LOCUS       NM_010835               1931 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus msh homeobox 1 (Msx1), mRNA.
ACCESSION   NM_010835
VERSION     NM_010835.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1931)
  AUTHORS   Zhang,C., Zheng,Y., Qu,Y., Huang,R., Huang,H., Li,J., Qiu,M. and
            Li,F.
  TITLE     Transcriptional factor ISL1 regulates palate development by tuning
            the SHH cascade
  JOURNAL   FEBS J 292 (4), 851-863 (2025)
   PUBMED   39704783
REFERENCE   2  (bases 1 to 1931)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1931)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   4  (bases 1 to 1931)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 1931)
  AUTHORS   Padmanabhan,A., de Soysa,T.Y., Pelonero,A., Sapp,V., Shah,P.P.,
            Wang,Q., Li,L., Lee,C.Y., Sadagopan,N., Nishino,T., Ye,L., Yang,R.,
            Karnay,A., Poleshko,A., Bolar,N., Linares-Saldana,R., Ranade,S.S.,
            Alexanian,M., Morton,S.U., Jain,M., Haldar,S.M., Srivastava,D. and
            Jain,R.
  TITLE     A genome-wide CRISPR screen identifies BRD4 as a regulator of
            cardiomyocyte differentiation
  JOURNAL   Nat Cardiovasc Res 3 (3), 317-331 (2024)
   PUBMED   39196112
REFERENCE   6  (bases 1 to 1931)
  AUTHORS   Song,K., Wang,Y. and Sassoon,D.
  TITLE     Expression of Hox-7.1 in myoblasts inhibits terminal
            differentiation and induces cell transformation
  JOURNAL   Nature 360 (6403), 477-481 (1992)
   PUBMED   1360150
REFERENCE   7  (bases 1 to 1931)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   8  (bases 1 to 1931)
  AUTHORS   Lyons,G.E., Houzelstein,D., Sassoon,D., Robert,B. and
            Buckingham,M.E.
  TITLE     Multiple sites of Hox-7 expression during mouse embryogenesis:
            comparison with retinoic acid receptor mRNA localization
  JOURNAL   Mol Reprod Dev 32 (4), 303-314 (1992)
   PUBMED   1353971
REFERENCE   9  (bases 1 to 1931)
  AUTHORS   Wang,Y., Benezra,R. and Sassoon,D.A.
  TITLE     Id expression during mouse development: a role in morphogenesis
  JOURNAL   Dev Dyn 194 (3), 222-230 (1992)
   PUBMED   1361374
REFERENCE   10 (bases 1 to 1931)
  AUTHORS   MacKenzie,A., Ferguson,M.W. and Sharpe,P.T.
  TITLE     Expression patterns of the homeobox gene, Hox-8, in the mouse
            embryo suggest a role in specifying tooth initiation and shape
  JOURNAL   Development 115 (2), 403-420 (1992)
   PUBMED   1358591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY240100.1, AC114671.14, BU922533.1 and AV323104.1.
            
            On Aug 25, 2006 this sequence version replaced NM_010835.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077524.1, X14759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               BY240100.1         2-122
            122-459             AC114671.14        5722-6059
            460-1059            BU922533.1         1-600
            1060-1853           AC114671.14        8824-9617
            1854-1931           AV323104.1         93-170
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 20.21 cM"
     gene            1..1931
                     /gene="Msx1"
                     /gene_synonym="Hox-7; Hox7; Hox7.1; msh"
                     /note="msh homeobox 1"
                     /db_xref="GeneID:17701"
                     /db_xref="MGI:MGI:97168"
     exon            1..721
                     /gene="Msx1"
                     /gene_synonym="Hox-7; Hox7; Hox7.1; msh"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1164
                     /gene="Msx1"
                     /gene_synonym="Hox-7; Hox7; Hox7.1; msh"
                     /note="hox-7.1; homeobox protein Hox-7; msh homeobox
                     1-like protein; muscle-segment homeobox; homeo box,
