LOCUS       NM_026002               4832 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus metadherin (Mtdh), transcript variant 3, mRNA.
ACCESSION   NM_026002
VERSION     NM_026002.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4832)
  AUTHORS   Saverino,A., Qu,X., Mendoza,R.G., Raha,S., Manna,D., Ermi,A.G.,
            Subler,M.A., Windle,J.J., Liu,J. and Sarkar,D.
  TITLE     Spatial transcriptomics unravels palmitoylation and
            zonation-dependent gene regulation by AEG-1 in mouse liver
  JOURNAL   J Biol Chem 300 (6), 107322 (2024)
   PUBMED   38677511
  REMARK    GeneRIF: Spatial transcriptomics unravels palmitoylation and
            zonation-dependent gene regulation by AEG-1 in mouse liver.
REFERENCE   2  (bases 1 to 4832)
  AUTHORS   Chen,X., Xiao,J., Tao,D., Liang,Y., Chen,S., Shen,L., Li,S.,
            Zheng,Z., Zeng,Y., Luo,C., Peng,F. and Long,H.
  TITLE     Metadherin orchestrates PKA and PKM2 to activate beta-catenin
            signaling in podocytes during proteinuric chronic kidney disease
  JOURNAL   Transl Res 266, 68-83 (2024)
   PUBMED   37995969
  REMARK    GeneRIF: Metadherin orchestrates PKA and PKM2 to activate
            beta-catenin signaling in podocytes during proteinuric chronic
            kidney disease.
REFERENCE   3  (bases 1 to 4832)
  AUTHORS   Leem,E., Kim,S., Sharma,C., Nam,Y., Kim,T.Y., Shin,M., Lee,S.G.,
            Kim,J. and Kim,S.R.
  TITLE     Inhibition of Granule Cell Dispersion and Seizure Development by
            Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe
            Epilepsy
  JOURNAL   Biomolecules 14 (3), 380 (2024)
   PUBMED   38540798
  REMARK    GeneRIF: Inhibition of Granule Cell Dispersion and Seizure
            Development by Astrocyte Elevated Gene-1 in a Mouse Model of
            Temporal Lobe Epilepsy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4832)
  AUTHORS   Kim,H., Choi,M., Han,S., Park,S.Y., Jeong,M., Kim,S.R., Hwang,E.M.
            and Lee,S.G.
  TITLE     Expression patterns of AEG-1 in the normal brain
  JOURNAL   Brain Struct Funct 228 (7), 1629-1641 (2023)
   PUBMED   37421418
  REMARK    GeneRIF: Expression patterns of AEG-1 in the normal brain.
REFERENCE   5  (bases 1 to 4832)
  AUTHORS   Komaniecki,G., Camarena,M.D.C., Gelsleichter,E., Mendoza,R.,
            Subler,M., Windle,J.J., Dozmorov,M.G., Lai,Z., Sarkar,D. and Lin,H.
  TITLE     Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6
            Regulates Its Biological Activity
  JOURNAL   Biochemistry 62 (2), 543-553 (2023)
   PUBMED   36548985
  REMARK    GeneRIF: Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6
            Regulates Its Biological Activity.
REFERENCE   6  (bases 1 to 4832)
  AUTHORS   Brown,D.M. and Ruoslahti,E.
  TITLE     Metadherin, a cell surface protein in breast tumors that mediates
            lung metastasis
  JOURNAL   Cancer Cell 5 (4), 365-374 (2004)
   PUBMED   15093543
  REMARK    GeneRIF: overexpression of metadherin is associated with metastatic
            breast cancer
REFERENCE   7  (bases 1 to 4832)
  AUTHORS   Sutherland,H.G., Lam,Y.W., Briers,S., Lamond,A.I. and Bickmore,W.A.
  TITLE     3D3/lyric: a novel transmembrane protein of the endoplasmic
            reticulum and nuclear envelope, which is also present in the
            nucleolus
  JOURNAL   Exp Cell Res 294 (1), 94-105 (2004)
   PUBMED   14980505
  REMARK    GeneRIF: Lyric is localized to the membrane of the endoplasmic
            reticulum, nuclear envelope, and the nucleolus.
