LOCUS       NM_001290273            2148 bp    mRNA    linear   ROD 20-MAY-2024
DEFINITION  Mus musculus mitochondrial amidoxime reducing component 1 (Mtarc1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001290273 XM_006497191
VERSION     NM_001290273.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2148)
  AUTHORS   Guo,Y., Gao,Z., LaGory,E.L., Kristin,L.W., Gupte,J., Gong,Y.,
            Rardin,M.J., Liu,T., Nguyen,T.T., Long,J., Hsu,Y.H., Murray,J.K.,
            Lade,J., Jackson,S. and Zhang,J.
  TITLE     Liver-specific mitochondrial amidoxime-reducing component 1
            (Mtarc1) knockdown protects the liver from diet-induced MASH in
            multiple mouse models
  JOURNAL   Hepatol Commun 8 (5), e0419 (2024)
   PUBMED   38696369
  REMARK    GeneRIF: Liver-specific mitochondrial amidoxime-reducing component
            1 (Mtarc1) knockdown protects the liver from diet-induced MASH in
            multiple mouse models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2148)
  AUTHORS   Jones,A.K., Bajrami,B., Campbell,M.K., Erzurumluoglu,A.M., Guo,Q.,
            Chen,H., Zhang,X., Zeveleva,S., Kvaskoff,D., Brunner,A.D.,
            Muller,S., Gathey,V., Dave,R.M., Tanner,J.W., Rixen,S.,
            Struwe,M.A., Phoenix,K., Klumph,K.J., Robinson,H., Veyel,D.,
            Muller,A., Noyvert,B., Bartholdy,B.A., Steixner-Kumar,A.A.,
            Stutzki,J., Drichel,D., Omland,S., Sheehan,R., Hill,J.,
            Bretschneider,T., Gottschling,D., Scheidig,A.J., Clement,B.,
            Giera,M., Ding,Z., Broadwater,J. and Warren,C.R.
  TITLE     mARC1 in MASLD: Modulation of lipid accumulation in human
            hepatocytes and adipocytes
  JOURNAL   Hepatol Commun 8 (5), e0365 (2024)
   PUBMED   38619429
  REMARK    GeneRIF: mARC1 in MASLD: Modulation of lipid accumulation in human
            hepatocytes and adipocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2148)
  AUTHORS   Wu,M., Tie,M., Hu,L., Yang,Y., Chen,Y., Ferguson,D., Chen,Y. and
            He,A.
  TITLE     Fatty liver disease protective MTARC1 p.A165T variant reduces the
            protein stability of MTARC1
  JOURNAL   Biochem Biophys Res Commun 702, 149655 (2024)
   PUBMED   38340654
  REMARK    GeneRIF: Fatty liver disease protective MTARC1 p.A165T variant
            reduces the protein stability of MTARC1.
REFERENCE   4  (bases 1 to 2148)
  AUTHORS   Smagris,E., Shihanian,L.M., Mintah,I.J., Bigdelou,P., Livson,Y.,
            Brown,H., Verweij,N., Hunt,C., Johnson,R.O., Greer,T.J.,
            Hartford,S.A., Hindy,G., Sun,L., Nielsen,J.B., Halasz,G.,
            Lotta,L.A., Murphy,A.J., Sleeman,M.W. and Gusarova,V.
  TITLE     Divergent role of Mitochondrial Amidoxime Reducing Component 1
            (MARC1) in human and mouse
  JOURNAL   PLoS Genet 20 (3), e1011179 (2024)
   PUBMED   38437227
  REMARK    GeneRIF: Divergent role of Mitochondrial Amidoxime Reducing
            Component 1 (MARC1) in human and mouse.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2148)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2148)
  AUTHORS   Jakobs,H.H., Mikula,M., Havemeyer,A., Strzalkowska,A.,
            Borowa-Chmielak,M., Dzwonek,A., Gajewska,M., Hennig,E.E.,
            Ostrowski,J. and Clement,B.
  TITLE     The N-reductive system composed of mitochondrial amidoxime reducing
            component (mARC), cytochrome b5 (CYB5B) and cytochrome b5 reductase
            (CYB5R) is regulated by fasting and high fat diet in mice
  JOURNAL   PLoS One 9 (8), e105371 (2014)
   PUBMED   25144769
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2148)
  AUTHORS   Wahl,B., Reichmann,D., Niks,D., Krompholz,N., Havemeyer,A.,
            Clement,B., Messerschmidt,T., Rothkegel,M., Biester,H., Hille,R.,
            Mendel,R.R. and Bittner,F.
