LOCUS       NM_013603                538 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus metallothionein 3 (Mt3), mRNA.
ACCESSION   NM_013603
VERSION     NM_013603.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 538)
  AUTHORS   Xiong,T., Li,Y., Yang,M., Huo,B., Guo,X., Liu,L., Huang,Y., Zhu,X.,
            Hu,Q., Wei,X., Jiang,D.S. and Yi,X.
  TITLE     Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell
            Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated
            Autophagosome Formation
  JOURNAL   Int J Biol Sci 20 (8), 2904-2921 (2024)
   PUBMED   38904023
  REMARK    GeneRIF: Metallothionein 3 Potentiates Pulmonary Artery Smooth
            Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated
            Autophagosome Formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 538)
  AUTHORS   Okamoto,M., Sasai,M., Kuratani,A., Okuzaki,D., Arai,M., Wing,J.B.,
            Sakaguchi,S. and Yamamoto,M.
  TITLE     A genetic method specifically delineates Th1-type Treg cells and
            their roles in tumor immunity
  JOURNAL   Cell Rep 42 (7), 112813 (2023)
   PUBMED   37440410
REFERENCE   3  (bases 1 to 538)
  AUTHORS   Lee,D.R., Rhodes,C., Mitra,A., Zhang,Y., Maric,D., Dale,R.K. and
            Petros,T.J.
  TITLE     Transcriptional heterogeneity of ventricular zone cells in the
            ganglionic eminences of the mouse forebrain
  JOURNAL   Elife 11, e71864 (2022)
   PUBMED   35175194
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 538)
  AUTHORS   Cole,J.D., Sarabia Del Castillo,J., Gut,G., Gonzalez-Bohorquez,D.,
            Pelkmans,L. and Jessberger,S.
  TITLE     Characterization of the neurogenic niche in the aging dentate gyrus
            using iterative immunofluorescence imaging
  JOURNAL   Elife 11, e68000 (2022)
   PUBMED   35089129
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 538)
  AUTHORS   Chowdhury,D., Gardner,J.C., Satpati,A., Nookala,S., Mukundan,S.,
            Porollo,A., Landero Figueroa,J.A. and Subramanian Vignesh,K.
  TITLE     Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome
            Activation and Impairs Antibacterial Immunity
  JOURNAL   Front Immunol 12, 755961 (2021)
   PUBMED   34867993
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 538)
  AUTHORS   Imagawa,M., Ishikawa,Y., Shimano,H., Osada,S. and Nishihara,T.
  TITLE     CTG triplet repeat in mouse growth inhibitory
            factor/metallothionein III gene promoter represses the
            transcriptional activity of the heterologous promoters
  JOURNAL   J Biol Chem 270 (36), 20898-20900 (1995)
   PUBMED   7673112
REFERENCE   7  (bases 1 to 538)
  AUTHORS   Zheng,H., Berman,N.E. and Klaassen,C.D.
  TITLE     Chemical modulation of metallothionein I and III mRNA in mouse
            brain
  JOURNAL   Neurochem Int 27 (1), 43-58 (1995)
   PUBMED   7655347
REFERENCE   8  (bases 1 to 538)
  AUTHORS   Choudhuri,S., Kramer,K.K., Berman,N.E., Dalton,T.P., Andrews,G.K.
            and Klaassen,C.D.
  TITLE     Constitutive expression of metallothionein genes in mouse brain
  JOURNAL   Toxicol Appl Pharmacol 131 (1), 144-154 (1995)
   PUBMED   7878670
REFERENCE   9  (bases 1 to 538)
  AUTHORS   Masters,B.A., Quaife,C.J., Erickson,J.C., Kelly,E.J.,
            Froelick,G.J., Zambrowicz,B.P., Brinster,R.L. and Palmiter,R.D.
  TITLE     Metallothionein III is expressed in neurons that sequester zinc in
            synaptic vesicles
  JOURNAL   J Neurosci 14 (10), 5844-5857 (1994)
   PUBMED   7931547
REFERENCE   10 (bases 1 to 538)
  AUTHORS   Palmiter,R.D., Findley,S.D., Whitmore,T.E. and Durnam,D.M.
  TITLE     MT-III, a brain-specific member of the metallothionein gene family
  JOURNAL   Proc Natl Acad Sci U S A 89 (14), 6333-6337 (1992)
   PUBMED   1631128
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140209.1 and AC131733.3.
            
            On Jul 10, 2009 this sequence version replaced NM_013603.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140209.1, BU842101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-488               AK140209.1         2-489
            489-538             AC131733.3         88781-88830
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.29 cM"
     gene            1..538
                     /gene="Mt3"
                     /gene_synonym="Mt-3"
                     /note="metallothionein 3"
                     /db_xref="GeneID:17751"
                     /db_xref="MGI:MGI:97173"
     exon            1..224
                     /gene="Mt3"
                     /gene_synonym="Mt-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..400
                     /gene="Mt3"
                     /gene_synonym="Mt-3"
                     /note="GIF; MT-III; metallothionein-III; growth inhibitory
                     factor"
                     /codon_start=1
                     /product="metallothionein-3"
                     /protein_id="NP_038631.1"
                     /db_xref="CCDS:CCDS40436.1"
                     /db_xref="GeneID:17751"
                     /db_xref="MGI:MGI:97173"
                     /translation="MDPETCPCPTGGSCTCSDKCKCKGCKCTNCKKSCCSCCPAGCEK
                     CAKDCVCKGEEGAKAEAEKCSCCQ"
     exon            225..290
                     /gene="Mt3"
                     /gene_synonym="Mt-3"
                     /inference="alignment:Splign:2.1.0"
     exon            291..538
                     /gene="Mt3"
                     /gene_synonym="Mt-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      515..520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mt3"
                     /gene_synonym="Mt-3"
                     /note="hexamer: AATAAA"
     polyA_site      538
                     /gene="Mt3"
                     /gene_synonym="Mt-3"
                     /note="major polyA site"
ORIGIN      
        1 acactcagtg gagactcggg acagcagtgc acacacacgg agagcaggcg ctgtgcgtgc
       61 ataggggcgg gcgccaagtc gctgcttgcg cgcccccgcc tggggctata aaagccttgc
      121 cacctgctgc cctggctacg tagcgcatcc gcttgccggg aggaaccaag ctacggcggc
      181 tgctggactg gatatggacc ctgagacctg cccctgtcct actggtggtt cctgcacctg
      241 ctcggacaaa tgcaagtgca agggctgcaa atgcacgaac tgcaagaaga gctgctgctc
      301 ctgctgccct gccggatgtg agaagtgtgc caaggactgt gtgtgcaaag gtgaagaggg
      361 ggccaaggca gaggccgaga aatgcagctg ctgccagtga ggacccagac cctcccacac
      421 agcctatgta aatagtgctg ggtgtccctg gtggggcaca actgttgtct tccccccccc
      481 cccccccccc gccggctgcc tgctccgggg tgtgaataaa tcccatgcac aacatgaa
//
