LOCUS       NM_054081               2775 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus metastasis associated 1 (Mta1), transcript variant 1,
            mRNA.
ACCESSION   NM_054081 XM_207015
VERSION     NM_054081.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2775)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2775)
  AUTHORS   Ishikawa,M., Osaki,M., Uno,N., Ohira,T., Kugoh,H. and Okada,F.
  TITLE     MTA1, a metastasis-associated protein, in endothelial cells is an
            essential molecule for angiogenesis
  JOURNAL   Mol Med Rep 25 (1) (2022)
   PUBMED   34779499
  REMARK    GeneRIF: MTA1, a metastasisassociated protein, in endothelial cells
            is an essential molecule for angiogenesis.
REFERENCE   3  (bases 1 to 2775)
  AUTHORS   Yan,L., Jin,W., Zhao,Q., Cui,X., Shi,T., Xu,Y., Li,F., Jin,W.,
            Zhang,Z., Zhang,Z., Tang,Q.Q. and Pan,D.
  TITLE     PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a
            NuRD Subcomplex
  JOURNAL   Adv Sci (Weinh) 8 (16), e2102060 (2021)
   PUBMED   34180153
REFERENCE   4  (bases 1 to 2775)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2775)
  AUTHORS   Hooper,J.E., Jones,K.L., Smith,F.J., Williams,T. and Li,H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2775)
  AUTHORS   Kiefer,S.M., McDill,B.W., Yang,J. and Rauchman,M.
  TITLE     Murine Sall1 represses transcription by recruiting a histone
            deacetylase complex
  JOURNAL   J Biol Chem 277 (17), 14869-14876 (2002)
   PUBMED   11836251
REFERENCE   7  (bases 1 to 2775)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 2775)
  AUTHORS   Osterod,M., Hollenbach,S., Hengstler,J.G., Barnes,D.E., Lindahl,T.
            and Epe,B.
  TITLE     Age-related and tissue-specific accumulation of oxidative DNA base
            damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient
            mice
  JOURNAL   Carcinogenesis 22 (9), 1459-1463 (2001)
   PUBMED   11532868
REFERENCE   9  (bases 1 to 2775)
  AUTHORS   Simpson,A., Uitto,J., Rodeck,U. and Mahoney,M.G.
  TITLE     Differential expression and subcellular distribution of the mouse
            metastasis-associated proteins Mta1 and Mta3
  JOURNAL   Gene 273 (1), 29-39 (2001)
   PUBMED   11483358
REFERENCE   10 (bases 1 to 2775)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC112910.1, CF171555.1, CJ139622.1, CX203022.1, CX213009.1 and
            AC073562.6.
            
            On Apr 8, 2006 this sequence version replaced NM_054081.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB794094.1, SRR7345562.1870523.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               BC112910.1         1-227
            228-878             CF171555.1         1-651
            879-1340            CJ139622.1         30-491
            1341-1866           CX203022.1         37-562
            1867-2201           CX213009.1         312-646
            2202-2775           AC073562.6         5554-6127           c
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.57 cM"
     gene            1..2775
                     /gene="Mta1"
                     /note="metastasis associated 1"
                     /db_xref="GeneID:116870"
                     /db_xref="MGI:MGI:2150037"
     exon            1..168
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..2237
                     /gene="Mta1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     metastasis-associated protein MTA1"
                     /codon_start=1
                     /product="metastasis-associated protein MTA1 isoform 1"
                     /protein_id="NP_473422.2"
                     /db_xref="CCDS:CCDS36574.1"
                     /db_xref="GeneID:116870"
                     /db_xref="MGI:MGI:2150037"
                     /translation="MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVC
                     FYRRRDISSSLIALADKHAREVEEEVENPEMVDLPEKLKHQLRHRELFLSRQLESLPA
                     THIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADI
                     TDLLKEGEEDGRDQSKLETKVWEAHNPLVDKQIDQFLVVARSVGTFARALDCSSSVRQ
                     PSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEA
                     NLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKL
                     KQVYIPNYNKPNPNQISASSVKATVVNGTGTPGQSPGAGRACESCYTTQSYQWYSWGP
                     PNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRNNMSPHGIPARSSGSPKFAMKT
                     RQAFYLHTTKLTRIARRLCREILRPWHAARHPYMPINSAAIKAECTARLPEASQSPLV
                     LKQVVRKPLEAVLRYLETHPRPPKPDPVKSSSSVLSSLTPAKSAPVINNGSPTILGKR
                     SYEQHNGVDGNMKKRLLMPSRGLANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGSLP
                     PVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPLR
                     PPPPAPVNDEPIVIED"
     exon            169..236
