LOCUS       NM_133684               1946 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus mitochondrial amidoxime reducing component 2 (Mtarc2),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_133684 XM_001000513 XM_001000533
VERSION     NM_133684.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Smagris,E., Shihanian,L.M., Mintah,I.J., Bigdelou,P., Livson,Y.,
            Brown,H., Verweij,N., Hunt,C., Johnson,R.O., Greer,T.J.,
            Hartford,S.A., Hindy,G., Sun,L., Nielsen,J.B., Halasz,G.,
            Lotta,L.A., Murphy,A.J., Sleeman,M.W. and Gusarova,V.
  TITLE     Divergent role of Mitochondrial Amidoxime Reducing Component 1
            (MARC1) in human and mouse
  JOURNAL   PLoS Genet 20 (3), e1011179 (2024)
   PUBMED   38437227
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1946)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1946)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1946)
  AUTHORS   Rixen,S., Havemeyer,A., Tyl-Bielicka,A., Pysniak,K., Gajewska,M.,
            Kulecka,M., Ostrowski,J., Mikula,M. and Clement,B.
  TITLE     Mitochondrial amidoxime-reducing component 2 (MARC2) has a
            significant role in N-reductive activity and energy metabolism
  JOURNAL   J Biol Chem 294 (46), 17593-17602 (2019)
   PUBMED   31554661
  REMARK    GeneRIF: Striking phenotypical features of MARC2 Knockout Mice mice
            were lower body weight, increased body temperature, decreased
            levels of total cholesterol, and increased glucose levels,
            supporting previous findings that MARC2 affects energy pathways.
REFERENCE   5  (bases 1 to 1946)
  AUTHORS   Jakobs,H.H., Mikula,M., Havemeyer,A., Strzalkowska,A.,
            Borowa-Chmielak,M., Dzwonek,A., Gajewska,M., Hennig,E.E.,
            Ostrowski,J. and Clement,B.
  TITLE     The N-reductive system composed of mitochondrial amidoxime reducing
            component (mARC), cytochrome b5 (CYB5B) and cytochrome b5 reductase
            (CYB5R) is regulated by fasting and high fat diet in mice
  JOURNAL   PLoS One 9 (8), e105371 (2014)
   PUBMED   25144769
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1946)
  AUTHORS   Wahl,B., Reichmann,D., Niks,D., Krompholz,N., Havemeyer,A.,
            Clement,B., Messerschmidt,T., Rothkegel,M., Biester,H., Hille,R.,
            Mendel,R.R. and Bittner,F.
  TITLE     Biochemical and spectroscopic characterization of the human
            mitochondrial amidoxime reducing components hmARC-1 and hmARC-2
            suggests the existence of a new molybdenum enzyme family in
            eukaryotes
  JOURNAL   J Biol Chem 285 (48), 37847-37859 (2010)
   PUBMED   20861021
REFERENCE   7  (bases 1 to 1946)
  AUTHORS   Kerns,R.T., Ravindranathan,A., Hassan,S., Cage,M.P., York,T.,
            Sikela,J.M., Williams,R.W. and Miles,M.F.
  TITLE     Ethanol-responsive brain region expression networks: implications
            for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J
            mice
  JOURNAL   J Neurosci 25 (9), 2255-2266 (2005)
   PUBMED   15745951
REFERENCE   8  (bases 1 to 1946)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1946)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 1946)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131992.8.
            
            On Feb 2, 2019 this sequence version replaced NM_133684.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051230.1, BC042686.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               AC131992.8         108236-108598
            364-537             AC131992.8         112717-112890
            538-706             AC131992.8         120116-120284
            707-847             AC131992.8         121428-121568
            848-909             AC131992.8         131594-131655
            910-981             AC131992.8         131738-131809
            982-1128            AC131992.8         134797-134943
            1129-1946           AC131992.8         140261-141078
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 89.12 cM"
     gene            1..1946
                     /gene="Mtarc2"
                     /gene_synonym="2810484M10Rik; mARC1; Marc2; Mosc2"
                     /note="mitochondrial amidoxime reducing component 2"
                     /db_xref="GeneID:67247"
                     /db_xref="MGI:MGI:1914497"
     exon            1..363
                     /gene="Mtarc2"
                     /gene_synonym="2810484M10Rik; mARC1; Marc2; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1108
                     /gene="Mtarc2"
                     /gene_synonym="2810484M10Rik; mARC1; Marc2; Mosc2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; MOSC domain-containing protein 2,
                     mitochondrial; moco sulfurase C-terminal domain-containing
                     protein 2; molybdenum cofactor sulfurase C-terminal
