LOCUS       NM_029619               1204 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus methionine sulfoxide reductase B2 (Msrb2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_029619
VERSION     NM_029619.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1204)
  AUTHORS   Lai,L., Sun,J., Tarafdar,S., Liu,C., Murphy,E., Kim,G. and
            Levine,R.L.
  TITLE     Loss of methionine sulfoxide reductases increases resistance to
            oxidative stress
  JOURNAL   Free Radic Biol Med 145, 374-384 (2019)
   PUBMED   31606431
  REMARK    Erratum:[Free Radic Biol Med. 2024 Aug 1;220:166. doi:
            10.1016/j.freeradbiomed.2024.05.002.. PMID: 38718559]
REFERENCE   2  (bases 1 to 1204)
  AUTHORS   Lee,S.H., Lee,S., Du,J., Jain,K., Ding,M., Kadado,A.J., Atteya,G.,
            Jaji,Z., Tyagi,T., Kim,W.H., Herzog,R.I., Patel,A., Ionescu,C.N.,
            Martin,K.A. and Hwa,J.
  TITLE     Mitochondrial MsrB2 serves as a switch and transducer for mitophagy
  JOURNAL   EMBO Mol Med 11 (8), e10409 (2019)
   PUBMED   31282614
  REMARK    GeneRIF: Release of the enzyme MsrB2 from damaged mitochondria,
            initiating autophagosome formation, represents a novel regulatory
            mechanism for oxidative stress-induced mitophagy.
REFERENCE   3  (bases 1 to 1204)
  AUTHORS   Xiang,X.J., Song,L., Deng,X.J., Tang,Y., Min,Z., Luo,B., Wen,Q.X.,
            Li,K.Y., Chen,J., Ma,Y.L., Zhu,B.L., Yan,Z. and Chen,G.J.
  TITLE     Mitochondrial methionine sulfoxide reductase B2 links oxidative
            stress to Alzheimer's disease-like pathology
  JOURNAL   Exp Neurol 318, 145-156 (2019)
   PUBMED   31078523
  REMARK    GeneRIF: the role for mitochondrial MSRB2 in Alzheimer's disease
            pathology is indispensible.
REFERENCE   4  (bases 1 to 1204)
  AUTHORS   Kwon,T.J., Cho,H.J., Kim,U.K., Lee,E., Oh,S.K., Bok,J., Bae,Y.C.,
            Yi,J.K., Lee,J.W., Ryoo,Z.Y., Lee,S.H., Lee,K.Y. and Kim,H.Y.
  TITLE     Methionine sulfoxide reductase B3 deficiency causes hearing loss
            due to stereocilia degeneration and apoptotic cell death in
            cochlear hair cells
  JOURNAL   Hum Mol Genet 23 (6), 1591-1601 (2014)
   PUBMED   24191262
REFERENCE   5  (bases 1 to 1204)
  AUTHORS   Lee,B.C., Peterfi,Z., Hoffmann,F.W., Moore,R.E., Kaya,A.,
            Avanesov,A., Tarrago,L., Zhou,Y., Weerapana,E., Fomenko,D.E.,
            Hoffmann,P.R. and Gladyshev,V.N.
  TITLE     MsrB1 and MICALs regulate actin assembly and macrophage function
            via reversible stereoselective methionine oxidation
  JOURNAL   Mol Cell 51 (3), 397-404 (2013)
   PUBMED   23911929
REFERENCE   6  (bases 1 to 1204)
  AUTHORS   Kwak,G.H., Kim,J.R. and Kim,H.Y.
  TITLE     Expression, subcellular localization, and antioxidant role of
            mammalian methionine sulfoxide reductases in Saccharomyces
            cerevisiae
  JOURNAL   BMB Rep 42 (2), 113-118 (2009)
   PUBMED   19250613
  REMARK    GeneRIF: Results show that mammalian MsrB and MsrA proteins perform
            crucial functions in protection against oxidative stress in lower
            eukaryotic yeast cells.
REFERENCE   7  (bases 1 to 1204)
  AUTHORS   Le,D.T., Liang,X., Fomenko,D.E., Raza,A.S., Chong,C.K.,
            Carlson,B.A., Hatfield,D.L. and Gladyshev,V.N.
  TITLE     Analysis of methionine/selenomethionine oxidation and methionine
            sulfoxide reductase function using methionine-rich proteins and
            antibodies against their oxidized forms
  JOURNAL   Biochemistry 47 (25), 6685-6694 (2008)
   PUBMED   18505275
  REMARK    GeneRIF: Studies show all Met sulfoxide residues in an MRP can be
            reduced by MsrA and MsrB.
REFERENCE   8  (bases 1 to 1204)
  AUTHORS   Kim,H.Y. and Gladyshev,V.N.
  TITLE     Different catalytic mechanisms in mammalian selenocysteine- and
            cysteine-containing methionine-R-sulfoxide reductases
  JOURNAL   PLoS Biol 3 (12), e375 (2005)
   PUBMED   16262444
REFERENCE   9  (bases 1 to 1204)
  AUTHORS   Kim,H.Y. and Gladyshev,V.N.
