LOCUS       NM_010833               3840 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus moesin (Msn), mRNA.
ACCESSION   NM_010833
VERSION     NM_010833.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3840)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3840)
  AUTHORS   Bondarenko,V., Nikolaev,M., Kromm,D., Belousov,R., Wolny,A.,
            Blotenburg,M., Zeller,P., Rezakhani,S., Hugger,J., Uhlmann,V.,
            Hufnagel,L., Kreshuk,A., Ellenberg,J., van Oudenaarden,A.,
            Erzberger,A., Lutolf,M.P. and Hiiragi,T.
  TITLE     Embryo-uterine interaction coordinates mouse embryogenesis during
            implantation
  JOURNAL   EMBO J 42 (17), e113280 (2023)
   PUBMED   37522872
REFERENCE   3  (bases 1 to 3840)
  AUTHORS   Jena,S.K., Das,S., Chakraborty,S. and Ain,R.
  TITLE     Molecular determinants of epithelial mesenchymal transition in
            mouse placenta and trophoblast stem cell
  JOURNAL   Sci Rep 13 (1), 10978 (2023)
   PUBMED   37414855
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3840)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   5  (bases 1 to 3840)
  AUTHORS   Avery,L., Robertson,T.F., Wu,C.F., Roy,N.H., Chauvin,S.D.,
            Perkey,E., Vanderbeck,A., Maillard,I. and Burkhardt,J.K.
  TITLE     A Murine Model of X-Linked Moesin-Associated Immunodeficiency
            (X-MAID) Reveals Defects in T Cell Homeostasis and Migration
  JOURNAL   Front Immunol 12, 726406 (2022)
   PUBMED   35069520
  REMARK    GeneRIF: A Murine Model of X-Linked Moesin-Associated
            Immunodeficiency (X-MAID) Reveals Defects in T Cell Homeostasis and
            Migration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3840)
  AUTHORS   Liang,H.C., McKinnon,R.A. and Nebert,D.W.
  TITLE     Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in
            Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice
  JOURNAL   Biochem Pharmacol 54 (10), 1127-1131 (1997)
   PUBMED   9464455
REFERENCE   7  (bases 1 to 3840)
  AUTHORS   Wilgenbus,K.K., Hsieh,C.L., Lankes,W.T., Milatovich,A., Francke,U.
            and Furthmayr,H.
  TITLE     Structure and localization on the X chromosome of the gene coding
            for the human filopodial protein moesin (MSN)
  JOURNAL   Genomics 19 (2), 326-333 (1994)
   PUBMED   8188263
REFERENCE   8  (bases 1 to 3840)
  AUTHORS   Fazioli,F., Wong,W.T., Ullrich,S.J., Sakaguchi,K., Appella,E. and
            Di Fiore,P.P.
  TITLE     The ezrin-like family of tyrosine kinase substrates:
            receptor-specific pattern of tyrosine phosphorylation and
            relationship to malignant transformation
  JOURNAL   Oncogene 8 (5), 1335-1345 (1993)
   PUBMED   8479753
REFERENCE   9  (bases 1 to 3840)
  AUTHORS   Sato,N., Funayama,N., Nagafuchi,A., Yonemura,S., Tsukita,S. and
            Tsukita,S.
  TITLE     A gene family consisting of ezrin, radixin and moesin. Its specific
            localization at actin filament/plasma membrane association sites
  JOURNAL   J Cell Sci 103 (Pt 1), 131-143 (1992)
   PUBMED   1429901
REFERENCE   10 (bases 1 to 3840)
  AUTHORS   Furthmayr,H., Lankes,W. and Amieva,M.
  TITLE     Moesin, a new cytoskeletal protein and constituent of filopodia:
            its role in cellular functions
  JOURNAL   Kidney Int 41 (3), 665-670 (1992)
   PUBMED   1573844
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY336882.1, M86390.1, CF584663.1, BQ950368.1, BQ712805.1,
            CB320714.1, CB183208.1 and AL805963.23.
