LOCUS       NM_177092               3711 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus methionine sulfoxide reductase B3 (Msrb3), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_177092
VERSION     NM_177092.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3711)
  AUTHORS   Dai,Y., Gao,M., Li,L., Mao,Z., Xu,L., Yin,L., Qi,Y. and Peng,J.
  TITLE     MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte
            Injury via Targeting Methionine Sulfoxide Reductase B3
  JOURNAL   Oxid Med Cell Longev 2020, 9481841 (2020)
   PUBMED   32908641
  REMARK    GeneRIF: MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal
            Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3711)
  AUTHORS   Lai,L., Sun,J., Tarafdar,S., Liu,C., Murphy,E., Kim,G. and
            Levine,R.L.
  TITLE     Loss of methionine sulfoxide reductases increases resistance to
            oxidative stress
  JOURNAL   Free Radic Biol Med 145, 374-384 (2019)
   PUBMED   31606431
  REMARK    Erratum:[Free Radic Biol Med. 2024 Aug 1;220:166. doi:
            10.1016/j.freeradbiomed.2024.05.002.. PMID: 38718559]
REFERENCE   3  (bases 1 to 3711)
  AUTHORS   Kwak,G.H., Kim,K.Y. and Kim,H.Y.
  TITLE     Methionine sulfoxide reductase B3 deficiency stimulates heme
            oxygenase-1 expression via ROS-dependent and Nrf2 activation
            pathways
  JOURNAL   Biochem Biophys Res Commun 473 (4), 1033-1038 (2016)
   PUBMED   27059143
REFERENCE   4  (bases 1 to 3711)
  AUTHORS   Kim,M.A., Cho,H.J., Bae,S.H., Lee,B., Oh,S.K., Kwon,T.J.,
            Ryoo,Z.Y., Kim,H.Y., Cho,J.H., Kim,U.K. and Lee,K.Y.
  TITLE     Methionine Sulfoxide Reductase B3-Targeted In Utero Gene Therapy
            Rescues Hearing Function in a Mouse Model of Congenital
            Sensorineural Hearing Loss
  JOURNAL   Antioxid Redox Signal 24 (11), 590-602 (2016)
   PUBMED   26649646
  REMARK    GeneRIF: results provide insight into the role of MsrB3 in hearing
            function and bring us one step closer to hearing restoration as a
            fundamental therapy
REFERENCE   5  (bases 1 to 3711)
  AUTHORS   Lee,E., Kwak,G.H., Kamble,K. and Kim,H.Y.
  TITLE     Methionine sulfoxide reductase B3 deficiency inhibits cell growth
            through the activation of p53-p21 and p27 pathways
  JOURNAL   Arch Biochem Biophys 547, 1-5 (2014)
   PUBMED   24583268
  REMARK    GeneRIF: MsrB3 deficiency activates the cell cycle inhibitors p21
            and p27.
REFERENCE   6  (bases 1 to 3711)
  AUTHORS   Kwon,T.J., Cho,H.J., Kim,U.K., Lee,E., Oh,S.K., Bok,J., Bae,Y.C.,
            Yi,J.K., Lee,J.W., Ryoo,Z.Y., Lee,S.H., Lee,K.Y. and Kim,H.Y.
  TITLE     Methionine sulfoxide reductase B3 deficiency causes hearing loss
            due to stereocilia degeneration and apoptotic cell death in
            cochlear hair cells
  JOURNAL   Hum Mol Genet 23 (6), 1591-1601 (2014)
   PUBMED   24191262
  REMARK    GeneRIF: data suggest that MsrB3 plays an essential role in
            maintaining the integrity of hair cells, possibly explaining the
            pathogenesis of DFNB74 deafness in humans caused by MSRB3
            deficiency.
REFERENCE   7  (bases 1 to 3711)
  AUTHORS   Kim,H.Y. and Gladyshev,V.N.
  TITLE     Characterization of mouse endoplasmic reticulum
            methionine-R-sulfoxide reductase
  JOURNAL   Biochem Biophys Res Commun 320 (4), 1277-1283 (2004)
   PUBMED   15249228
  REMARK    GeneRIF: data suggest that, in mice, MsrB3 is largely or
            exclusively an endoplasmic reticulum-resident protein, and that the
            reduction of methionine-R-sulfoxides in different cellular
            compartments is provided by individual MsrB isozymes. [MsrB3]
REFERENCE   8  (bases 1 to 3711)
  AUTHORS   Kim,H.Y. and Gladyshev,V.N.
  TITLE     Methionine sulfoxide reduction in mammals: characterization of
            methionine-R-sulfoxide reductases
  JOURNAL   Mol Biol Cell 15 (3), 1055-1064 (2004)
   PUBMED   14699060
REFERENCE   9  (bases 1 to 3711)
  AUTHORS   Tavtigian,S.V., Zabludoff,S.D. and Wold,B.J.
