LOCUS       NM_001317242            2623 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial carrier 2 (Mtch2), transcript variant 2,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001317242
VERSION     NM_001317242.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2623)
  AUTHORS   de Melo,D.G., da Cruz Rodrigues,V.C., de Sa Pereira,G.J., de
            Campos,T.D.P., Dos Santos Canciglieri,R., Pauli,J.R., da
            Silva,A.S.R., da Costa Fernandes,C.J. and de Moura,L.P.
  TITLE     Effects of aerobic exercise on the regulation of mitochondrial
            carrier homolog-2 and its influence on the catabolic and anabolic
            activity of lipids in the mesenteric adipose tissue of obese mice
  JOURNAL   Life Sci 345, 122567 (2024)
   PUBMED   38492919
  REMARK    GeneRIF: Effects of aerobic exercise on the regulation of
            mitochondrial carrier homolog-2 and its influence on the catabolic
            and anabolic activity of lipids in the mesenteric adipose tissue of
            obese mice.
REFERENCE   2  (bases 1 to 2623)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2623)
  AUTHORS   Zhou,G., Liu,J., Li,X., Sang,Y., Zhang,Y., Gao,L., Wang,J., Yu,Y.,
            Ge,W., Sun,Z. and Zhou,X.
  TITLE     Silica nanoparticles inducing the apoptosis via microRNA-450b-3p
            targeting MTCH2 in mice and spermatocyte cell
  JOURNAL   Environ Pollut 277, 116771 (2021)
   PUBMED   33652185
  REMARK    GeneRIF: Silica nanoparticles inducing the apoptosis via
            microRNA-450b-3p targeting MTCH2 in mice and spermatocyte cell.
REFERENCE   4  (bases 1 to 2623)
  AUTHORS   Zhou,X., Zhang,K., He,Z., Deng,Y. and Gao,Y.
  TITLE     Downregulated miR-150 in bone marrow mesenchymal stem cells
            attenuates the apoptosis of LPS-stimulated RAW264.7 via
            MTCH2-dependent mitochondria transfer
  JOURNAL   Biochem Biophys Res Commun 526 (3), 560-567 (2020)
   PUBMED   32247615
  REMARK    GeneRIF: Downregulated miR-150 in bone marrow mesenchymal stem
            cells attenuates the apoptosis of LPS-stimulated RAW264.7 via
            MTCH2-dependent mitochondria transfer.
REFERENCE   5  (bases 1 to 2623)
  AUTHORS   Eswarappa,S.M., Potdar,A.A., Koch,W.J., Fan,Y., Vasu,K.,
            Lindner,D., Willard,B., Graham,L.M., DiCorleto,P.E. and Fox,P.L.
  TITLE     Programmed translational readthrough generates antiangiogenic
            VEGF-Ax
  JOURNAL   Cell 157 (7), 1605-1618 (2014)
   PUBMED   24949972
REFERENCE   6  (bases 1 to 2623)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   7  (bases 1 to 2623)
  AUTHORS   Grinberg,M., Schwarz,M., Zaltsman,Y., Eini,T., Niv,H.,
            Pietrokovski,S. and Gross,A.
  TITLE     Mitochondrial carrier homolog 2 is a target of tBID in cells
            signaled to die by tumor necrosis factor alpha
  JOURNAL   Mol Cell Biol 25 (11), 4579-4590 (2005)
   PUBMED   15899861
REFERENCE   8  (bases 1 to 2623)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 2623)
  AUTHORS   Ruivenkamp,C.A., van Wezel,T., Zanon,C., Stassen,A.P., Vlcek,C.,
            Csikos,T., Klous,A.M., Tripodis,N., Perrakis,A., Boerrigter,L.,
            Groot,P.C., Lindeman,J., Mooi,W.J., Meijjer,G.A., Scholten,G.,
            Dauwerse,H., Paces,V., van Zandwijk,N., van Ommen,G.J. and
            Demant,P.
