LOCUS       NM_024433               2558 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus methylthioadenosine phosphorylase (Mtap), mRNA.
ACCESSION   NM_024433 XM_131452
VERSION     NM_024433.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2558)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2558)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2558)
  AUTHORS   Bigaud,E. and Corrales,F.J.
  TITLE     Methylthioadenosine (MTA) Regulates Liver Cells Proteome and
            Methylproteome: Implications in Liver Biology and Disease
  JOURNAL   Mol Cell Proteomics 15 (5), 1498-1510 (2016)
   PUBMED   26819315
  REMARK    GeneRIF: Data demonstrate that MTAP deficiency leads to
            accumulation of MTA inducing deregulation of central cellular
            pathways that control cell fate and contributes to the onset of a
            proliferative and antiapoptotic phenotype in the liver.
REFERENCE   4  (bases 1 to 2558)
  AUTHORS   Czech,B., Dettmer,K., Valletta,D., Saugspier,M., Koch,A.,
            Stevens,A.P., Thasler,W.E., Muller,M., Oefner,P.J., Bosserhoff,A.K.
            and Hellerbrand,C.
  TITLE     Expression and function of methylthioadenosine phosphorylase in
            chronic liver disease
  JOURNAL   PLoS One 8 (12), e80703 (2013)
   PUBMED   24324622
  REMARK    GeneRIF: MTAP-mediated regulation of methylthioadenosine links
            polyamine metabolism with NF-kappaB activation and apoptosis in
            hepatic stellate cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2558)
  AUTHORS   Kadariya,Y., Tang,B., Wang,L., Al-Saleem,T., Hayakawa,K.,
            Slifker,M.J. and Kruger,W.D.
  TITLE     Germline Mutations in Mtap Cooperate with Myc to Accelerate
            Tumorigenesis in Mice
  JOURNAL   PLoS One 8 (6), e67635 (2013)
   PUBMED   23840755
  REMARK    GeneRIF: Germline Mutations in Mtap is associated with
            lymphomagenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2558)
  AUTHORS   Fernandez-Irigoyen,J., Santamaria,M., Sanchez-Quiles,V.,
            Latasa,M.U., Santamaria,E., Munoz,J., Sanchez Del Pino,M.M.,
            Valero,M.L., Prieto,J., Avila,M.A. and Corrales,F.J.
  TITLE     Redox regulation of methylthioadenosine phosphorylase in liver
            cells: molecular mechanism and functional implications
  JOURNAL   Biochem J 411 (2), 457-465 (2008)
   PUBMED   18237276
  REMARK    GeneRIF: Regulation of MTAP by reactive oxygen species might
            participate in the redox regulation of the methionine catabolic
            pathway in the liver
REFERENCE   7  (bases 1 to 2558)
  AUTHORS   Williamson,R.E., Darrow,K.N., Michaud,S., Jacobs,J.S., Jones,M.C.,
            Eberl,D.F., Maas,R.L., Liberman,M.C. and Morton,C.C.
  TITLE     Methylthioadenosine phosphorylase (MTAP) in hearing: gene
            disruption by chromosomal rearrangement in a hearing impaired
            individual and model organism analysis
  JOURNAL   Am J Med Genet A 143A (14), 1630-1639 (2007)
   PUBMED   17534888
REFERENCE   8  (bases 1 to 2558)
  AUTHORS   Kadariya,Y., Nishioka,J., Nakamura,A., Kato-Nakazawa,K. and
            Nobori,T.
  TITLE     Molecular characterization of 5'-deoxy-5'-methylthioadenosine
            phosphorylase-deficient mutant clones of murine lymphoma cell line
            R1.1
  JOURNAL   Cancer Sci 94 (6), 519-522 (2003)
   PUBMED   12824877
REFERENCE   9  (bases 1 to 2558)
  AUTHORS   Talamillo,A., Quinn,J.C., Collinson,J.M., Caric,D., Price,D.J.,
            West,J.D. and Hill,R.E.
  TITLE     Pax6 regulates regional development and neuronal migration in the
            cerebral cortex
  JOURNAL   Dev Biol 255 (1), 151-163 (2003)
   PUBMED   12618140
REFERENCE   10 (bases 1 to 2558)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK167319.1 and AK005064.1.
