LOCUS       NM_011842               3127 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus metastasis-associated gene family, member 2 (Mta2),
            transcript variant 1, mRNA.
ACCESSION   NM_011842
VERSION     NM_011842.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3127)
  AUTHORS   Price,J.D., Lindtner,S., Ypsilanti,A., Binyameen,F., Johnson,J.R.,
            Newton,B.W., Krogan,N.J. and Rubenstein,J.L.R.
  TITLE     DLX1 and the NuRD complex cooperate in enhancer decommissioning and
            transcriptional repression
  JOURNAL   Development 149 (11) (2022)
   PUBMED   35695185
REFERENCE   2  (bases 1 to 3127)
  AUTHORS   Yan,L., Jin,W., Zhao,Q., Cui,X., Shi,T., Xu,Y., Li,F., Jin,W.,
            Zhang,Z., Zhang,Z., Tang,Q.Q. and Pan,D.
  TITLE     PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a
            NuRD Subcomplex
  JOURNAL   Adv Sci (Weinh) 8 (16), e2102060 (2021)
   PUBMED   34180153
REFERENCE   3  (bases 1 to 3127)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3127)
  AUTHORS   El-Nikhely,N., Karger,A., Sarode,P., Singh,I., Weigert,A.,
            Wietelmann,A., Stiewe,T., Dammann,R., Fink,L., Grimminger,F.,
            Barreto,G., Seeger,W., Pullamsetti,S.S., Rapp,U.R. and Savai,R.
  TITLE     Metastasis-Associated Protein 2 Represses NF-kappaB to Reduce Lung
            Tumor Growth and Inflammation
  JOURNAL   Cancer Res 80 (19), 4199-4211 (2020)
   PUBMED   32816854
  REMARK    GeneRIF: Metastasis-Associated Protein 2 Represses NF-kappaB to
            Reduce Lung Tumor Growth and Inflammation.
            Erratum:[Cancer Res. 2022 Feb 15;82(4):736. doi:
            10.1158/0008-5472.CAN-21-4331.. PMID: 35180307]
REFERENCE   5  (bases 1 to 3127)
  AUTHORS   Lu,X., Chu,C.S., Fang,T., Rayon-Estrada,V., Fang,F., Patke,A.,
            Qian,Y., Clarke,S.H., Melnick,A.M., Zhang,Y., Papavasiliou,F.N. and
            Roeder,R.G.
  TITLE     MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in
            Controlling the Pre-B to Immature B Cell Transition
  JOURNAL   Cell Rep 28 (2), 472-485 (2019)
   PUBMED   31291582
REFERENCE   6  (bases 1 to 3127)
  AUTHORS   Kiefer,S.M., McDill,B.W., Yang,J. and Rauchman,M.
  TITLE     Murine Sall1 represses transcription by recruiting a histone
            deacetylase complex
  JOURNAL   J Biol Chem 277 (17), 14869-14876 (2002)
   PUBMED   11836251
REFERENCE   7  (bases 1 to 3127)
  AUTHORS   Matsusue,K., Takiguchi,S., Toh,Y. and Kono,A.
  TITLE     Characterization of mouse metastasis-associated gene 2: genomic
            structure, nuclear localization signal, and alternative potentials
            as transcriptional activator and repressor
  JOURNAL   DNA Cell Biol 20 (10), 603-611 (2001)
   PUBMED   11749719
REFERENCE   8  (bases 1 to 3127)
  AUTHORS   Xia,L. and Zhang,Y.
  TITLE     Sp1 and ETS family transcription factors regulate the mouse Mta2
            gene expression
  JOURNAL   Gene 268 (1-2), 77-85 (2001)
   PUBMED   11368903
REFERENCE   9  (bases 1 to 3127)
  AUTHORS   Downes,M., Ordentlich,P., Kao,H.Y., Alvarez,J.G. and Evans,R.M.
  TITLE     Identification of a nuclear domain with deacetylase activity
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10330-10335 (2000)
   PUBMED   10984530
REFERENCE   10 (bases 1 to 3127)
  AUTHORS   Zhang,Y., Ng,H.H., Erdjument-Bromage,H., Tempst,P., Bird,A. and
            Reinberg,D.
  TITLE     Analysis of the NuRD subunits reveals a histone deacetylase core
            complex and a connection with DNA methylation
  JOURNAL   Genes Dev 13 (15), 1924-1935 (1999)
   PUBMED   10444591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129217.3 and AC130819.4.
