LOCUS       NM_019758               2596 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial carrier 2 (Mtch2), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_019758
VERSION     NM_019758.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2596)
  AUTHORS   de Melo,D.G., da Cruz Rodrigues,V.C., de Sa Pereira,G.J., de
            Campos,T.D.P., Dos Santos Canciglieri,R., Pauli,J.R., da
            Silva,A.S.R., da Costa Fernandes,C.J. and de Moura,L.P.
  TITLE     Effects of aerobic exercise on the regulation of mitochondrial
            carrier homolog-2 and its influence on the catabolic and anabolic
            activity of lipids in the mesenteric adipose tissue of obese mice
  JOURNAL   Life Sci 345, 122567 (2024)
   PUBMED   38492919
  REMARK    GeneRIF: Effects of aerobic exercise on the regulation of
            mitochondrial carrier homolog-2 and its influence on the catabolic
            and anabolic activity of lipids in the mesenteric adipose tissue of
            obese mice.
REFERENCE   2  (bases 1 to 2596)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2596)
  AUTHORS   Zhou,G., Liu,J., Li,X., Sang,Y., Zhang,Y., Gao,L., Wang,J., Yu,Y.,
            Ge,W., Sun,Z. and Zhou,X.
  TITLE     Silica nanoparticles inducing the apoptosis via microRNA-450b-3p
            targeting MTCH2 in mice and spermatocyte cell
  JOURNAL   Environ Pollut 277, 116771 (2021)
   PUBMED   33652185
  REMARK    GeneRIF: Silica nanoparticles inducing the apoptosis via
            microRNA-450b-3p targeting MTCH2 in mice and spermatocyte cell.
REFERENCE   4  (bases 1 to 2596)
  AUTHORS   Zhou,X., Zhang,K., He,Z., Deng,Y. and Gao,Y.
  TITLE     Downregulated miR-150 in bone marrow mesenchymal stem cells
            attenuates the apoptosis of LPS-stimulated RAW264.7 via
            MTCH2-dependent mitochondria transfer
  JOURNAL   Biochem Biophys Res Commun 526 (3), 560-567 (2020)
   PUBMED   32247615
  REMARK    GeneRIF: Downregulated miR-150 in bone marrow mesenchymal stem
            cells attenuates the apoptosis of LPS-stimulated RAW264.7 via
            MTCH2-dependent mitochondria transfer.
REFERENCE   5  (bases 1 to 2596)
  AUTHORS   Eswarappa,S.M., Potdar,A.A., Koch,W.J., Fan,Y., Vasu,K.,
            Lindner,D., Willard,B., Graham,L.M., DiCorleto,P.E. and Fox,P.L.
  TITLE     Programmed translational readthrough generates antiangiogenic
            VEGF-Ax
  JOURNAL   Cell 157 (7), 1605-1618 (2014)
   PUBMED   24949972
REFERENCE   6  (bases 1 to 2596)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   7  (bases 1 to 2596)
  AUTHORS   Grinberg,M., Schwarz,M., Zaltsman,Y., Eini,T., Niv,H.,
            Pietrokovski,S. and Gross,A.
  TITLE     Mitochondrial carrier homolog 2 is a target of tBID in cells
            signaled to die by tumor necrosis factor alpha
  JOURNAL   Mol Cell Biol 25 (11), 4579-4590 (2005)
   PUBMED   15899861
REFERENCE   8  (bases 1 to 2596)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 2596)
  AUTHORS   Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C.,
            Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L.,
            Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G.,
            Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and
            Demant,P.
  TITLE     Ptprj is a candidate for the mouse colon-cancer susceptibility
            locus Scc1 and is frequently deleted in human cancers
  JOURNAL   Nat Genet 31 (3), 295-300 (2002)
   PUBMED   12089527
REFERENCE   10 (bases 1 to 2596)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK008712.1 and AK164169.1.
