LOCUS       NM_001357926            4922 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus metadherin (Mtdh), transcript variant 1, mRNA.
ACCESSION   NM_001357926 XM_006520148
VERSION     NM_001357926.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4922)
  AUTHORS   Saverino,A., Qu,X., Mendoza,R.G., Raha,S., Manna,D., Ermi,A.G.,
            Subler,M.A., Windle,J.J., Liu,J. and Sarkar,D.
  TITLE     Spatial transcriptomics unravels palmitoylation and
            zonation-dependent gene regulation by AEG-1 in mouse liver
  JOURNAL   J Biol Chem 300 (6), 107322 (2024)
   PUBMED   38677511
  REMARK    GeneRIF: Spatial transcriptomics unravels palmitoylation and
            zonation-dependent gene regulation by AEG-1 in mouse liver.
REFERENCE   2  (bases 1 to 4922)
  AUTHORS   Chen,X., Xiao,J., Tao,D., Liang,Y., Chen,S., Shen,L., Li,S.,
            Zheng,Z., Zeng,Y., Luo,C., Peng,F. and Long,H.
  TITLE     Metadherin orchestrates PKA and PKM2 to activate beta-catenin
            signaling in podocytes during proteinuric chronic kidney disease
  JOURNAL   Transl Res 266, 68-83 (2024)
   PUBMED   37995969
  REMARK    GeneRIF: Metadherin orchestrates PKA and PKM2 to activate
            beta-catenin signaling in podocytes during proteinuric chronic
            kidney disease.
REFERENCE   3  (bases 1 to 4922)
  AUTHORS   Leem,E., Kim,S., Sharma,C., Nam,Y., Kim,T.Y., Shin,M., Lee,S.G.,
            Kim,J. and Kim,S.R.
  TITLE     Inhibition of Granule Cell Dispersion and Seizure Development by
            Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe
            Epilepsy
  JOURNAL   Biomolecules 14 (3), 380 (2024)
   PUBMED   38540798
  REMARK    GeneRIF: Inhibition of Granule Cell Dispersion and Seizure
            Development by Astrocyte Elevated Gene-1 in a Mouse Model of
            Temporal Lobe Epilepsy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4922)
  AUTHORS   Kim,H., Choi,M., Han,S., Park,S.Y., Jeong,M., Kim,S.R., Hwang,E.M.
            and Lee,S.G.
  TITLE     Expression patterns of AEG-1 in the normal brain
  JOURNAL   Brain Struct Funct 228 (7), 1629-1641 (2023)
   PUBMED   37421418
  REMARK    GeneRIF: Expression patterns of AEG-1 in the normal brain.
REFERENCE   5  (bases 1 to 4922)
  AUTHORS   Komaniecki,G., Camarena,M.D.C., Gelsleichter,E., Mendoza,R.,
            Subler,M., Windle,J.J., Dozmorov,M.G., Lai,Z., Sarkar,D. and Lin,H.
  TITLE     Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6
            Regulates Its Biological Activity
  JOURNAL   Biochemistry 62 (2), 543-553 (2023)
   PUBMED   36548985
  REMARK    GeneRIF: Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6
            Regulates Its Biological Activity.
REFERENCE   6  (bases 1 to 4922)
  AUTHORS   Brown,D.M. and Ruoslahti,E.
  TITLE     Metadherin, a cell surface protein in breast tumors that mediates
            lung metastasis
  JOURNAL   Cancer Cell 5 (4), 365-374 (2004)
   PUBMED   15093543
  REMARK    GeneRIF: overexpression of metadherin is associated with metastatic
            breast cancer
REFERENCE   7  (bases 1 to 4922)
  AUTHORS   Sutherland,H.G., Lam,Y.W., Briers,S., Lamond,A.I. and Bickmore,W.A.
  TITLE     3D3/lyric: a novel transmembrane protein of the endoplasmic
            reticulum and nuclear envelope, which is also present in the
            nucleolus
  JOURNAL   Exp Cell Res 294 (1), 94-105 (2004)
   PUBMED   14980505
  REMARK    GeneRIF: Lyric is localized to the membrane of the endoplasmic
            reticulum, nuclear envelope, and the nucleolus.