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            237..330
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..457
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..521
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..639
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..742
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..842
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1031
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1106
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1165
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1281
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1433
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1623
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1713
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1866
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1902
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1934
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2086
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2775
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2744..2749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mta1"
                     /note="hexamer: AAGAAA"
     polyA_site      2775
                     /gene="Mta1"
                     /note="major polyA site"
ORIGIN      
        1 gcggcggcgg cggcggcgga gcagcgcggt ccctttaaac cgcccgccgg cgcccccgcg
       61 cccgcccccg ccccggcccg cgcccggccc gccgcccgcg ctcgcgcccc gcgccccgcg
      121 gccccgccgc cggcccggac atggccgcca acatgtacag ggtcggagac tatgtctact
      181 ttgagaactc ctccagcaac ccgtacctga tccgcaggat tgaagagctt aacaagacag
      241 ccaacgggaa tgtggaggcc aaagtggtgt gtttctacag aaggcgggac atttccagca
      301 gcctcatcgc gctggcggac aagcatgcaa gggaagtgga ggaggaggta gaaaacccag
      361 agatggtgga cctgcctgag aaacttaagc atcagctgcg gcatcgagaa ctgttcctgt
      421 ctcggcagtt ggagtctctg cctgccaccc acatcagggg caagtgcagt gttaccctgc
      481 tcaatgagac ggagtcactc aagtcctact tggagcgtga ggatttcttc ttctactctc
      541 tagtctacga cccacagcag aagaccctcc tggctgataa aggggaaatt cgtgtaggaa
      601 accggtacca ggctgacatc actgacttgc tgaaagaagg tgaggaggac ggccgcgatc
      661 agtcaaaact ggagaccaag gtgtgggaag cccacaatcc acttgtggat aagcagattg
      721 accagtttct ggtggtggcc cgctctgtgg gtacctttgc acgggccctg gattgcagca
      781 gctccgtgcg gcagcctagc ctgcacatga gtgccgcagc ggcctcccga gacatcaccc
      841 tgttccatgc tatggacacg ctgcacaaga acatctacga catctccaag gccatctcgg
      901 ccctcgtgcc ccagggtggg ccagtgctct gccgcgatga gatggaggag tggtccgcat
      961 cagaagccaa cctttttgag gaagctctgg aaaaatatgg gaaagatttc accgacattc
     1021 aacaagattt tctcccatgg aagtcgctca ccagcatcat tgagtattac tacatgtgga
     1081 agaccaccga cagatacgtc cagcagaaac gcttgaaagc agctgaagct gagagcaagt
     1141 taaagcaggt ttatattccc aactataaca agcccaaccc aaaccagatc agcgccagca
     1201 gtgtcaaggc cactgtagtg aatggcacag ggacaccagg ccagagcccc ggggccggtc
     1261 gggcctgcga gagctgttac accacacagt cttaccagtg gtattcttgg ggtcccccta
     1321 acatgcagtg tcgcctctgc gcatcttgtt ggacatattg gaagaaatat ggtggcttga
     1381 aaatgccaac ccggttagat ggagagaggc cgggaccaaa ccgcaataac atgagtcccc
     1441 atggcatccc agctcggagc agtgggagcc ccaagtttgc catgaagaca aggcaggcct
     1501 tctacctgca tactaccaag ttgacacgca ttgcccggcg cttgtgccgt gagatcctac
     1561 gcccatggca tgctgcccgc cacccctaca tgcccatcaa cagcgcagca atcaaggctg
     1621 aatgcacagc acggctgccc gaagcctccc agagcccact ggtgctgaag caggtagtac
     1681 ggaagcccct ggaggccgtg ctccggtatc ttgagaccca tccccgcccg cctaagcccg
     1741 accccgtgaa gagttcatcc agtgtgctca gcagtctgac ccctgccaag tcagcccctg
     1801 tcatcaacaa cggctcccct accatcctgg gcaagaggag ctacgagcag cacaatgggg
     1861 tagatggcaa catgaagaag cgcctcttga tgcccagtag gggtctggca aaccatggac
     1921 agaccaggca catgggacca agtcggaatc tcctgctcaa tgggaagtcc taccccacca
     1981 aagtgcgcct aatccgtggt ggctccctgc ctccagtcaa gcggcggcga atgaactgga
     2041 tcgacgcccc agatgatgta ttttacatgg ccaccgaaga gaccaggaaa atccgaaagc
     2101 tgctctcatc ctcagaaacc aagcgtgctg cccgccggcc ctacaaaccc attgccctgc
     2161 gccagagcca ggccctgccg ctgcggccac ccccacctgc accagtcaat gatgagccca
     2221 ttgttattga ggactaggcg gtcacccaca ccgtggcctg cctgggcccc tccatcagcc
     2281 ccagagtatc cagtgaggcc tgcagaggcc aagcggcctc cctcccccac cagactgctg
     2341 cccaccccac cctctgtttc cgtagtgccc caactcccgc cctcacatgc agagaaactg
     2401 ctcctctggt ggacatgtgg ggaagaagtg tggtctaact tattccgaga caccgaggag
     2461 gagtcttttt tagctttgtg tttactttct ggctggagca gagctgagga gcgccctggg
     2521 ccgtgtgctg cagggcttct cacccggggt gggctctaag gttttgttgt gttctgttga
     2581 aggtgccatt ttaaatttta tttttattac ttttttgtag atgaacttga gctctgtaac
     2641 ttacacctgg atgttaggat tggtgcagca gccagcagcg gccaagctgc ctgcagggtt
     2701 ggtcccctgt cttttcaagt aattttcata ttaaacaaaa acaaagaaaa aaatctcata
     2761 aaaaggaaaa cccca
//
