LOCUS       NM_178051               1330 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus mitochondrial transcription termination factor 4
            (Mterf4), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_178051
VERSION     NM_178051.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1330)
  AUTHORS   Castillo,A., Vila,M., Pedriza,I., Pardo,R., Camara,Y., Martin,E.,
            Beiroa,D., Torres-Torronteras,J., Oteo,M., Morcillo,M.A., Marti,R.,
            Simo,R., Nogueiras,R. and Villena,J.A.
  TITLE     Adipocyte MTERF4 regulates non-shivering adaptive thermogenesis and
            sympathetic-dependent glucose homeostasis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (6), 1298-1312 (2019)
   PUBMED   30690068
  REMARK    GeneRIF: The results demonstrate that MTERF4 regulates
            mitochondrial protein translation and is essential for proper brown
            adipose tissue thermogenic activity.
REFERENCE   2  (bases 1 to 1330)
  AUTHORS   Kuhl,I., Miranda,M., Atanassov,I., Kuznetsova,I., Hinze,Y.,
            Mourier,A., Filipovska,A. and Larsson,N.G.
  TITLE     Transcriptomic and proteomic landscape of mitochondrial dysfunction
            reveals secondary coenzyme Q deficiency in mammals
  JOURNAL   Elife 6, e30952 (2017)
   PUBMED   29132502
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1330)
  AUTHORS   Wang,X.L., Liu,Q., Chen,G.J., Li,M.L. and Ding,Y.H.
  TITLE     Overexpression of MTERF4 promotes the amyloidogenic processing of
            APP by inhibiting ADAM10
  JOURNAL   Biochem Biophys Res Commun 482 (4), 928-934 (2017)
   PUBMED   27894840
  REMARK    GeneRIF: The levels of MTERF4 protein were significantly increased
            in the hippocampus of APP/PS1 mice, an animal model of Alzheimer's
            disease.
REFERENCE   4  (bases 1 to 1330)
  AUTHORS   Camara,Y., Asin-Cayuela,J., Park,C.B., Metodiev,M.D., Shi,Y.,
            Ruzzenente,B., Kukat,C., Habermann,B., Wibom,R., Hultenby,K.,
            Franz,T., Erdjument-Bromage,H., Tempst,P., Hallberg,B.M.,
            Gustafsson,C.M. and Larsson,N.G.
  TITLE     MTERF4 regulates translation by targeting the methyltransferase
            NSUN4 to the mammalian mitochondrial ribosome
  JOURNAL   Cell Metab 13 (5), 527-539 (2011)
   PUBMED   21531335
REFERENCE   5  (bases 1 to 1330)
  AUTHORS   Xu,Q., Zhang,F., He,H., Xu,S., Li,K., Liu,S., Li,Y. and Wu,Q.
  TITLE     Expression profile of mouse Mterfd2, a novel component of the
            mitochondrial transcription termination factor (MTERF) family
  JOURNAL   Genes Genet Syst 86 (4), 269-275 (2011)
   PUBMED   22214595
  REMARK    GeneRIF: Mterfd2 might have multiple roles in organogenesis.
REFERENCE   6  (bases 1 to 1330)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033043.1, DV058715.1 and AK077142.1.