            
            On Jul 13, 2005 this sequence version replaced NM_010833.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145746.1, AK150869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               BY336882.1         1-220
            221-726             M86390.1           1-506
            727-1167            CF584663.1         215-655
            1168-1179           M86390.1           948-959
            1180-1188           CF584663.1         668-676
            1189-1299           M86390.1           969-1079
            1300-1693           BQ950368.1         437-830
            1694-1941           M86390.1           1474-1721
            1942-2275           BQ712805.1         341-674
            2276-2772           CB320714.1         14-510
            2773-3242           CB183208.1         330-799
            3243-3840           AL805963.23        203984-204581
FEATURES             Location/Qualifiers
     source          1..3840
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 42.65 cM"
     gene            1..3840
                     /gene="Msn"
                     /note="moesin"
                     /db_xref="GeneID:17698"
                     /db_xref="MGI:MGI:97167"
     exon            1..199
                     /gene="Msn"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1921
                     /gene="Msn"
                     /note="membrane-organizing extension spike protein"
                     /codon_start=1
                     /product="moesin"
                     /protein_id="NP_034963.2"
                     /db_xref="CCDS:CCDS53139.1"
                     /db_xref="GeneID:17698"
                     /db_xref="MGI:MGI:97167"
                     /translation="MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWF
                     FGLQYQDTKAFSTWLKLNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLF
                     FLQVKEGILNDDIYCPPETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQ
                     HKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWL
                     GVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRI
                     NKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMERALLENEKKKRELAE
                     KEKEKIEREKEELMEKLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKE
                     RQEAEEAKEALLQASRDQKKTQEQLASEMAELTARISQLEMARKKKESEAVEWQQKAQ
                     MVQEDLEKTRAELKTAMSTPHVAEPAENEHDEQDENGAEASAELRADAMAKDRSEEER
                     TTEAEKNERVQKHLKALTSELANARDESKKTANDMIHAENMRLGRDKYKTLRQIRQGN
                     TKQRIDEFESM"
     exon            200..283
                     /gene="Msn"
                     /inference="alignment:Splign:2.1.0"
     exon            284..379
                     /gene="Msn"
                     /inference="alignment:Splign:2.1.0"
     exon            380..654
                     /gene="Msn"
                     /inference="alignment:Splign:2.1.0"
     exon            655..738
                     /gene="Msn"
                     /inference="alignment:Splign:2.1.0"
     exon            739..885
                     /gene="Msn"
                     /inference="alignment:Splign:2.1.0"
     exon            886..982
                     /gene="Msn"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1146
                     /gene="Msn"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1277
                     /gene="Msn"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1438
                     /gene="Msn"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1531
                     /gene="Msn"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1756
                     /gene="Msn"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..3840
