LOCUS       NM_008243               2286 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus macrophage stimulating 1 (hepatocyte growth
            factor-like) (Mst1), mRNA.
ACCESSION   NM_008243
VERSION     NM_008243.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2286)
  AUTHORS   Guo,Z.F., Tongmuang,N., Li,C., Zhang,C., Hu,L., Capreri,D.,
            Zuo,M.X., Summer,R. and Sun,J.
  TITLE     Inhibiting endothelial cell Mst1 attenuates acute lung injury in
            mice
  JOURNAL   JCI Insight 9 (17), e178208 (2024)
   PUBMED   39253972
  REMARK    GeneRIF: Inhibiting endothelial cell Mst1 attenuates acute lung
            injury in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2286)
  AUTHORS   Feng,P., Luo,L., Yang,Q., Meng,W., Guan,Z., Li,Z., Sun,G., Dong,Z.
            and Yang,M.
  TITLE     Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by
            orchestrating metabolic state and transcriptional activity
  JOURNAL   Cell Death Dis 15 (6), 430 (2024)
   PUBMED   38898027
  REMARK    GeneRIF: Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis
            by orchestrating metabolic state and transcriptional activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2286)
  AUTHORS   Huang,W., Wu,D., Cai,C., Yao,H., Tian,Z., Yang,Y., Pang,M., Rong,L.
            and Liu,B.
  TITLE     Inhibition of MST1 ameliorates neuronal apoptosis via
            GSK3beta/beta-TrCP/NRF2 pathway in spinal cord injury accompanied
            by diabetes
  JOURNAL   Redox Biol 71, 103104 (2024)
   PUBMED   38430683
  REMARK    Erratum:[Redox Biol. 2024 Aug;74:103198. doi:
            10.1016/j.redox.2024.103198. PMID: 38806302]
REFERENCE   4  (bases 1 to 2286)
  AUTHORS   Rehmani,T., Dias,A.P., Kamal,M., Salih,M. and Tuana,B.S.
  TITLE     Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3
            (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of
            Myocardium without Affecting Hippo Pathway
  JOURNAL   Int J Mol Sci 25 (5), 2888 (2024)
   PUBMED   38474134
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2286)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2286)
  AUTHORS   Bezerra,J.A., Witte,D.P., Aronow,B.J. and Degen,S.J.
  TITLE     Hepatocyte-specific expression of the mouse hepatocyte growth
            factor-like protein
  JOURNAL   Hepatology 18 (2), 394-399 (1993)
   PUBMED   8340069
REFERENCE   7  (bases 1 to 2286)
  AUTHORS   Li,K., Christiano,A.M., Copeland,N.G., Gilbert,D.J., Chu,M.L.,
            Jenkins,N.A. and Uitto,J.
  TITLE     cDNA cloning and chromosomal mapping of the mouse type VII collagen
            gene (Col7a1): evidence for rapid evolutionary divergence of the
            gene
  JOURNAL   Genomics 16 (3), 733-739 (1993)
   PUBMED   8325648
REFERENCE   8  (bases 1 to 2286)
  AUTHORS   Yeung,R.S., Hino,O., Vilensky,M., Buetow,K., Szpirer,C.,
            Szpirer,J., Klinga-Levan,K., Levan,G. and Knudson,A.G.
  TITLE     Assignment of 22 loci in the rat by somatic hybrid and linkage
            analysis
  JOURNAL   Mamm Genome 4 (10), 585-588 (1993)
   PUBMED   8268657
REFERENCE   9  (bases 1 to 2286)
  AUTHORS   Degen,S.J., Gilbert,D.J., Jenkins,N.A. and Copeland,N.G.
  TITLE     Assignment of the gene coding for hepatocyte growth factor-like
            protein to mouse chromosome 9
  JOURNAL   Genomics 13 (4), 1368-1369 (1992)
   PUBMED   1354648
REFERENCE   10 (bases 1 to 2286)
  AUTHORS   Degen,S.J., Stuart,L.A., Han,S. and Jamison,C.S.
  TITLE     Characterization of the mouse cDNA and gene coding for a hepatocyte
            growth factor-like protein: expression during development
  JOURNAL   Biochemistry 30 (40), 9781-9791 (1991)
   PUBMED   1832957
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137678.11, AK134222.1 and M74181.1.