  TITLE     Ptprj is a candidate for the mouse colon-cancer susceptibility
            locus Scc1 and is frequently deleted in human cancers
  JOURNAL   Nat Genet 31 (3), 295-300 (2002)
   PUBMED   12089527
REFERENCE   10 (bases 1 to 2623)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK008712.1, AK011814.1 and
            AK164169.1.
            
            Summary: This gene encodes a member of the SLC25 family of
            nuclear-encoded transporters that are localized in the inner
            mitochondrial membrane. Members of this superfamily are involved in
            many metabolic pathways and cell functions. Genome-wide association
            studies in human have identified single-nucleotide polymorphisms in
            several loci associated with obesity. This gene is one such locus,
            which is highly expressed in white adipose tissue and adipocytes,
            and thought to play a regulatory role in adipocyte differentiation
            and biology. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. A recent study
            showed this gene to be an authentic stop codon readthrough target
            that can produce two isoforms from the same mRNA by use of
            alternative in-frame translation termination codons. [provided by
            RefSeq, Dec 2017].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            acceptor splice site at an internal coding exon compared to variant
            1. The resulting isoform (2) is longer containing a 9 aa protein
            segment not found in isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011814.1, BY711034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AK008712.1         2-77
            77-1203             AK011814.1         2-1128
            1204-2623           AK164169.1         1062-2481
FEATURES             Location/Qualifiers
     source          1..2623
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.41 cM"
     gene            1..2623
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /note="mitochondrial carrier 2"
                     /db_xref="GeneID:56428"
                     /db_xref="MGI:MGI:1929260"
     exon            1..231
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1083
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /note="isoform 2 is encoded by transcript variant 2;
                     mitochondrial carrier homolog 2; met-induced mitochondrial
                     protein"
                     /codon_start=1
                     /product="mitochondrial carrier homolog 2 isoform 2"
                     /protein_id="NP_001304171.1"
                     /db_xref="CCDS:CCDS84547.1"
                     /db_xref="GeneID:56428"
                     /db_xref="MGI:MGI:1929260"
                     /translation="MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIF
                     GRQVCQLPGLFCYAQHIASIDGRRGLFTGLTPRLCSGVLGTVVHGKVLQYYQESEKPE
                     ISVFAFDFQELGSVTVQKEYSSSFDRVIKETTREMIARSAATLITHPFHVITLRSMVQ
                     FIGRESKYCGLCDSIVTIYREEGIVGFFAGLIPRLLGDIISLWLCNSLAYLINTYALD
                     SGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGSPPYSPIYTSWID
                     CWCMLQKAGNMSRGNSLFFRKVPCGKTYCYDLRMLI"
     exon            232..316
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            317..423
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            424..450
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            451..540
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            541..598
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            599..650
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            651..710
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            711..804
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            805..852
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            853..920