REFERENCE   8  (bases 1 to 4832)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4832)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 4832)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149588.4.
            
            On Nov 10, 2017 this sequence version replaced NM_026002.4.
            
            Transcript Variant: This variant (3) lacks an exon in the coding
            region, compared to variant 1. The encoded isoform (3) is shorter,
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029915.1, AK151269.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-695               AC149588.4         105427-106121
            696-797             AC149588.4         122192-122293
            798-882             AC149588.4         136732-136816
            883-1059            AC149588.4         137507-137683
            1060-1125           AC149588.4         139019-139084
            1126-1356           AC149588.4         140588-140818
            1357-1455           AC149588.4         146376-146474
            1456-1580           AC149588.4         153872-153996
            1581-1688           AC149588.4         156999-157106
            1689-1829           AC149588.4         159395-159535
            1830-1986           AC149588.4         162449-162605
            1987-4832           AC149588.4         163400-166245
FEATURES             Location/Qualifiers
     source          1..4832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 13.98 cM"
     gene            1..4832
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /note="metadherin"
                     /db_xref="GeneID:67154"
                     /db_xref="MGI:MGI:1914404"
     exon            1..695
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..2057
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /note="isoform 3 is encoded by transcript variant 3;
                     metastasis adhesion protein; protein LYRIC; lysine-rich
                     CEACAM1 co-isolated protein"
                     /codon_start=1
                     /product="protein LYRIC isoform 3"
                     /protein_id="NP_080278.3"
                     /db_xref="CCDS:CCDS27415.1"
                     /db_xref="GeneID:67154"
                     /db_xref="MGI:MGI:1914404"
                     /translation="MAARSWQDELAQQAEEGSARLRELLSVGLGFLRTELGLDLGLEP
                     KRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAPPTPAPDDL
                     AQLKNLRSEEQKKKNRKKLPEKPKPNGRTVEVPEDEVVRNPRSITAKQAPETDKKNEK
                     SKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDS
                     TIPGIENIITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSRLNE
                     NLTVNGGGWSEKSVKLSSQLSEEKWNSVPPASAGKRKTEPSAWTQDTGDTNANGKDWG
                     RNWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPSSDWN
                     APAEEWGNWVDEDRASLLKSQEPISNDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQG
                     EDNSHTQDTEDLEKDTREELPVNTSKARPKQEKACSLKTMSTSDPAEVLIKNSQPVKT
                     LPPAISAEPSITLSKGDSDNSSSQVPPMLQDTDKPKSNAKQNSVPPSQTKSETNWESP
                     KQIKKKKKARRET"
     exon            696..797
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            798..882
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1059
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1125
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1356