REFERENCE   8  (bases 1 to 4922)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4922)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 4922)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149588.4.
            
            On Nov 10, 2017 this sequence version replaced XM_006520148.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.161073.1,
                                           SRR7345562.1769973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-695               AC149588.4         105427-106121
            696-797             AC149588.4         122192-122293
            798-882             AC149588.4         136732-136816
            883-1059            AC149588.4         137507-137683
            1060-1125           AC149588.4         139019-139084
            1126-1356           AC149588.4         140588-140818
            1357-1446           AC149588.4         144131-144220
            1447-1545           AC149588.4         146376-146474
            1546-1670           AC149588.4         153872-153996
            1671-1778           AC149588.4         156999-157106
            1779-1919           AC149588.4         159395-159535
            1920-2076           AC149588.4         162449-162605
            2077-4922           AC149588.4         163400-166245
FEATURES             Location/Qualifiers
     source          1..4922
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 13.98 cM"
     gene            1..4922
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /note="metadherin"
                     /db_xref="GeneID:67154"
                     /db_xref="MGI:MGI:1914404"
     exon            1..695
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..2147
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /note="isoform 1 is encoded by transcript variant 1;
                     metastasis adhesion protein; protein LYRIC; lysine-rich
                     CEACAM1 co-isolated protein"
                     /codon_start=1
                     /product="protein LYRIC isoform 1"
                     /protein_id="NP_001344855.1"
                     /db_xref="GeneID:67154"
                     /db_xref="MGI:MGI:1914404"
                     /translation="MAARSWQDELAQQAEEGSARLRELLSVGLGFLRTELGLDLGLEP
                     KRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAPPTPAPDDL
                     AQLKNLRSEEQKKKNRKKLPEKPKPNGRTVEVPEDEVVRNPRSITAKQAPETDKKNEK
                     SKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDS
                     TIPGIENIITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSRLNE
                     NLTVNGGGWSEKSVKLSSQLSEEKWNSVPPASAGKRKTEPSAWTQDTGDTNANGKDWG
                     RNWSDRSIFSGIAAWSSVARGMSASQQNSASFASLTLNSAVSGSTAEPVSQSTTSDYQ
                     WDVSRNQPYIDDEWSGLNGLSSADPSSDWNAPAEEWGNWVDEDRASLLKSQEPISNDQ
                     KVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSHTQDTEDLEKDTREELPVNTSKAR
                     PKQEKACSLKTMSTSDPAEVLIKNSQPVKTLPPAISAEPSITLSKGDSDNSSSQVPPM
                     LQDTDKPKSNAKQNSVPPSQTKSETNWESPKQIKKKKKARRET"
     exon            696..797
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            798..882
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1059
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1125
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1356
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1446
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1545
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1670
