LOCUS       NM_001164663           13232 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus microtubule crosslinking factor 2 (Mtcl2), mRNA.
ACCESSION   NM_001164663 XM_283804
VERSION     NM_001164663.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 13232)
  AUTHORS   Kruse,R., Krantz,J., Barker,N., Coletta,R.L., Rafikov,R., Luo,M.,
            Hojlund,K., Mandarino,L.J. and Langlais,P.R.
  TITLE     Characterization of the CLASP2 Protein Interaction Network
            Identifies SOGA1 as a Microtubule-Associated Protein
  JOURNAL   Mol Cell Proteomics 16 (10), 1718-1735 (2017)
   PUBMED   28550165
  REMARK    GeneRIF: The novel protein SOGA1 was confirmed to colocalize with a
            microtubule-associated protein CLASP2 and with tubulin, which
            identifies SOGA1 as a new microtubule-associated protein.
REFERENCE   2  (bases 1 to 13232)
  AUTHORS   Cowherd,R.B., Asmar,M.M., Alderman,J.M., Alderman,E.A.,
            Garland,A.L., Busby,W.H., Bodnar,W.M., Rusyn,I., Medoff,B.D.,
            Tisch,R., Mayer-Davis,E., Swenberg,J.A., Zeisel,S.H. and Combs,T.P.
  TITLE     Adiponectin lowers glucose production by increasing SOGA
  JOURNAL   Am J Pathol 177 (4), 1936-1945 (2010)
   PUBMED   20813965
  REMARK    Erratum:[Am J Pathol. 2011 Mar;178(3):1406. Cowerd, Rachael B
            [corrected to Cowherd, Rachael B]]
REFERENCE   3  (bases 1 to 13232)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   4  (bases 1 to 13232)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ164427.1, AK147227.1 and AL669932.14.
            
            On Sep 10, 2009 this sequence version replaced XM_283804.7.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147227.1, FJ977045.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-399               CJ164427.1         1-399
            400-915             AK147227.1         390-905
            916-991             AL669932.14        142871-142946       c
            992-1061            AK147227.1         983-1052
            1062-1077           AL669932.14        124969-124984       c
            1078-7875           AK147227.1         1069-7866
            7876-13232          AL669932.14        75038-80394         c
FEATURES             Location/Qualifiers
     source          1..13232
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.91 cM"
     gene            1..13232
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /note="microtubule crosslinking factor 2"
                     /db_xref="GeneID:320706"
                     /db_xref="MGI:MGI:2444575"
     exon            1..1037
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..5321
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /note="suppressor of glucose by autophagy; SOGA family
                     member 1; suppressor of glucose, autophagy-associated
                     protein 1; protein SOGA1; suppressor of glucose, autophagy
                     associated 1"
                     /codon_start=1
