LOCUS       NM_001113326            5735 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus macrophage scavenger receptor 1 (Msr1), transcript
            variant 2, mRNA.
ACCESSION   NM_001113326
VERSION     NM_001113326.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5735)
  AUTHORS   Wei,C., Wang,T., Shi,R., Yu,X., Jiang,J., Chen,Y., Cao,M. and
            Chen,X.
  TITLE     Macrophage Scavenger Receptor 1 attenuates ischemic white matter
            injury via HRH1-mediated microglial phagocytosis
  JOURNAL   Neurosci Lett 841, 137952 (2024)
   PUBMED   39214333
REFERENCE   2  (bases 1 to 5735)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   3  (bases 1 to 5735)
  AUTHORS   Zhang,H., Wu,D., Wang,Y., Shi,Y., Shao,Y., Zeng,F., Spencer,C.B.,
            Ortoga,L., Wu,D. and Miao,C.
  TITLE     Ferritin-mediated neutrophil extracellular traps formation and
            cytokine storm via macrophage scavenger receptor in
            sepsis-associated lung injury
  JOURNAL   Cell Commun Signal 22 (1), 97 (2024)
   PUBMED   38308264
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5735)
  AUTHORS   Huang,J., Jiang,Y., Ji,R., Jia,Y., Wang,S., Zhou,Z., Wang,S.,
            Wang,J., Yang,Q., Bai,H., Zhu,X., Jiang,B., Ben,J., Zhang,H., Li,X.
            and Chen,Q.
  TITLE     Macrophage scavenger receptor A1 antagonizes abdominal aortic
            aneurysm via upregulating IRG1
  JOURNAL   Biochem Pharmacol 213, 115631 (2023)
   PUBMED   37257722
  REMARK    GeneRIF: Macrophage scavenger receptor A1 antagonizes abdominal
            aortic aneurysm via upregulating IRG1.
REFERENCE   5  (bases 1 to 5735)
  AUTHORS   Nance,S.A., Muir,L., Delproprosto,J. and Lumeng,C.N.
  TITLE     MSR1 is not required for obesity-associated inflammation and
            insulin resistance in mice
  JOURNAL   Sci Rep 13 (1), 2651 (2023)
   PUBMED   36788340
  REMARK    GeneRIF: MSR1 is not required for obesity-associated inflammation
            and insulin resistance in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5735)
  AUTHORS   Cross,J.C., Flannery,M.L., Blanar,M.A., Steingrimsson,E.,
            Jenkins,N.A., Copeland,N.G., Rutter,W.J. and Werb,Z.
  TITLE     Hxt encodes a basic helix-loop-helix transcription factor that
            regulates trophoblast cell development
  JOURNAL   Development 121 (8), 2513-2523 (1995)
   PUBMED   7671815
REFERENCE   7  (bases 1 to 5735)
  AUTHORS   Aftring,R.P. and Freeman,M.W.
  TITLE     Structure of the murine macrophage scavenger receptor gene and
            evaluation of sequences that regulate expression in the macrophage
            cell line, P388D
  JOURNAL   J Lipid Res 36 (6), 1305-1314 (1995)
   PUBMED   7666008
REFERENCE   8  (bases 1 to 5735)
  AUTHORS   Elomaa,O., Kangas,M., Sahlberg,C., Tuukkanen,J., Sormunen,R.,
            Liakka,A., Thesleff,I., Kraal,G. and Tryggvason,K.
  TITLE     Cloning of a novel bacteria-binding receptor structurally related
            to scavenger receptors and expressed in a subset of macrophages
  JOURNAL   Cell 80 (4), 603-609 (1995)
   PUBMED   7867067
REFERENCE   9  (bases 1 to 5735)
  AUTHORS   Hughes,D.A., Fraser,I.P. and Gordon,S.
  TITLE     Murine macrophage scavenger receptor: in vivo expression and
            function as receptor for macrophage adhesion in lymphoid and
            non-lymphoid organs
  JOURNAL   Eur J Immunol 25 (2), 466-473 (1995)
   PUBMED   7875210
REFERENCE   10 (bases 1 to 5735)
  AUTHORS   Freeman,M., Ashkenas,J., Rees,D.J., Kingsley,D.M., Copeland,N.G.,
            Jenkins,N.A. and Krieger,M.