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1455
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1580
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1688
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1829
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1986
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..4832
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3664..3669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /note="hexamer: AATAAA"
     polyA_site      3681
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
     regulatory      4802..4807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /note="hexamer: AATAAA"
     polyA_site      4832
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /note="major polyA site"
ORIGIN      
        1 gccgccattg ttccgccggg ggaggacagc gggtcctggc gctggcgccc cgacgccgct
       61 tagcggccgc ctctggagac actctgtccc cgccgccccg tgtcctcctg gtggcggcgg
      121 cgtgaggccg gctgcggaga ctgggaacct ttggctctcc ccgtggcggc ggcggccctc
      181 tatcccctac tccggcgtga gggttggccg cgatgcgctc ggcctgaggt gtcgcggccc
      241 tgtcgcctcc cacgactgtt ccagcggcgg ctccgctccc cggcgtcatc ccgcgagtct
      301 ctctgacggg agggaagatg gctgcacgaa gctggcagga cgagctggcc cagcaggccg
      361 aggagggctc tgcccggctg cgggagttgc tctcggtcgg cctaggtttt ctgcgcacgg
      421 agttgggcct cgacctgggg ctagagccga agcggtaccc gggctgggtg atcctggtgg
      481 gcaccggcgc tctcgggctg ctcctgctct tccttctagg ttacggctgg gccgcggctt
      541 gcgccggcgc ccgcaagaag cgaaggagcc cgccccgcaa acgggaggag gcggccccgc
      601 cgactccggc ccccgacgac ctagcccagc tgaagaatct cagaagcgag gagcaaaaga
      661 agaagaaccg gaagaagctt cctgaaaagc ccaaaccaaa tggacggact gttgaagtac
      721 ccgaggatga agttgttaga aatccccgaa gtataactgc aaaacaagca ccagagacag
      781 acaagaaaaa tgaaaagtca aagaaaaata agaagaaatc aaagtcagat gctaaagcag
      841 tgcaaaacag ttcacgccat gatggaaagg aagttgatga aggagcctgg gaaactaaaa
      901 ttagtcacag agagaaacga caacagcgta aacgtgataa agtgctgact gattctggtt
      961 cattggattc aactatccct gggatagaaa atatcatcac agttaccacc gagcaactta
     1021 caactgcatc atttcctgtt ggttccaaga agaataaagg tgattctcat ctaaatgttc
     1081 aagttagcaa ctttaagtct ggaaaaggag attctacact gcaggtttct tcaaggctga
     1141 atgaaaatct tactgtcaat ggaggaggct ggagtgaaaa gtctgtaaaa ctctcctcac
     1201 aattgagtga ggagaagtgg aactctgtcc cacctgcttc tgcaggcaag aggaaaacag
     1261 agccatcggc ttggactcaa gacactggtg acactaatgc aaatgggaaa gactggggaa
     1321 ggaattggag tgatcgctca atattttctg gcattggatc tactgctgag ccagtttctc
     1381 agtctaccac ttctgattat cagtgggatg ttagccgtaa tcaaccttat atcgatgatg
     1441 aatggtctgg gttaaatggt ttgtcttctg ctgaccctag ctcagactgg aatgcaccag
     1501 cagaggagtg ggggaactgg gtagatgaag atagagcttc acttctgaag tcccaggaac
     1561 caatttctaa tgatcaaaag gtttcagatg atgataaaga aaaaggggag ggagctcttc
     1621 caactggaaa atctaaaaag aaaaagaaga aaaagaagaa gcaaggggaa gataactctc
     1681 acacacagga cacagaagac ctagaaaagg acactagaga agagcttcca gtgaatacct
     1741 caaaagcccg accaaaacag gagaaagctt gttccctgaa gaccatgagc actagtgacc
     1801 cagctgaagt actcatcaaa aatagccagc ctgtcaagac tcttcctcct gctatctctg
     1861 ccgagccatc tattacctta tcaaaaggtg actctgacaa cagctcttcc caagtgccac
     1921 cgatgttaca agacacagac aagcccaagt caaatgctaa gcaaaacagt gtgcctccct
     1981 cacagaccaa gtctgaaact aactgggaat ctccaaaaca aataaaaaag aagaaaaagg
     2041 ccagacggga aacgtgaatt tttttttcct gaattggaca tgtgtttaca aacactgtct