                     /product="microtubule cross-linking factor 2"
                     /protein_id="NP_001158135.1"
                     /db_xref="CCDS:CCDS50781.1"
                     /db_xref="GeneID:320706"
                     /db_xref="MGI:MGI:2444575"
                     /translation="METPAGESSARGYGPPPAPAPAAERKKSHRAPSPARPKDVAGWS
                     LAKGRRGTGPGSATACGTASSARPDKKGRAVAPGTRGTGPRVAGVRTGVRAKGRPRPG
                     TGPRPPPPPPSLTDSSSEVSDCASEEARQLGLELALSSDAESAAGGPAGTRTGQPPQP
                     AQSGQQPPRPPASPDEPSVAASSVGSSRLPLSASLAFSDLTEEMLDCGPGGLVRELEE
                     LRSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKA
                     ERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLHKELEVVEKKRMRLEEENEGLRQ
                     RLIETELAKQVLQTELDRPREHSLKKRGTRSLGKTDKKPTAQEDSADLKCQLHFAKEE
                     SALMCKKLTKLAKENDSMKEELLKYRSLYGDLDAALSAEELADAPHSRETELKVHLKL
                     VEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGGGPEARLAFSSLGGECGESLAEL
                     RRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKYRSEHELDVTLSEDSCSVLSEPSQ
                     EELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQC
                     VPAPLGETLEPHAARLCRAREAEALPGLREQAALVSKAIDVLVADANGFSVGLRLCLD
                     NECADLRLHEAPDNSEGPRDAKLIHAILVRLSVLQQELNAFTRKADVALGSSGKEQPE
                     PFPALPALGSQGPAKEIMLSKDLGSDFQPPDFRDLLEWEPRIREAFRTGDLESKPDPS
                     RNFRPYRAEDNDSYASEIKDLQLVLAEAHDSLRGLQEQLSQERQLRKEEADSFNQKMV
                     QLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNILVQESQQFKHNFLLLFMKLRW
                     FLKRWRQGKVLPSEEDDFLEVNSMKELYLLMEEEEMNAQHSDNKACTGESWTQNTPNE
                     CIKTLADMKVTLKELCWLLQDERRGLTELQQQFAKAKATWETERAELKGHASQMELKA
                     GKGASERPGPDWKAALQREREEQQHLLAESYSAVMELTRQLQLSERHWSQEKLQLVER
                     LQGEKQQVEQQVKELQNRLSQLQKAAEPWVLKHSDMEKQDNSWKEARSEKTHDKEGVS
                     EAELGGTGLKRTKSVSSMSEFESLLDCSPYLAGGDARNKKLPNGPAFAFVSTEPVEPE
                     KDAKEKAGLSTRDCSHIGSLACQEPAGRQMQRSYTAPDKTGIRVYYSPPVARRLGVPV
                     VHDKEGKILIEPGFLFTTAKPKESAEADGLAESSYSRWLCNFSRQRLDGGSGASTSGS
                     GPAFPALHDFEMSGNMSDDMKEITNCVRQAMRSGSLERKVKNTSSQTVGVATVGTQTI
                     RTVSVGLQTDPPRSSLHSKSWSPRSSSLVSVRSKQISSSLDKVHSRIERPCCSPKYGS
                     PKLQRRSVSKLDSTKDRSLWNLHQGKQNGSAWARSTTTRDSPVLRNINDGLSSLFSVV
                     EHSGSTESVWKLGMSEARTKPEPPKYGIVQEFFRNVCGRAPSPTTAAGEESCKKPEPL
                     SPASYHQPEGVSRILNKKAAKAGGSEEVRPTMLSQVGKDGILRDGDGSLILPSEDAVC
                     DCSAQSLASCFIRPSRNTIRHSPSKCRLHPSESGWGGEERAAPQ"
     exon            1038..1262
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1421
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1484
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..2660
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2801
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2927