  TITLE     Biochemical and spectroscopic characterization of the human
            mitochondrial amidoxime reducing components hmARC-1 and hmARC-2
            suggests the existence of a new molybdenum enzyme family in
            eukaryotes
  JOURNAL   J Biol Chem 285 (48), 37847-37859 (2010)
   PUBMED   20861021
REFERENCE   8  (bases 1 to 2148)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131992.8, AK004989.1, AC164539.4 and AI480973.1.
            
            On Mar 6, 2014 this sequence version replaced XM_006497191.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004989.1, AK011722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               AC131992.8         142844-143173
            331-1239            AK004989.1         228-1136
            1240-1621           AK004989.1         1138-1519
            1622-1867           AC164539.4         23673-23918         c
            1868-2148           AI480973.1         1-281               c
FEATURES             Location/Qualifiers
     source          1..2148
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 89.07 cM"
     gene            1..2148
                     /gene="Mtarc1"
                     /gene_synonym="1300013F15Rik; Marc1; Mosc1"
                     /note="mitochondrial amidoxime reducing component 1"
                     /db_xref="GeneID:66112"
                     /db_xref="MGI:MGI:1913362"
     exon            1..455
                     /gene="Mtarc1"
                     /gene_synonym="1300013F15Rik; Marc1; Mosc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1194
                     /gene="Mtarc1"
                     /gene_synonym="1300013F15Rik; Marc1; Mosc1"
                     /note="MOSC domain-containing protein 1, mitochondrial;
                     moco sulfurase C-terminal domain-containing protein 1;
                     molybdenum cofactor sulfurase C-terminal domain-containing
                     protein 1; MOCO sulphurase C-terminal domain containing 1"
                     /codon_start=1
                     /product="mitochondrial amidoxime-reducing component 1"
                     /protein_id="NP_001277202.1"
                     /db_xref="CCDS:CCDS69987.1"
                     /db_xref="GeneID:66112"
                     /db_xref="MGI:MGI:1913362"
                     /translation="MGAGSWALTLFGFSAFRVPGQPRSTWLGVAALGLAAVALGTVAW
                     RRARPRRRRRLQQVGTVAQLWIYPIKSCKGLSVSEAECTAMGLRYGHLRDRFWLVINE
                     EGNMVTARQEPRLVLISLTCEDDTLTLSAAYTKDLLLPITPPATNPLLQCRVHGLEIQ
                     GRDCGEDAAQWVSSFLKMQSCRLVHFEPHMRPRSSRQMKAVFRTKDQVAYSDASPFLV
                     LSEASLEDLNSRLERRVKATNFRPNIVISGCGVYAEDSWNEVLIGDVELKRVMACTRC
                     LLTTVDPDTGISDRKEPLETLKSYRLCDPSEQALYGKLPIFGQYFALENPGTIRVGDP
                     VYLLGQ"
     exon            456..629
                     /gene="Mtarc1"
                     /gene_synonym="1300013F15Rik; Marc1; Mosc1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..792
                     /gene="Mtarc1"
                     /gene_synonym="1300013F15Rik; Marc1; Mosc1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..933
                     /gene="Mtarc1"
                     /gene_synonym="1300013F15Rik; Marc1; Mosc1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..995
                     /gene="Mtarc1"
                     /gene_synonym="1300013F15Rik; Marc1; Mosc1"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1067
                     /gene="Mtarc1"
