LOCUS       NM_134092               3147 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus Mdm2, transformed 3T3 cell double minute p53 binding
            protein (Mtbp), transcript variant 1, mRNA.
ACCESSION   NM_134092
VERSION     NM_134092.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3147)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   2  (bases 1 to 3147)
  AUTHORS   Grieb,B.C., Boyd,K., Mitra,R. and Eischen,C.M.
  TITLE     Haploinsufficiency of the Myc regulator Mtbp extends survival and
            delays tumor development in aging mice
  JOURNAL   Aging (Albany NY) 8 (10), 2590-2602 (2016)
   PUBMED   27803394
  REMARK    GeneRIF: Mtbp haploinsufficiency significantly increased longevity
            and maximal survival in mice. Reduced levels of Mtbp did not alter
            locomotor activity, litter size, or body size, but Mtbp
            heterozygous mice did exhibit elevated markers of metabolism,
            particularly in the liver. Mtbp(+/-) mice also had a significant
            delay in spontaneous cancer development
REFERENCE   3  (bases 1 to 3147)
  AUTHORS   Koss,M., Bolze,A., Brendolan,A., Saggese,M., Capellini,T.D.,
            Bojilova,E., Boisson,B., Prall,O.W., Elliott,D.A., Solloway,M.,
            Lenti,E., Hidaka,C., Chang,C.P., Mahlaoui,N., Harvey,R.P.,
            Casanova,J.L. and Selleri,L.
  TITLE     Congenital asplenia in mice and humans with mutations in a
            Pbx/Nkx2-5/p15 module
  JOURNAL   Dev Cell 22 (5), 913-926 (2012)
   PUBMED   22560297
REFERENCE   4  (bases 1 to 3147)
  AUTHORS   Agarwal,N., Tochigi,Y., Adhikari,A.S., Cui,S., Cui,Y. and
            Iwakuma,T.
  TITLE     MTBP plays a crucial role in mitotic progression and chromosome
            segregation
  JOURNAL   Cell Death Differ 18 (7), 1208-1219 (2011)
   PUBMED   21274008
REFERENCE   5  (bases 1 to 3147)
  AUTHORS   Machold,R., Klein,C. and Fishell,G.
  TITLE     Genes expressed in Atoh1 neuronal lineages arising from the
            r1/isthmus rhombic lip
  JOURNAL   Gene Expr Patterns 11 (5-6), 349-359 (2011)
   PUBMED   21440680
REFERENCE   6  (bases 1 to 3147)
  AUTHORS   Katayama,K., Furuno,A., Akiyama,K., Tsuji,T. and Kunieda,T.
  TITLE     Characterization of chromosomal inversion of the mouse hairy ears
            (Eh) mutation associated with cleft palate
  JOURNAL   Mamm Genome 18 (4), 246-254 (2007)
   PUBMED   17520166
REFERENCE   7  (bases 1 to 3147)
  AUTHORS   Stolt,C.C., Schmitt,S., Lommes,P., Sock,E. and Wegner,M.
  TITLE     Impact of transcription factor Sox8 on oligodendrocyte
            specification in the mouse embryonic spinal cord
  JOURNAL   Dev Biol 281 (2), 309-317 (2005)
   PUBMED   15893981
REFERENCE   8  (bases 1 to 3147)
  AUTHORS   Phelps,M., Darley,M., Primrose,J.N. and Blaydes,J.P.
  TITLE     p53-independent activation of the hdm2-P2 promoter through multiple
            transcription factor response elements results in elevated hdm2
            expression in estrogen receptor alpha-positive breast cancer cells
  JOURNAL   Cancer Res 63 (10), 2616-2623 (2003)
   PUBMED   12750288
REFERENCE   9  (bases 1 to 3147)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3147)
  AUTHORS   Boyd,M.T., Vlatkovic,N. and Haines,D.S.
  TITLE     A novel cellular protein (MTBP) binds to MDM2 and induces a G1
            arrest that is suppressed by MDM2
  JOURNAL   J Biol Chem 275 (41), 31883-31890 (2000)
   PUBMED   10906133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123682.13.
