LOCUS       NM_025547               1486 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus mitochondrial transcription termination factor 3
            (Mterf3), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025547
VERSION     NM_025547.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1486)
  AUTHORS   Wredenberg,A., Lagouge,M., Bratic,A., Metodiev,M.D., Spahr,H.,
            Mourier,A., Freyer,C., Ruzzenente,B., Tain,L., Gronke,S.,
            Baggio,F., Kukat,C., Kremmer,E., Wibom,R., Polosa,P.L.,
            Habermann,B., Partridge,L., Park,C.B. and Larsson,N.G.
  TITLE     MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates
            and mammals
  JOURNAL   PLoS Genet 9 (1), e1003178 (2013)
   PUBMED   23300484
REFERENCE   2  (bases 1 to 1486)
  AUTHORS   Andersson,D.C., Fauconnier,J., Park,C.B., Zhang,S.J., Thireau,J.,
            Ivarsson,N., Larsson,N.G. and Westerblad,H.
  TITLE     Enhanced cardiomyocyte Ca(2+) cycling precedes terminal AV-block in
            mitochondrial cardiomyopathy Mterf3 KO mice
  JOURNAL   Antioxid Redox Signal 15 (9), 2455-2464 (2011)
   PUBMED   21381862
REFERENCE   3  (bases 1 to 1486)
  AUTHORS   Dorado,B., Area,E., Akman,H.O. and Hirano,M.
  TITLE     Onset and organ specificity of Tk2 deficiency depends on Tk1
            down-regulation and transcriptional compensation
  JOURNAL   Hum Mol Genet 20 (1), 155-164 (2011)
   PUBMED   20940150
REFERENCE   4  (bases 1 to 1486)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   5  (bases 1 to 1486)
  AUTHORS   Park,C.B., Asin-Cayuela,J., Camara,Y., Shi,Y., Pellegrini,M.,
            Gaspari,M., Wibom,R., Hultenby,K., Erdjument-Bromage,H., Tempst,P.,
            Falkenberg,M., Gustafsson,C.M. and Larsson,N.G.
  TITLE     MTERF3 is a negative regulator of mammalian mtDNA transcription
  JOURNAL   Cell 130 (2), 273-285 (2007)
   PUBMED   17662942
  REMARK    GeneRIF: MTERF3 is the first example of a mitochondrial protein
            that acts as a specific repressor of mammalian mtDNA transcription
            initiation in vivo.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124433.4.
            
            On Jan 23, 2019 this sequence version replaced NM_025547.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025173.1, AK010525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC124433.4         47138-47275         c
            139-477             AC124433.4         44088-44426         c
            478-630             AC124433.4         42373-42525         c
            631-820             AC124433.4         36959-37148         c
            821-968             AC124433.4         31229-31376         c
            969-1040            AC124433.4         30816-30887         c
            1041-1202           AC124433.4         28830-28991         c
            1203-1486           AC124433.4         26298-26581         c
FEATURES             Location/Qualifiers
     source          1..1486
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 34.54 cM"
     gene            1..1486
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
                     /note="mitochondrial transcription termination factor 3"
                     /db_xref="GeneID:66410"
                     /db_xref="MGI:MGI:1913660"
     exon            1..138
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..477
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1397
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
                     /note="mTERF domain-containing protein 1, mitochondrial;
                     MTERF domain containing 1; transcription termination
                     factor 3, mitochondrial"
