LOCUS       NM_001013023            1376 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus mitochondrial transcription termination factor 1a
            (Mterf1a), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001013023 XM_485553
VERSION     NM_001013023.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1376)
  AUTHORS   Terzioglu,M., Ruzzenente,B., Harmel,J., Mourier,A., Jemt,E.,
            Lopez,M.D., Kukat,C., Stewart,J.B., Wibom,R., Meharg,C.,
            Habermann,B., Falkenberg,M., Gustafsson,C.M., Park,C.B. and
            Larsson,N.G.
  TITLE     MTERF1 binds mtDNA to prevent transcriptional interference at the
            light-strand promoter but is dispensable for rRNA gene
            transcription regulation
  JOURNAL   Cell Metab 17 (4), 618-626 (2013)
   PUBMED   23562081
  REMARK    GeneRIF: MTERF1 does not regulate heavy-strand transcription, but
            rather acts to block transcription on the opposite strand of mtDNA
            to prevent transcription interference at the light-strand promoter.
REFERENCE   2  (bases 1 to 1376)
  AUTHORS   McNally,R.S., Davis,B.K., Clements,C.M., Accavitti-Loper,M.A.,
            Mak,T.W. and Ting,J.P.
  TITLE     DJ-1 enhances cell survival through the binding of Cezanne, a
            negative regulator of NF-kappaB
  JOURNAL   J Biol Chem 286 (6), 4098-4106 (2011)
   PUBMED   21097510
REFERENCE   3  (bases 1 to 1376)
  AUTHORS   Li,X., Zhang,L.S. and Guan,M.X.
  TITLE     Cloning and characterization of mouse mTERF encoding a
            mitochondrial transcriptional termination factor
  JOURNAL   Biochem Biophys Res Commun 326 (2), 505-510 (2005)
   PUBMED   15582606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049308.1 and AC027653.3.
            
            On Aug 4, 2006 this sequence version replaced NM_001013023.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094442.1, BC051251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-903               AK049308.1         2-904
            904-1376            AC027653.3         67784-68256
FEATURES             Location/Qualifiers
     source          1..1376
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 2.26 cM"
     gene            1..1376
                     /gene="Mterf1a"
                     /gene_synonym="4931431L11Rik; 9230106K09Rik; Mterf;
                     Mterf1; mTERF1b"
                     /note="mitochondrial transcription termination factor 1a"
                     /db_xref="GeneID:545725"
                     /db_xref="MGI:MGI:1918240"
     exon            1..59
                     /gene="Mterf1a"
                     /gene_synonym="4931431L11Rik; 9230106K09Rik; Mterf;
                     Mterf1; mTERF1b"
                     /inference="alignment:Splign:2.1.0"
     exon            60..1376
                     /gene="Mterf1a"
                     /gene_synonym="4931431L11Rik; 9230106K09Rik; Mterf;
                     Mterf1; mTERF1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1230
                     /gene="Mterf1a"
                     /gene_synonym="4931431L11Rik; 9230106K09Rik; Mterf;
                     Mterf1; mTERF1b"
                     /note="mitochondrial transcription termination factor 1;
                     transcription termination factor, mitochondrial;
                     transcription termination factor 1a, mitochondrial;
                     mitochondrial transcription termination factor 1b"
                     /codon_start=1
                     /product="transcription termination factor 1a,
                     mitochondrial precursor"
                     /protein_id="NP_001013041.2"
                     /db_xref="CCDS:CCDS39003.1"
                     /db_xref="GeneID:545725"
                     /db_xref="MGI:MGI:1918240"
                     /translation="MASRNIWCVRRNFLFDLRDWMLQYSAEVFLKSISFRPFSAECDS
                     KDKESLEEEREDLLSNLVTMGVDIDMARRRQPGVFNKAVTNEQELKLFLLSKGASDKV
                     IGSIISRYPRAITRTPESLSKRWDLWRKIMASDLEIVNILERSPESFFRSNNNLNLEN
                     NIKFLCSVGLTHKCLCRLLTNAPRTFSNSLNLNKQMVEFLQETGMSLGHNDPRDFVRK
                     IISKNPSILIQSTKRVKTNIEFLQSTFNLNKRDLLLLICGPGARILDLSNDCTKKNYT
                     NIRERLLSLGCSEEEVQRFVLSYLNMVFLSEKKFNDKIDCLIEEKISASQIIENPRIL
                     DSSINTLKTRIRELSHAGYDLSTSSIALLSWSQRRYEAKLKRLCG"
     regulatory      1349..1354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mterf1a"
                     /gene_synonym="4931431L11Rik; 9230106K09Rik; Mterf;
                     Mterf1; mTERF1b"
                     /note="hexamer: AATAAA"
     polyA_site      1376
                     /gene="Mterf1a"
                     /gene_synonym="4931431L11Rik; 9230106K09Rik; Mterf;
                     Mterf1; mTERF1b"
                     /note="major polyA site"
ORIGIN      
        1 actccgctcc ctcccgggcg tccagaggcg gaagtgaaag gtgtctaccg ggagcgttgc
       61 atttgaaaaa ctttgggcta cctgatgatt atggcatcaa gaaacatctg gtgtgtgaga
      121 agaaactttc tctttgattt aagagactgg atgcttcaat attcagcaga agttttcctc
      181 aagtcgattt cattcaggcc gtttagtgcg gaatgcgaca gtaaggacaa ggagtctttg
      241 gaggaggaga gggaggacct gctgagcaac ttagtcacca tgggcgttga tatcgacatg
      301 gcaaggaggc gacagcctgg agtttttaac aaggctgtta cgaatgagca ggagctgaag
      361 ttattccttc tgtccaaggg agctagtgac aaagtgattg gtagcatcat atcaagatat
      421 ccacgagcta taacacgcac tcctgaaagt ctttcaaaac ggtgggatct gtggagaaag
      481 attatggcat cagaccttga aattgtaaat attttggagc gttctcctga atcctttttt
      541 cgatctaata acaatctaaa cttagagaat aatataaagt tcctttgctc tgttggattg
      601 actcataaat gcctctgcag actgttgacc aatgctccca gaaccttctc caacagtctg
      661 aatttgaata agcaaatggt tgaatttttg caggagactg gtatgtcctt aggtcacaat
      721 gatcccagag attttgtcag gaagataatt tctaaaaacc cttccatctt aattcagagc
      781 accaaacgtg tgaaaactaa cattgaattt ttacaatcaa ctttcaactt gaacaaacgg
      841 gacctgctgc ttctgatatg tggcccagga gctagaatct tagacctttc caatgactgt
      901 accaaaaaaa attacacaaa cataagagag aggctgcttt ctcttggatg cagcgaggag
      961 gaggtacaga ggtttgtcct aagctatctg aatatggtct tcttgtcaga gaaaaagttt
     1021 aatgataaaa tagactgcct tatagaagaa aaaatcagtg cttcacaaat aattgaaaat
     1081 ccgaggattt tagactccag cataaatact ttaaaaactc gcatccgaga gctgtcccat
     1141 gctgggtatg acttgagcac atccagcatt gctctgctgt cctggagtca gagaagatat
     1201 gaagctaaac tgaagagatt atgtggatag gacagtgcag gaggagtcgc aggcaatcgg
     1261 acaggtgtgg cactggttcc agtttggact tttaaaacag gagaggtttg tttttgtttt
     1321 ttaattattt ttttatttaa attttttaaa taaaaatttt aaaatattta agatta
//
