LOCUS       NM_029104               1829 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus MSS51 mitochondrial translational activator (Mss51),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_029104 XM_127602 XM_907249
VERSION     NM_029104.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1829)
  AUTHORS   Mousa,M.G., Vuppaladhadiam,L., Kelly,M.O., Pietka,T., Ek,S.,
            Shen,K.C., Meyer,G.A., Finck,B.N. and Brookheart,R.T.
  TITLE     Site-1 protease inhibits mitochondrial respiration by controlling
            the TGF-beta target gene Mss51
  JOURNAL   Cell Rep 42 (4), 112336 (2023)
   PUBMED   37002920
  REMARK    GeneRIF: Site-1 protease inhibits mitochondrial respiration by
            controlling the TGF-beta target gene Mss51.
REFERENCE   2  (bases 1 to 1829)
  AUTHORS   Rovira Gonzalez,Y.I., Moyer,A.L., LeTexier,N.J., Bratti,A.D.,
            Feng,S., Pena,V., Sun,C., Pulcastro,H., Liu,T., Iyer,S.R.,
            Lovering,R.M., O'Rourke,B. and Wagner,K.R.
  TITLE     Mss51 deletion increases endurance and ameliorates histopathology
            in the mdx mouse model of Duchenne muscular dystrophy
  JOURNAL   FASEB J 35 (2), e21276 (2021)
   PUBMED   33423297
  REMARK    GeneRIF: Mss51 deletion increases endurance and ameliorates
            histopathology in the mdx mouse model of Duchenne muscular
            dystrophy.
REFERENCE   3  (bases 1 to 1829)
  AUTHORS   Yoshioka,K., Fujita,R., Seko,D., Suematsu,T., Miura,S. and Ono,Y.
  TITLE     Distinct Roles of Zmynd17 and PGC1alpha in Mitochondrial Quality
            Control and Biogenesis in Skeletal Muscle
  JOURNAL   Front Cell Dev Biol 7, 330 (2019)
   PUBMED   31921843
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1829)
  AUTHORS   Fujita,R., Yoshioka,K., Seko,D., Suematsu,T., Mitsuhashi,S.,
            Senoo,N., Miura,S., Nishino,I. and Ono,Y.
  TITLE     Zmynd17 controls muscle mitochondrial quality and whole-body
            metabolism
  JOURNAL   FASEB J 32 (9), 5012-5025 (2018)
   PUBMED   29913553
  REMARK    GeneRIF: indicate that Zmynd17 is a metabolic stress-inducible
            factor that maintains muscle mitochondrial integrity
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY341628.1, AK014794.1 and AC121801.2.
            
            On or before Jul 25, 2009 this sequence version replaced
            XM_907249.2, XM_127602.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119816.1, AK014794.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               BY341628.1         3-234
            233-1824            AK014794.1         14-1605
            1825-1829           AC121801.2         7315-7319
FEATURES             Location/Qualifiers
     source          1..1829
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.53 cM"
     gene            1..1829
                     /gene="Mss51"
                     /gene_synonym="4833444M15Rik; Zmynd17"
                     /note="MSS51 mitochondrial translational activator"
                     /db_xref="GeneID:74843"
                     /db_xref="MGI:MGI:1922093"
     exon            1..267
                     /gene="Mss51"
                     /gene_synonym="4833444M15Rik; Zmynd17"
                     /inference="alignment:Splign:2.1.0"
     exon            268..509
                     /gene="Mss51"
                     /gene_synonym="4833444M15Rik; Zmynd17"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1632
                     /gene="Mss51"
                     /gene_synonym="4833444M15Rik; Zmynd17"
                     /note="zinc finger MYND domain-containing protein 17; zinc
                     finger, MYND domain containing 17"
                     /codon_start=1
                     /product="putative protein MSS51 homolog, mitochondrial"
                     /protein_id="NP_083380.1"
                     /db_xref="CCDS:CCDS49414.1"
                     /db_xref="GeneID:74843"
                     /db_xref="MGI:MGI:1922093"
                     /translation="MAPRSRRRKHKKPPPVIPMIEIPPTEVSPVSPALSKPGPSIDAL