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3158
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3263
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3431
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3683
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3684..3755
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3756..3826
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3827..5174
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     exon            5175..13232
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6295..6300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /note="hexamer: TATAAA"
     polyA_site      6312
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /note="major polyA site"
     polyA_site      7880
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
     regulatory      13212..13217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /note="hexamer: AATAAA"
     polyA_site      13231
                     /gene="Mtcl2"
                     /gene_synonym="9830001H06Rik; D430036N24Rik; Soga; Soga1"
                     /note="major polyA site"
ORIGIN      
        1 gagccggggc cctggcctca gccggactgg gagtccgagg cggcgatcgc cgagcaggct
       61 gcagtcgggg tccgggcgca ctccgggggc gcggcgaggc ggagggggcg ggcaccgggc
      121 ggagccggag tcggagtcgc ggcgcctgga ggagatcggg ccgcgcgctg agagcaccga
      181 gtggcggaga ggccgcgcgg cgcggggcag ggcccgagcg cagcccccgg acgcaggaga
      241 ccggagcgca gtcgcggcct gagcggcggg agcgcatccg agacccgccg cagggacacc
      301 caagccggcc actcccgggc catgcgcgcc gctcgctgag acccggggag gccgcgatgg
      361 agacgccagc gggagagtca tcggcgcggg gctacggccc cccgcctgcg cccgcgcccg
      421 ccgcggagag gaagaaaagc caccgcgcgc catcaccagc ccggcccaag gacgtggccg
      481 gctggtctct ggccaaaggc cgccgcggca caggcccggg ctccgctaca gcctgtggca
      541 ccgcgtcctc ggcgaggccc gacaagaagg ggcgcgcggt ggctcctggt acccgaggca
      601 cggggcctcg ggtggccggg gtgcgcacgg gggtccgcgc caagggtcgc cctcgtcccg
      661 gtaccgggcc ccgcccgccg ccgccgccgc ccagcctcac ggacagtagc tccgaggtgt
      721 cggactgcgc gtcggaggag gcgcgccagt tgggcctgga gctggcgctg agcagcgacg
      781 ccgagtctgc ggcgggcggc ccggcgggga cccgcaccgg gcagccgccc cagccagcgc
      841 agtcggggca gcagcctccg cggcctcccg cctccccgga tgagccgtcg gtggccgcat
      901 cgtcggtggg cagcagccgc ttgccactca gcgcctcgct agccttctcc gacctcaccg
      961 aggagatgct ggactgtggg cccggaggct tggtgcggga gctggaagag ctgcgttccg
     1021 agaacgacta tctcaaggat gagattgagg agctacgggc tgagatgctg gagatgcggg
     1081 atgtctacat ggaggaagac gtgtatcagc tgcaggagtt gcggcagcag ctggaccaag
     1141 ccagcaaaac ctgtcgcatc ctgcagtacc gactgcgtaa ggctgagcgc cgcagcctcc
     1201 gcgctgccca gacaggccag gttgatgggg aactcatccg aggtctggaa caggacgtca
     1261 aggtctctaa ggacatctcc atgcggcttc acaaggagct ggaggtggtg gagaagaagc
     1321 ggatgaggct ggaggaggag aacgaggggc ttcgacagag gctcattgag acagagctgg
     1381 ccaagcaggt gctacagacg gagctggatc gtcccagaga gcattccttg aagaaaagag