            
            On Jul 24, 2009 this sequence version replaced NM_008243.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134222.1, BC051393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC137678.11        92963-92980
            19-374              AK134222.1         2-357
            375-2259            M74181.1           332-2216
            2260-2286           AK134222.1         2243-2269
FEATURES             Location/Qualifiers
     source          1..2286
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.07 cM"
     gene            1..2286
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /note="macrophage stimulating 1 (hepatocyte growth
                     factor-like)"
                     /db_xref="GeneID:15235"
                     /db_xref="MGI:MGI:96080"
     exon            1..95
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            96..243
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            244..356
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            357..471
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            472..608
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            609..729
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            730..848
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1044
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1175
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1278
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1415
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1451
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1560
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1638
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1785
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1892
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2032
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2286
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2235..2240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /note="hexamer: CATAAA"
     polyA_site      2263
                     /gene="Mst1"
                     /gene_synonym="D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl"
                     /note="major polyA site"
ORIGIN      
        1 atggggctgt ggtgggtcac cgtgcagcct ccagcttagg agaatggggt ggctcccact
       61 tctgctgctt ctggtacagt gttcaagggc tcttgggcag cgctcaccac tgaatgactt
      121 ccagctgttc cggggcacag agttaaggaa cctgttacac acagcggtgc cggggccatg
      181 gcaggaggat gtggcagatg ctgaggagtg tgctaggcgc tgtgggcccc ttctggactg
      241 tcgggccttc cactacaaca tgagcagcca tggttgccag ctgctgccgt ggacccagca
      301 ctcgctgcac acacagctat accactcgag tctgtgccat ctcttccaga agaaagatta
      361 tgtgcggacc tgcattatgg acaatggggt cagctaccgg ggcactgtgg ccaggacagc
      421 tggtggcctg ccctgccaag cctggagtcg caggttcccc aatgaccaca agtatacgcc
      481 cacgccaaag aatggcctgg aagagaactt ctgtaggaac cctgatgggg atcccagagg
      541 tccctggtgc tacacaacaa accgcagtgt gcgtttccag agctgtggca tcaaaacctg
      601 cagggaggct gtttgtgttc tgtgcaacgg tgaggattac cgtggcgagg tagacgttac
      661 agagtcaggg cgggagtgtc aacgctggga cctgcagcac ccccactcgc accctttcca
      721 gcctgaaaag ttcctagaca aagatctgaa agacaactat tgtcgtaatc cggacggatc
      781 tgagcggccc tggtgctaca ccacagaccc gaatgttgag cgagaattct gcgacctgcc
      841 cagttgcggg cctaacctgc ctccgaccgt caaaggatcc aagtcacagc ggcgcaacaa
      901 gggcaaggct cttaactgct tccgcggaaa aggtgaagac tatcgaggca caaccaatac
      961 cacctctgcg ggcgtgccct gccagcggtg ggatgcgcag agtccacacc agcaccgctt
     1021 tgtgccagag aaatatgctt gcaaggacct tcgtgagaat ttctgccgga atcctgatgg
     1081 ctccgaggcg ccttggtgct tcacatctcg acctggtttg cgcatggcct tctgccacca
     1141 gatcccacgc tgcactgaag aactggtgcc agagggatgc taccacggct caggtgaaca
     1201 gtatcgtggc tcagtcagca agacgcgcaa gggcgttcag tgccagcact ggtcctctga
     1261 gacaccgcac aagccacaat ttacacccac ctcggcaccg caggcgggac tggaggccaa
     1321 cttctgcagg aatcctgatg gggatagcca tgggccctgg tgctatacct tggacccgga
     1381 tatcctgttt gactactgtg ccctacagcg ctgtgatgat gaccagccac catccattct
     1441 ggacccccca gaccaggtgg tgtttgaaaa gtgtggcaag agagttgaca agagtaataa
     1501 acttcgtgtg gtgggaggcc atcctgggaa ctccccatgg acggtcagct tgcggaatcg
     1561 acagggccag catttctgtg ggggctccct agtgaaggag cagtgggtac tgactgcccg
     1621 gcaatgcatc tggtcatgcc acgaacctct cacaggatac gaggtatggt tgggtacaat
     1681 taaccagaac ccacagcctg gagaggcaaa cctgcagagg gtcccagtgg ccaaggcagt
     1741 gtgcggccct gcaggctccc agcttgttct gctcaagctg gagagacctg tgatcctgaa
     1801 ccatcacgtg gccctgattt gcctgcctcc tgaacagtat gtggtacctc cagggaccaa
     1861 gtgtgagatc gcaggctggg gtgaatccat cggtacaagc aataacacag tccttcatgt
     1921 ggcctcgatg aatgtcatct ccaaccagga atgtaacacg aagtaccgag gacacataca
     1981 agagagtgag atatgcaccc agggactggt ggtccctgtg ggggcttgtg agggtgacta
     2041 cgggggccca cttgcctgct atacccatga ctgctgggtc ctacagggac ttatcatccc
     2101 gaacagagtg tgtgcacggc cccgctggcc agctatcttc acacgggtgt ctgtgttcgt
     2161 ggactggatt aacaaggtca tgcagctgga gtaggcctgc ttttgagccc ttagagatgt
     2221 caagacttct caaacataaa gcggcctttt ctctctgtct gtatagagtg cttcttagtt
     2281 tctgtc
//