                     GFISLDNNVPGLSQLILQKLNMKNYEEYKLVINGGTPVSSFGFRCQQEMFQKMEDTFR
                     FCAYCKVLPHGLSNCKVLRHCKRCRNVYYCDTECQRSDWPAHRKVCRELRLVAVDRVM
                     EWLLVTGDFVLPSGPWPWLPEDIQNWDTWFSMRGLQLESTLNALLGSHSMTMLWASLG
                     RPRPDPDVLHGSLKRLMTDVLSRPLTLGLGLRTVAIDVGKTGGSTLHVVGASHVETFL
                     IRSGDYDELGYMFPEHLGFHVIMVGVDVATDLLQSSSSLSLEPGTIQLSGHRALYHDF
                     WEEQIETGILAHPDLVAAFHPGFHASPGLMEAWLPTLLLLRDYEIPTLITVYSQQELE
                     ASLQILVNLDTHIIACGANPFASLKPEQVYSNPNKQPVYSSAYYIMFLGSSPAN"
     exon            510..665
                     /gene="Mss51"
                     /gene_synonym="4833444M15Rik; Zmynd17"
                     /inference="alignment:Splign:2.1.0"
     exon            666..790
                     /gene="Mss51"
                     /gene_synonym="4833444M15Rik; Zmynd17"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1357
                     /gene="Mss51"
                     /gene_synonym="4833444M15Rik; Zmynd17"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1451
                     /gene="Mss51"
                     /gene_synonym="4833444M15Rik; Zmynd17"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1829
                     /gene="Mss51"
                     /gene_synonym="4833444M15Rik; Zmynd17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1807..1812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mss51"
                     /gene_synonym="4833444M15Rik; Zmynd17"
                     /note="hexamer: AATAAA"
     polyA_site      1826
                     /gene="Mss51"
                     /gene_synonym="4833444M15Rik; Zmynd17"
                     /note="major polyA site"
ORIGIN      
        1 gagtcttgag ccctcttggc agagaataag agtcagaaag agaactccag caggtgtcca
       61 ggtcctgact tgtctcgtta gggagaattc atccttgtct gtctggttgg cagggcacgt
      121 tagtcactga gacccagcat ttcagcagtt tgcagaaaaa gtgatgtgaa cagacagctg
      181 caagtgagac acagcctagg tctgaagaga tgaagcattt acttcacttg gaggaaagag
      241 aaggaaggaa gcctagggct taacaggcac tggtccccaa gttcattggt catggctcct
      301 cgttcacggc ggcgaaagca caagaaaccc ccaccagtga ttcccatgat tgaaatccca
      361 cccacagaag tgtctccagt atctccagcc ctctcaaaac ctggccctag cattgatgca
      421 cttggcttca tttccttgga caataatgta ccaggtctgt cccagttgat cctccaaaag
      481 ctgaacatga aaaactatga agaatacaag ttggtgataa atgggggaac cccagtatca
      541 agctttggat ttcgatgtca acaagaaatg ttccagaaga tggaggacac attcagattc
      601 tgtgcttatt gtaaagtgct ccctcatggc ctttccaatt gcaaggttct ccggcactgt
      661 aagaggtgca gaaatgtcta ttactgtgat acagagtgcc agaggtcaga ttggccagca
      721 cataggaagg tttgtcgaga gctccgtctt gtggctgtag atcgtgtcat ggaatggctt
      781 ctggtcacag gtgattttgt cctaccctca ggaccttggc catggctacc tgaagatata
      841 cagaattggg atacctggtt ttctatgagg ggtttacagc tagaatctac attgaatgct
      901 cttctgggta gtcactctat gaccatgctt tgggcaagtc taggaaggcc acggccagac
      961 ccagatgtct tgcatggctc tttgaagcgg ttgatgacag atgttctgtc acggcccttg
     1021 accctgggct tagggcttcg gactgtggca atagatgttg ggaagactgg aggaagcaca
     1081 ttgcatgtgg ttggtgcttc ccacgtagag acatttctta ttcgttctgg agattatgat
     1141 gagcttggct acatgtttcc tgaacacctt ggctttcatg tgatcatggt gggtgtggat
     1201 gtggctactg accttttaca gagttcttca tctttatcct tggagcctgg aacaattcag
     1261 cttagtggcc acagggccct gtatcatgac ttctgggagg agcaaataga gactgggatt
     1321 ctggcccatc cagatttggt ggctgcattc catccaggtt tccatgcctc cccaggcttg
     1381 atggaagctt ggttacccac cctgctgcta cttcgtgact atgagattcc aacattgatt
     1441 actgtttaca gccaacagga actggaagcc tctttgcaga ttctggtgaa cttggataca
     1501 cacatcattg cttgtggagc taatcctttc gcatccctca aaccagaaca agtctattct
     1561 aatcccaaca agcaaccagt atacagcagt gcctactaca tcatgtttct tggaagttcc
     1621 cctgccaatt agataagaag caacgagaag gaaaaaaaaa aaaaacaaaa ccagatgatt
     1681 tttcagtaat tgaaccaagt ctttactgaa tgcctggaaa atgaaagctt aatcaactta
     1741 ccctgttgat gtcagatttt tgccagcttt gaaccctgtg gtatgctaaa ccttattcac
     1801 agttcaaata aagatgttta aaccaatgg
//
