LOCUS       NM_010834               2705 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus myostatin (Mstn), mRNA.
ACCESSION   NM_010834
VERSION     NM_010834.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2705)
  AUTHORS   Wang,H., Guo,S., Gao,H., Ding,J., Li,H., Kong,X., Zhang,S., He,M.,
            Feng,Y., Wu,W., Xu,K., Chen,Y., Zhang,H., Liu,T. and Kong,X.
  TITLE     Myostatin regulates energy homeostasis through autocrine- and
            paracrine-mediated microenvironment communication
  JOURNAL   J Clin Invest 134 (16), e178303 (2024)
   PUBMED   38889010
  REMARK    GeneRIF: Myostatin regulates energy homeostasis through autocrine-
            and paracrine-mediated microenvironment communication.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2705)
  AUTHORS   Morel,J., Pignard,A.S., Castells,J., Allibert,V., Hatimi,L.,
            Buhot,B., Velarde,M., Durieux,A.C. and Freyssenet,D.
  TITLE     Myostatin gene invalidation does not prevent skeletal muscle mass
            loss during experimental sepsis in mice
  JOURNAL   J Physiol 602 (12), 2839-2854 (2024)
   PUBMED   38748517
  REMARK    GeneRIF: Myostatin gene invalidation does not prevent skeletal
            muscle mass loss during experimental sepsis in mice.
REFERENCE   3  (bases 1 to 2705)
  AUTHORS   Martin Gil,C., Raoof,R., Versteeg,S., Willemen,H.L.D.M.,
            Lafeber,F.P.J.G., Mastbergen,S.C. and Eijkelkamp,N.
  TITLE     Myostatin and CXCL11 promote nervous tissue macrophages to maintain
            osteoarthritis pain
  JOURNAL   Brain Behav Immun 116, 203-215 (2024)
   PUBMED   38070625
  REMARK    GeneRIF: Myostatin and CXCL11 promote nervous tissue macrophages to
            maintain osteoarthritis pain.
REFERENCE   4  (bases 1 to 2705)
  AUTHORS   Riasi,M., Mozaffari-Jovin,S. and Javadmanesh,A.
  TITLE     The effect of modification of DNA interference on myostatin gene
            expression in mice
  JOURNAL   J Genet 103 (2024)
   PUBMED   38185835
  REMARK    GeneRIF: The effect of modification of DNA interference on
            myostatin gene expression in mice.
REFERENCE   5  (bases 1 to 2705)
  AUTHORS   Knapp,M., Supruniuk,E. and Gorski,J.
  TITLE     Myostatin and the Heart
  JOURNAL   Biomolecules 13 (12), 1777 (2023)
   PUBMED   38136649
  REMARK    GeneRIF: Myostatin and the Heart.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2705)
  AUTHORS   Conlon,I. and Raff,M.
  TITLE     Size control in animal development
  JOURNAL   Cell 96 (2), 235-244 (1999)
   PUBMED   9988218
  REMARK    Review article
REFERENCE   7  (bases 1 to 2705)
  AUTHORS   Szabo,G., Dallmann,G., Muller,G., Patthy,L., Soller,M. and Varga,L.
  TITLE     A deletion in the myostatin gene causes the compact (Cmpt)
            hypermuscular mutation in mice
  JOURNAL   Mamm Genome 9 (8), 671-672 (1998)
   PUBMED   9680391
REFERENCE   8  (bases 1 to 2705)
  AUTHORS   McPherron,A.C. and Lee,S.J.
  TITLE     Double muscling in cattle due to mutations in the myostatin gene
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12457-12461 (1997)
   PUBMED   9356471
REFERENCE   9  (bases 1 to 2705)
  AUTHORS   Varga,L., Szabo,G., Darvasi,A., Muller,G., Sass,M. and Soller,M.
  TITLE     Inheritance and mapping of Compact (Cmpt), a new mutation causing
            hypermuscularity in mice
  JOURNAL   Genetics 147 (2), 755-764 (1997)
   PUBMED   9335610
REFERENCE   10 (bases 1 to 2705)
  AUTHORS   McPherron,A.C., Lawler,A.M. and Lee,S.J.
  TITLE     Regulation of skeletal muscle mass in mice by a new TGF-beta
            superfamily member
  JOURNAL   Nature 387 (6628), 83-90 (1997)
   PUBMED   9139826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK142222.1 and AK132415.1.
