LOCUS       NM_001346696            2790 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus metastasis associated 1 (Mta1), transcript variant 2,
            mRNA.
ACCESSION   NM_001346696 XM_006515426
VERSION     NM_001346696.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2790)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2790)
  AUTHORS   Ishikawa,M., Osaki,M., Uno,N., Ohira,T., Kugoh,H. and Okada,F.
  TITLE     MTA1, a metastasis-associated protein, in endothelial cells is an
            essential molecule for angiogenesis
  JOURNAL   Mol Med Rep 25 (1) (2022)
   PUBMED   34779499
  REMARK    GeneRIF: MTA1, a metastasisassociated protein, in endothelial cells
            is an essential molecule for angiogenesis.
REFERENCE   3  (bases 1 to 2790)
  AUTHORS   Yan,L., Jin,W., Zhao,Q., Cui,X., Shi,T., Xu,Y., Li,F., Jin,W.,
            Zhang,Z., Zhang,Z., Tang,Q.Q. and Pan,D.
  TITLE     PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a
            NuRD Subcomplex
  JOURNAL   Adv Sci (Weinh) 8 (16), e2102060 (2021)
   PUBMED   34180153
REFERENCE   4  (bases 1 to 2790)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2790)
  AUTHORS   Hooper,J.E., Jones,K.L., Smith,F.J., Williams,T. and Li,H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2790)
  AUTHORS   Kiefer,S.M., McDill,B.W., Yang,J. and Rauchman,M.
  TITLE     Murine Sall1 represses transcription by recruiting a histone
            deacetylase complex
  JOURNAL   J Biol Chem 277 (17), 14869-14876 (2002)
   PUBMED   11836251
REFERENCE   7  (bases 1 to 2790)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 2790)
  AUTHORS   Osterod,M., Hollenbach,S., Hengstler,J.G., Barnes,D.E., Lindahl,T.
            and Epe,B.
  TITLE     Age-related and tissue-specific accumulation of oxidative DNA base
            damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient
            mice
  JOURNAL   Carcinogenesis 22 (9), 1459-1463 (2001)
   PUBMED   11532868
REFERENCE   9  (bases 1 to 2790)
  AUTHORS   Simpson,A., Uitto,J., Rodeck,U. and Mahoney,M.G.
  TITLE     Differential expression and subcellular distribution of the mouse
            metastasis-associated proteins Mta1 and Mta3
  JOURNAL   Gene 273 (1), 29-39 (2001)
   PUBMED   11483358
REFERENCE   10 (bases 1 to 2790)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073562.6, AB794096.1 and BU053969.1.
            
            On Oct 26, 2016 this sequence version replaced XM_006515426.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC112910.1, AB794096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC073562.6         44343-44482         c
            141-1225            AB794096.1         1-1085
            1226-1226           BU053969.1         551-551
            1227-2252           AB794096.1         1087-2112
            2253-2790           AC073562.6         5554-6091           c
FEATURES             Location/Qualifiers
     source          1..2790
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.57 cM"
     gene            1..2790
                     /gene="Mta1"
                     /note="metastasis associated 1"
                     /db_xref="GeneID:116870"
                     /db_xref="MGI:MGI:2150037"
     exon            1..168
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..2252
                     /gene="Mta1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     metastasis-associated protein MTA1"
                     /codon_start=1
                     /product="metastasis-associated protein MTA1 isoform 2"
                     /protein_id="NP_001333625.1"
                     /db_xref="CCDS:CCDS84004.1"
                     /db_xref="GeneID:116870"
                     /db_xref="MGI:MGI:2150037"
                     /translation="MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVC
                     FYRRRDISSSLIALADKHATLSVCYRAGPGADTGEEGEVEEEVENPEMVDLPEKLKHQ
                     LRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTL
                     LADKGEIRVGNRYQADITDLLKEGEEDGRDQSKLETKVWEAHNPLVDKQIDQFLVVAR
                     SVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQG
                     GPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTD
                     RYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQISASSVKATVVNGTGTPGQSPGAGRA
                     CESCYTTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRNNMSP
                     HGIPARSSGSPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYMPINSAAI
                     KAECTARLPEASQSPLVLKQVVRKPLEAVLRYLETHPRPPKPDPVKSSSSVLSSLTPA
                     KSAPVINNGSPTILGKRSYEQHNGVDGLANHGQTRHMGPSRNLLLNGKSYPTKVRLIR
                     GGSLPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQ
                     ALPLRPPPPAPVNDEPIVIED"
     exon            169..236
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            237..330
