LOCUS       NM_010836               2287 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus msh homeobox 3 (Msx3), transcript variant 1, mRNA.
ACCESSION   NM_010836
VERSION     NM_010836.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2287)
  AUTHORS   Gupta,I., Yeung,J., Rahimi-Balaei,M., Wu,S.R. and Goldowitz,D.
  TITLE     Msx genes delineate a novel molecular map of the developing
            cerebellar neuroepithelium
  JOURNAL   Front Mol Neurosci 17, 1356544 (2024)
   PUBMED   38742226
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2287)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2287)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   4  (bases 1 to 2287)
  AUTHORS   Nie,X., Zheng,J., Ricupero,C.L., He,L., Jiao,K. and Mao,J.J.
  TITLE     mTOR acts as a pivotal signaling hub for neural crest cells during
            craniofacial development
  JOURNAL   PLoS Genet 14 (7), e1007491 (2018)
   PUBMED   29975682
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2287)
  AUTHORS   Langer,D., Martianov,I., Alpern,D., Rhinn,M., Keime,C., Dolle,P.,
            Mengus,G. and Davidson,I.
  TITLE     Essential role of the TFIID subunit TAF4 in murine embryogenesis
            and embryonic stem cell differentiation
  JOURNAL   Nat Commun 7, 11063 (2016)
   PUBMED   27026076
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2287)
  AUTHORS   Fowler,K.J., Kalitsis,P. and Choo,K.H.
  TITLE     Mouse mitotic spindle checkpoint Bub3 gene maps to the distal
            region of chromosome 7 by interspecific backcross analysis
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 91-92 (1999)
   PUBMED   10640819
REFERENCE   7  (bases 1 to 2287)
  AUTHORS   Wang,W., Chen,X., Xu,H. and Lufkin,T.
  TITLE     Msx3: a novel murine homologue of the Drosophila msh homeobox gene
            restricted to the dorsal embryonic central nervous system
  JOURNAL   Mech Dev 58 (1-2), 203-215 (1996)
   PUBMED   8887328
REFERENCE   8  (bases 1 to 2287)
  AUTHORS   Shimeld,S.M., McKay,I.J. and Sharpe,P.T.
  TITLE     The murine homeobox gene Msx-3 shows highly restricted expression
            in the developing neural tube
  JOURNAL   Mech Dev 55 (2), 201-210 (1996)
   PUBMED   8861099
REFERENCE   9  (bases 1 to 2287)
  AUTHORS   Cosgrove,D., Gray,D., Dierich,A., Kaufman,J., Lemeur,M., Benoist,C.
            and Mathis,D.
  TITLE     Mice lacking MHC class II molecules
  JOURNAL   Cell 66 (5), 1051-1066 (1991)
   PUBMED   1909605
REFERENCE   10 (bases 1 to 2287)
  AUTHORS   Holland,P.W.
  TITLE     Cloning and evolutionary analysis of msh-like homeobox genes from
            mouse, zebrafish and ascidian
  JOURNAL   Gene 98 (2), 253-257 (1991)
   PUBMED   1673109
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK012556.1 and BC051983.1.
            
            On Aug 12, 2009 this sequence version replaced NM_010836.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U62523.1, BC051983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AK012556.1         2-32
            32-2070             BC051983.1         1-2039
            2071-2287           AK012556.1         2140-2356
FEATURES             Location/Qualifiers
     source          1..2287
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 85.04 cM"
     gene            1..2287
                     /gene="Msx3"
                     /note="msh homeobox 3"
                     /db_xref="GeneID:17703"
                     /db_xref="MGI:MGI:106587"
     exon            1..303
                     /gene="Msx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..704
                     /gene="Msx3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox, msh-like 3; homeo box, msh-like 3"
                     /codon_start=1
                     /product="homeobox protein MSX-3 isoform 1"
