LOCUS       NM_001253712            1481 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus methionine sulfoxide reductase A (Msra), transcript
            variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001253712
VERSION     NM_001253712.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1481)
  AUTHORS   Thyne,K.M. and Salmon,A.B.
  TITLE     Sexually dimorphic effects of methionine sulfoxide reductase A
            (MsrA) on murine longevity and health span during methionine
            restriction
  JOURNAL   Geroscience 45 (5), 3003-3017 (2023)
   PUBMED   37391679
  REMARK    GeneRIF: Sexually dimorphic effects of methionine sulfoxide
            reductase A (MsrA) on murine longevity and health span during
            methionine restriction.
REFERENCE   2  (bases 1 to 1481)
  AUTHORS   Mazzoni,F., Dun,Y., Vargas,J.A., Nandrot,E.F. and Finnemann,S.C.
  TITLE     Lack of the antioxidant enzyme methionine sulfoxide reductase A in
            mice impairs RPE phagocytosis and causes photoreceptor cone
            dysfunction
  JOURNAL   Redox Biol 42, 101918 (2021)
   PUBMED   33674251
REFERENCE   3  (bases 1 to 1481)
  AUTHORS   Fan,H., Li,D., Guan,X., Yang,Y., Yan,J., Shi,J., Ma,R. and Shu,Q.
  TITLE     MsrA Suppresses Inflammatory Activation of Microglia and Oxidative
            Stress to Prevent Demyelination via Inhibition of the
            NOX2-MAPKs/NF-kappaB Signaling Pathway
  JOURNAL   Drug Des Devel Ther 14, 1377-1389 (2020)
   PUBMED   32308370
  REMARK    GeneRIF: MsrA Suppresses Inflammatory Activation of Microglia and
            Oxidative Stress to Prevent Demyelination via Inhibition of the
            NOX2-MAPKs/NF-kappaB Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1481)
  AUTHORS   Lai,L., Sun,J., Tarafdar,S., Liu,C., Murphy,E., Kim,G. and
            Levine,R.L.
  TITLE     Loss of methionine sulfoxide reductases increases resistance to
            oxidative stress
  JOURNAL   Free Radic Biol Med 145, 374-384 (2019)
   PUBMED   31606431
  REMARK    Erratum:[Free Radic Biol Med. 2024 Aug 1;220:166. doi:
            10.1016/j.freeradbiomed.2024.05.002. PMID: 38718559]
REFERENCE   5  (bases 1 to 1481)
  AUTHORS   Tarafdar,S., Kim,G. and Levine,R.L.
  TITLE     Drosophila methionine sulfoxide reductase A (MSRA) lacks methionine
            oxidase activity
  JOURNAL   Free Radic Biol Med 131, 154-161 (2019)
   PUBMED   30529269
REFERENCE   6  (bases 1 to 1481)
  AUTHORS   Kim,H.Y. and Gladyshev,V.N.
  TITLE     Role of structural and functional elements of mouse
            methionine-S-sulfoxide reductase in its subcellular distribution
  JOURNAL   Biochemistry 44 (22), 8059-8067 (2005)
   PUBMED   15924425
  REMARK    GeneRIF: Proper structure-function organization of MsrA plays a
            role in subcellular distribution of this protein in mouse cells.
REFERENCE   7  (bases 1 to 1481)
  AUTHORS   Moskovitz,J. and Stadtman,E.R.
  TITLE     Selenium-deficient diet enhances protein oxidation and affects
            methionine sulfoxide reductase (MsrB) protein level in certain
            mouse tissues
  JOURNAL   Proc Natl Acad Sci U S A 100 (13), 7486-7490 (2003)
   PUBMED   12792026
  REMARK    GeneRIF: msra expression is regulated by (dietary)selenium
REFERENCE   8  (bases 1 to 1481)
  AUTHORS   Moskovitz,J., Bar-Noy,S., Williams,W.M., Requena,J., Berlett,B.S.
            and Stadtman,E.R.
  TITLE     Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant
            defense and lifespan in mammals
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 12920-12925 (2001)
   PUBMED   11606777
REFERENCE   9  (bases 1 to 1481)
  AUTHORS   Bilsborough,J., Van Pel,A., Uyttenhove,C., Boon,T. and Van den
            Eynde,B.J.
  TITLE     Identification of a second major tumor-specific antigen recognized
            by CTLs on mouse mastocytoma P815
  JOURNAL   J Immunol 162 (6), 3534-3540 (1999)
   PUBMED   10092811
REFERENCE   10 (bases 1 to 1481)
  AUTHORS   Moskovitz,J., Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Jursky,F.,
            Weissbach,H. and Brot,N.