  TITLE     An ancient, highly conserved family of cysteine-rich protein
            domains revealed by cloning type I and type II murine macrophage
            scavenger receptors
  JOURNAL   Proc Natl Acad Sci U S A 87 (22), 8810-8814 (1990)
   PUBMED   1978939
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111028.10.
            
            On Sep 1, 2022 this sequence version replaced NM_001113326.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF203781.1, L04274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC111028.10        100032-100094
            64-169              AC111028.10        109878-109983
            170-283             AC111028.10        111309-111422
            284-693             AC111028.10        118368-118777
            694-880             AC111028.10        122639-122825
            881-961             AC111028.10        126881-126961
            962-1051            AC111028.10        130982-131071
            1052-1105           AC111028.10        134565-134618
            1106-1294           AC111028.10        153225-153413
            1295-5735           AC111028.10        160838-165278
FEATURES             Location/Qualifiers
     source          1..5735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     gene            1..5735
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /note="macrophage scavenger receptor 1"
                     /db_xref="GeneID:20288"
                     /db_xref="MGI:MGI:98257"
     exon            1..63
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /inference="alignment:Splign:2.1.0"
     exon            64..169
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /inference="alignment:Splign:2.1.0"
     exon            170..283
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /inference="alignment:Splign:2.1.0"
     exon            284..693
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /inference="alignment:Splign:2.1.0"
     exon            694..880
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /inference="alignment:Splign:2.1.0"
     exon            881..961
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1051
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1105
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1294
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..5735
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1475
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /note="major polyA site"
     regulatory      4877..4882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /note="hexamer: AATAAA"
     polyA_site      4895
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
     regulatory      5719..5724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
                     /note="hexamer: AATAAA"
     polyA_site      5735
                     /gene="Msr1"
                     /gene_synonym="MRS-A; MSR; MSR-A; Scara1; Scvr; SR-A;
                     SR-AI; SR-AII"
ORIGIN      
        1 aattgtaaag agagggaagt ggataaatca gtgctgtctt ctttaccagc aatgacaaaa
       61 gagatgacag agaatcagag gctctgccct catgaacaag aggatgctga ctgcagttca
      121 gaatccgtga aatttgacgc acgttcaatg acagcatccc ttcctcacag cactaaaaat
      181 ggcccctccc ttcaggagaa gttgaagtcc ttcaaggctg ccctcattgc tctctacctc
      241 cttgtgtttg cagtactaat acctgttgtt ggaatagtaa cagctcagct tttgaattgg
      301 gaaatgaaga actgcttagt ttgttcactt aacacaagtg acacatctca aggtcctatg
