LOCUS       NM_001413562            4691 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus macrophage stimulating 1 receptor (c-met-related
            tyrosine kinase) (Mst1r), transcript variant 4, mRNA.
ACCESSION   NM_001413562 XM_006511656
VERSION     NM_001413562.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4691)
  AUTHORS   Hunt,B.G., Davis,J.C., Fox,L.H., Vicente-Munoz,S., Lester,C.,
            Wells,S.I. and Waltz,S.E.
  TITLE     RON-augmented cholesterol biosynthesis in breast cancer metastatic
            progression and recurrence
  JOURNAL   Oncogene 42 (21), 1716-1727 (2023)
   PUBMED   37029299
  REMARK    GeneRIF: RON-augmented cholesterol biosynthesis in breast cancer
            metastatic progression and recurrence.
REFERENCE   2  (bases 1 to 4691)
  AUTHORS   Hunt,B.G., Jones,A., Lester,C., Davis,J.C., Benight,N.M. and
            Waltz,S.E.
  TITLE     RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast
            Tumorigenesis through Autocrine and Paracrine Cellular Crosstalk
  JOURNAL   Cancers (Basel) 14 (10), 2493 (2022)
   PUBMED   35626096
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4691)
  AUTHORS   Yu,Q., Wang,J., Li,T., Xu,X., Guo,X., Ding,S., Zhu,L., Zou,G.,
            Chen,Y. and Zhang,X.
  TITLE     RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma
  JOURNAL   Biomed Res Int 2021, 2282916 (2021)
   PUBMED   34712728
  REMARK    GeneRIF: RON Mediates Tumor-Promoting Effects in Endometrial
            Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4691)
  AUTHORS   Batth,I.S., Huang,S.B., Villarreal,M., Gong,J., Chakravarthy,D.,
            Keppler,B., Jayamohan,S., Osmulski,P., Xie,J., Rivas,P.,
            Bedolla,R., Liss,M.A., Yeh,I.T., Reddick,R., Miyamoto,H., Ghosh,R.
            and Kumar,A.P.
  TITLE     Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor
            Tyrosine Kinase RON in the Management of Prostate Cancer
  JOURNAL   Int J Mol Sci 22 (4), 1852 (2021)
   PUBMED   33673346
  REMARK    GeneRIF: Evidence for 2-Methoxyestradiol-Mediated Inhibition of
            Receptor Tyrosine Kinase RON in the Management of Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4691)
  AUTHORS   Wetzel,C.C., Leonis,M.A., Dent,A., Olson,M.A., Longmeier,A.M.,
            Ney,P.A., Boivin,G.P., Kader,S.A., Caldwell,C.C., Degen,S.J. and
            Waltz,S.E.
  TITLE     Short-form Ron receptor is required for normal IFN-gamma production
            in concanavalin A-induced acute liver injury
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 292 (1), G253-G261 (2007)
   PUBMED   17008558
  REMARK    GeneRIF: Ron impacts the progression of inflammatory immune
            responses in vivo and further support a role for the Ron receptor
            and its various forms in liver pathophysiology.
REFERENCE   6  (bases 1 to 4691)
  AUTHORS   Iwama,A., Okano,K., Sudo,T., Matsuda,Y. and Suda,T.
  TITLE     Molecular cloning of a novel receptor tyrosine kinase gene, STK,
            derived from enriched hematopoietic stem cells
  JOURNAL   Blood 83 (11), 3160-3169 (1994)
   PUBMED   8193352
REFERENCE   7  (bases 1 to 4691)
  AUTHORS   Mak,T.W., Axelrad,A.A. and Bernstein,A.
  TITLE     Fv-2 locus controls expression of Friend spleen focus-forming
            virus-specific sequences in normal and infected mice
  JOURNAL   Proc Natl Acad Sci U S A 76 (11), 5809-5812 (1979)
   PUBMED   293685
REFERENCE   8  (bases 1 to 4691)
  AUTHORS   Risser,R.
  TITLE     Friend erythroleukemia antigen. A viral antigen specified by spleen
            focus-forming virus and differentiation antigen controlled by the
            Fv-2 locus
  JOURNAL   J Exp Med 149 (5), 1152-1167 (1979)
   PUBMED   448285
REFERENCE   9  (bases 1 to 4691)
  AUTHORS   Odaka,T. and Ikeda,H.