     1441 gaacccggtc tctggggaag acagataaga agcctactgc acaggaggat agtgcagacc
     1501 tgaagtgcca gctgcatttt gcaaaggagg agtcggccct catgtgcaag aagctcacca
     1561 agttggctaa ggagaacgac agcatgaagg aggagctgct caagtacaga tcgctctatg
     1621 gggacctgga tgcagccctg tcggcagagg agctggcgga tgctccgcac tcccgtgaga
     1681 ctgagctgaa ggtgcacctg aagctggtgg aggaggaggc caacctgctg agccggcgca
     1741 tagtggagct ggaggtggag aaccgtggcc tgcgagccga gatggacgac atgaaggacc
     1801 acgggggtgg cgggggtccc gaggccaggc tggccttctc ttctctgggt ggtgagtgcg
     1861 gggagagcct agccgagttg cggcgccacc tgcagttcgt ggaagaggag gctgagctgc
     1921 tgaggcgctc ctcagctgag ctggaggacc agaacaagtt gctgctgaac gagctggcca
     1981 aataccgctc ggagcacgag ctggacgtga cgctgtcgga ggacagctgc tccgtgctca
     2041 gcgagccctc gcaggaggag ctggcagccg ccaagctgca gatcggcgag ctcagcggca
     2101 aggtcaagaa gctgcagtat gagaaccgcg tgctcctctc caatctgcag cgctgtgacc
     2161 tggcctcctg ccagagcaca cgccccatgc tggagacgga cgctgaggct ggggactctg
     2221 cgcagtgcgt gcctgcccct ctgggtgaga cgctggagcc ccacgccgcc cggctgtgca
     2281 gggcccgtga agccgaggcg ctgcccggcc tacgggagca ggccgctttg gtcagcaagg
     2341 ccatcgacgt cctggtggct gatgccaatg gcttctcagt cggcctccgc ctgtgcctgg
     2401 acaatgagtg tgctgacttg cgactgcacg aggcgcctga caacagcgag ggccccaggg
     2461 atgccaagct catccacgcc atcctggtgc ggctgagtgt gttgcaacag gagctgaacg
     2521 ccttcacccg caaggcagat gtggccttgg ggagctctgg caaggagcag cctgagccct
     2581 tccctgctct gcctgccttg ggctcccagg gccctgctaa ggagatcatg ctgtccaaag
     2641 accttggctc tgacttccag ccacctgact tcagagacct gcttgagtgg gagcccagga
     2701 tccgagaggc cttccgtacc ggggacttgg agtccaagcc tgaccctagt cggaacttca
     2761 ggccctaccg agctgaagat aacgattctt atgcctctga gatcaaggat cttcagctgg
     2821 tcctggccga ggcccacgac agcctccggg gcttgcaaga gcagctgtcc caggagcggc
     2881 agctccggaa ggaggaggct gacagcttca accagaaaat ggtccagctg aaggaagacc
     2941 agcagagggc gctgctgaga cgggagtttg agctgcagag tctgagcctc cagcggcgac
     3001 tggagcagaa gttctggagc caagagaaga acatcctggt gcaggagtcc cagcagttca
     3061 agcacaactt tctgctgctc ttcatgaagc tccggtggtt cctgaagcgc tggcggcagg
     3121 gcaaggttct gcccagcgaa gaggatgact tcctggaggt gaacagcatg aaggaactgt
     3181 acctgctgat ggaggaagag gagatgaacg cccagcactc ggataacaag gcctgcacag
     3241 gggagagctg gacccagaac acgcctaatg agtgcatcaa gaccctggcc gacatgaagg
     3301 tcaccctgaa ggagctgtgc tggctgctcc aggacgagcg tcggggtctg actgaacttc
     3361 agcagcagtt cgcaaaggcc aaggccacct gggagacaga gcgtgcagag ctcaagggcc
     3421 acgcctcgca gatggagctg aaggctggga agggtgccag tgagaggccc gggcctgact
     3481 ggaaggctgc actgcagaga gagcgggagg agcagcaaca cctcctggca gagtcctaca
     3541 gcgccgtcat ggagctgacg aggcagctgc agctgagcga gcgccactgg agccaggaga
     3601 agctgcagct ggtggagcgg ctgcagggag aaaagcagca ggtggagcag caggtgaagg
     3661 agctgcagaa ccgcctcagt cagttgcaga aggctgccga gccctgggtc ctgaagcact
     3721 cagacatgga gaagcaagac aacagctgga aagaggcacg aagtgagaag acccatgaca
     3781 aggagggtgt ctctgaagct gagctcgggg gaactggctt aaagaggacc aaatcagtct