  TITLE     Cloning of mid-G1 serum response genes and identification of a
            subset regulated by conditional myc expression
  JOURNAL   Mol Biol Cell 5 (3), 375-388 (1994)
   PUBMED   8049528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138388.3.
            
            On May 13, 2022 this sequence version replaced NM_177092.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137163.1, SRR17253012.4946811.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC138388.3         140596-140736       c
            142-258             AC138388.3         112798-112914       c
            259-367             AC138388.3         93747-93855         c
            368-445             AC138388.3         91739-91816         c
            446-474             AC138388.3         66871-66899         c
            475-572             AC138388.3         33165-33262         c
            573-3711            AC138388.3         22863-26001         c
FEATURES             Location/Qualifiers
     source          1..3711
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 68.75 cM"
     gene            1..3711
                     /gene="Msrb3"
                     /gene_synonym="D430026P16Rik; I-8-23; MsrB2"
                     /note="methionine sulfoxide reductase B3"
                     /db_xref="GeneID:320183"
                     /db_xref="MGI:MGI:2443538"
     exon            1..141
                     /gene="Msrb3"
                     /gene_synonym="D430026P16Rik; I-8-23; MsrB2"
                     /inference="alignment:Splign:2.1.0"
     exon            142..258
                     /gene="Msrb3"
                     /gene_synonym="D430026P16Rik; I-8-23; MsrB2"
                     /inference="alignment:Splign:2.1.0"
     exon            259..367
                     /gene="Msrb3"
                     /gene_synonym="D430026P16Rik; I-8-23; MsrB2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..445
                     /gene="Msrb3"
                     /gene_synonym="D430026P16Rik; I-8-23; MsrB2"
                     /inference="alignment:Splign:2.1.0"
     exon            446..474
                     /gene="Msrb3"
                     /gene_synonym="D430026P16Rik; I-8-23; MsrB2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..572
                     /gene="Msrb3"
                     /gene_synonym="D430026P16Rik; I-8-23; MsrB2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..3711
                     /gene="Msrb3"
                     /gene_synonym="D430026P16Rik; I-8-23; MsrB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3691..3696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msrb3"
                     /gene_synonym="D430026P16Rik; I-8-23; MsrB2"
                     /note="hexamer: AATAAA"
     polyA_site      3711
                     /gene="Msrb3"
                     /gene_synonym="D430026P16Rik; I-8-23; MsrB2"
                     /note="major polyA site"
ORIGIN      
        1 ctgtcgcccg gagccgggag ggaggaggga tcggacagcg gaggctcgtc ttccccaaga
       61 gtgcgcggcg gaccctcccg tgcccaatcg cgctctgcct gggtctctgc ctagccgcgg
      121 ccgcggccac cacgacgcgc gcttctgccg ctgcctttgc ctctgctgga gataccacag
      181 ctatgtctgc cttcaacctg ctgcacttgg tgacgaagag ccagcccgtg gccccgagag
      241 cctgcgggct cccctcaggg tcatgtaggg ataaaaagaa ctgtaaggtg gtcttttccc
      301 agcaggaact gaggaagcgg ctgacacccc tacagtacca tgtcactcag gagaaaggaa
      361 ctgaaagtgc ctttgaagga gagtacacac atcacaaaga tcctggaata tataaatgtg
      421 ttgtctgtgg aactccgttg ttcaagtcag aaaccaaatt tgactctggt tcaggctggc
      481 ctgccttcca tgatgtgatc agttcggagg ccatcgagtt cacagatgac ttttcctacg
      541 ggatgcacag ggtggaaacc agctgttctc agtgtggtgc tcatctcggg cacatttttg
      601 acgatggacc tcgtccgacc ggcaaaagat actgcatcaa ctcagcatcc ttgtccttca