            
            On Jul 18, 2015 this sequence version replaced NM_178051.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077142.1, BC064709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AK033043.1         2-36
            36-789              DV058715.1         46-799
            790-1330            AK077142.1         781-1321
FEATURES             Location/Qualifiers
     source          1..1330
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 47.24 cM"
     gene            1..1330
                     /gene="Mterf4"
                     /gene_synonym="1810059A23Rik; 4933412H03Rik; Mterfd2"
                     /note="mitochondrial transcription termination factor 4"
                     /db_xref="GeneID:69821"
                     /db_xref="MGI:MGI:1918355"
     exon            1..55
                     /gene="Mterf4"
                     /gene_synonym="1810059A23Rik; 4933412H03Rik; Mterfd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1075
                     /gene="Mterf4"
                     /gene_synonym="1810059A23Rik; 4933412H03Rik; Mterfd2"
                     /note="isoform 1 is encoded by transcript variant 1; mTERF
                     domain-containing protein 2; MTERF domain containing 2;
                     transcription termination factor 4, mitochondrial"
                     /codon_start=1
                     /product="transcription termination factor 4,
                     mitochondrial isoform 1"
                     /protein_id="NP_835152.1"
                     /db_xref="CCDS:CCDS35671.1"
                     /db_xref="GeneID:69821"
                     /db_xref="MGI:MGI:1918355"
                     /translation="MASLGRQVPEWHRLLALSWACLVRQTPHLREQKQMSPSLSCKLT
                     TVPGRGSFQEFSSITPQKYMQEPENRTRLVQCLHEEQKPCVDPESLEPEKVIRSLQDM
                     GFAEAHIHSLFSIQPSVHPQQLLGIVSELLLLGLNPEPVFNALKKNPQLLKLSSMQMK
                     RRSSYLRKLGLGEGKLKRVLSVCPEVFTMHQRDIDRVVKVLREKCLFTAQHITDVLHR
                     CPTVLQEDPNELEYKFQYAYFRMGLTHLDIVRTNFLQYSITKIKQRHIYLERLGRYQT
                     PDKKGQTQIPNPSLRNILRVSEAEFLARTACSSVEEFQVFKKLLDQEEEEESESHASE
                     EEEEEEEEEELL"
     exon            56..554
                     /gene="Mterf4"
                     /gene_synonym="1810059A23Rik; 4933412H03Rik; Mterfd2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..739
                     /gene="Mterf4"
                     /gene_synonym="1810059A23Rik; 4933412H03Rik; Mterfd2"
                     /inference="alignment:Splign:2.1.0"
     exon            740..1330
                     /gene="Mterf4"
                     /gene_synonym="1810059A23Rik; 4933412H03Rik; Mterfd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1287..1292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mterf4"
                     /gene_synonym="1810059A23Rik; 4933412H03Rik; Mterfd2"
                     /note="hexamer: AATAAA"
     polyA_site      1309
                     /gene="Mterf4"
                     /gene_synonym="1810059A23Rik; 4933412H03Rik; Mterfd2"
                     /note="major polyA site"
ORIGIN      
        1 ttccggtctc acagttgttc ttcgcttggt ctccatggct tcgctgggaa ggcaggttcc
       61 tgagtggcat cgtctactgg ccctctcctg ggcctgtttg gttaggcaga cccctcatct
      121 cagagaacag aaacagatga gcccttcttt gtcttgcaaa ctgactacag tgcccggtag
      181 aggaagcttt caagagtttt ccagcattac accccaaaag tacatgcagg aaccagaaaa
      241 caggacacga cttgttcagt gtcttcatga ggaacagaag ccttgtgtgg atcctgagtc
      301 cttggagcct gaaaaggtca tccgttccct ccaggacatg ggttttgctg aagcccacat
      361 tcacagcttg tttagtatac agccaagtgt ccatcctcaa cagttgctgg gtatagtttc
      421 agaactccta ctcttggggt tgaacccaga gcctgtattt aatgccttga agaaaaatcc
      481 ccagttgctg aaactgtcta gcatgcagat gaagaggcgt tccagttacc ttcggaagct
      541 tggccttgga gaagggaaac tgaagcgggt gctgtccgtt tgccctgagg ttttcaccat
      601 gcatcagcgg gacattgacc gagttgtgaa ggtcctcagg gagaagtgct tgttcacggc
      661 acagcacatc acagacgttc tgcacagatg ccccactgtt ttgcaggagg accccaacga
      721 gctagaatac aaattccagt atgcatattt caggatggga ctcacacatc tagacatagt
      781 caggacgaat ttcttacagt attcaataac caagatcaag cagagacaca tttacctgga
      841 gcgccttgga cggtaccaga cccctgataa gaaggggcag acacagatcc ctaatccctc
      901 actgaggaac attctcagag tttctgaagc tgagtttttg gccaggacag cctgttcctc
      961 tgtcgaggag tttcaagttt ttaaaaaact cttggatcaa gaggaggagg aggagtctga
     1021 gagccatgca tctgaggagg aagaggaaga ggaggaagag gaggagctac tgtgacacag
     1081 cactggggtg tcagaggtca ttctcatatt ctcgaagtgc tggggacctt cacctggatc
     1141 ttctcaagca cttttgatcc caacactggt attttgatgg gggaaaaaac caacctgtaa
     1201 tgatccactg gagatacagg tagataaacc aaaccaaatg aggggtgctt tgttgtgggt
     1261 tctttgggag gccctactcc atcctaaata aaggactcgg ctgtcaaaat ccagggggtg
     1321 caacccttcc
//