     3841 cctccatgtc tgagtttgaa agtttgctcg actgctcccc gtaccttgct ggcggggatg
     3901 cccggaacaa gaagctgccc aacggccctg cttttgcctt tgtgagtact gagccagtgg
     3961 agcctgagaa agacgccaag gagaaggcgg ggctttccac ccgggactgt agccacattg
     4021 gtagcttggc ctgtcaggaa cctgcaggga gacagatgca gcgcagctac acggctccag
     4081 acaagacggg aatccgagtc tactatagtc cgccagtggc ccggcgcctg ggtgtccctg
     4141 tggtccatga caaggagggc aagatcctca ttgagccagg cttcctcttc actaccgcca
     4201 agcccaagga gtcagccgag gctgacgggc tggccgagag ctcctacagc cggtggcttt
     4261 gcaatttctc ccggcagcgg ctggatggag gatccggggc cagcacctcg ggttccggac
     4321 ctgctttccc cgccttgcat gactttgaga tgtcgggcaa catgagtgac gacatgaagg
     4381 agatcaccaa ctgcgtgcgg caggccatgc gctccggctc tctggagagg aaggtaaaga
     4441 acacatccag ccagacggta ggcgtggcca ccgtgggcac ccagaccatt cggacggtca
     4501 gtgtaggtct tcagaccgac ccaccccgca gcagcctcca cagcaagagc tggtcacccc
     4561 gcagctcctc gcttgtgtct gtgcgcagca agcagatctc ttcctccctg gacaaggtcc
     4621 attctcgcat tgagcggcca tgttgctcgc ccaagtacgg ctcacccaag ctccagagac
     4681 gatcggtgtc caagctggat agcaccaagg accgcagcct gtggaacctg caccagggca
     4741 agcaaaatgg ctccgcctgg gctcgctcca ccaccacacg ggatagccct gtactgagga
     4801 acatcaatga tgggctttct agcctcttta gtgtggtgga gcactctggg agcaccgagt
     4861 ctgtgtggaa actgggcatg tctgaggccc gaaccaaacc tgagcctccc aagtatggca
     4921 ttgttcagga gttcttccgg aacgtgtgtg gccgggcacc gagccccact actgcagcag
     4981 gcgaggaaag ctgcaagaaa ccagagcccc tttcgccagc cagctaccat caacccgagg
     5041 gtgtatccag gatcctgaac aagaaggcgg ccaaggcagg tggtagcgaa gaggtcagac
     5101 ccaccatgct gtcccaggtg gggaaggatg gcatccttcg ggatggagat ggatccttga
     5161 tccttcccag tgaggatgcc gtatgtgact gtagcgccca gtcacttgcc tcctgcttca
     5221 tccggccatc ccgcaacacc atccggcact ctccttccaa gtgcaggctg cacccttcag
     5281 agtcaggctg gggcggggag gagagggcag ctccccagtg agtccctgag caaccaagca
     5341 cccacctcaa gcagcccaga ccctggagat gaggcaaggg ctcgtgtcct cagcctcagt
     5401 ccatccagga ggaatggcag ctgtgccact gccacagaag agctttcaca ttaaggtaaa
     5461 gcaaggtgtc ttgctgactg ctgggcagtg acctctgatt tccaggggaa gacagtgagc
     5521 aaggagaacg accaaacctg ggtgaccagg actgggcctc aaaagcacct gaagagctca
     5581 gcaagtcagc tctggatccc aaagggggcc tggtaccacc cacaccgctt cttagaagga
     5641 tccagaaaag gaggcatttc tggccaggct ccaggaccaa gactggcaga ggtgctccct
     5701 tctgaccacg tgtggaggag aagccaccca gagaattcca ctttgctcag ggcccggctt
     5761 gaggctctca gaagagttgg gcctgggtgt gaccgtcact tcttgctccc tcctctcagc
     5821 cctgctgctc tggttgttag acctgcctgg agcagggaat ggggacatga tagagcagat
     5881 ttcagggcta agtacacttg gaatcctgga gctctggaga cccctgtctg tgcctacatg
     5941 tagcaagaac tgggaggcag gtaggagtat gtagggttca gagtaggagg ccagaagagc
     6001 tgactccctt gtcatgggga catgagggcc caacttttgt agtacatgag aacaaaaatg
     6061 gtagcatcta tctcagcacc tgacaaagag gtacattcct caatgccatg tctcgatccc
     6121 tagggcctct tggtagcagg gttcggcgtc acagacctgc agcagcagaa acacttcctg