            
            On Jan 13, 2023 this sequence version replaced NM_134092.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052197.1, AK133855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               AC123682.13        121132-121464       c
            334-414             AC123682.13        120288-120368       c
            415-488             AC123682.13        116093-116166       c
            489-640             AC123682.13        115781-115932       c
            641-699             AC123682.13        114198-114256       c
            700-844             AC123682.13        112531-112675       c
            845-962             AC123682.13        111574-111691       c
            963-1076            AC123682.13        109710-109823       c
            1077-1171           AC123682.13        107480-107574       c
            1172-1244           AC123682.13        105901-105973       c
            1245-1362           AC123682.13        101304-101421       c
            1363-1536           AC123682.13        92385-92558         c
            1537-1644           AC123682.13        90106-90213         c
            1645-1806           AC123682.13        81366-81527         c
            1807-1924           AC123682.13        75568-75685         c
            1925-2080           AC123682.13        72070-72225         c
            2081-2176           AC123682.13        67836-67931         c
            2177-2443           AC123682.13        61121-61387         c
            2444-2681           AC123682.13        58994-59231         c
            2682-2795           AC123682.13        58133-58246         c
            2796-2861           AC123682.13        53413-53478         c
            2862-3147           AC123682.13        52446-52731         c
FEATURES             Location/Qualifiers
     source          1..3147
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 22.05 cM"
     gene            1..3147
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /note="Mdm2, transformed 3T3 cell double minute p53
                     binding protein"
                     /db_xref="GeneID:105837"
                     /db_xref="MGI:MGI:2146005"
     exon            1..333
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..2900
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mdm2-binding protein; mMTBP"
                     /codon_start=1
                     /product="mdm2-binding protein isoform 1"
                     /protein_id="NP_598853.3"
                     /db_xref="CCDS:CCDS27478.1"
                     /db_xref="GeneID:105837"
                     /db_xref="MGI:MGI:2146005"
                     /translation="MDRYLLLVTWREGKFRSVAGGEIEPGTEATSLESTDKQPDLTAT
                     NIYHLLKRSISDSIHPDDSTFPACSVGGTPHSRKWFFAVQAICGFYQFCSSDWQEIHF
                     DAEKDKIEDVLQANIEECQSAVECFEEDDSNSRESLPLADLYEESAENLHQLSDKLPA
                     PGRAMIDIILLPSDKDPPKLKECLPIVGALKHLKEWHSAKVIIAGSYCEINCQKIAEY
                     LSASVVPLEEFRNAIDPRELWRGEIQMRERKFGFEISFPEFCLKGVTPTNVSAYNLNT
                     CFLAKKIASSKVFHYYGPALEFVQMIKLSDLPSCYMSDIEFELEVTGHCTRQNSMLLL
                     EQISSLCGKVGALFVLPCTVSNVLIPPPSQLASRKWKEYMAKKPKTISVPDVAVKGEF
                     SGYHLLLQGMGKRKCRATLLHSASQINGSFALSVIHGKMKTKAGEARPSFPFDFSSLP
                     RFSEEQVLQREKQLASFQVLALKECLKRRKAANQPEAFSADELKSLLALTRERFLGHF
                     DVLPTEAALAQTDTVKAAGVVNDDGTVEPYSSSLMETNPLEWPERHVLQNLETSEKAK
                     QKMRTGSLPRSSEQLLGHKEGPRDSLTLLDAKELLKYFTSDGLPVGDLQPLHIQRGEK
                     PFVLTPELSPGKLQVLPFEKASECHYHGIEYCLDDQKALERDGGFSELQSRLIRYETQ
                     TTCTRDSFPVPTVLSPLPSPAVLSEPQSVPEGEALQGELRTEVSGLKRRSKDPSCLYP
                     QKRLTRSESSDCLPSQASCNSNHHHHTGKPRKPQAERCVSGLPLPGREASKDTSKTSS
                     GQKRAHESKSSKQMKESRSQKHTRMLKEVVKDTLKRHHITEAHESFTACSQRLFDISK
                     FYLKDLKTSRGLFEEMKKTANNNVVQVIEWVVEKMSKK"
     exon            334..414
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            415..488
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            489..640
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            641..699
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            700..844
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            845..962
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1076
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1171
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1244
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1362
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1536
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1644
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1806
