaatattga
     2581 aatttctttc aagcaaaatg taaaaaaata tattgagcct gtaaattgct ctgtgactag
     2641 acttcattgt cgtcttaata tattctttgc atgtacatgt atatacacac atgtgtatat
     2701 atatgtgtgt gattatgtga cctatgcaat acaaattatg ggaatgggca gctttggagt
     2761 atatatccca taattcttat ttcaggaata gttgcagtat ttacacagca gcatttcttc
     2821 tcaggcgttt attgggtgct gttgcttgct atgtatgaag agaaatgtgt caagtttagt
     2881 gtgtactgaa gaagggtgtg aacaacagtg tacatgggct tttagagggc ttttcagtcc
     2941 ttgtaactca gctgttgaat acctaaaaca aattcgagtg ataactacat tatttcctat
     3001 tagaagtgac gttttcaagt gattgtggca cattatgatt gtaaatgtct cagttttaac
     3061 agcaagtctg tgggagccca gtgaagactc ctgaaatgtc tgtagtaact gttagtcatg
     3121 tttgagtaag cgtagtatga acaaagtctt ttattgcaca gggttaacaa acagtatgtt
     3181 gctagctgag gctaactgct gttttattac aacattacct cttgttttta taaaatgtac
     3241 caagatttta aattgatatc tttattttac gtgttaaaaa aaagtttctt ttatcaccag
     3301 tgttagagtt gtcttctgtt tttttggttt gttttggttt ggtttttttc ttgttgtttt
     3361 ctttcttagc caaagagtaa acagaagaat attattttgg tagctcttca ttttactttt
     3421 ataatgattg gtggatttta gactaaaaat tggggaaatt tctgccaaaa tgaaaaaata
     3481 tgtgacgtgt attgatgaca gaatgctaaa attgtggtta gtgcttattt attccattaa
     3541 ttgattattt gcctgttttt aaagaaacat gctttatttc cttaagcatc ttcaaaagat
     3601 gacttttctt gtcacattgt agccaaaaga agcagagaat ttcttgtcct gcttttggtt
     3661 cctggttaac caggtataat gagctttaca aagtgcaaat tacaaactgt cacttctgtt
     3721 cacctccacc aaaacttgat ttcccctagc tattaattta aagttgcctt tcctgcagct
     3781 gcaatatttt gaataacaca gagattgtgt taatttttga atgtttgttt atatctaggg
     3841 gtaatggaaa atgtaattcc cgtgtaacct tattcactcc agctgtatca tatttcattt
     3901 ttcccaaagt tctttaattt taactgaaca ccagcagtat ttttagtaat tctttaagat
     3961 acttggaaga caatttatca agctgaactg tctctagact taattattgt gaatgtctgt
     4021 tttcttttat catggtggtt cacatggctc tgatgttcag tttgtatttt tgaaattgct
     4081 ttacttagaa ttaaaacaga ccaacattaa atgtgtgtat ttttaaaaga gctaatgagt
     4141 ttttcttctg tatctgcttg aaaatacaca ctggtgcagc agttaactgc ttttatttag
     4201 ctagggagga ggaattttcc aattctttta tatacttgaa ttagtcttga agaactttgc
     4261 ttccatttcc ttttgtcata atgataatag tgtatgttca ctgtgagtga tcttttaaaa
     4321 aaggattaca tgctttgtat ttg
//