     6181 ggagagacta ttggataggt cagaccagag ggagagccaa gaggccaaga catagcccaa
     6241 gacaagggac tacattgttt atttgcctag attgtttatt tgaatttttc atactataaa
     6301 tatttaaggt gatttacttt attttaataa tttaacttac cccaccctca cccccccaga
     6361 gcccctaagg taatttatta gaggtatcct tgccactggg acagtgtggg gcttgtgaca
     6421 gcatggagtc ccccgtgtgg ctgaggcagc tcagtagcag gctcaggtct cctggtcttg
     6481 tcagaagggc cctcagcgga gctggggctc tgcaccttgt tcctccagta ccatttagtc
     6541 tcagagcact acatttccct cgtcacccgg taggtggccc ggcctctaca ggccagactg
     6601 taagtgcttc agacaaactg caggcccgaa tgatgtcatc actccccaga catcctccac
     6661 catccttccc atccctccct tcccgccagc acctcttctc atgagagtca aacacagatg
     6721 actgcggctc tgttccttcc acattcccga agtaagaact cgcaggaaaa caggatggac
     6781 ttgtagaatg ttgtcgattg cagctttgca cacggatctg agagtgtcta ccagcctgcc
     6841 agcctgttca ccagcgcttc tcttagcctt atagccactc gtggctcctc atgcccaaac
     6901 tcgactgcct gtccttccta cacccctagg agtcgcctga accacaccag tataactcaa
     6961 ctgcagtatg gggagggctc acattgcctc cccttggtgc caaggaacca attacagttg
     7021 tacacatgtg acgtgccacc ctcctgttcc tggctgggga cccggactca tccagggatg
     7081 gattggcttt tgtgcagagg tccccttgga aaggcagaga gccagctagc tgcatagctg
     7141 gtttgctcca gaactaggga gatgcctcta cactcccacc tacctgtacc caggctatct
     7201 ttttagaaac acctgggcca gttacccaaa gcccctcgac cccatttcct atgggcagta
     7261 tatcagggtc agtgctttct agcagctgtt gactcgtgtc cagtaacttg cgtgggcata
     7321 gtcagcaggc cattggaccg aggaccaggt ccctccagga tgcaaatgct ctcctctaag
     7381 aggtcagagg cccctctaag gttatttcta gctgagggga ccacaccagg ccacaagcca
     7441 ccagaggcct tctgccacct cccagagcta ctgagagctt gggaggcttt gagaaaagtc
     7501 cctacagccc tgaacttcag ggcttagggg ccgttcagcc ttaccatcgt ctctgtatgg
     7561 gttgtgcatt tccactgtct cagcacctgg ctcctgtggc ccccaacagg tgttgcaagc
     7621 tccaggtctt gtttttcagt caccgtttct aattcttgct tgccactgtg caaggccact
     7681 tgtcactgtc cctatggaag cctctggaca tagggctcag tggggttgaa aatgttccgt
     7741 gtaaatattg gtttggtttg atctttagca ttttacttgg taactggttc tgttttcttt
     7801 gggggtgggg tggaagggtc agtttgtaaa tctctctact cttttgaaat gtaatttcta
     7861 agtttgtttg tttcttcaaa tgccttttat gtcttggtaa cattcccaaa gcagaaaact
     7921 gcctggctta catgggggca cgccccttga ggcctggggt catgggaagg agctccaccc
     7981 ctcctcctat ctatgctctt tctgttcacc tctgtttttc tcctcctctt cctcttcctc
     8041 tccctccttc tcctcttcat cctcttcttc ctcctcctcc agcttctacc ctactcccag
     8101 aaccaacgtc ccaaggaacc ttagggtccc atcctctaaa agattgcctg gcttgtgctc
     8161 acagggttga cacagattgg ctggaggcac gagggagagc taagttacat ggttgaaact
     8221 aagctatgtc tcacctcttc ccagggctaa accaaatgag actgtctagg aggcattggt
     8281 gactggtttt gaattgagac tcagagcctt ttagggaccc ctgactgaat aaggcatcat
     8341 cagcatttat cgccctttac cctgtagcct tcctcccacc aaggctggcc tctagagatc
     8401 ttgttctcta ggtgctcaag tcaggccctg tctcttggcc tatccaggga tattcatcta
     8461 ccagctggcc tccaggtgac aagaatgagt actcaaaaga cttgaccttc taggcaccac