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1778
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1919
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2076
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..4922
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3754..3759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /note="hexamer: AATAAA"
     polyA_site      3771
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
     regulatory      4892..4897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /note="hexamer: AATAAA"
     polyA_site      4922
                     /gene="Mtdh"
                     /gene_synonym="2610103J23Rik; 3D3; 3D3/Lyric; AEG-1;
                     D8Bwg1112e; Lyric"
                     /note="major polyA site"
ORIGIN      
        1 gccgccattg ttccgccggg ggaggacagc gggtcctggc gctggcgccc cgacgccgct
       61 tagcggccgc ctctggagac actctgtccc cgccgccccg tgtcctcctg gtggcggcgg
      121 cgtgaggccg gctgcggaga ctgggaacct ttggctctcc ccgtggcggc ggcggccctc
      181 tatcccctac tccggcgtga gggttggccg cgatgcgctc ggcctgaggt gtcgcggccc
      241 tgtcgcctcc cacgactgtt ccagcggcgg ctccgctccc cggcgtcatc ccgcgagtct
      301 ctctgacggg agggaagatg gctgcacgaa gctggcagga cgagctggcc cagcaggccg
      361 aggagggctc tgcccggctg cgggagttgc tctcggtcgg cctaggtttt ctgcgcacgg
      421 agttgggcct cgacctgggg ctagagccga agcggtaccc gggctgggtg atcctggtgg
      481 gcaccggcgc tctcgggctg ctcctgctct tccttctagg ttacggctgg gccgcggctt
      541 gcgccggcgc ccgcaagaag cgaaggagcc cgccccgcaa acgggaggag gcggccccgc
      601 cgactccggc ccccgacgac ctagcccagc tgaagaatct cagaagcgag gagcaaaaga
      661 agaagaaccg gaagaagctt cctgaaaagc ccaaaccaaa tggacggact gttgaagtac
      721 ccgaggatga agttgttaga aatccccgaa gtataactgc aaaacaagca ccagagacag
      781 acaagaaaaa tgaaaagtca aagaaaaata agaagaaatc aaagtcagat gctaaagcag
      841 tgcaaaacag ttcacgccat gatggaaagg aagttgatga aggagcctgg gaaactaaaa
      901 ttagtcacag agagaaacga caacagcgta aacgtgataa agtgctgact gattctggtt
      961 cattggattc aactatccct gggatagaaa atatcatcac agttaccacc gagcaactta
     1021 caactgcatc atttcctgtt ggttccaaga agaataaagg tgattctcat ctaaatgttc
     1081 aagttagcaa ctttaagtct ggaaaaggag attctacact gcaggtttct tcaaggctga
     1141 atgaaaatct tactgtcaat ggaggaggct ggagtgaaaa gtctgtaaaa ctctcctcac
     1201 aattgagtga ggagaagtgg aactctgtcc cacctgcttc tgcaggcaag aggaaaacag
     1261 agccatcggc ttggactcaa gacactggtg acactaatgc aaatgggaaa gactggggaa
     1321 ggaattggag tgatcgctca atattttctg gcattgctgc ttggtctagt gtggctaggg
     1381 ggatgagtgc ctctcaacag aactctgctt cttttgcatc tctcacactt aactctgctg
     1441 tctctggatc tactgctgag ccagtttctc agtctaccac ttctgattat cagtgggatg
     1501 ttagccgtaa tcaaccttat atcgatgatg aatggtctgg gttaaatggt ttgtcttctg
     1561 ctgaccctag ctcagactgg aatgcaccag cagaggagtg ggggaactgg gtagatgaag
     1621 atagagcttc acttctgaag tcccaggaac caatttctaa tgatcaaaag gtttcagatg
     1681 atgataaaga aaaaggggag ggagctcttc caactggaaa atctaaaaag aaaaagaaga
     1741 aaaagaagaa gcaaggggaa gataactctc acacacagga cacagaagac ctagaaaagg
     1801 acactagaga agagcttcca gtgaatacct caaaagcccg accaaaacag gagaaagctt
     1861 gttccctgaa gaccatgagc actagtgacc cagctgaagt actcatcaaa aatagccagc
     1921 ctgtcaagac tcttcctcct gctatctctg ccgagccatc tattacctta tcaaaaggtg
     1981 actctgacaa cagctcttcc caagtgccac cgatgttaca agacacagac aagcccaagt
     2041 caaatgctaa gcaaaacagt gtgcctccct cacagaccaa gtctgaaact aactgggaat
     2101 ctccaaaaca aataaaaaag aagaaaaagg ccagacggga aacgtgaatt tttttttcct