                     /gene_synonym="1300013F15Rik; Marc1; Mosc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..2142
                     /gene="Mtarc1"
                     /gene_synonym="1300013F15Rik; Marc1; Mosc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1603..1608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtarc1"
                     /gene_synonym="1300013F15Rik; Marc1; Mosc1"
                     /note="hexamer: ATTAAA"
     polyA_site      1624
                     /gene="Mtarc1"
                     /gene_synonym="1300013F15Rik; Marc1; Mosc1"
                     /note="major polyA site"
     polyA_site      2142
                     /gene="Mtarc1"
                     /gene_synonym="1300013F15Rik; Marc1; Mosc1"
ORIGIN      
        1 agctgagcca ccacctcccg cccaggccga atgaagatgc acaatttgga ttggagggga
       61 agggtcagga gctgctgacc tttgggctca ggcccaggcc gctggccaca gtagctcttg
      121 gtccagtcgg cgccggaggt gtatcaagcg ctcatcccgc cctctccagt catgggtgcg
      181 gggtcctggg cgctgaccct cttcggcttc tccgcgtttc gggtcccggg ccagccgcgg
      241 tccacctggc tcggcgtcgc cgcgctggga ctggccgcgg tggccctggg gacagtggcc
      301 tggcgtcgtg cgcgtccccg gcgacgccgg cggctacagc aagtgggaac ggtggcacag
      361 ctctggatct acccaatcaa gtcctgcaag gggttgtcgg tgagcgaggc agagtgcact
      421 gccatggggc tgcgctatgg ccacctgcgc gacaggtttt ggctcgtgat caatgaagag
      481 gggaacatgg tcactgcccg gcaggagcct cgattggtcc tgatttctct gacctgtgag
      541 gacgacacct tgactctcag tgcagcttac acaaaggacc tgctgctgcc tatcaccccg
      601 cctgccacaa acccactcct ccagtgcaga gtgcatggcc tggagataca gggcagggat
      661 tgtggagagg atgcagctca gtgggtcagc agcttcttga agatgcagtc ctgtcgcctg
      721 gtgcacttcg agccgcacat gcgccccaga agttctcggc aaatgaaggc tgtgttccgg
      781 accaaggacc aggtggccta ctcagatgca agtccattct tggtcctttc tgaggcatcc
      841 ttggaagatc tcaactccag gctggagcgc agagtgaaag cgacaaactt caggcctaac
      901 attgtcatct cgggatgtgg cgtttatgct gaggattctt ggaacgaggt tctcattgga
      961 gatgtggaac tgaaacgggt gatggcttgt acccggtgcc ttttaacaac agtggatcca
     1021 gacactggca tctcggacag gaaggagcct ctggaaacac tgaagagcta ccgcctgtgt
     1081 gacccttccg agcaagcact atatggaaag ttacccatct ttggacaata cttcgctctg
     1141 gaaaatccag ggacaatcag agtgggagac cctgtgtacc tcctgggcca gtgatgggaa
     1201 ctgttcgttc tggaagaaca gatggctctt aaaaaaaaac ttttacaaac agacatcgct
     1261 tgaaacagtt cttcagcctg ttctttggat cggccagttc caagtttctc ttctttcaga
     1321 tttccgtctg tttcaatgtt tcctggggcc agcccacaaa gcaggcaaat acagctttgc
     1381 gaacttagca ggtccctgtt atgtttcttg tagaatgaag ggattatcat attgccctgt
     1441 ttataaatac ggagtaatcc ttctacgtcg gaattcactt gccaagacat catctcccta
     1501 gccttctttt gggaaagaga agaaaaaggg agggacactg tgtaagccag aagaatgttc
     1561 cagaatgttc tgttacccct ggacatggtg catacaacgg gaattaaata ctctcccaag
     1621 taaagttgga atgacggctt ttacttttct ccttgagccc aggctttgga aagagtttaa
     1681 agagcaagcc ctaaagatat tggatgctgt tgcttactga cagtgtgaag tttgacagac
     1741 cctttagccc aagaacacga agtgtcaggg tcaaagccag ctctctacag catccagacg
     1801 ggctctcagc tctgtgaaaa aggtgtttcc actcttgaag caaagtgttg atgcgcctca
     1861 ctaaaggatt caagatcgtt cctagcatgt ggggacagat agtgacacca gagagggaga
     1921 tacctccgcc tgggtgtcta agatgagatt tgatcttgcc caggaaaatg gtggctctct
     1981 taatatgagc aaaatgaaat ggtggcgccc cctagtggta gtgaatggta ggtcggccca
     2041 ccttgagaaa aatttaaaaa ggggaaaaac aaaacaaaac aaaaccaaag caatcttgtg
     2101 cttgttgttt agttttaaat tttaaaacgt tttaaaaact gaaaaaaa
//