     8521 cgtgctgctc tcgctctgta cctttgatgg atacatctgt cactcagctt tgtcccttac
     8581 ctggacagaa cccagactct tacccttacc caaaatggat ccagttccac tgcctccctc
     8641 tccctcctca ctgtaatagc aaccatcctt ccaccatcct ccctagagca ctatactgtt
     8701 tagggggtca cgtcaccatc tccccatctc tccttagtct ctcaagggca actcttgagg
     8761 ggcagttttg acaggatagg gtttagtgct ctcattctat aaaggagaaa acagagtttt
     8821 tgccctagag cctgaaccag gaagtcatca actgtatagc tggattcttc cctgctttct
     8881 atacaaactc actgggacgc tggctagatt caaagcatcc caaactcgcc actgccaaac
     8941 ccagagacag acttccaatt ctggaccaga gggtagttcc agggacccac tgcacctgaa
     9001 cctctgagag caagttcatc atgaagattt ctaggcctta ccacagcctc tggacagagg
     9061 tcctatgggc ttagccccct ggagatccat aggcaccagt gaccagtgtt tacatccaca
     9121 gtaccagcca ttcctaactt tagcatcctg agtcagtgtt catagtgccc tgagccctga
     9181 gctgtgatct ggggctgagg gtgtctcagc caaactctgc tttgggtaaa ttactccaag
     9241 ggttttcaaa gggcatcaaa acagtcttcc gtcttagtca tacgtttcat aaaacgacaa
     9301 agccagaaag gctggtggca caggccttaa atcctggctg ctgaggaggc agaaacagga
     9361 ggattgagtt caaagcatgt ttgggctgtg gagtgagttc aagatcagcc tgggcaattt
     9421 tctaaggtct tagctcaatg attttagcaa gtggttggta gctcagtggt cgacgcttgt
     9481 ttcacatgtg taaggccctg ggttctctcc ctactgttgg gaaacaaaac tgggaaatca
     9541 gaggacaaga actaagggta tgtcttaatt acatacttta aagtatactc ccttcctccc
     9601 cctgctgttt gtttgtcttg tttttgtttt tagatataat cttgctatgt atccctggcc
     9661 ggtctggaaa tagccatgca gaccttaaat ctgtggtaat tttcctgcct ctgcctctca
     9721 agttctggaa ttgcaggcat gcgctaccat acccagcctt aaatttcatt ctccagtttc
     9781 ctagaggcca tggcgagaag tgaaacatgg gactcactct gtagaccagg ctagccttga
     9841 acacagaaat ccgcctgcct ctgcctctca agtgctggga ttaaaggtgt gtgccaccac
     9901 cgcccggcca gaagtgaaac acttttatca gcaaatcatg attactccta gagacaaact
     9961 gatgtggaac tggagatctc tttacagacc ctggatctga ctggtgtaat accaggttag
    10021 cctaagataa gacatgtttt ccagaagact agttacaaaa tattaaactg cccccacttt
    10081 gaatgacctt ggcccaatca cgtggctagt ctatgtctca gttcccccag ctataaagtg
    10141 gtggctgtgg agaagaccac atatatcatg cctgtttgtc tgaaaaaaaa gctggcattc
    10201 tatataaatc cgaatgaatc tgaccatgct ctttatagca ttgagcccct cagttgccct
    10261 ggctccaagc acctccttcc ctcattggcc tttaatagaa gggggccaga ggagaatctc
    10321 accaacctgc tcacgtttta aaatgctact gtagtccttc tgtgtgtgta tgtgcatgcg
    10381 tttgcacatg cgagggatga gactcagagc ctagtccatg tgaggcaagc atcttaccac
    10441 tgagttacac cctcagcacc taagaggctt tttaaaaact atttactttg agacagggtc
    10501 tcttgtatca tcaggtggcc tccaactcac tgtgtaaccg cggatggact tgaatctcct
    10561 actacctttc tgcctctatc gcctttggca tttgccatcg ctgctggcct tagatgtcct
    10621 tgaagtacat tctcaatgct ttgttaacca ccactgctgc tatctccaga acttcttatt
    10681 ggtcccaaac tgaaatacca cacccccata ataattacta actaacccct acacagtaac
    10741 tcccatcctg ccccaggccg atgacctctg gtggtctgct ttctcccttc ttcactggcc
    10801 tgatttaggt actcatggag atagaacccg gtatttatca ttttgcctca cccctttatg