            
            On Nov 24, 2015 this sequence version replaced NM_019758.2.
            
            Summary: This gene encodes a member of the SLC25 family of
            nuclear-encoded transporters that are localized in the inner
            mitochondrial membrane. Members of this superfamily are involved in
            many metabolic pathways and cell functions. Genome-wide association
            studies in human have identified single-nucleotide polymorphisms in
            several loci associated with obesity. This gene is one such locus,
            which is highly expressed in white adipose tissue and adipocytes,
            and thought to play a regulatory role in adipocyte differentiation
            and biology. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. A recent study
            showed this gene to be an authentic stop codon readthrough target
            that can produce two isoforms from the same mRNA by use of
            alternative in-frame translation termination codons. [provided by
            RefSeq, Dec 2017].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes two isoforms, which result from the use of
            alternative in-frame translation termination codons. The shorter
            isoform (1) results from translation termination at the upstream
            UGA stop codon, while the longer isoform (1x) results from UGA stop
            codon readthrough to the downstream UAG termination codon. This
            RefSeq represents the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164169.1, SRR1660813.152147.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-762               AK008712.1         2-763
            763-2596            AK164169.1         648-2481
FEATURES             Location/Qualifiers
     source          1..2596
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.41 cM"
     gene            1..2596
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /note="mitochondrial carrier 2"
                     /db_xref="GeneID:56428"
                     /db_xref="MGI:MGI:1929260"
     exon            1..231
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1056
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitochondrial carrier homolog 2; met-induced mitochondrial
                     protein"
                     /codon_start=1
                     /product="mitochondrial carrier homolog 2 isoform 1"
                     /protein_id="NP_062732.1"
                     /db_xref="CCDS:CCDS16416.1"
                     /db_xref="GeneID:56428"
                     /db_xref="MGI:MGI:1929260"
                     /translation="MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIF
                     GRQVCQLPGLFCYAQHIASIDGRRGLFTGLTPRLCSGVLGTVVHGKVLQYYQESEKPE
                     ELGSVTVQKEYSSSFDRVIKETTREMIARSAATLITHPFHVITLRSMVQFIGRESKYC
                     GLCDSIVTIYREEGIVGFFAGLIPRLLGDIISLWLCNSLAYLINTYALDSGVSTMNEM
                     KSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGSPPYSPIYTSWIDCWCMLQKAG
                     NMSRGNSLFFRKVPCGKTYCYDLRMLI"
     exon            232..316
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            317..423
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            424..450
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            451..513
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            514..571
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            572..623
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            624..683
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            684..777
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            778..825
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            826..893
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            894..969