      661 ctcctgcaga cagcagtgag gcagaaggaa gcggcatcaa agagagcggc agcccagcag
      721 cagcagacag agctgagctg taaaatcagg ggtagcggtg aaaacaaagt gttcttaatg
      781 cacaactgat tgaaaaaaac caaaaagtgg tttatcttaa cagagctatt ttttcagaag
      841 ctataagggc agtttatgct gctgaaaatg tttctctctc tctctctctc tctctctctc
      901 tctttctctc tctctcgtct agatggcagt tctgcccatc catgtatttt gctgttgact
      961 aggtccagaa ctgtgtgtag ctcttgcaaa cggagatggc tttgtggagc ttcttggtaa
     1021 gcttctatgt agccttggca tcattttctt ccaatgcata ccttccttca agttttgtcc
     1081 ttgtaggtac cctccttttg attaagaggt ggaggttgtg tagtgacatc atagagctgg
     1141 tgctcagcag cagagaggag aactggcaag gacagagcat ctagacatgt ggcctttgcg
     1201 ataaagatgg agtgttgtgt tagattgcta ggctgcgata acgatggagc gctgcgttag
     1261 attgctaggc tgcacggaaa gtctgagcta aggttgtttt ttctcactcg aagggtgtga
     1321 aggtctgaag tcgttcctta tgttacattg ttgccagatg tgagaggact cagggaaggt
     1381 tgccgcagag atgcaaaaca ttacctctgg gcaggtcttt attttatatt ttccactgaa
     1441 aacagcagaa tgtaagacaa gtgtaaaata ctaggctcca tttttttttt ttttttgtcc
     1501 aaagttcaca aagaagaatg cttgcccatt gcctctgcat aagcctttct ctgcatgcct
     1561 catgtgaact ccatctggac gagcatttta gaagatttcc cccgtgcaaa ataaaatatt
     1621 agggacaaca cacttcatca gtaggaaaga gagagatcag agaagaccta gtatgaagtc
     1681 ttgagcacta aataatccca tgctgtgcaa aaaggccaac aggatctcac aggtactgca
     1741 cctaaaccag actttcacat agcatcagaa ggtcggagca aggatgtcgg ggattaagac
     1801 agaatagtca ggcccaaggt ccacacttca ctgtgtgtac aagggacaag ccatttagcc
     1861 ccattgtgcc tatatcttcg tgtacacaat aggactcata tctttataaa atatattgat
     1921 actctcaggg caacattact atattgctgt acaattaata agatcagtat tttaaaatca
     1981 cactgatccg gttgtaattg cacagagcag gccaaatttg caatggaaga agcagaggtg
     2041 cacttggctg gttggtatgg aaacagccga aagccagacc tttatcttgt agcaatatgg
     2101 caggtgtctc agtagtgagc gttgtggttt ttgaatgcta atcctgaaat gtggctttaa
     2161 aagacgctta gacttctaaa ttttttgagg aagactggca tctgcccctc gtactcagta
     2221 atgatgatga gaacaggcga gtgacagttg cagacacagt gggaagcaat aaaagccggg
     2281 gcaagcaagc tgagactacc catatccagc agctctgcct ttctcaggta cctcctgaag
     2341 gtcctgccat cctgccgagt cttcagtatc acccagttct agagacgtct gtgcttttaa
     2401 cttggaacac acaggaaaat tacctaagca ctggggtccc cccagctcca gatgtttacc
     2461 ccaagctcag ggctactctg cacaccccgg gcttcattct tctctagaaa catggggaga
     2521 gtcccgggtg aggcttccag acttccataa agttttcaca tcatctcgaa ggattccatg
     2581 tagggtggct aaggacagac gtgggtctca cgggatattg tcacagcttg gcatccatcc
     2641 ttcggagaca cacacagccc tttctgccca ctcccatctg tgtggtggcc ttcccagggt
     2701 cccttggata taagccagag tgttggagta gacaaagaag ataaataagg aggttctcac
     2761 tccacagaga tgctaggttg ttttactctt ccttcatttt tctcatacta tagtactaac
     2821 cacacacaca cacacacaca cacacacacc aataacgaaa attttgtttc cctttaactt
     2881 ttactgtttt gttttgtaac aaaagccatc tttttccagc accaacttat atatataatc
     2941 ctatatatat atatatatat atatatatat atataatcct atatatatat atgtgtgtat
     3001 atatatatat atatcatcca ttgaaataaa aaaaggaaaa agaaagaaaa tgagtacata
     3061 caatttaatt ccagatttct ttttgggggg cttaagtggc atcaaatttt ggtatatttc
     3121 tgtcttatgt taaagaaata tattgctaaa atgtcaggga gcgctaatgt cagctgtcaa
     3181 ggactagatt tactttcgca ggatatggag ctcagtgagc tgaggtggtg aggtgtatgt
     3241 gatctgtggg aattctgcca tttaacacag gaggttgcac ggtcttcctt gtcaacaccc
     3301 cagctctgac tgcaccgttg ggccatgcag agatgggcta gtaggcagga accacgtccc
     3361 tatgagtgca cagaacagat cggaaggaag cagcaacatc caatgtattt ctgagtattt
     3421 aaactcttca cttcttttat atatgtaaaa tcttaatgca aatgacgtag ctgttggaac
     3481 aaagactctc catgttgttt aaaatgtctt gctttcaata cagaaaaaaa taccaatgag
     3541 aattagtacc atgtgctggg ggtgtgtatg atgcttgatc tagaaagctt tttaataact
     3601 tttcttctga tagtttaaaa cttttgaaaa gtgacaagaa accttcattg agaagccttt
     3661 ttcgatattt gttgtataca gaaattcggt aataaagttt ctttataaaa a
//
