LOCUS       NP_473422                698 aa            linear   ROD 27-APR-2025
DEFINITION  metastasis-associated protein MTA1 isoform 1 [Mus musculus].
ACCESSION   NP_473422 XP_207015
VERSION     NP_473422.2
DBSOURCE    REFSEQ: accession NM_054081.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 698)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 698)
  AUTHORS   Ishikawa,M., Osaki,M., Uno,N., Ohira,T., Kugoh,H. and Okada,F.
  TITLE     MTA1, a metastasis-associated protein, in endothelial cells is an
            essential molecule for angiogenesis
  JOURNAL   Mol Med Rep 25 (1) (2022)
   PUBMED   34779499
  REMARK    GeneRIF: MTA1, a metastasisassociated protein, in endothelial cells
            is an essential molecule for angiogenesis.
REFERENCE   3  (residues 1 to 698)
  AUTHORS   Yan,L., Jin,W., Zhao,Q., Cui,X., Shi,T., Xu,Y., Li,F., Jin,W.,
            Zhang,Z., Zhang,Z., Tang,Q.Q. and Pan,D.
  TITLE     PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a
            NuRD Subcomplex
  JOURNAL   Adv Sci (Weinh) 8 (16), e2102060 (2021)
   PUBMED   34180153
REFERENCE   4  (residues 1 to 698)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 698)
  AUTHORS   Hooper,J.E., Jones,K.L., Smith,F.J., Williams,T. and Li,H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 698)
  AUTHORS   Kiefer,S.M., McDill,B.W., Yang,J. and Rauchman,M.
  TITLE     Murine Sall1 represses transcription by recruiting a histone
            deacetylase complex
  JOURNAL   J Biol Chem 277 (17), 14869-14876 (2002)
   PUBMED   11836251
REFERENCE   7  (residues 1 to 698)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (residues 1 to 698)
  AUTHORS   Osterod,M., Hollenbach,S., Hengstler,J.G., Barnes,D.E., Lindahl,T.
            and Epe,B.
  TITLE     Age-related and tissue-specific accumulation of oxidative DNA base
            damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient
            mice
  JOURNAL   Carcinogenesis 22 (9), 1459-1463 (2001)
   PUBMED   11532868
REFERENCE   9  (residues 1 to 698)
  AUTHORS   Simpson,A., Uitto,J., Rodeck,U. and Mahoney,M.G.
  TITLE     Differential expression and subcellular distribution of the mouse
            metastasis-associated proteins Mta1 and Mta3
  JOURNAL   Gene 273 (1), 29-39 (2001)
   PUBMED   11483358
REFERENCE   10 (residues 1 to 698)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC112910.1, CF171555.1, CJ139622.1, CX203022.1, CX213009.1 and
            AC073562.6.
            
            On Apr 8, 2006 this sequence version replaced NP_473422.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB794094.1, SRR7345562.1870523.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..698
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.57 cM"
     Protein         1..698
                     /product="metastasis-associated protein MTA1 isoform 1"
                     /note="metastasis-associated protein MTA1"
                     /calculated_mol_wt=79059
     Region          3..171
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          150..202
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          270..315
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(271,301..302,304..305,307..309,311..313)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          371..424
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          447..524
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..698
                     /gene="Mta1"
                     /coded_by="NM_054081.2:141..2237"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS36574.1"
                     /db_xref="GeneID:116870"
                     /db_xref="MGI:MGI:2150037"
ORIGIN      
        1 maanmyrvgd yvyfensssn pylirrieel nktangnvea kvvcfyrrrd issslialad
       61 khareveeev enpemvdlpe klkhqlrhre lflsrqlesl pathirgkcs vtllnetesl
      121 ksyleredff fyslvydpqq ktlladkgei rvgnryqadi tdllkegeed grdqskletk
      181 vweahnplvd kqidqflvva rsvgtfaral dcsssvrqps lhmsaaaasr ditlfhamdt
      241 lhkniydisk aisalvpqgg pvlcrdemee wsaseanlfe ealekygkdf tdiqqdflpw
      301 ksltsiieyy ymwkttdryv qqkrlkaaea esklkqvyip nynkpnpnqi sassvkatvv
      361 ngtgtpgqsp gagracescy ttqsyqwysw gppnmqcrlc ascwtywkky gglkmptrld
      421 gerpgpnrnn msphgipars sgspkfamkt rqafylhttk ltriarrlcr eilrpwhaar
      481 hpympinsaa ikaectarlp easqsplvlk qvvrkpleav lrylethprp pkpdpvksss
      541 svlssltpak sapvinngsp tilgkrsyeq hngvdgnmkk rllmpsrgla nhgqtrhmgp
      601 srnlllngks yptkvrlirg gslppvkrrr mnwidapddv fymateetrk irkllssset
      661 kraarrpykp ialrqsqalp lrppppapvn depivied
//