    10861 atatacatgt ggagaaggat gcggcttgcc cgaggcctct gagcatgaca aaggcgtagc
    10921 taccagcaca acccagagct cctaactctt caaagattct atacagagtg aatgaagcat
    10981 gctcaggggt gtggctgaat ccccatctag gttggagttc atttcccacc tcacacacct
    11041 tccgtcctcc tttatcatta tctatagttt ccttcctgtc attacaccct acctggtttc
    11101 tgccaccgta gggagtggcc ctaacctagg gccaggcttt ctcctctggg gccctgggct
    11161 ctctatagca ctagtcctca gcttcctatg tcctctggtg tgctgtttcc tcctttggat
    11221 ttgtatgtga ccttagcagt ctcctccctg tcccaacaaa ctcacccgcc cgccccatct
    11281 cggaagtgcc atgtgcagtc tgtctcccga ttccaaggtc tgctctcaga tctggaatta
    11341 tcctgtcctg tgtttatttt gtattttctc tcactagagg tgtccgctgc ttctatggat
    11401 catgctattc catctcctcc agtcctcctc atcagattca tctcactctc tgcctcctgc
    11461 cttccctgtc ctcagtctcc ccgtagcatc accttcccct gggaggatgt ggagtggaca
    11521 gggacttgct cttcaccttt ggatcttctc tgcccagcct acttccggtg gctttgctat
    11581 aaagcagggg aagcttgaaa gctctcttct ttggttttgt gcctctgtct ccatcccatc
    11641 agttctcccc tgctgatcag ctcatcttgg cagaacctac taccctgaac cagcggcatc
    11701 tgcagtttgc agagtccaca gatccacgaa aggggaccaa ggacatgatc ctgggccaca
    11761 gtccctgctc cacctgacca ctttccttct tcaccgtccc gggaccctcc tcttctctct
    11821 gcctacccca ttgacatggc cttcactagc tccctggacc ctaatgggag aggctttggt
    11881 ttccttcaag tatcctggaa ggactgaggc agttgagtcc ttatctcgac acatgcaaag
    11941 ccacctgtgc cacttatata acgagagacc tcagctggca gtctggagac ctatcccaag
    12001 tttgagcctc ccagttttat ggtcctctta ggagctctat gacctatggg cctcagatat
    12061 cctttctgtt ttgggctcta cagcctctgg atccactggg ccttggcaac ccttgttctt
    12121 ggctcaacta ttgatctctg tgccttagtt tacttcttca cacagggggc tcacccacca
    12181 catcattcct agcatctatc cagacctttt ggtgcctctt cagttaggcc ttgccaatgt
    12241 gatcaaggca gctggggcac caatggcaac tctgtcccca tagtagaagc atcaccaggg
    12301 aaattggcag aagtgcagat tgttggcccc actgcagcag acccagatgt ctggggcatg
    12361 aaagagcctc tagtcattct gactagacaa gtttgccaac agcaacaggg ttgtgggccc
    12421 aggtgagctt tcagtgcaac ttgggcagga acaatggaaa acaaccagtc agcgggactc
    12481 ctagattcag ggcgtctggc cccacacaga acagcactgt ggcatttcct ctttctggaa
    12541 gctggagtgg gggcaatggt cttgcaggtt tcctgttatc tctctggctc catctcagcc
    12601 cagctcaccc tccccgagta atcggtggtc acagtaggca agggggagag tccctggagg
    12661 caggaggcca gaaggaccag agggcctctg ccaagggaaa gaaacctaag actgcaagaa
    12721 caaaattcgg tgcctgctca cctcaccctc ccatgccaca cctcctcgtc ctcctgattc
    12781 cagggagacc atgaagacag tgccaaaaat cagttccaac ccccagcgcc tagggaagag
    12841 ctagagactg cctctcctct ccatcctggc tccccgcctc accctggcca atactgtgac
    12901 gcccctcctg ctcagcctgg tttcctggtg agggtcctgc agtcgtgggc cctgccggac
    12961 cactcaggag ggaagggacc aagggcatcc ttgggccaac tgtccaccta tcccttccac
    13021 tgttctgtcc ttctcctctc ccttctgtca cctcgccccc tgcctttctt tctttaaagg
    13081 ctccttccca ggacatattg ggtggtagga cagcatctgg tccaccagct atccttgccc
    13141 tgtgtcttat tttagacatg agaactgtac agtgtaaact tacaaagtgt ttttaatggt
    13201 tgtagattgg aaataaagta tgtcatataa ac
//
