LOCUS       NM_008631                391 bp    mRNA    linear   ROD 10-FEB-2024
DEFINITION  Mus musculus metallothionein 4 (Mt4), mRNA.
ACCESSION   NM_008631
VERSION     NM_008631.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 391)
  AUTHORS   Meloni,G., Zovo,K., Kazantseva,J., Palumaa,P. and Vasak,M.
  TITLE     Organization and assembly of metal-thiolate clusters in
            epithelium-specific metallothionein-4
  JOURNAL   J Biol Chem 281 (21), 14588-14595 (2006)
   PUBMED   16556599
  REMARK    GeneRIF: analysis of metal-thiolate clusters in epithelium-specific
            metallothionein-4
REFERENCE   2  (bases 1 to 391)
  AUTHORS   Tio,L., Villarreal,L., Atrian,S. and Capdevila,M.
  TITLE     Functional differentiation in the mammalian metallothionein gene
            family: metal binding features of mouse MT4 and comparison with its
            paralog MT1
  JOURNAL   J Biol Chem 279 (23), 24403-24413 (2004)
   PUBMED   15033980
  REMARK    GeneRIF: MT4 plays a physiological role related with copper
            requirements in epithelial differentiating tissues, where MT4 is
            expressed
REFERENCE   3  (bases 1 to 391)
  AUTHORS   Liang,L., Fu,K., Lee,D.K., Sobieski,R.J., Dalton,T. and
            Andrews,G.K.
  TITLE     Activation of the complete mouse metallothionein gene locus in the
            maternal deciduum
  JOURNAL   Mol Reprod Dev 43 (1), 25-37 (1996)
   PUBMED   8720110
REFERENCE   4  (bases 1 to 391)
  AUTHORS   Quaife,C.J., Findley,S.D., Erickson,J.C., Froelick,G.J.,
            Kelly,E.J., Zambrowicz,B.P. and Palmiter,R.D.
  TITLE     Induction of a new metallothionein isoform (MT-IV) occurs during
            differentiation of stratified squamous epithelia
  JOURNAL   Biochemistry 33 (23), 7250-7259 (1994)
   PUBMED   8003488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131733.3.
            
            On Aug 14, 2018 this sequence version replaced NM_008631.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131894.1, BY708806.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC131733.3         71886-71954
            70-135              AC131733.3         72913-72978
            136-391             AC131733.3         73458-73713
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.26 cM"
     gene            1..391
                     /gene="Mt4"
                     /gene_synonym="MT-IV"
                     /note="metallothionein 4"
                     /db_xref="GeneID:17752"
                     /db_xref="MGI:MGI:99692"
     exon            1..69
                     /gene="Mt4"
                     /gene_synonym="MT-IV"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..227
                     /gene="Mt4"
                     /gene_synonym="MT-IV"
                     /note="MT-4; metallothionein-IV"
                     /codon_start=1
                     /product="metallothionein-4"
                     /protein_id="NP_032657.1"
                     /db_xref="CCDS:CCDS40435.1"
                     /db_xref="GeneID:17752"
                     /db_xref="MGI:MGI:99692"
                     /translation="MDPGECTCMSGGICICGDNCKCTTCSCKTCRKSCCPCCPPGCAK
                     CARGCICKGGSDKCSCCP"
     exon            70..135
                     /gene="Mt4"
                     /gene_synonym="MT-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            136..391
                     /gene="Mt4"
                     /gene_synonym="MT-IV"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagcctcc ctttcttagc tgctcacaca cctggaccat ggaccctggg gaatgcacgt
       61 gtatgtctgg agggatctgc atctgcggag ataattgcaa atgcacaacc tgcagctgta
      121 aaacctgtcg taaaagctgc tgtccctgct gtcccccagg ctgtgccaag tgtgcccggg
      181 gctgcatctg caaagggggt tcagacaagt gcagctgctg tccctgaaac ccacctatgg
      241 cagcgggaga gatcctggga agtgactaca cagtacctga gtcaagggat ttaatttgta
      301 taataaattg tactttttat atgtgtgccc acatgcgggg caggtgatgt ccatgtaaag
      361 ttcttggagt aataaagttt ccattcatgg c
//