      361 gaaaaagaaa ataccagtaa agtggaaatg agatttacaa ttatcatgga acacatgaag
      421 gacatggagg agagaatcga aagcatttca aactcaaaag ccgaccttat agacacggaa
      481 cgcttccaga atttcagcat ggcaactgac caaagactta atgatattct tctgcagtta
      541 aattccttga tttcgtcagt ccaggaacat gggaattcac tggatgcaat ctccaagtcc
      601 ttgcagagtc tgaatatgac actgcttgat gttcaactcc atacagaaac actgaatgtc
      661 agagtccgtg aatctacagc aaagcaacag gaggacatca gtaaattgga ggaacgtgtg
      721 tacaaagtat cagcagaagt ccagtctgtg aaagaagaac aagcgcacgt ggaacaggaa
      781 gtaaaacagg aagtgagagt attgaacaac atcaccaacg acctcagact gaaggactgg
      841 gaacactcac agacactgaa aaacatcacc ttcattcaag ggcctcctgg accccaaggt
      901 gaaaagggag acagagggct tactggacaa actggtccac ctggtgctcc aggaataaga
      961 ggtattccag gtgttaaagg tgatcgggga caaattggct tccctggagg tcgaggaaac
     1021 ccaggagcac caggaaagcc agggaggtcg ggatctcctg gacctaaagg acaaaaggga
     1081 gagaagggga gtgtaggcgg atcaaccccc cttaagacag ttcgactggt tggtggtagt
     1141 ggagcccatg agggccgagt ggagatcttc caccaaggcc agtggggcac aatctgtgat
     1201 gatcgctggg atatacgggc tggacaagtt gtctgccgga gtctaggata ccaagaagtt
     1261 ctagctgtgc acaagagagc tcactttgga caaggtactg gtccaatatg gctgaatgaa
     1321 gtgatgtgtt ttggaagaga atcatctatt gagaactgta aaatcaacca gtggggagta
     1381 ctaagctgtt cacattcaga agatgctggg gtcacttgta cttcataatg tatcatattt
     1441 tcaatggcat ttatgaaatt gcaattatga aaccattttt gttgccctgc tccactaaaa
     1501 tcattttaat gaatagtaaa tggattcaca atattggata aaagaaaggg aatattagaa
     1561 atgagtggga ataagtctta aacacatcaa actttatgtc aatagataag ggattcaaat
     1621 ttcttgcaaa gttaatgtag attgtcaaat tgacataatt ttcaaatgcc caggaagaca
     1681 aaaatatgtt tatttatatg agggcatttc cagcgaggtt tattcaaagg tagcatcatt
     1741 ctatgggcac aggatgcaga cagaaataaa aggataaaga gagtgtggca ccatcattaa
     1801 tccctctctg cttcctgact gtgaacacaa tgtcattatc tatatcatgc ttctgtcacc
     1861 aagatggacc actcaaatcc acgaatcaaa ataagttctg tcttctcaag tttcatttag
     1921 ggcaatgagg gaaaaagcta acagaaaaaa aatgttttgt tttattttgt tttgttttac
     1981 cagaagtgag gttgtaacta tcataaactt gaggacaatt tgttaaattg ttgaattaat
     2041 ttgcgaagag tagagaaaaa aatcagagcc atagactata ggtgatctaa aatggtatca
     2101 gcagaactta ataggatatt ctgatagaaa tttgaatttt tagattggca aataaataga
     2161 aaaatggata aacaaataaa atgaaaacac taaagctcag tttccagagg cttcaggatg
     2221 aaataagaat tgtatcaaga attaaaaaaa ggtattcacg tcacatgctg gcaatgactc
     2281 tgacttcatt ctactcatat cctgagactt ggagtaagac catgagataa gcttctttaa
     2341 tgttaaaact tcaagatata atagaatcgg gctgtagcat tgctacaagt ctctgttctt
     2401 actcatatat gcagtggcaa agagcagcaa gagaggagga agatatatta actctgctgt
     2461 tttaggaaga aataagcaag gctggtttaa agttgctgac aaagagaaca aagttatgat
     2521 tgttaaagag gttagaaaaa ttaatgagaa acctcaccct ttgcagaaga aaattataat
     2581 gggccttggt ggcaaaacca ttgaaaggct ccaatgtata caaaatgcaa atttatttga
     2641 aaggataaaa gttaaactgg aaattctgtt caagggttct ctgctaaaaa gaaattgccc
     2701 agagaagtat ttgtcctaga atcagccacc aatgtccaga gacacctttg tagctgtgct
     2761 agaaaaatcc ccaactctat ttcaagatag tagcagaact tacaaaccta atccacatgg
     2821 tataaaataa aagagggatt gattcacaaa gatttacaat agatgccaga aagatactga
     2881 ggtcagaaaa tgtgtttcag agtcagtttc cccataaaga attccctaga ggacactgta
     2941 tgaagctata aaggtgaacc taagttgaag tagggctgca ggaaccagaa atatcccgtg
     3001 agacaagttt catgtagaga gtggaacttg ttcaagaaga agttgaagtg ttctgagata