                     /codon_start=1
                     /product="transcription termination factor 3,
                     mitochondrial precursor"
                     /protein_id="NP_079823.2"
                     /db_xref="CCDS:CCDS26611.1"
                     /db_xref="GeneID:66410"
                     /db_xref="MGI:MGI:1913660"
                     /translation="MALLAQQLPRRFNSVKLTSFIKAKQVTKRSARAGKAVLPGFSAQ
                     PLLSSDTSFLRRGIKTYRTLFWNRFHSASTNRTKSSAESTLLPSVAEQQERILSLESE
                     LPLEEVDDLPPLSPLQSVSEEEAIQIAAYSPLPISSFTLADYVDHSKTLQKLVQLGVD
                     LSKIEKHPDAANLLLRLDFEKHIKQILLFLKDLGLEDNQLGPFLTKNYAIFSEDLENL
                     KTRVAYLQSKNFSKTDIARMVKNAPFLLSFSVERLDNRLGFFQKELELNVKKTRDLVV
                     RLPRLLTGSLEPVKENMKVYHLELGFKHNEIQHMVIKIPKMLTANKRKLTEIFDYVHN
                     VMNIPHHIIVKFPQLFNTRVFKIKERHLFLAYLGRAQYDPAKPNYVSLDKFVSFPDKI
                     FCKEIAKASLNDFEKFLKTL"
     exon            478..630
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..820
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..968
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1040
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1202
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1486
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1441..1446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
                     /note="hexamer: AATAAA"
     regulatory      1458..1463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
                     /note="hexamer: AATAAA"
     polyA_site      1463
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
                     /note="major polyA site"
     polyA_site      1483
                     /gene="Mterf3"
                     /gene_synonym="2410017I18Rik; Mterfd1"
ORIGIN      
        1 ggcttgcgaa gctacggtgc accgtatccc cggcgtaggt tgcacggtcg ctgtgaagca
       61 ggagcgcgag accgccgccc ggccggatta ctgtccggcc tacctgtacc cagcagcgtc
      121 cgggagcctc gcggcttgac taaaatgtca aaaagaaaat ggctctgtta gcccaacagt
      181 tacccagacg gttcaactca gttaagttga ctagcttcat taaagccaaa caagtcacca
      241 aacgctctgc aagagcagga aaagccgtgt tgcccggctt ctcagctcag cctctgctct
      301 cctctgacac gagctttctc cggcggggaa ttaagactta caggactttg ttctggaatc
      361 gtttccattc tgccagcaca aataggacaa agagttctgc cgaaagcact ctgcttcctt
      421 cagtggctga acagcaggag aggatactta gtcttgaatc agagctgcct cttgaagaag
      481 tggatgacct gcctccattg tctccgttac agtcagtttc agaggaggag gctattcaga
      541 ttgctgcgta ctctccgctg cccatctcct ccttcacact tgcagattac gtagaccatt
      601 ccaagactct gcagaagcta gtgcagcttg gagtggattt gtctaagata gaaaaacatc
      661 cagatgcagc caacctcctt ctaaggctgg attttgaaaa gcacattaag caaatactgc
      721 tatttcttaa agatttgggt ttagaagata accagctggg accatttctg acaaaaaatt
      781 atgctatttt ctctgaagac cttgaaaacc ttaagaccag agtagcttat ctacagtcaa
      841 aaaatttcag taagacagac attgcacgga tggtcaaaaa tgcaccattt ctgttgagct
      901 tctccgtgga aagactagat aacagactgg gattttttca gaaagaactt gaactgaatg
      961 tgaagaagac tagagatctg gttgttcgcc ttccaaggct actaacagga agtctggagc
     1021 ctgtgaagga aaacatgaag gtttatcatc ttgaacttgg ttttaaacat aatgaaattc
     1081 aacatatggt catcaagatt cctaagatgc taactgcaaa caaaagaaaa cttacagaga
     1141 tttttgatta tgtacacaat gtgatgaata ttccccacca catcatcgtc aagtttccac
     1201 agttatttaa cacaagagtg tttaaaatta aagaaagaca cttgtttctt gcctacctgg
     1261 gaagagcaca gtatgaccca gcaaaaccta actatgtttc tttggacaag ttcgtatctt
     1321 ttcctgataa aatattttgt aaagagattg ccaaagcttc actaaatgat tttgagaaat
     1381 tcttaaaaac gctttagttt ttgatgaatg tttaaatata ttcttgtaaa tatatatatg
     1441 aataaatgta tttttaaaat aaatgtttct ggtttcaata ttacaa
//