  TITLE     Genetic resistance to Friend leukemia virus in mice: masking of
            Fv-2 phenotype by an epistatic gene, Fv-4
  JOURNAL   Jpn J Exp Med 47 (6), 515-521 (1977)
   PUBMED   609115
REFERENCE   10 (bases 1 to 4691)
  AUTHORS   Varet,B., Cannat,A. and Gisselbrecht,S.
  TITLE     Genetic control of antinuclear antibodies in mice infected with
            Rauscher leukemia virus
  JOURNAL   Cancer Res 37 (4), 1115-1118 (1977)
   PUBMED   300277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731808.26.
            
            On Nov 3, 2022 this sequence version replaced XM_006511656.4.
            
            Summary: This gene encodes a precursor protein that is
            proteolytically cleaved to yield an alpha chain and a beta chain
            which form a membrane-spanning heterodimer. The encoded protein
            belongs to a family of cell-surface receptor tyrosine kinases
            involved in signaling from the cell surface to the intracellular
            environment. The binding of the encoded protein to its ligand,
            macrophage-stimulating protein, mediates several biological
            activities including wound healing, tumor immunity, macrophage
            activation and hematopoiesis as well as cell growth, motility,
            survival and adhesion. The protein encoded by this gene also
            functions in early development and the macrophage-mediated
            inflammatory response. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.3065514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1474              AL731808.26        10464-11937
            1475-1663           AL731808.26        15077-15265
            1664-1792           AL731808.26        15351-15479
            1793-1963           AL731808.26        15635-15805
            1964-2124           AL731808.26        16129-16289
            2125-2290           AL731808.26        16633-16798
            2291-2427           AL731808.26        16906-17042
            2428-2589           AL731808.26        17777-17938
            2590-2683           AL731808.26        18033-18126
            2684-2902           AL731808.26        18266-18484
            2903-3049           AL731808.26        18567-18713
            3050-3215           AL731808.26        18794-18959
            3216-3443           AL731808.26        19261-19488
            3444-3524           AL731808.26        19844-19924
            3525-3706           AL731808.26        20109-20290
            3707-3816           AL731808.26        20372-20481
            3817-3982           AL731808.26        20756-20921
            3983-4119           AL731808.26        21321-21457
            4120-4691           AL731808.26        23369-23940
FEATURES             Location/Qualifiers
     source          1..4691
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.07 cM"
     gene            1..4691
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /note="macrophage stimulating 1 receptor (c-met-related
                     tyrosine kinase)"
                     /db_xref="GeneID:19882"
                     /db_xref="MGI:MGI:99614"
     exon            1..1474
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1663
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1792
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1963
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2124
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2290
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2427
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2589