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1924
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2080
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2176
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2443
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2681
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2795
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2861
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..3147
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3126..3131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /note="hexamer: AATAAA"
     polyA_site      3147
                     /gene="Mtbp"
                     /gene_synonym="MDM2BP"
                     /note="major polyA site"
ORIGIN      
        1 atctgcttcc ccgccacact cgggtccccg ccggtagcgg tttcgttatg agaggagcag
       61 agagtgtggc tcctgagaga ataatttccc acaataattg gcgggaaaac cgacgtagga
      121 cattattttg cagccaacct gagcggcagg aaaccggaag tgcacgttgc gcgcggctct
      181 tttgagacct aacactgagt ccgggcgcga agaggatgga tcggtacttg ctgctggtca
      241 cctggaggga agggaagttt cgatccgtgg cgggtgggga gatcgagcct ggcactgagg
      301 cgacatccct ggagagcacc gacaaacagc ccgatttgac cgcaaccaat atttatcacc
      361 tcttgaagag aagcatcagc gattcaatcc atccagatga cagtacattc cctgcttgtt
      421 cagtgggtgg cacacctcat tccaggaagt ggttctttgc ggtgcaagca atatgcggat
      481 tttaccagtt ttgtagttct gattggcaag agatacattt tgatgctgaa aaagataaaa
      541 tcgaagatgt tcttcaagca aatatagaag aatgtcagag tgctgttgag tgttttgaag
      601 aagatgacag taatagcagg gaatccttac ccttggctga cctatatgaa gaatcagcag
      661 aaaatttgca tcagttatca gacaagcttc ccgctcctgg tagagcaatg atagacataa
      721 tactgttgcc ttctgacaaa gaccctccta agctaaaaga gtgcttgccc attgtagggg
      781 ccttgaaaca tctgaaggaa tggcattcag caaaagttat catagcagga agttactgtg
      841 agataaattg tcagaaaatt gctgaatacc tttcagctag tgttgtgcct ttagaagaat
      901 tcagaaatgc cattgatccg agggaactgt ggcggggaga gattcagatg cgggaacgaa
      961 agtttggatt tgaaattagt tttcctgaat tttgtttaaa aggagttacg cctacgaatg
     1021 ttagtgcgta taatttaaat acctgcttcc ttgccaagaa gatagcatct tctaaggttt
     1081 tccattatta tggtcctgct ttggaatttg tgcagatgat aaaactatca gatcttccct
     1141 cctgttacat gtcggatatc gagtttgagt tagaggtgac tgggcactgc acgaggcaga
     1201 attccatgct gctgttggaa cagatctctt ccctgtgtgg caaggttggt gctctctttg
     1261 tgctgccgtg tactgttagc aatgtactca tcccacctcc cagccaactg gcctcaagaa
     1321 agtggaagga atacatggct aagaagccca agaccatcag tgttcccgat gttgccgtga
     1381 agggagagtt ttctggctat catctcctgc tgcaaggtat gggcaagaga aaatgcagag
     1441 ccaccctgct gcactcggcc agccagatca atggctcgtt tgcactcagt gtcattcatg
     1501 ggaagatgaa aacaaaggca ggagaagcca gaccgagttt cccctttgac ttctcgtcac
     1561 tcccaaggtt ttcggaggag caggttttac agagagagaa acaattagcc agctttcaag
     1621 ttttggcttt gaaagaatgc ctgaaaagaa gaaaggctgc aaaccagccc gaagcctttt
     1681 ctgccgatga actcaaaagt ctgttggcac tcacgaggga gcgcttccta ggtcactttg
     1741 atgttctccc cactgaagca gctttagcac aaacagacac cgtgaaagct gccggcgtgg
     1801 taaatgatga cggtacagtt gaaccttatt cttcaagcct aatggaaacc aatcctctgg
     1861 aatggccaga aagacatgtt cttcagaatt tagaaacttc tgaaaaagct aaacaaaaaa
     1921 tgagaactgg ctcattaccg cgttcgtctg aacagttgct gggccataaa gagggtcccc
     1981 gggactcact cacattactg gatgctaagg agctgctgaa gtatttcacc tcggatgggt
     2041 taccagtcgg agatcttcag ccgttacaca ttcaacgggg ggaaaagcct tttgttttga
     2101 caccagagct tagtcctgga aaacttcagg tcttaccttt tgaaaaagcc tcggaatgcc
     2161 attaccacgg gattgaatat tgcctggatg accaaaaagc tttagaaaga gatgggggat
     2221 tttctgaact tcagtcgcgc cttattcgtt acgagacgca gaccacctgc accagagaca
     2281 gttttccagt ccccaccgtg ctgagccctc ttccatcccc tgcagttctg tcagagcctc
     2341 agagtgtccc cgaaggagaa gcactgcaag gcgaactgag gactgaagtt tctggattga
     2401 agcggagatc taaagacccc agctgcctgt acccccagaa aagacttacg agatcagaaa
     2461 gttctgattg tttgccttcc caagcgagtt gcaatagtaa tcatcaccat cacacaggga
     2521 aacccaggaa gcctcaggca gagcgctgtg tgtcagggct tcctctgcct ggccgggaag
     2581 cttccaaaga tacctcaaag accagttcag gacaaaaacg agcacacgaa tcaaaatcat
     2641 caaagcaaat gaaggaatca cggtcccaga aacacacacg gatgctgaag gaggtggtaa
     2701 aagacacctt gaagaggcac cacatcacgg aggcccatga gagcttcacg gcctgcagcc
     2761 agagactctt cgacatctcc aagttctacc tgaaggatct gaaaacatca aggggtctct
     2821 ttgaagaaat gaagaaaaca gccaacaaca atgtggtgca ggtgatcgaa tgggtggtag
     2881 aaaagatgag caagaaataa gctactgcac cccctttcct tagagaactg tacacagcct
     2941 gtaaactttc cccaaagagc agatgcctca tttgtaagga gggtccatgg tgtcctgtat
     3001 ctatatagtt ttgtgacact cagttatttt caactaatgc acttattttt acagttttac
     3061 aatattttaa tctatgaaat ttttatatat tttaaatgtt ttaactcttg gttatttaat
     3121 tgttaaataa acagtaatat ttcatta
//