            
            On Oct 22, 2022 this sequence version replaced NM_011842.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079847.1, AK147099.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               AC129217.3         174674-175181
            509-576             AC130819.4         195937-196004       c
            577-670             AC130819.4         195363-195456       c
            671-788             AC130819.4         193596-193713       c
            789-852             AC130819.4         193400-193463       c
            853-970             AC130819.4         193085-193202       c
            971-1073            AC130819.4         192719-192821       c
            1074-1173           AC130819.4         192333-192432       c
            1174-1362           AC130819.4         192029-192217       c
            1363-1437           AC130819.4         191870-191944       c
            1438-1496           AC130819.4         191684-191742       c
            1497-1594           AC130819.4         191347-191444       c
            1595-1734           AC130819.4         191073-191212       c
            1735-1963           AC130819.4         190290-190518       c
            1964-2053           AC130819.4         189080-189169       c
            2054-2172           AC130819.4         188439-188557       c
            2173-2321           AC130819.4         188185-188333       c
            2322-3127           AC130819.4         187174-187979       c
FEATURES             Location/Qualifiers
     source          1..3127
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.04 cM"
     gene            1..3127
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /note="metastasis-associated gene family, member 2"
                     /db_xref="GeneID:23942"
                     /db_xref="MGI:MGI:1346340"
     exon            1..508
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..2487
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     metastais-associated gene family, member 2;
                     metastasis-associated protein MTA2; metastasis-associated
                     protein 2; metastasis-associated 1-like 1"
                     /codon_start=1
                     /product="metastasis-associated protein MTA2 isoform 1"
                     /protein_id="NP_035972.3"
                     /db_xref="CCDS:CCDS29561.1"
                     /db_xref="GeneID:23942"
                     /db_xref="MGI:MGI:1346340"
                     /translation="MAANMYRVGDYVYFENSSSNPYLVRRIEELNKTANGNVEAKVVC
                     LFRRRDISSSLNSLADSNAREFEEESKQPGVSEQQRHQLKHRELFLSRQFESLPATHI
                     RGKCSVTLLNETDILNQYLDKEDCFFYSLVFDPVQKTLLADQGEIRVGCKFQAEIPDR
                     LAEGESDNRNQQKMEMKVWDPDNPLTDRQIDQFLVVARAVGTFARALDCSSSIRQPSL
                     HMSAAAASRDITLFHAMDTLQRNGYDLAKAMSTLVPQGGPVLCRDEMEEWSASEAMLF
                     EEALEKYGKDFNDIRQDFLPWKSLASIVQFYYMWKTTDRYIQQKRLKAAEADSKLKQV
                     YIPTYTKPNPNQIISVGSKPGMNGAGFQKGLTCESCHTTQSAQWYAWGPPNMQCRLCA
                     SCWIYWKKYGGLKTPTQLEGAARGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLAKN
                     RQTFLLQTTKLTRLARRMCRDLLQPRRAARRPYAPINANAIKAECSIRLPKAAKTPLK
                     IHPLVRLPLATIVKDLVAQAPLKPKTPRGTKTPINRNQLTQNRGLGGIMVKRSYETMA
                     GAGVPFSANGRPLASGIRSSSQPAAKRQKLNPADAPNPVVFVATKDTRALRKALTHLE
                     MRRAARRPNLPLKVKPTLMTVRPPVPLPASSHPASTNEPIVLED"
     exon            509..576
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..670
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..788
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..852
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..970
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1073
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1173
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1362
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1437
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1496
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1594
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1734
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1963
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2053
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2172
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2321