            
            On Aug 27, 2015 this sequence version replaced NM_010834.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein negatively regulates
            skeletal muscle cell proliferation and differentiation. Homozygous
            knockout mice for this gene exhibit increased muscle mass and bone
            density, and reduced adiposity. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142222.1, AK132415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-971               AK142222.1         1-971
            972-2705            AK132415.1         974-2707
FEATURES             Location/Qualifiers
     source          1..2705
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.99 cM"
     gene            1..2705
                     /gene="Mstn"
                     /gene_synonym="Cmpt; Gdf8"
                     /note="myostatin"
                     /db_xref="GeneID:17700"
                     /db_xref="MGI:MGI:95691"
     exon            1..502
                     /gene="Mstn"
                     /gene_synonym="Cmpt; Gdf8"
                     /inference="alignment:Splign:2.1.0"
     exon            503..876
                     /gene="Mstn"
                     /gene_synonym="Cmpt; Gdf8"
                     /inference="alignment:Splign:2.1.0"
     exon            877..2705
                     /gene="Mstn"
                     /gene_synonym="Cmpt; Gdf8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggactccct ggcgtggcag gttgtctctc ggacggtaca tgcactaata tttcacttgg
       61 cattactcaa aagcaaaaag aagaaataag aacaagggaa aaaaaaagat tgtgctgatt
      121 tttaaaatga tgcaaaaact gcaaatgtat gtttatattt acctgttcat gctgattgct
      181 gctggcccag tggatctaaa tgagggcagt gagagagaag aaaatgtgga aaaagagggg
      241 ctgtgtaatg catgtgcgtg gagacaaaac acgaggtact ccagaataga agccataaaa
      301 attcaaatcc tcagtaagct gcgcctggaa acagctccta acatcagcaa agatgctata
      361 agacaacttc tgccaagagc gcctccactc cgggaactga tcgatcagta cgacgtccag
      421 agggatgaca gcagtgatgg ctctttggaa gatgacgatt atcacgctac cacggaaaca
      481 atcattacca tgcctacaga gtctgacttt ctaatgcaag cggatggcaa gcccaaatgt
      541 tgctttttta aatttagctc taaaatacag tacaacaaag tagtaaaagc ccaactgtgg
      601 atatatctca gacccgtcaa gactcctaca acagtgtttg tgcaaatcct gagactcatc
      661 aaacccatga aagacggtac aaggtatact ggaatccgat ctctgaaact tgacatgagc
      721 ccaggcactg gtatttggca gagtattgat gtgaagacag tgttgcaaaa ttggctcaaa
      781 cagcctgaat ccaacttagg cattgaaatc aaagctttgg atgagaatgg ccatgatctt
      841 gctgtaacct tcccaggacc aggagaagat gggctgaatc cctttttaga agtcaaggtg
      901 acagacacac ccaagaggtc ccggagagac tttgggcttg actgcgatga gcactccacg
      961 gaatcccggt gctgccgcta ccccctcacg gtcgattttg aagcctttgg atgggactgg
     1021 attatcgcac ccaaaagata taaggccaat tactgctcag gagagtgtga atttgtgttt
     1081 ttacaaaaat atccgcatac tcatcttgtg caccaagcaa accccagagg ctcagcaggc
     1141 ccttgctgca ctccgacaaa aatgtctccc attaatatgc tatattttaa tggcaaagaa
     1201 caaataatat atgggaaaat tccagccatg gtagtagacc gctgtgggtg ctcatgagct
     1261 ttgcattagg ttagaaattt cccaagtcat ggaaggtctt cccctcaatt tcgaaactgt
     1321 gaattcaagc accacaggct gtaggccttg agtatgctct agtaacgtaa gcacaagcta
     1381 cagtgtatga actaaaagag agaatagatg caatggttgg cattcaacca ccaaaataaa
     1441 ccatactata ggatgttgta tgatttccag agtttttgaa atagatggag atcaaattac
     1501 atttatgtcc atatatgtat attacaacta caatctaggc aaggaagtga gagcacatct
     1561 tgtggtctgc tgagttagga gggtatgatt aaaaggtaaa gtcttatttc ctaacagttt
     1621 cacttaatat ttacggaaga atctatatgt agcctttgta aagtgtagga ttgttatcat
     1681 ttaaaaacat catgtacact tatatttgta ttgtatactt ggtaagataa aattccacaa
     1741 agtaggaatg gggccttaca tacacattgc cattcctatt ataattggac aatccaccac
     1801 ggtgctaatg cagtgctgaa tggctcctac tggacctctc gatagaacac tctacaaagt
     1861 acgagtctct ctctcccttc caggtgcatc tccacacaca cagcactaag tgttcaatgc
     1921 attttcttta aggaaagaag aatctttttt tctagaggtc aactttcagt caactctagc
     1981 acagcgggag tgactgctgc atcttaaaag gcagccaaac agtattcatt ttttaatcta
     2041 aatttcaaaa tcactgtctg cctttatcac atggcaattt tgtggtaaaa taatggaaat
     2101 gactggttct atcaatattg tataaaagac tctgaaacaa ttacatttat ataatatgta
     2161 tacaatattg ttttgtaaat aagtgtctcc ttttatattt actttggtat atttttacac
     2221 taatgaaatt tcaaatcatt aaagtacaaa gacatgtcat gtatcacaaa aaaggtgact
     2281 gcttctattt cagagtgaat tagcagattc aatagtggtc ttaaaactct gtatgttaag
     2341 attagaaggt tatattacaa tcaatttatg tattttttac attatcaaca ttcacttatg
     2401 gtttcatggt ggctgtatct atgaatgtgg ctcccagtca aatttcaatg ccccaccatt
     2461 ttaaaaatta caagcattac taaacatacc aacatgtatc taaagaaata caaatatggt
     2521 atctcaataa cagctacttt tttattttat aatttgacaa tgaatacatt tcttttattt
     2581 acttcagttt tataaattgg aactttgttt atcaaatgta ttgtactcat agctaaatga
     2641 aattatttct tacataaaaa tgtgtagaaa ctataaatta aagtgttttc acatttttga
     2701 aaggc
//