  TITLE     Chromosomal localization of the mammalian peptide-methionine
            sulfoxide reductase gene and its differential expression in various
            tissues
  JOURNAL   Proc Natl Acad Sci U S A 93 (8), 3205-3208 (1996)
   PUBMED   8622914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049714.1 and CX200370.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049714.1, AK002356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1457              AK049714.1         2-1458
            1458-1481           CX200370.1         259-282
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.36 cM"
     gene            1..1481
                     /gene="Msra"
                     /gene_synonym="2310045J23Rik; 6530413P12Rik; MSR-A"
                     /note="methionine sulfoxide reductase A"
                     /db_xref="GeneID:110265"
                     /db_xref="MGI:MGI:106916"
     exon            1..331
                     /gene="Msra"
                     /gene_synonym="2310045J23Rik; 6530413P12Rik; MSR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            332..400
                     /gene="Msra"
                     /gene_synonym="2310045J23Rik; 6530413P12Rik; MSR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            401..520
                     /gene="Msra"
                     /gene_synonym="2310045J23Rik; 6530413P12Rik; MSR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            521..625
                     /gene="Msra"
                     /gene_synonym="2310045J23Rik; 6530413P12Rik; MSR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            626..732
                     /gene="Msra"
                     /gene_synonym="2310045J23Rik; 6530413P12Rik; MSR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            733..1465
                     /gene="Msra"
                     /gene_synonym="2310045J23Rik; 6530413P12Rik; MSR-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1437..1442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msra"
                     /gene_synonym="2310045J23Rik; 6530413P12Rik; MSR-A"
                     /note="hexamer: AATAAA"
     polyA_site      1461
                     /gene="Msra"
                     /gene_synonym="2310045J23Rik; 6530413P12Rik; MSR-A"
                     /note="major polyA site"
ORIGIN      
        1 actttgtggt tgagtgagta catcgcaccc ggaaccctgg ctgcggaggt ggagaaacgg
       61 cagcaactct gacctcccgc ggtggcgccc agccagcatc aattttggcc cgcgcggctt
      121 cacgtactct gggaactttg tccctcagag acagccaggc ctggaggtct gccccgcgag
      181 acggacacgc cgcccatgct ctccgcctct agaagggctc tccagctcct ctctagcgcc
      241 aacccggtac ggaggatggg cgactcagct tcgaaagtca tctccgcaga ggaagccttg
      301 ccgggacgca ccgagccgat ccctgtaaca gccaaacacc atgtcagtgg caacagaacg
      361 gttgaacctt tcccagaggg aacacagatg gctgtatttg gaatgggctg cttctgggga
      421 gctgagcgca agttctgggt cttgaaagga gtgtactcaa cccaagtggg ctttgcagga
      481 ggccacacac gcaatcccac ctacaaagag gtctgctcag aaaaaactgg ccacgccgaa
      541 gtcgtccggg ttgtgtaccg gccagagcac atcagctttg aggaactgct caaggtcttc
      601 tgggagaatc acgacccgac ccaaggcatg cgccaaggca atgactttgg tacacagtac
      661 cggtcagcag tctatcccac atccgccgtg cagatggaag cagccctgag atccaaggaa
      721 gaataccaaa aggttctttc aaagcataac tttggcccca tcaccaccga catccgagag
      781 ggacaagtgt tctactatgc cgaagactac caccagcaat acctgagcaa gaacccagac
      841 ggctactgtg gcctcggggg tactggagtt tcctgcccga tggccattaa aaaataattt
      901 ctctccacga agctgtccct gaaggttcca tcaacaccat gattgctgga tggagtggca
      961 ctgctgtgat tcacatctgt cactttatgc aaagcacaca caccacacgg acctttacat
     1021 gaatctggtt gttattgggg tttgatttcc agagagtagc atgacaaggt gatacactgt
     1081 aatctgcctt ctgatcagtc cgggtgggga caaatcatga cattttagtg gattgtttgg
     1141 atctgctcag actggaagga tgctgagggt tctgaagcag ggggatggcc aggagagcac
     1201 agggtactgg gaccccttgg tctgtgctga catacctcac ccacttccct gccctcgggt
     1261 gcccaattca ttagtgtcta cagatcccat gaatcatttg ccaaatcgct ttgctctgct
     1321 ggctctagat gtgtactagg ggtttctctc cccctccatc ctctctgcag agaaaagaca
     1381 ggagtgacct taatgaattc taacattctg cttacagcta tgataaagct tgttctaata
     1441 aaaatctgca gtttggtaat agcaaaaaaa aaaaaaaaaa a
//