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            921..996
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     exon            997..2623
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1178..1183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /note="hexamer: AATAAT"
     polyA_site      1205
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /note="major polyA site"
     regulatory      2431..2436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
                     /note="hexamer: AGTAAA"
     polyA_site      2455
                     /gene="Mtch2"
                     /gene_synonym="2310034D24Rik; 4930539J07Rik; HSPC032"
ORIGIN      
        1 gtttctttgg gcgggccggt gggcggagcc taagcgggcg gcgcgccgcg ggcgggccag
       61 tgaagccggc gcccccgaca cgtgatctgg aaccggctgt gtcgcttggt gactccgtct
      121 gtccgtccgt ccgcgggtgc catcatggcg gacgcggcca gtcaggtgct cctgggctcc
      181 ggtctcacca tcctgtccca gccgctcatg tacgtgaaag tgctcatcca ggtgggatat
      241 gagcctcttc ctccaacaat aggacgaaat atttttgggc gacaagtatg tcagcttcct
      301 ggcctctttt gctatgctca gcacattgca agcatcgatg ggaggcgtgg gttgttcaca
      361 ggcttgactc caagactgtg ttcaggagtc cttggaactg tggtccatgg gaaagtctta
      421 cagtattacc aggagtctga gaaacctgag atttctgttt ttgcttttga tttccaggag
      481 ttaggatctg taactgtaca aaaagaatat tcatcctcct ttgaccgagt tatcaaagag
      541 acaactcgag agatgattgc tcgttctgct gctaccctca ttacacatcc cttccacgtg
      601 atcactctga ggtccatggt acagtttatt ggcagagagt ctaagtactg tggactgtgt
      661 gactccatag taaccatcta ccgggaagaa ggcatcgtag gattttttgc gggtctcatt
      721 cctcgcctcc taggtgacat catttctttg tggctgtgta actcactggc ctatctcatc
      781 aatacctatg cactggacag tggggtttct accatgaatg aaatgaaaag ttactcccaa
      841 gctgtcacag gattctttgc cagtatgttg acatatccct ttgtgcttgt atctaatctt
      901 atggccgtca acaactgtgg gcttgctggt ggatctcctc cttattcccc aatatacact
      961 tcttggatag attgctggtg catgctacaa aaagcgggaa atatgagccg aggaaacagc
     1021 ttgtttttcc ggaaggttcc ttgtgggaag acttactgtt atgacctaag aatgttaatc
     1081 tgaagatgtg gggcagggac agtgacattt ctatagtccc aatgcacaga attatgggag
     1141 agaatgttga tttctataca gtgtggcacg cttttttaat aatcatttaa tcttgggaaa
     1201 atggaggtga ttggtgtctg ccttttttgt tctttgtcct agcacaacat cttttaccac
     1261 tggggttccc cattagttat ttgaagtgag acatttattt ctccaaattc ttgttttaaa
     1321 cagaaaacag acacatttcc ctaaaggaac aagcaggttt tcatgtagat ttgagtctca
     1381 ggttagggct ttgtcaaatg aagaatagaa ccccaataag aagcagctaa ttctataagt
     1441 tgataaaatt aagaaagcat accatgtggg agtttatgaa tgacctgagt agacagatgc
     1501 tagaaagtca gcagcaacca ctagtctacc tcccaccatg cttccaagca gccgacccat
     1561 cttacctttc agtgctgctg agttactgta gatttctgcc ttctgttcct acagaaggga
     1621 aaggcatcac caccaccaag aagaaggtca ggtacagagg cttaaggaag ctttgggaag
     1681 gaagggagta tgatggcctt tcactccaaa gaagctccta gcctcgtgta gcacgagaag
     1741 caagcactgc agcacacaca gcagcacccc gagtgctcag tgcccacagc ctccaaggtc
     1801 tggcctcacc gcggctccca ttgcctataa gcttctgctc ctaagcgttt gtttccttct
     1861 tgttactgca gaaggtgagt agtttgggtc ttatttctga tgacaccctt gaaagtgtaa
     1921 ctccttatct gatgacgtgg accaaagtcc acatggttct taggatattg tccagctcaa
     1981 atgtcagacc ctcagttagg catgtaaaaa acacttaatg aaggcaaaat cactttagaa
     2041 ggaaaatttt caactcaagc attgagctcc ttcctattca ctcaggcctt tcaatggcag
     2101 ttaaaatgct cataagatga gaaagccctg tggtgtcgat tcctgatact ttgccaaatg
     2161 agtaagcact gactttgctg cttttagact tctgtcaatg cagcagaggc catgatgtta
     2221 ggtagtgtga gcgcgcaggg tcttctccca ctcagggtta gggatgcgac cagaagctca
     2281 tgagtagctt agtttgaaat gtctttgatg tcaaaagtac tttgtctcaa aagtaatgta
     2341 aattttatat tctattcatt attatctgca tctgttttaa tataaaatgt gttttgcatt
     2401 acctactctt ttctcccaga aaaaaagtca agtaaagatg atgtaggaaa atgcaccatg
     2461 cttagcctgc tgcttctgta cacatatacg ctccccggtt ctgagcaccg ctggctgtga
     2521 gaacctgtcc accaccagag ggcagcagaa ctttggttgt gcctgtgcat ctggcctgct
     2581 gaatggtcta ggattgctca gtgaaaatta aaagtcttat ttc
//