     3061 gcagaaatag attttccagg tgtcagagta ttgtagaagt tcaaaggatt ccttcaggaa
     3121 cccatgtgcc caacaccaga ttatatgatt tcggtatttc tctaattgtt ctttcctcac
     3181 tatgattcat tttgttgttt ttggactggg gatgttcatt ctgtaggact atgtactgta
     3241 agtatgcaac atgtaggttt taaaaataga cattcacagt taagagactg tctgattctc
     3301 agaaggggtt ctgaacttct attttgaaca attttgaaat tcttatgact ttagtgaatc
     3361 tctgaagaca cactaaatgt attttacact atgagattaa tgtgagactt tagggaccag
     3421 gggtggaacg ttgtaattta aatgatgtgt ttggatgtta atttgacaag actggatatg
     3481 tgatggttaa cattactcgt aaagttattg ggatttagaa aatccagcat atacactgct
     3541 agccatctct tgagaacatt tccaaagaga attaactgag aagggaagac ctgaatttgg
     3601 tgactccatc ttactatttg gagtttcagc accaaatgaa aatagaaaag aaggtagaga
     3661 acagatgttc atttctttgt ttcctgatgt tacccatggg ctcatgatcc tgtcatcttg
     3721 cctccttgca gtgatggact ataccccaat cacttgccag aagaaatcca ccattcctta
     3781 agttgatctt atcaattgtc ttgtacaaca atgagaaaag taaggaagac actttctgag
     3841 cttttaagtg gaaaatttaa aataatgatg cattaagtga atacttttaa atatgaaatt
     3901 tctacaaatg agaagagagt agagaagata gaagtcctct catactagga acacaggaag
     3961 agttttttgg attttgaaac ttagatacaa tagatagaat agagacttgc agaactgtgt
     4021 gtatgtgctg ggctgggttc tcttcagctt accttttaaa gtaggatgac atttaagact
     4081 tcactgctaa actttgcttt atgagggcaa tactatgcag agattgaatc atatattctc
     4141 agattttaaa tgagtattat aaagcataaa actattgtat tgctatgtga tttctttttt
     4201 tctacaaaaa tgtcagatac caaaaataca aggggcatta ttgtattcag tttcaaaact
     4261 gtagaagcaa atgtgactct taaagttcaa tgatgttccc tgaatcaaac aaaaatatat
     4321 gagaaataca tagtggaata attttaggta ataaagagac tgaaatatag tggtaaccat
     4381 ctatgaggaa tctctccagt gccatacaac ttcaagcaaa cttcctggaa aatatttctt
     4441 ctgttaatca caaaaaagtc tttgatgctt cattttttaa aacagatggt taatattaat
     4501 gatgttgttg tatttgtttc cttaaatagc aaaataacca ttcccactgt gaaaatataa
     4561 tgctagaatg aagagagaac atccctatta atctggataa atagtgacta ggaatttcaa
     4621 gtatttctct gacacttggc atgccataaa tcccagttgg ctgctagagt gattagatag
     4681 aagtggtagt ttgggaaggt taatgaaaaa aagaagaatg aaggagtgaa gagaaggagg
     4741 gaaagtgaat gagagaatat gaagtaaatt tcaagaaata acatatttgc taatcatcac
     4801 cgttacatgt taaacatttt gagtaagtca gtttggtata ccttgaagtg gcttatgata
     4861 gacatgggta tgaggcaata aatcaattga agaagtccct gtgtgccatt agtgatatta
     4921 ggtgattatt tctaccttac tactcaaatt ctattttgtg tgtatttgta tgtataatgt
     4981 gtatgcacat ttgtgcattt gtgtaattgt gaatgaatgt gtatgcatgt atgtgcgtgt
     5041 gtgcatttat atgtatgtgc aatcatgtat atatacatgt gtgtatgtgt gcatgtgtgt
     5101 atgtgtgttc atgaacatgt atacacatgt gtgtatacat gtacatgcat gttttgtgag
     5161 catctttgtg tatgtatatg tgtgtacatg tgaggaagcc aaaggctgat agtgactttt
     5221 caatcactat gcaccttact ttttgagaca ggatctctta atgaacctgg acattactga
     5281 ttcaggtaga ctatctggcc aacaagccct aagaattcac ccaatgtgga gtgtgaagaa
     5341 tgtatgattt tgtgggtgtg catgcatgtg tcaacagttg ggtgtcttcc tcatttcttc
     5401 ttcatataaa attcatttat gtgccatgta tgcatgaaac ctggagatga aacctgtgat
     5461 tctggtttgt tttgttttgt tttgttttgt tttttatcaa aatgttcaga cgagggtatt
     5521 tgacattgca agacagtcaa cctataatgc ttatccttat atcatgggaa atagaactat
     5581 tctatgtgac ctggttaatt caggctgagt ctctaagtgg ccaaggtgga catgaatcat
     5641 ggacagggca aaaactactt gtttgcaaac ccttcaaatc attgctttcc ctccctcatt
     5701 tgatgtccat aaaatgataa taaagagttt tcttt
//