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            970..2596
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1151..1156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /note="hexamer: AATAAT"
     polyA_site      1178
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /note="major polyA site"
     regulatory      2404..2409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /note="hexamer: AGTAAA"
     polyA_site      2428
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
ORIGIN      
        1 gtttctttgg gcgggccggt gggcggagcc taagcgggcg gcgcgccgcg ggcgggccag
       61 tgaagccggc gcccccgaca cgtgatctgg aaccggctgt gtcgcttggt gactccgtct
      121 gtccgtccgt ccgcgggtgc catcatggcg gacgcggcca gtcaggtgct cctgggctcc
      181 ggtctcacca tcctgtccca gccgctcatg tacgtgaaag tgctcatcca ggtgggatat
      241 gagcctcttc ctccaacaat aggacgaaat atttttgggc gacaagtatg tcagcttcct
      301 ggcctctttt gctatgctca gcacattgca agcatcgatg ggaggcgtgg gttgttcaca
      361 ggcttgactc caagactgtg ttcaggagtc cttggaactg tggtccatgg gaaagtctta
      421 cagtattacc aggagtctga gaaacctgag gagttaggat ctgtaactgt acaaaaagaa
      481 tattcatcct cctttgaccg agttatcaaa gagacaactc gagagatgat tgctcgttct
      541 gctgctaccc tcattacaca tcccttccac gtgatcactc tgaggtccat ggtacagttt
      601 attggcagag agtctaagta ctgtggactg tgtgactcca tagtaaccat ctaccgggaa
      661 gaaggcatcg taggattttt tgcgggtctc attcctcgcc tcctaggtga catcatttct
      721 ttgtggctgt gtaactcact ggcctatctc atcaatacct atgcactgga cagtggggtt
      781 tctaccatga atgaaatgaa aagttactcc caagctgtca caggattctt tgccagtatg
      841 ttgacatatc cctttgtgct tgtatctaat cttatggccg tcaacaactg tgggcttgct
      901 ggtggatctc ctccttattc cccaatatac acttcttgga tagattgctg gtgcatgcta
      961 caaaaagcgg gaaatatgag ccgaggaaac agcttgtttt tccggaaggt tccttgtggg
     1021 aagacttact gttatgacct aagaatgtta atctgaagat gtggggcagg gacagtgaca
     1081 tttctatagt cccaatgcac agaattatgg gagagaatgt tgatttctat acagtgtggc
     1141 acgctttttt aataatcatt taatcttggg aaaatggagg tgattggtgt ctgccttttt
     1201 tgttctttgt cctagcacaa catcttttac cactggggtt ccccattagt tatttgaagt
     1261 gagacattta tttctccaaa ttcttgtttt aaacagaaaa cagacacatt tccctaaagg
     1321 aacaagcagg ttttcatgta gatttgagtc tcaggttagg gctttgtcaa atgaagaata
     1381 gaaccccaat aagaagcagc taattctata agttgataaa attaagaaag cataccatgt
     1441 gggagtttat gaatgacctg agtagacaga tgctagaaag tcagcagcaa ccactagtct
     1501 acctcccacc atgcttccaa gcagccgacc catcttacct ttcagtgctg ctgagttact
     1561 gtagatttct gccttctgtt cctacagaag ggaaaggcat caccaccacc aagaagaagg
     1621 tcaggtacag aggcttaagg aagctttggg aaggaaggga gtatgatggc ctttcactcc
     1681 aaagaagctc ctagcctcgt gtagcacgag aagcaagcac tgcagcacac acagcagcac
     1741 cccgagtgct cagtgcccac agcctccaag gtctggcctc accgcggctc ccattgccta
     1801 taagcttctg ctcctaagcg tttgtttcct tcttgttact gcagaaggtg agtagtttgg
     1861 gtcttatttc tgatgacacc cttgaaagtg taactcctta tctgatgacg tggaccaaag
     1921 tccacatggt tcttaggata ttgtccagct caaatgtcag accctcagtt aggcatgtaa
     1981 aaaacactta atgaaggcaa aatcacttta gaaggaaaat tttcaactca agcattgagc
     2041 tccttcctat tcactcaggc ctttcaatgg cagttaaaat gctcataaga tgagaaagcc
     2101 ctgtggtgtc gattcctgat actttgccaa atgagtaagc actgactttg ctgcttttag
     2161 acttctgtca atgcagcaga ggccatgatg ttaggtagtg tgagcgcgca gggtcttctc
     2221 ccactcaggg ttagggatgc gaccagaagc tcatgagtag cttagtttga aatgtctttg
     2281 atgtcaaaag tactttgtct caaaagtaat gtaaatttta tattctattc attattatct
     2341 gcatctgttt taatataaaa tgtgttttgc attacctact cttttctccc agaaaaaaag
     2401 tcaagtaaag atgatgtagg aaaatgcacc atgcttagcc tgctgcttct gtacacatat
     2461 acgctccccg gttctgagca ccgctggctg tgagaacctg tccaccacca gagggcagca
     2521 gaactttggt tgtgcctgtg catctggcct gctgaatggt ctaggattgc tcagtgaaaa
     2581 ttaaaagtct tatttc
//