  TITLE     Characterization of mouse endoplasmic reticulum
            methionine-R-sulfoxide reductase
  JOURNAL   Biochem Biophys Res Commun 320 (4), 1277-1283 (2004)
   PUBMED   15249228
REFERENCE   10 (bases 1 to 1204)
  AUTHORS   Kim,H.Y. and Gladyshev,V.N.
  TITLE     Methionine sulfoxide reduction in mammals: characterization of
            methionine-R-sulfoxide reductases
  JOURNAL   Mol Biol Cell 15 (3), 1055-1064 (2004)
   PUBMED   14699060
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC021619.1.
            
            On Jan 15, 2003 this sequence version replaced NM_029619.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021619.1, AK009912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1204
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 13.26 cM"
     gene            1..1204
                     /gene="Msrb2"
                     /gene_synonym="2310050L06Rik; Mrsb; Msrb; Pilb"
                     /note="methionine sulfoxide reductase B2"
                     /db_xref="GeneID:76467"
                     /db_xref="MGI:MGI:1923717"
     exon            1..144
                     /gene="Msrb2"
                     /gene_synonym="2310050L06Rik; Mrsb; Msrb; Pilb"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..575
                     /gene="Msrb2"
                     /gene_synonym="2310050L06Rik; Mrsb; Msrb; Pilb"
                     /EC_number="1.8.4.12"
                     /EC_number="1.8.4.14"
                     /note="pilin-like transcription factor;
                     methionine-R-sulfoxide reductase B2, mitochondrial"
                     /codon_start=1
                     /product="methionine-R-sulfoxide reductase B2,
                     mitochondrial precursor"
                     /protein_id="NP_083895.1"
                     /db_xref="CCDS:CCDS15714.1"
                     /db_xref="GeneID:76467"
                     /db_xref="MGI:MGI:1923717"
                     /translation="MARLLRALRGLPLLQAPGRLARGCAGSGSKDTGSLTKSKRSLSE
                     ADWQKKLTPEQFYVTREKGTEAPFSGMYLNNKETGMYHCVCCDSPLFSSEKKYCSGTG
                     WPSFSEAYGSKGSDESHTGILRRLDTSLGCPRMEVVCKQCEAHLGHVFPDGPKPTGQR
                     FCINSVALKFKPSKP"
     exon            145..245
                     /gene="Msrb2"
                     /gene_synonym="2310050L06Rik; Mrsb; Msrb; Pilb"
                     /inference="alignment:Splign:2.1.0"
     exon            246..322
                     /gene="Msrb2"
                     /gene_synonym="2310050L06Rik; Mrsb; Msrb; Pilb"
                     /inference="alignment:Splign:2.1.0"
     exon            323..470
                     /gene="Msrb2"
                     /gene_synonym="2310050L06Rik; Mrsb; Msrb; Pilb"
                     /inference="alignment:Splign:2.1.0"
     exon            471..1190
                     /gene="Msrb2"
                     /gene_synonym="2310050L06Rik; Mrsb; Msrb; Pilb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgggggtt gggtaggctt gggaggaaac ccgttggtgg cagcgtcatg gcgcgactgc
       61 tgcgagcgct gcggggtctg cctttgctgc aggcgcctgg acggctggct cggggttgcg
      121 cgggatcggg aagcaaggac acagggtctc ttacaaagtc caagcgctct ctaagcgaag
      181 cagactggca gaagaaactg accccggaac agttctatgt caccagagag aaaggaactg
      241 aagcgccttt cagtggaatg tatttgaaca acaaggagac agggatgtac cattgtgtgt
      301 gctgtgatag cccactcttc agttctgaga agaagtactg ttctggcacc ggctggcctt
      361 cattttctga ggcttacggc tcaaaaggct cagatgaaag tcacacaggg atcctgagac
      421 gactggacac ttccttagga tgtcctcgca tggaggtggt ctgcaagcag tgtgaagctc
      481 accttggcca tgtgtttcct gatggaccca agcccactgg ccaaaggttt tgcatcaaca
      541 gtgtggccct gaagttcaaa cccagcaagc cctgactgtt tgcaggaggc ctgtgttttg
      601 cccttccttg tggagccttg gttctgtaac tcggatggat gccttgcttt atgtactgaa
      661 ggcttaggtg aaggttgtta ctggccacag gggaatcaca gcttcttagt cacctgaaag
      721 caactcaacc tgacttccgc ttgggccatg ggatttcaat tggctgccaa ggcttcgggt
      781 gagaccacag ggtgggacct aggcaggatt tccacaggtt cgtggactga cgagggtccc
      841 taaagcctct gaagggaacc tgagttgccc atctccattc atttcttcat ggatgtacac
      901 agatgagggc tcagggggaa gagaaaagag atgggctgga acagatgaga gatgagagat
      961 cccagtgttg aagaggagga caaagtagcc gagcatggga cacacatacc catgatgata
     1021 taatggatga aacttgtggc ttcttatcca aaactccact gactcagcct tacaacacac
     1081 agctgggatc catgtgaatt gagtgaattt tagcgactac gacaatgctc tccttctttt
     1141 ctttgttaca gcactaaact tcaaatatta aaataaaata ttgagatcaa aaaaaaaaaa
     1201 aaaa
//