                     domain-containing protein 2; MOCO sulphurase C-terminal
                     domain containing 2"
                     /codon_start=1
                     /product="mitochondrial amidoxime reducing component 2
                     isoform 1 precursor"
                     /protein_id="NP_598445.1"
                     /db_xref="CCDS:CCDS15594.1"
                     /db_xref="GeneID:67247"
                     /db_xref="MGI:MGI:1914497"
                     /translation="MGSSSSTALARLGLPGQPRSTWLGVAALGLAAVALGTVAWRRTR
                     PRRRRQLQQVGTVSKVWIYPIKSCKGVSVCETECTDMGLRCGKVRDRFWMVVKEDGHM
                     VTARQEPRLVLVSITLENNYLTLEAPGMEQIVLPIKLPSSNKIHNCRLFGLDIKGRDC
                     GDEVAQWFTNYLKTQAYRLVQFDTSMKGRTTKKLYPSESYLQNYEVAYPDCSPVHLIS
                     EASLVDLNTRLKKKVKMEYFRPNIVVSGCEAFEEDTWDELLIGDVEMKRVLSCPRCVL
                     TTVDPDTGIIDRKEPLETLKSYRLCDPSVKSIYQSSPLFGMYFSVEKLGSLRVGDPVY
                     RMVD"
     exon            364..537
                     /gene="Mtarc2"
                     /gene_synonym="2810484M10Rik; mARC1; Marc2; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..706
                     /gene="Mtarc2"
                     /gene_synonym="2810484M10Rik; mARC1; Marc2; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..847
                     /gene="Mtarc2"
                     /gene_synonym="2810484M10Rik; mARC1; Marc2; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..909
                     /gene="Mtarc2"
                     /gene_synonym="2810484M10Rik; mARC1; Marc2; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..981
                     /gene="Mtarc2"
                     /gene_synonym="2810484M10Rik; mARC1; Marc2; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1128
                     /gene="Mtarc2"
                     /gene_synonym="2810484M10Rik; mARC1; Marc2; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1946
                     /gene="Mtarc2"
                     /gene_synonym="2810484M10Rik; mARC1; Marc2; Mosc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1299..1304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtarc2"
                     /gene_synonym="2810484M10Rik; mARC1; Marc2; Mosc2"
                     /note="hexamer: AATAAA"
     polyA_site      1335
                     /gene="Mtarc2"
                     /gene_synonym="2810484M10Rik; mARC1; Marc2; Mosc2"
                     /note="major polyA site"
ORIGIN      
        1 gccaaccctg gctcctccca cactcccgga gccttaagcc ccgcctcgac accgcggccc
       61 agtagcccag gcctgcccgg gatagtgtaa catgggttcc tccagctcta cggctctggc
      121 tcgcctcggc ctccctgggc agccgcggtc cacctggctc ggcgtcgccg cgctggggct
      181 ggctgcggtg gcgctgggga ccgtagcttg gcgtcgcacg cgtccccggc ggcgccggca
      241 gctgcagcag gtgggcacgg tgtcgaaggt ttggatctac ccgatcaagt cctgcaaggg
      301 ggtgtcggtg tgtgagaccg agtgcacgga catggggctg cgctgtggca aagtgcgcga
      361 caggttctgg atggtggtga aggaggacgg acacatggtc actgcccgcc aggagcctcg
      421 ccttgtgctg gtctccatca ccctggagaa caattacctg acgctggaag ctccaggcat
      481 ggagcagata gttctgccaa tcaagctccc ttcttcgaat aagatccaca actgcaggct
      541 gtttggtctc gacatcaaag gcagagattg tggcgatgag gtagctcagt ggttcaccaa
      601 ctacctgaag acgcaagcct acaggttggt tcagtttgat accagcatga aaggaagaac
      661 aacgaagaaa ctttaccctt ctgaaagtta ccttcagaac tatgaggtag cctacccgga
      721 ctgcagccct gtccacctga tttctgaagc ctccttagtc gatctcaaca ccaggctgaa
      781 gaagaaagtg aagatggaat atttcaggcc aaacatcgtg gtgtcaggct gtgaggcttt
      841 cgaggaggat acttgggatg aactcctgat tggtgacgtg gagatgaaaa gggtgttgag
      901 ctgtcccagg tgcgttctga ctacagtgga cccagacacc ggcatcatag acaggaagga
      961 gccactggag accctgaaga gctatcgcct gtgtgatcct tctgtgaaga gtatatacca
     1021 gtcatctcca ctttttggga tgtatttctc ggtggagaag cttgggagcc tgagagtggg
     1081 tgaccctgtg taccggatgg tggattagtg gatcccatgg ctgacacgct tccaggtccg
     1141 aggagacata tctgcgagtc ctcatggcca tcttcctgga accggatctc tatttttctt
     1201 tcggagctgt gtacgccttg acttaattca agaaaagtgc cagaggtggt ttaggaatgt
     1261 gaggctgtat aaattttaga taatgaggtt tttagaaaaa taaatggaat ttgtctgcaa
     1321 ttattctgaa tgctacaccc gctattacgt ttttctcatt cctgcctcta cgattgctga
     1381 agtttaaaga cacagctcga aagctgccac ttttaaaaaa tgtttatact tttcagtagg
     1441 tctgtcgctt gagaaaggta agaaaaggag ccctcttgcc ctgaatgtgc agggaatgtg
     1501 cacatatctg atgtgctcgc atgctcacga aagcctgttg gccggtcttg gcctggctgt
     1561 tgagccctgc tgagtttggt ttcattattg tttaccttgc tgttatagaa gtatgcttac
     1621 atacagaaat gacttcagag gtcatggggt tattttgttc atagactgtg gctttacatt
     1681 tcattctgtt cctatcaaga caggtagaac ttatctataa ttgtgaattc ttccaattct
     1741 acaagagagt ggaccttaaa ggaatggaat cttccttcgg aagaaggaac aaggagaaac
     1801 catgaactca gtcttaaagg ctcacggtag cacaggatga tgcactagct tgcagtaaca
     1861 gtacaaacac taagttaaca tggagccgag ttagctctct tacagctgtg tggttccatt
     1921 gtcattaata agtgcgagtc tctcct
//
