LOCUS       NM_013602                583 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus metallothionein 1 (Mt1), mRNA.
ACCESSION   NM_013602
VERSION     NM_013602.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 583)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 583)
  AUTHORS   Tanaka,K.I., Shiota,S., Sakakibara,O., Shimoda,M., Takafuji,A.,
            Takabatake,M., Kadota,Y., Kawakami,T., Suzuki,S. and Kawahara,M.
  TITLE     Exacerbation of Elastase-Induced Emphysema via Increased Oxidative
            Stress in Metallothionein-Knockout Mice
  JOURNAL   Biomolecules 12 (4), 583 (2022)
   PUBMED   35454172
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 583)
  AUTHORS   Chowdhury,D., Gardner,J.C., Satpati,A., Nookala,S., Mukundan,S.,
            Porollo,A., Landero Figueroa,J.A. and Subramanian Vignesh,K.
  TITLE     Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome
            Activation and Impairs Antibacterial Immunity
  JOURNAL   Front Immunol 12, 755961 (2021)
   PUBMED   34867993
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 583)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 583)
  AUTHORS   Gu,C., Wang,F., Zhang,Y.T., Wei,S.Z., Liu,J.Y., Sun,H.Y., Wang,G.H.
            and Liu,C.F.
  TITLE     Microglial MT1 activation inhibits LPS-induced neuroinflammation
            via regulation of metabolic reprogramming
  JOURNAL   Aging Cell 20 (6), e13375 (2021)
   PUBMED   33964119
  REMARK    GeneRIF: Microglial MT1 activation inhibits LPS-induced
            neuroinflammation via regulation of metabolic reprogramming.
            Erratum:[Aging Cell. 2024 Feb;23(2):e14068. doi:
            10.1111/acel.14068.. PMID: 38124231]
REFERENCE   6  (bases 1 to 583)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   7  (bases 1 to 583)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   8  (bases 1 to 583)
  AUTHORS   Spitkovsky,D.D., Royer-Pokora,B., Delius,H., Kisseljov,F.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Royer,H.D.
  TITLE     Tissue restricted expression and chromosomal localization of the
            YB-1 gene encoding a 42 kD nuclear CCAAT binding protein
  JOURNAL   Nucleic Acids Res 20 (4), 797-803 (1992)
   PUBMED   1542575
REFERENCE   9  (bases 1 to 583)
  AUTHORS   Nishimura,N., Nishimura,H., Ghaffar,A. and Tohyama,C.
  TITLE     Localization of metallothionein in the brain of rat and mouse
  JOURNAL   J Histochem Cytochem 40 (2), 309-315 (1992)
   PUBMED   1552172
REFERENCE   10 (bases 1 to 583)
  AUTHORS   Huang,I.Y. and Yoshida,A.
  TITLE     Mouse liver metallothioneins. Complete amino acid sequence of
            metallothionein-I
  JOURNAL   J Biol Chem 252 (22), 8217-8221 (1977)
   PUBMED   914867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131733.3, AK018727.1 and AA050166.1.
            
            On Dec 30, 2008 this sequence version replaced NM_013602.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK793634.1, BU938576.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC131733.3         113771-113908
            139-539             AK018727.1         2-402
            540-583             AA050166.1         319-362
FEATURES             Location/Qualifiers
     source          1..583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.34 cM"
     gene            1..583
                     /gene="Mt1"
                     /gene_synonym="Mt-1; MT-I"
                     /note="metallothionein 1"
                     /db_xref="GeneID:17748"
                     /db_xref="MGI:MGI:97171"
     exon            1..250
                     /gene="Mt1"
                     /gene_synonym="Mt-1; MT-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..408
                     /gene="Mt1"
                     /gene_synonym="Mt-1; MT-I"
                     /note="metallothionein-I"
                     /codon_start=1
                     /product="metallothionein-1"
                     /protein_id="NP_038630.1"
                     /db_xref="CCDS:CCDS40438.1"
                     /db_xref="GeneID:17748"
                     /db_xref="MGI:MGI:97171"
                     /translation="MDPNCSCSTGGSCTCTSSCACKNCKCTSCKKSCCSCCPVGCSKC
                     AQGCVCKGAADKCTCCA"
     exon            251..316
                     /gene="Mt1"
                     /gene_synonym="Mt-1; MT-I"
                     /inference="alignment:Splign:2.1.0"
     exon            317..542
                     /gene="Mt1"
                     /gene_synonym="Mt-1; MT-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      520..525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mt1"
                     /gene_synonym="Mt-1; MT-I"
                     /note="hexamer: AATAAA"
     polyA_site      542
                     /gene="Mt1"
                     /gene_synonym="Mt-1; MT-I"
                     /note="major polyA site"
ORIGIN      
        1 tctgcactcc gcccgaaaag tgcgctcggc tctgccaagg acgcggggcg cgtgactatg
       61 cgtgggctgg agcaaccgcc tgctgggtgc aaaccctttg cgcccggact cgtccaacga
      121 ctataaagag ggcaggctgt cctctaagcg tcaccacgac ttcaacgtcc tgagtacctt
      181 ctcctcactt actccgtagc tccagcttca ccagatctcg gaatggaccc caactgctcc
      241 tgctccaccg gcggctcctg cacttgcacc agctcctgcg cctgcaagaa ctgcaagtgc
      301 acctcctgca agaagagctg ctgctcctgc tgtcccgtgg gctgctccaa atgtgcccag
      361 ggctgtgtct gcaaaggcgc cgcggacaag tgcacgtgct gtgcctgatg tgacgaacag
      421 cgctgccacc acgtgtaaat agtatcggac caacccagcg tcttcctata cagttccacc
      481 ctgtttacta aacccccgtt ttctaccgag tacgtgaata ataaaagcct gtttgagtct
      541 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