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..381
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..508
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..572
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..690
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..793
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..893
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1082
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1157
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1216
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1332
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1484
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1674
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1764
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1917
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..1949
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2101
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2790
                     /gene="Mta1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2759..2764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mta1"
                     /note="hexamer: AAGAAA"
     polyA_site      2790
                     /gene="Mta1"
                     /note="major polyA site"
ORIGIN      
        1 gcggcggcgg cggcggcgga gcagcgcggt ccctttaaac cgcccgccgg cgcccccgcg
       61 cccgcccccg ccccggcccg cgcccggccc gccgcccgcg ctcgcgcccc gcgccccgcg
      121 gccccgccgc cggcccggac atggccgcca acatgtacag ggtcggagac tatgtctact
      181 ttgagaactc ctccagcaac ccgtacctga tccgcaggat tgaagagctt aacaagacag
      241 ccaacgggaa tgtggaggcc aaagtggtgt gtttctacag aaggcgggac atttccagca
      301 gcctcatcgc gctggcggac aagcatgcaa ccctgtcagt ctgctataga gccggaccgg
      361 gggcggacac cggcgaggaa ggggaagtgg aggaggaggt agaaaaccca gagatggtgg
      421 acctgcctga gaaacttaag catcagctgc ggcatcgaga actgttcctg tctcggcagt
      481 tggagtctct gcctgccacc cacatcaggg gcaagtgcag tgttaccctg ctcaatgaga
      541 cggagtcact caagtcctac ttggagcgtg aggatttctt cttctactct ctagtctacg
      601 acccacagca gaagaccctc ctggctgata aaggggaaat tcgtgtagga aaccggtacc
      661 aggctgacat cactgacttg ctgaaagaag gtgaggagga cggccgcgat cagtcaaaac
      721 tggagaccaa ggtgtgggaa gcccacaatc cacttgtgga taagcagatt gaccagtttc
      781 tggtggtggc ccgctctgtg ggtacctttg cacgggccct ggattgcagc agctccgtgc
      841 ggcagcctag cctgcacatg agtgccgcag cggcctcccg agacatcacc ctgttccatg
      901 ctatggacac gctgcacaag aacatctacg acatctccaa ggccatctcg gccctcgtgc
      961 cccagggtgg gccagtgctc tgccgcgatg agatggagga gtggtccgca tcagaagcca
     1021 acctttttga ggaagctctg gaaaaatatg ggaaagattt caccgacatt caacaagatt
     1081 ttctcccatg gaagtcgctc accagcatca ttgagtatta ctacatgtgg aagaccaccg
     1141 acagatacgt ccagcagaaa cgcttgaaag cagctgaagc tgagagcaag ttaaagcagg
     1201 tttatattcc caactataac aagcccaacc caaaccagat cagcgccagc agtgtcaagg
     1261 ccactgtagt gaatggcaca gggacaccag gccagagccc cggggccggt cgggcctgcg
     1321 agagctgtta caccacacag tcttaccagt ggtattcttg gggtccccct aacatgcagt
     1381 gtcgcctctg cgcatcttgt tggacatatt ggaagaaata tggtggcttg aaaatgccaa
     1441 cccggttaga tggagagagg ccgggaccaa accgcaataa catgagtccc catggcatcc
     1501 cagctcggag cagtgggagc cccaagtttg ccatgaagac aaggcaggcc ttctacctgc
     1561 atactaccaa gttgacacgc attgcccggc gcttgtgccg tgagatccta cgcccatggc
     1621 atgctgcccg ccacccctac atgcccatca acagcgcagc aatcaaggct gaatgcacag
     1681 cacggctgcc cgaagcctcc cagagcccac tggtgctgaa gcaggtagta cggaagcccc
     1741 tggaggccgt gctccggtat cttgagaccc atccccgccc gcctaagccc gaccccgtga
     1801 agagttcatc cagtgtgctc agcagtctga cccctgccaa gtcagcccct gtcatcaaca
     1861 acggctcccc taccatcctg ggcaagagga gctacgagca gcacaatggg gtagatggtc
     1921 tggcaaacca tggacagacc aggcacatgg gaccaagtcg gaatctcctg ctcaatggga
     1981 agtcctaccc caccaaagtg cgcctaatcc gtggtggctc cctgcctcca gtcaagcggc
     2041 ggcgaatgaa ctggatcgac gccccagatg atgtatttta catggccacc gaagagacca
     2101 ggaaaatccg aaagctgctc tcatcctcag aaaccaagcg tgctgcccgc cggccctaca
     2161 aacccattgc cctgcgccag agccaggccc tgccgctgcg gccaccccca cctgcaccag
     2221 tcaatgatga gcccattgtt attgaggact aggcggtcac ccacaccgtg gcctgcctgg
     2281 gcccctccat cagccccaga gtatccagtg aggcctgcag aggccaagcg gcctccctcc
     2341 cccaccagac tgctgcccac cccaccctct gtttccgtag tgccccaact cccgccctca
     2401 catgcagaga aactgctcct ctggtggaca tgtggggaag aagtgtggtc taacttattc
     2461 cgagacaccg aggaggagtc ttttttagct ttgtgtttac tttctggctg gagcagagct
     2521 gaggagcgcc ctgggccgtg tgctgcaggg cttctcaccc ggggtgggct ctaaggtttt
     2581 gttgtgttct gttgaaggtg ccattttaaa ttttattttt attacttttt tgtagatgaa
     2641 cttgagctct gtaacttaca cctggatgtt aggattggtg cagcagccag cagcggccaa
     2701 gctgcctgca gggttggtcc cctgtctttt caagtaattt tcatattaaa caaaaacaaa
     2761 gaaaaaaatc tcataaaaag gaaaacccca
//