                     /protein_id="NP_034966.1"
                     /db_xref="CCDS:CCDS21961.1"
                     /db_xref="GeneID:17703"
                     /db_xref="MGI:MGI:106587"
                     /translation="MARATFDMNAAGLEARGGGHTEHGPLPFSVESLLEAERVPGSES
                     GELGVERPLGASKPGAWPPPVAHSCPPRAPSPPPCTLRKHKTNRKPRTPFTTAQLLAL
                     ERKFHQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKLAAKPL
                     LPAAFALPFPLGTQLHSSAATFGGNAVPGILAGPVAAYGMYYLS"
     exon            304..2287
                     /gene="Msx3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1114..1119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msx3"
                     /note="hexamer: AATAAA"
     polyA_site      1141
                     /gene="Msx3"
                     /note="major polyA site"
ORIGIN      
        1 cacagagccc aaggtcctag caaaataaac cgccgctggg tcccacgcgt cccagccggg
       61 cggctagccc cgcacccgcc atcccatgca tggcccgggc gacattcgac atgaacgcgg
      121 cggggctcga agctcgcggc gggggccaca cagagcacgg accactcccc ttcagcgtcg
      181 agtctctgct ggaggctgag cgcgtaccgg gctccgagtc tggggagctg ggggtggaga
      241 ggccgctcgg cgcctcgaag cctggagcct ggccccctcc agtcgcgcac tcttgtcccc
      301 cacgtgcccc gagccctcca ccctgcaccc tccgcaaaca caaaaccaat cgcaaaccac
      361 ggacgccatt caccaccgcg cagctgctgg cgcttgagcg caagtttcac cagaagcaat
      421 acttatccat tgcggagcgc gccgagttct ccagcagctt gagcctcact gagactcagg
      481 tcaagatctg gtttcagaac cgccgagcca aagccaagcg gctgcaggaa gctgagctgg
      541 agaagctgaa gctggcagcg aagccactac tgccggcggc gtttgccctg cccttcccgc
      601 tgggcaccca gctgcacagc tccgcggcca ctttcggcgg caacgcggtt cctgggatcc
      661 tcgccgggcc tgtcgcggcc tatggcatgt actacttgtc ttagatcatg gaatcaagcc
      721 ctaacctctt ggttaggctc agggttgcgc acagttctgc ctgccgctga tgctcctggt
      781 aacttttgac ttttcatttt agtcttcccc ccccccctcc tcctgtttat acggtgttat
      841 acttgatgac tggagcctat ttatagacat cttacaaata ctttaaacct tcctaaaacc
      901 ttgcccacat caatctgttt ttctgaaaga aaacacaccg tcatatagtc cttgaaacag
      961 acaaaagcag ttcttcctat ttcttacaaa gcagtcgaca aagtatttct ggagtgggtg
     1021 tgctccctgt attcactctg cccggacacc gaggacttca gagaggctcg attgagctgg
     1081 cataagaaaa caaattccat aagaagaaat caaaataaaa aatgagataa tcggacggtt
     1141 agaaattact gtctctccaa ctgttgtgac caaatggaaa cttttacact ttttaggttt
     1201 tataccatta ttattttttt ttttagagta tatgtcgttc aaggagctag aggcaaacgc
     1261 tggatggact tggaagtagg ggaggggact gttggcgcca tgccctaatg taagggtggc
     1321 tgctgccccc agcatcttct gagcttcttc gaaaagagcc tgctgggggg agacagaggg
     1381 ctgaaggcag cagggaccaa cctctagcct cttgccagca ggtgtccagt caataaagag
     1441 aagaaagtga gagttgagca tctcagatct cccattgtgg gtgcggtagg aggtgaggcc
     1501 tgtgaaggtc ccagaagagt tactctgagt gccggctgcc tctgtaattc tggtgctccg
     1561 tagaaaagcg gaggacttgt ttaggaatcc ggacttgtac ctttattcta cctttatccg
     1621 aggaaagaaa acaggccatc tgagctgttc tgtcctatcc tgttcggtct caatcctatc
     1681 atgcaagatt gaggccctta gggtacctga caacgggcac taatacaccc catggctgtt
     1741 tccacaggac acttttgctg caatctagag actttagctg gagtgtgttg agggctcaca
     1801 acagtcccct ggagtcacag cccaggacct ttgacaggcc ctcctgccag ccttcgggca
     1861 ggggaggaag aacctgcctg cagagggctg ctggttgtgt gttcatgaga acatggaatt
     1921 tcacagtgat agatggccca gggttaggat gctctggttg ggaggaaggg aaggactggg
     1981 ctatgctcgg cagtccaagc cagctccagg aaaactgctg tcccgtgacc ttcactggtc
     2041 catcagctcc aaataaaacc gaaaagataa tattgcatgg aattgcctat tgatacgtat
     2101 tgacagtctt ctgccctgtg tctcttggaa aaattggaaa ccagataggt ttggttttgt
     2161 tttgagacca aatcgtcact atgtagccct aactgatcta ggacttgcta ttctccaagg
     2221 acagccttag acttaccttg cctccacttg cctcccaagt tctgggatta aagacatacc
     2281 acaatgc
//