                     msh-like 1; homeobox, msh-like 1"
                     /codon_start=1
                     /product="homeobox protein MSX-1"
                     /protein_id="NP_034965.2"
                     /db_xref="CCDS:CCDS19249.1"
                     /db_xref="GeneID:17701"
                     /db_xref="MGI:MGI:97168"
                     /translation="MAPAAAMTSLPLGVKVEDSAFAKPAGGGVGQAPGAAAATATAMG
                     TDEEGAKPKVPASLLPFSVEALMADHRKPGAKESVLVASEGAQAAGGSVQHLGTRPGS
                     LGAPDAPSSPRPLGHFSVGGLLKLPEDALVKAESPEKLDRTPWMQSPRFSPPPARRLS
                     PPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKI
                     WFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPLGGPAAVAAAAGASLYSASG
                     PFQRAALPVAPVGLYTAHVGYSMYHLT"
     exon            722..1931
                     /gene="Msx1"
                     /gene_synonym="Hox-7; Hox7; Hox7.1; msh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1908..1913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msx1"
                     /gene_synonym="Hox-7; Hox7; Hox7.1; msh"
                     /note="hexamer: AATAAA"
     polyA_site      1930
                     /gene="Msx1"
                     /gene_synonym="Hox-7; Hox7; Hox7.1; msh"
                     /note="major polyA site"
ORIGIN      
        1 ggcggacccg gagccggcga gtgcgcctgg gaactcggcc tgagcggcgc agggatccag
       61 gccccgctcg ctcgagttgg ccttctgggg aagccgcagg aggctcgcgc gcgagagccg
      121 gccgggccag gaacccagga gctcgcagaa gccggtcagg agctcgcaga agccggtcgc
      181 gctcccagcc tgcccgaaac ccatgatcca gggctgtctc gagctgcggc tggagggggg
      241 gtccggctct gcatggcccc ggctgctgct atgacttctt tgccactcgg tgtcaaagtg
      301 gaggactccg ccttcgccaa gcctgctggg ggaggcgttg gccaagcccc cggggctgct
      361 gcggccaccg caaccgccat gggcacagat gaggaggggg ccaagcccaa agtgcccgct
      421 tcactcctgc ccttcagcgt ggaggccctc atggccgatc acaggaagcc cggggccaag
      481 gagagcgtcc tggtggcctc cgaaggggct caggcagcgg gtggctcggt gcagcacttg
      541 ggcacccggc ccgggtctct gggcgccccg gatgcgccct cctcgccgcg gcctctcggc
      601 catttctcag tcggaggact cctcaagctg ccagaagatg ctctggtgaa ggccgaaagc
      661 cccgagaaac tagatcggac cccgtggatg cagagtcccc gcttctcccc gcccccagcc
      721 agacggctga gtcccccagc atgcacccta cgcaagcaca agaccaaccg caagcccagg
      781 acgcctttca ccacagctca gctgctggct ctggagcgca agttccgcca gaagcagtac
      841 ctgtctattg ccgagcgcgc ggaattctcc agctcgctca gcctcaccga gacccaggtg
      901 aagatctggt tccagaaccg tcgcgctaag gccaagagac tgcaggaggc ggagctggag
      961 aagctgaaga tggccgcgaa acccatgttg ccgcctgctg ccttcggcct ctcttttcct
     1021 cttggcggtc ctgcagcggt ggctgcagct gcgggcgcct cactctacag tgcctctggc
     1081 cctttccagc gcgccgcgct gcctgtagcg cccgtgggac tctacaccgc ccatgtaggc
     1141 tacagcatgt accacctgac ttaggtgggt ccagagtcac ctccctgtgg tgccatcccc
     1201 tccccagcca cctctttgag cagagcagcg ggagtccttc ctaggaagct ctgctgccct
     1261 ataccacctg gtcccttctc ttaaacccct tgctacacac ttcctcctgg ttgtcgcttc
     1321 ctaaaccttc ctcatctgac cccttctggg aagaaaaaga atggtcggaa gtgtctaggt
     1381 ttttcgagaa aaatctagat ttacatgcgc aagttataaa tgtggaaact aagggtgcag
     1441 aggccaagag atttatccgt ggtccccagc agaattagag gctgaaggag accagaggcc
     1501 aaaaggacta gaggccatga gactccatca gctgcttccg gtcctgaaac caggcaggac
     1561 ttgcacagag aaattgctaa tcggtgcttc aagagatgag cccagcccta tagaaagcaa
     1621 ggagcccagc tccttccact gtcaaactct aagcgctttg gcagcaaagc attgctctga
     1681 gggggcaggg cgcatgctgg tgcttcacca aggtaggtta aagagacttt cccaggacca
     1741 gaaaaaaaga agtaaaaaaa aaaaaaaaaa aaaccaaaat ctgtttctat ttaacagtac
     1801 attttcgtgg ctctcaagca tcccttttga agggactgtg tgtgtactat gtaatatact
     1861 gtatatttga aattttatta tcatttatat tatagctata tttgttaaat aaattaattt
     1921 taagctacaa g
//