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..3127
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3107..3112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /note="hexamer: AATAAA"
     polyA_site      3127
                     /gene="Mta2"
                     /gene_synonym="Mata1l1; mmta2; Mta1l1"
                     /note="major polyA site"
ORIGIN      
        1 gaaaggagcc gagttccttc cggaagtggc cgatctgcgg ggtcttgctc tccgacctga
       61 gccgagcgct gggccttgtt ctccggatcg gccgaaggtg ttccggaagg aggcgaaccc
      121 ggacgcgggc agggcaaacc ttgccagcgg ttggcaccgc acgacgtctg ctgggactcg
      181 gtgaggacgc taggagctgg aacctcactc cggtcaggca ggaatcgagc tcgttccgga
      241 agaagccgag tagaccggag ctggcctcgg tgtcccggcg tgaggctata gcagtgtcgt
      301 cgtcgcgcgg gcagtgatga gccgcggcgg ctgagcgagc agaggtgccg gctgctcggg
      361 ccccatcgac acttccgcga agcgtcagcc acgcgctggg ggcttcgtct ggagctgagc
      421 tttgcccccg cgagcctccg ggacctcttt gtgtggccgg aggcggcggc gggaacggcc
      481 atggcggcta acatgtaccg ggtgggagat tacgtctatt ttgagaactc ctccagcaat
      541 ccttacctgg ttagacggat tgaggagctc aataagactg caaatggaaa tgtggaagca
      601 aaggttgtct gtcttttccg gcgaagggat atttctagta gcctcaacag cttggctgac
      661 agtaatgctc gggagtttga ggaggaatca aaacagccag gggtctccga gcagcagaga
      721 catcaactga agcaccgaga gctttttctt tctcggcagt ttgaatcatt accagccacc
      781 cacataaggg ggaagtgcag cgtgactctc ttgaacgaga cagacatctt aaaccagtat
      841 ctagacaagg aggactgctt tttttactca ctggtgtttg atcctgtgca gaagacactt
      901 ctggctgatc aaggggagat cagagttggt tgcaaattcc aagctgagat cccagatcgt
      961 ttggcagagg gagaatcaga taatcgaaac caacagaaga tggagatgaa agtctgggac
     1021 ccagacaacc ctctcacaga ccggcagatt gatcagtttc tcgtggtggc ccgagctgtg
     1081 ggaaccttcg cgagagccct agactgcagc agctcaattc ggcagccaag cttgcacatg
     1141 agtgcagctg ctgcgtcccg agatatcact ctgttccatg ccatggatac cttgcaaagg
     1201 aatggctatg acttggccaa ggctatgtca accctagtac cacagggagg cccggtgctc
     1261 tgtcgggatg agatggagga atggtctgct tctgaagcca tgctgtttga agaggctctg
     1321 gagaagtacg ggaaggattt caatgatatc cgccaggact ttctaccctg gaagtcactt
     1381 gcaagcatag tccagtttta ttacatgtgg aaaaccacag accggtatat tcagcagaaa
     1441 agattgaaag ctgctgaagc agacagcaaa ctgaaacagg tctacatccc cacttatacc
     1501 aagccaaacc ctaaccagat catttctgtg ggttcaaaac ctggcatgaa tggggctgga
     1561 ttccagaagg gcctgacttg tgagagctgc cacaccacac agtctgccca gtggtatgcc
     1621 tggggacccc ctaacatgca gtgccgactt tgtgcttcct gttggattta ttggaagaaa
     1681 tacgggggac tgaagacccc tacccaactt gaaggggctg ctcggggcac cacagagcca
     1741 cactcaagag gtcatttatc cagacctgaa gcccaaagtc tctcccccta tacaaccagt
     1801 gctaaccggg ccaagttgct ggctaagaac aggcaaactt tcttgctcca gaccacaaag
     1861 ctaactcgtc tagccagacg aatgtgccga gatctattac agccaaggag ggctgcccga
     1921 agaccctatg cacctatcaa tgccaatgcc atcaaggcag agtgctcgat ccgacttcct
     1981 aaggctgcca agacgccact gaaaattcac cctctggtgc ggctgccctt ggcaactatc
     2041 gtcaaagatc tggtggctca ggcacctctg aaaccaaaaa cacctcgggg taccaagaca
     2101 ccaatcaaca gaaaccagct gacccagaat cgaggcctgg ggggcattat ggtgaaacgt
     2161 tcctatgaga ctatggcagg ggcaggggtc cccttctctg ccaatggaag gcctctggct
     2221 tcagggattc gttcaagctc acagccagca gccaagcgtc agaaactaaa ccctgctgat
     2281 gctcccaatc cagtggtatt tgtggccaca aaggacacca gggctttaag gaaagctcta
     2341 actcacctgg aaatgcgccg agcggcccga aggcccaacc tacccctgaa ggtgaaacca
     2401 acgctgatga cagtgcggcc cccagttcct ctgcccgctt cttcacatcc tgccagcacc
     2461 aatgagccca ttgtcctgga ggattgagca tcttagggga agggaggtgg gatgagaggt
     2521 agaggggtgg gtgcccagga catacaaatc ttcattcctt ttggtatcaa agggagtaag
     2581 gagtgaggga gggttgaccc tggtgtgtgt gtgtccttgc aggggttgga caccctctgg
     2641 tgttagttac tgcctgtaac tgccagtaac gtcccttttt gggcttcaca gcctatagga
     2701 acttgcctgt gtgtgtacct accctatttg gggcctggga cccacaggtg gtttggacag
     2761 ttggggggga gggtttttta attttttaaa aatgaacctc cctttgtaaa agggatggag
     2821 gaggggaaga gtaaacatat caggtgttag tccctggcag gggaagggaa gtacactgcc
     2881 atgtctcatt tttccttatt ttctaatggg gggttactct tactgtccgg tgtccggact
     2941 ttcctaattg gaatttgaga gccctaagat ggcgtcaacc ccagcccatg ctcactcttt
     3001 cttccctccc ctttctccct ctgcctttta tatgccaatt ctcagaaata aagatctttt
     3061 gtctgttttt taacctcaga ttctgtaatt ggttcttaca gtgacaaata aaaagctgtt
     3121 ttcttca
//