            
            On Dec 4, 2008 this sequence version replaced NM_024433.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005064.1, AK167319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AK167319.1         2-55
            55-2558             AK005064.1         2-2505
FEATURES             Location/Qualifiers
     source          1..2558
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 42.15 cM"
     gene            1..2558
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
                     /note="methylthioadenosine phosphorylase"
                     /db_xref="GeneID:66902"
                     /db_xref="MGI:MGI:1914152"
     exon            1..155
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..974
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
                     /EC_number="2.4.2.28"
                     /note="MTAPase; MTA phosphorylase; 5'-methylthioadenosine
                     phosphorylase"
                     /codon_start=1
                     /product="S-methyl-5'-thioadenosine phosphorylase"
                     /protein_id="NP_077753.1"
                     /db_xref="CCDS:CCDS18349.1"
                     /db_xref="GeneID:66902"
                     /db_xref="MGI:MGI:1914152"
                     /translation="MASGSACTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDA
                     LILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEI
                     QPGDMVIIDQFIDRTSLRPQTFYDGSHCSARGVCHIPMAEPFCPKTREVLIETAKKLG
                     LRCHSKGTIVTIEGPRFSSRAESLIFRTWGADVVNMTTVPEVVLAKEAGICYASIAMA
                     TDYDCWKEHEEAVSVDGVLKTMKENANKAKSLLLTTIPQIGSMEWSETLRNLKNMAQF
                     SVLPPRH"
     exon            156..242
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            243..301
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            302..469
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            470..572
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            573..812
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            813..935
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            936..2558
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
                     /note="hexamer: AATAAA"
     polyA_site      1691
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
                     /note="major polyA site"
     regulatory      2523..2528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
                     /note="hexamer: AATAAA"
     polyA_site      2554
                     /gene="Mtap"
                     /gene_synonym="1300019I21Rik; MSAP"
ORIGIN      
        1 gggaggaaga ggaggagcca gagcccgtgg gtccccgcac tgctcactcc cgcgccacgc
       61 cggccccgca gtctcctccc ggtcccacgc tgcggcccgc tgtggacttc cctggtgcag
      121 acatggcctc gggctccgcc tgcacggcgg tgaagattgg aataattggt ggaacaggct
      181 tggatgatcc cgaaatttta gaaggaagaa ctgagaaata tgtggatact ccattcggca
      241 agccatccga tgccttaatt ttggggaaga taaagaacgt tgattgtgta cttcttgcaa
      301 gacacggcag acaacacacc atcatgcctt caaaagtcaa ctaccaggca aacatctggg
      361 ccttgaagga agagggctgt acacatgtca tcgtgaccac agcttgcggg tccttgagag
      421 aggagatcca gcctggtgac atggtcatca ttgaccaatt cattgacagg acatccctaa
      481 ggcctcagac cttctatgat gggagtcatt gcagtgccag aggagtgtgc cacatcccca
      541 tggctgaacc gttttgcccc aaaacaagag aggtcctcat agaaactgct aagaagctag
      601 gacttcggtg ccattcaaag gggacaatag tcacaattga ggggccccgt ttcagctccc
      661 gggcagaaag ccttatattc cgtacttggg gcgcagatgt tgtcaacatg accactgttc
      721 cagaggtggt acttgctaag gaggctggaa tttgctatgc aagcattgcc atggcaaccg
      781 actatgattg ttggaaggag catgaagaag cagtgtcagt ggatggggtt ttaaagacca
      841 tgaaagaaaa tgccaataaa gccaaaagtt tactcctcac tactatacct cagatagggt
      901 cgatggaatg gtcagaaacg ctccgtaacc taaagaacat ggcccagttt tccgttttac
      961 caccaagaca ttaaaacagc atggctgaca caagaagacg ttctacttct agtctttggg
     1021 ggattttgct taaacaaaaa tgggaaagat ccgcagcctt catgcctttg cctagaaaga
     1081 aagacactgt tagcgactca accaagatcc caactcctcc gggacccaga aggaaagcag
     1141 acagcctgcc aaacagagcc ggagagcaca tctgtctcac tttccctatt aaactgacaa
     1201 caaggattac tagtgaaaac atccactacc ctacagcgct aaggagccaa tacgagctcg
     1261 agatgggact gtgtgattgt aaactggcgc catgtttccg acacttggta ttctaagagt
     1321 ttctcttgaa gaagttatga gatattcctt caaagaatca tgtgtaaaga agaatattac
     1381 ctgccatagt aaaataatca aaactatctg aatatcaaaa aaaattagct gtgccgtgtt
     1441 tccgttatac ttaggttatg gagcaatcaa gtggaaatca tgtttcctca cgaagaaatg
     1501 attaatcttt ttctctactt ttaaatataa tcaaataata aagctgtaaa aattaaaatg
     1561 gacttagaga actttgaaac tcctttggtg gtgaagtgaa gacaacaaca ataatataac
     1621 tgcgctgtgt atgtgaatca agatatataa gccaaataac cccctttccc aaataaagaa
     1681 ataaaggaaa atgctgtgtg aggagcttac taaacctttg ctaagaaaga tcctgggtca
     1741 ccacacagct aagatgatgt aactgagaaa gccaaggccg gtgtttaatg caagccagtg
     1801 tgactcatca cagtgtatcg agagttgaca cataatcagt tggcaatttt tttcttttgt
     1861 ttaaaagaag aaagtagaag cctaactttt tatttttcaa attactgttg ttacaggtgc
     1921 cctacagcgc ccgtaaaggg tctgtaaagt gagtgtgcct gtgtctgaaa ttgacttcaa
     1981 gataataagc tgttgattgt aagcaataaa tgaattattt gctccagtgt taatgtcgag
     2041 cgaggccctg gataagtgca attgttactt ccgcccatgt tgcagtgctc ccatctctgg
     2101 ctgtaagcag tccgtggaga ctccgtgagg cctgatcagg gctttaggtt gtttttactc
     2161 actgcagtgt caacacttct ttccccttag ccactgcggg gtgggcatcc gttttgttgc
     2221 ctttagaaaa tgctgctctc ttcaacatgg agaatgactt tcttcagtgg cctttctagc
     2281 atcatgtgca ggcttcttcc ccttttcctt aatccttcat catgatgaaa catgcatata
     2341 atcactgggt ctggctcaac atgatgctgt ccgttctgtc catcttccta cgggtatcgt
     2401 aattccattc tttttctgac aagatgaaat ctccttgtgt atcctttccg catccttatc
     2461 catgcatgtg ttgatggacg tgtgggctgc tcccataatg tacctgttct gagtagtgtt
     2521 tcaataaaca tcagtttgca gacttctcag atgatcag
//