     2101 tgaagattat gctgtttatg caataatttg tgaacatgta cagagtttta tataaattta
     2161 aaccaatttt taaaacaaaa ctgaacacaa ccaccataaa atggaatcaa aggaaagtta
     2221 atttatgaaa taaagaggtc aacagaatac acagtgctgg aagacacttg ggagagtctt
     2281 ttcaattgaa cgagaatgat cgtaatttaa gactattatc ctggttttac aacagttacc
     2341 tgtttacaac agactgtgcc ctgtctcctc tgcagctgag gaataatgaa tggattctga
     2401 ttagagagaa ggctgccgtg aggccagtag gcaagtcctt ggatcttatg cacgacctta
     2461 gaccatttga atctgtttta tgcttaaatc aaagtgcttt gatcaaatgt ataatctgcc
     2521 atatctttac atatttgttg tagcagtttg tattaaaaga atcacaagtg caaattaaaa
     2581 ggtcatttat catttattta actaaactgt cttggtttag tttacagttc tttaaaagtt
     2641 ctaaattaaa acattaaaaa atgcaattga cagacacttg tatgacttac aaagttattt
     2701 ttgatagtct taacattact tgaattattc aaaataacag tatattttaa attaagaaag
     2761 gtaaatatat tatttgtttg atacattaag actgagacta acaatgctct tgtttatgat
     2821 ttgaaaagtt ttcaggcaaa tccaacttag tgtttttcct ttccctagca attttccagt
     2881 gtcaactctt agttgctagt aattttttta ccttaaaaat gaagtaattc gcaacttttg
     2941 agcatatgac ggagaatgca aaagtagtca gacagcttta attgatattg tggagacctc
     3001 cggttatcag gaatacattt ttttactgcc ttaacctcct gtagtgagta gaatatgcat
     3061 cagtttcttg aaggggattc gtgtttttat aagaattttc atgtaactat tgcaattgtg
     3121 gttaaaaaca gaaaggaaca ttttctgctt gaaactgtgt tgatttgaat gacgtatgat
     3181 ctgtcaccat tttcaggcac tgtgtgatcc ctaggaaagt ggcaggcctc tctgtaactg
     3241 ttaatagtgc atgctcggcc atgtacactg taaatagcct ttaccaaacg tgtttgacaa
     3301 ggaccataat taacatcact ttagtaaatt gtgatttttt taaaaaaagc catgatttat
     3361 tgatgtgagt ggcttgtttt catgtggcgc cagaaatgaa cctgtttaaa agctataacc
     3421 aatggtactg atctatccat taaatactgt ccttaaactg tagtttaata gtattgtcaa
     3481 ctaggaaagc taaaatggtt tttgttctgt tgaagactgg ccttattaat ggacagcttt
     3541 cctcagaagt gattaacaac ttttttattg ggtgttaaca tctgtttcaa gaacatggca
     3601 gtatgtttac atgtcgtcag aagttttctt tgaatggaat ttctaaatta atttacttgt
     3661 ttaaataaat tcagaactgg gtagcattgt ttttatttgc ttcactattg aggtgaataa
     3721 gagctgatgt gccacaaatg gagccttcag atggctgctt tgagcttcgt gttccctcag
     3781 gggatgccaa gatatgtctc aaggagagat taatgagggg tttgtaatta cagagtgtgc
     3841 caaggtcagt gctcacaagt ttaattgaac tctctcaact ctacctcact gttccttttc
     3901 cttataattc tctgggctag gtcaaatcag aaactttatt tttcggttca gtatctcccg
     3961 attcaatcac ttgtaggagg tggtaactac acttagcagt aagaatatca cctttttgaa
     4021 gagatgtgta ttatgggagt ggaagcacag cgatacactg ggtaggtcag tgtggaagtc
     4081 gcctctgtgc cttccttctc gctggcttgt gagccaggcc cccctccccc ccaaccccca
     4141 cgccggtaga aggaggcagg tatatgagtc aaaatccagt tctcttaaaa tcgttgctct
     4201 ttacctctct atagatcttt gtgtggcagg gcagtgattt tttttttttt ttttttgtca
     4261 ctgaacagag gaactggctt ctgtcatcaa ctcagaaaac tctgatgcca cctgtttccc
     4321 tgaaataggc tctctgaaaa gcctttctgt tgtggagcag ggcgtggcca tgtcagagtt
     4381 ctccaactgc attataccta taccctaaat tgagaaacaa acagttgaga gagtccaaaa
     4441 ataaaagttg aaatatcatt gatgtaatta ccatgtttca tttgtgcatg cattttattg
     4501 gggatgggag gttggaataa tttatccaaa tctaatggta ttatttcata ggctaatcca
     4561 gtttgtattt gagttaaaga tcccagagtg tagtaattaa ttgcagcgtt tggtttttct
     4621 taattaaaag tagtcctcta ttaatatagt gtgaaatatc aaaatttagg atttaagttt
     4681 aaggtctaat ggctatttta aagtttttct gtaaattctt tgcacaaact agaattggaa
     4741 ttgctttcaa aagacttggg gaatgaaaat atgtcatgtg taagatgcac tgagtgttgt
     4801 aaataaaaca gaccattttt gttttgttta aa
//