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2683
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2902
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3049
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3215
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3443
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            3444..3524
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..3706
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3816
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            3817..3982
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            3983..4119
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     exon            4120..4691
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4661..4666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /note="hexamer: AATAAA"
     regulatory      4673..4678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /note="hexamer: AATGAA"
     polyA_site      4685
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /note="major polyA site"
     polyA_site      4691
                     /gene="Mst1r"
                     /gene_synonym="CD136; CDw136; Fv-2; Fv2; p185-Ron; PTK8;
                     Ron; STK"
                     /note="major polyA site"
ORIGIN      
        1 agaagcagca gctggggccc ctggtgaggt gatcgtgcca ttgccgtgtc cgtgggtcca
       61 cagccaggtg ctcagaccac aagccagaga gaaaggttgg gtttgccagg gaccagggca
      121 ggggggcagc tgcccaggag ctttcagtac cgctgcgtaa agctggtctc agctcggacc
      181 ctgagtctgg ttcgatcaag tcctggacct tctgggattc ccaaggggcc ccagctcaat
      241 ggggctgcct ctgccgctgc ttcaatcctc tcttctgcta atgcttcttt tgcggctgtc
      301 ggcggcgtcc accaacctga actggcagtg cccacgaata ccctacgcag cctcccgaga
      361 cttcagtgtc aagtacgtgg tccccagctt ctccgcgggg ggccgggtac aggccaccgc
      421 agcctacgag gacagtacaa atagtgcggt gtttgtggcc acacgcaatc acctgcacgt
      481 gcttgggcct gacctgcagt tcatagagaa cctgaccact ggccctatcg ggaaccctgg
      541 ctgccagact tgtgcgagct gtggtccagg ccctcatgga ccaccaaagg acacagacac
      601 actggtgcta gtgatggagc caggtttgcc agccctggtc agctgtggct caaccctaca
      661 gggccgctgc ttcctgcatg agctggagcc tcgggggaaa gccctgcact tagcagctcc
      721 agcctgccta ttctcagcaa acaataacaa gcctgaggcc tgcacggact gtgtggctag
      781 ccccctgggc actcgtgtga ctgtggtgga gcaggggcat gcttcctact tctatgtggc
      841 atcttcgcta gacccagagt tggccgctag ctttagcccc cgctcggtgt ccatccgtcg
      901 tctaaagtct gatacttctg gattccaacc aggttttccg tcgctgtcgg tgctgcccaa
      961 atatttggcc tcctacctca tcaaatatgt gtacagcttc cactcggggg attttgtcta
     1021 ctttctgact gtccagccca tcagtgtcac aagccctccc agtgccttgc atacacgtct
     1081 ggtccggctc aatgctgtag agccagagat tggtgactac cgggagctgg tcttggactg
     1141 tcattttgca cctaaacgcc ggcgccgtgg agccccggag ggcacacagc cctacccagt
     1201 gcttcaggca gcccactctg ctccagtgga tgccaaactg gctgtggaac tgagcatttc
     1261 agagggccag gaagtgcttt ttggggtctt tgtgaccgtc aaggatggtg gctctggcat
     1321 gggtcccaac tctgttgtat gtgccttccc catttaccac ctgaacatcc tgattgaaga
     1381 gggtgtcgaa tattgctgtc actcttcaaa ttcttcttcc ctgttgtcga gaggccttga
     1441 cttcttccag acgcccagtt tttgtcctaa tccgcctggt ggagaggcct ccggccccag
     1501 ctcccgttgc cactacttcc ctttgatggt ccacgctagc ttcacccgtg tggacctctt
     1561 caatggactg ttaggatcag tgaaggtcac cgcactgcat gtgacacgtc ttggcaatgt
     1621 tacagtggcc cacatgggca ctgtggatgg gcgtgtccta caggtggaga tagccaggtc
     1681 actcaactac ctgctgtatg tgtccaactt ctccctgggc agcagtggac agcctgttca
     1741 tcgggatgtc agccgcctcg ggaatgacct actctttgcc tctggggacc aggtcttcaa
     1801 ggtgcccatc cagggccctg gctgtcgtca ttttctcacc tgttggcgtt gcctgagagc