     2161 gaattggaca tgtgtttaca aacactgtct tgaagattat gctgtttatg caataatttg
     2221 tgaacatgta cagagtttta tataaattta aaccaatttt taaaacaaaa ctgaacacaa
     2281 ccaccataaa atggaatcaa aggaaagtta atttatgaaa taaagaggtc aacagaatac
     2341 acagtgctgg aagacacttg ggagagtctt ttcaattgaa cgagaatgat cgtaatttaa
     2401 gactattatc ctggttttac aacagttacc tgtttacaac agactgtgcc ctgtctcctc
     2461 tgcagctgag gaataatgaa tggattctga ttagagagaa ggctgccgtg aggccagtag
     2521 gcaagtcctt ggatcttatg cacgacctta gaccatttga atctgtttta tgcttaaatc
     2581 aaagtgcttt gatcaaatgt ataatctgcc atatctttac atatttgttg tagcagtttg
     2641 tattaaaaga atcacaagtg caaattaaaa ggtcatttat catttattta actaaactgt
     2701 cttggtttag tttacagttc tttaaaagtt ctaaattaaa acattaaaaa atgcaattga
     2761 cagacacttg tatgacttac aaagttattt ttgatagtct taacattact tgaattattc
     2821 aaaataacag tatattttaa attaagaaag gtaaatatat tatttgtttg atacattaag
     2881 actgagacta acaatgctct tgtttatgat ttgaaaagtt ttcaggcaaa tccaacttag
     2941 tgtttttcct ttccctagca attttccagt gtcaactctt agttgctagt aattttttta
     3001 ccttaaaaat gaagtaattc gcaacttttg agcatatgac ggagaatgca aaagtagtca
     3061 gacagcttta attgatattg tggagacctc cggttatcag gaatacattt ttttactgcc
     3121 ttaacctcct gtagtgagta gaatatgcat cagtttcttg aaggggattc gtgtttttat
     3181 aagaattttc atgtaactat tgcaattgtg gttaaaaaca gaaaggaaca ttttctgctt
     3241 gaaactgtgt tgatttgaat gacgtatgat ctgtcaccat tttcaggcac tgtgtgatcc
     3301 ctaggaaagt ggcaggcctc tctgtaactg ttaatagtgc atgctcggcc atgtacactg
     3361 taaatagcct ttaccaaacg tgtttgacaa ggaccataat taacatcact ttagtaaatt
     3421 gtgatttttt taaaaaaagc catgatttat tgatgtgagt ggcttgtttt catgtggcgc
     3481 cagaaatgaa cctgtttaaa agctataacc aatggtactg atctatccat taaatactgt
     3541 ccttaaactg tagtttaata gtattgtcaa ctaggaaagc taaaatggtt tttgttctgt
     3601 tgaagactgg ccttattaat ggacagcttt cctcagaagt gattaacaac ttttttattg
     3661 ggtgttaaca tctgtttcaa gaacatggca gtatgtttac atgtcgtcag aagttttctt
     3721 tgaatggaat ttctaaatta atttacttgt ttaaataaat tcagaactgg gtagcattgt
     3781 ttttatttgc ttcactattg aggtgaataa gagctgatgt gccacaaatg gagccttcag
     3841 atggctgctt tgagcttcgt gttccctcag gggatgccaa gatatgtctc aaggagagat
     3901 taatgagggg tttgtaatta cagagtgtgc caaggtcagt gctcacaagt ttaattgaac
     3961 tctctcaact ctacctcact gttccttttc cttataattc tctgggctag gtcaaatcag
     4021 aaactttatt tttcggttca gtatctcccg attcaatcac ttgtaggagg tggtaactac
     4081 acttagcagt aagaatatca cctttttgaa gagatgtgta ttatgggagt ggaagcacag
     4141 cgatacactg ggtaggtcag tgtggaagtc gcctctgtgc cttccttctc gctggcttgt
     4201 gagccaggcc cccctccccc ccaaccccca cgccggtaga aggaggcagg tatatgagtc
     4261 aaaatccagt tctcttaaaa tcgttgctct ttacctctct atagatcttt gtgtggcagg
     4321 gcagtgattt tttttttttt ttttttgtca ctgaacagag gaactggctt ctgtcatcaa
     4381 ctcagaaaac tctgatgcca cctgtttccc tgaaataggc tctctgaaaa gcctttctgt
     4441 tgtggagcag ggcgtggcca tgtcagagtt ctccaactgc attataccta taccctaaat
     4501 tgagaaacaa acagttgaga gagtccaaaa ataaaagttg aaatatcatt gatgtaatta
     4561 ccatgtttca tttgtgcatg cattttattg gggatgggag gttggaataa tttatccaaa
     4621 tctaatggta ttatttcata ggctaatcca gtttgtattt gagttaaaga tcccagagtg
     4681 tagtaattaa ttgcagcgtt tggtttttct taattaaaag tagtcctcta ttaatatagt
     4741 gtgaaatatc aaaatttagg atttaagttt aaggtctaat ggctatttta aagtttttct
     4801 gtaaattctt tgcacaaact agaattggaa ttgctttcaa aagacttggg gaatgaaaat
     4861 atgtcatgtg taagatgcac tgagtgttgt aaataaaaca gaccattttt gttttgttta
     4921 aa
//