     1861 acagcgcttc atgggatgtg gctggtgtgg ggaccggtgt gaccggcaga aggagtgtcc
     1921 tggctcctgg caacaggacc actgtccgcc tgagatcagt gagttctatc ctcacagcgg
     1981 gcctctaagg ggcactacga ggctcaccct ttgtggctcc aacttctacc tgcgacctga
     2041 tgatgtcgta cctgagggaa cacaccagat caccgtgggc caaagtccct gccgactgct
     2101 gcctaaggac tcttcaagcc ctaggccagg gtccctcaag gaattcatac aggaacttga
     2161 atgtgagctg gagcccctgg tcacccaggc agtggggact acaaacatca gccttgtcat
     2221 caccaacatg ccagcaggca agcacttccg agtggaaggc atctctgtac aggaaggctt
     2281 ctctttcgtg gagccagtgc tgacatcaat aaaacctgac tttggcccgc gggctggggg
     2341 tacttatctc acccttgaag gccagagcct gtctgtcggc accagccggg ctgtgctggt
     2401 caatggaacc cagtgccggc tggaacaggt caatgaggag cagatcttat gtgtcacgcc
     2461 tcctggagct ggcacggcca gggtccccct tcatctgcag atagggggtg ctgaggtgcc
     2521 tggctcctgg acctttcact acaaggaaga ccctattgtg ttggacatca gtcccaagtg
     2581 tggctacagt ggctcccaca tcatgatcca tggccagcat ctgacttcag catggcactt
     2641 cacgctatca ttccatgatg gacaaagtac agtggagagc aggcagtgtg cggggcagtt
     2701 tgtggaacaa cagcagcgtc gatgtcgcct gcctgaatat gtggtccgaa accctcaggg
     2761 gtgggcaaca gggaatctga gcgtctgggg tgatggagca gctggcttca cgctgcctgg
     2821 ttttcgcttc ctgcccccac ccagtccact cagagctggc ctggttgagt tgaaacctga
     2881 agaacattca gttaaagttg agtatgtcgg gctgggcgct gtggcagact gtgtgactgt
     2941 gaacatgacc gtgggtggtg aggtctgcca acatgagctc cggggggatg tggtgatctg
     3001 ccccctgccc ccttccctgc aacttggcaa ggatggtgtc ccattgcagg tctgtgtaga
     3061 cggtgggtgt cacatcctga gccaagtggt tcgctcaagc ccaggcaggg cctcacagag
     3121 gatactcctt attgctcttc tggtcttgat cctgcttgtg gctgtgctgg ccgttgccct
     3181 gatctttaac tcccgaagac ggaaaaagca gctaggtgct cactccctct ccccaacaac
     3241 actctctgac atcaacgata cagcttccgg ggctccgaac catgaagaat cgtcagagag
     3301 tagggatggg acaagtgtcc cactgctgcg gacagagtct atccggctcc aggatctgga
     3361 caggatgctc ctagctgagg tcaaggatgt actgattccc catgaacaag tggtcatcca
     3421 tactgaccaa gtcattggca aaggccactt tggtgttgtc taccacggag aatatacaga
     3481 cggagcacag aatcagaccc actgtgccat caagtctctg agtcgcatta cagaggtgca
     3541 ggaggtggag gctttcctgc gggaggggct gctcatgcgt ggcctacatc acccaaacat
     3601 cctggctctc atcggtatca tgctgccccc ggaggggctt ccccgggtgc tgttgcccta
     3661 tatgcgccac ggagacctgc ttcatttcat tcgctcccct cagaggaacc ccactgtgaa
     3721 ggatcttgtc agctttggcc tgcaggtagc ctgtggtatg gagtacctgg cagagcagaa
     3781 gttcgtgcac agagacctgg ctgctaggaa ctgcatgctg gacgagtcat tcacagtcaa
     3841 ggtggctgac tttggtctgg cacggggcgt cctagacaag gaatactaca gtgttcgcca
     3901 gcatcgccat gctcgcctgc cagtcaaatg gatggcactg gagagcctgc agacctacag
     3961 gttcaccacc aagtccgatg tgtggtcatt cggggtgctg ctctgggagc tactaacacg
     4021 gggtgctcca ccctaccccc atatcgatcc cttcgacctc tctcacttcc tggctcaggg
     4081 ccgtcgcctg cctcagcctg agtactgtcc tgattcactg tatcacgtga tgcttcgatg
     4141 ctgggaggct gacccagcgg cacgacccac cttcagagcc ctagtgctgg aagtaaagca
     4201 ggtagtggcc tcactgcttg gggaccacta tgtgcagctg acagcagctt atgtgaacgt
     4261 aggccccaga gcggtggatg atgggagtgt gcctccggag caggtacagc cctcgcctca
     4321 gcattgcagg agcacgtcaa agccccggcc tctctcagag ccacccctgc ccacttgacc
     4381 aaagccctga gtaggccaca ggcactagat ctgctaagtg gccttgagca aattacaagc
     4441 tgcctctggg cctaggacaa gcctcagcat ggaaaacctc cactctttag ctttctgggg
     4501 ccactgaagg tgggaaaccg ggcccatttg agcccctcgt tccagcatga gccagtgaca
     4561 tttttgtagc atgtatttat gtaatgtctg ttttgtacct gtttcggaat acagaggatc
     4621 cagcagtgat cacagagata ctacagtgta aaataatata aataaataaa tgaatgaata
     4681 ttcgagcaca a
//