                     /gene="Msn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3819..3824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msn"
                     /note="hexamer: AATAAA"
     polyA_site      3840
                     /gene="Msn"
                     /note="major polyA site"
ORIGIN      
        1 tctttcctgg gtggggtttg taaagtcgtg gcccgttagc aggaagcgga gcagtcgccc
       61 aacgctagag tgggacccaa tctgagcacc cggttctccg gagtccttgc cgaagtgtac
      121 tgcgcgctca gagcagcccg acagtttcca gccaaacttc accaactcct ctgcccttgc
      181 cgccaccatg ccgaagacga tcagtgtgcg tgtcaccacc atggatgcag agctggagtt
      241 tgccattcag cccaacacca ctggcaagca gctgtttgac caggtggtga aaactattgg
      301 tttgagggaa gtttggttct ttggtctgca gtaccaggac acaaaagctt tctctacttg
      361 gctgaaactc aataagaagg tgactgcaca ggatgtgcgg aaggaaagtc cattgctctt
      421 caagttccgg gccaagttct acccagagga tgtatctgaa gaactgatcc aggatatcac
      481 ccagcgcctg ttctttctgc aagtgaagga gggcattctc aatgacgaca tttactgtcc
      541 acctgaaact gcggtcctgt tggcttctta tgccgtccag tctaagtatg gtgacttcaa
      601 taaggaagtg cacaagtctg gctacctggc tggagataag ttgcttcccc aaagagtctt
      661 ggagcagcac aaactcaaca aggaccagtg ggaagagagg atccaggtgt ggcatgagga
      721 gcaccggggc atgctcaggg aggatgctgt cctggaatat ctcaagattg ctcaagacct
      781 ggaaatgtat ggtgtgaact atttcagcat caagaacaag aaaggctcag agctatggct
      841 gggcgtggat gccttgggtc tcaacatcta tgagcagaat gacagactga ctcctaagat
      901 tggcttcccg tggagtgaaa tcaggaatat ctctttcaat gataagaaat ttgtcatcaa
      961 gcccattgac aaaaaggccc cggactttgt gttctatgct ccccggcttc ggattaacaa
     1021 gcggatcttg gccctgtgca tgggaaatca tgagctgtac atgcgtcggc gcaagcctga
     1081 caccattgag gtgcagcaga tgaaggccca ggctcgggaa gagaagcacc agaagcagat
     1141 ggagcgtgct ctcctggaaa atgagaagaa gaagcgtgag ctggctgaga aagagaagga
     1201 gaagattgag cgggagaagg aagagctgat ggagaagctg aagcagattg aggagcagac
     1261 taagaaggct cagcaagagc tggaagagca gacccgcagg gccctagaac ttgagcagga
     1321 acggaagcgt gcccagagtg aggccgaaaa gctagccaag gagcgtcaag aagctgaaga
     1381 agccaaagag gccctgctgc aggcttctcg ggaccagaag aagacccagg aacagctggc
     1441 ttcagaaatg gcagagctga cggcacggat ctcccagttg gaaatggctc gaaagaagaa
     1501 ggaaagtgag gctgtggaat ggcagcaaaa ggcccagatg gtacaggaag acttggagaa
     1561 gactcgtgct gagctgaaga ctgccatgag tacacctcat gtggcagagc ctgctgagaa
     1621 tgaacatgat gagcaggatg agaatggagc agaggccagt gccgagctgc gggctgatgc
     1681 tatggccaag gaccgcagtg aggaggaacg taccactgag gcagagaaga atgagcgtgt
     1741 gcagaagcat ctgaaggccc ttacttcaga gctggccaat gcccgagatg agtccaagaa
     1801 gactgccaat gacatgatcc atgctgagaa catgcgactg ggacgagaca aatacaagac
     1861 cctgcgccag atccggcagg gcaacaccaa acaacgcatt gatgagtttg agtccatgta
     1921 gtgggcgtcc agccttcagg gacccctcct ccttcttcct tgtccccaca ctcccatagt
     1981 tttgcctaac taacactgtg ctggagccac taactagaaa agccttggag ccatgccaaa
     2041 cgttcagtat agccatggga ccaaacttaa tctccccact cataccctcg ggcaaacaaa
     2101 tggcccactg tggtgccaat ggaatctcct tttccttctt tgtcacactc attcaaccta
     2161 gctctctaga atagagcatt tctccccgcc ccagctcaga gacacgcatt ccttttggtt
     2221 tgacaagcac cccctcccca tatacactta ctgttgtcct ctgggactca tgtgtgaagt
     2281 aggttaacag ctagctccca tcccttgcca gtcctgtgat ttgcaaagat ggaatattgt
     2341 gttgtttagg gacagaagga gggaattggc tttatcattt agtatgtcag atgacctagg
     2401 atttagcctc ttaattaagt ctatcccttt tacagttact taggctttgt accgattgga
     2461 ggataaaaga gatgtttagc cattcttatt tcttctacct cccatattgg acctattaca
     2521 aatctagtcc cagtgggcct tgtctctgtg tttagggatt tagtttctaa tcaagatggg
     2581 atgaagagat aaaggaaata gtgcattcaa gagattcact aacaacctag aaaggcccct
     2641 gccccagcac atctttggag cctttcttct cttgagtgag gtctgtggtc agggctaccc
     2701 ctgcccatga tagtccaggt tcttggttcc ttttctaaat ctgtccctac cctctccaat
     2761 cctcagatct cttccagcta ggacagagag gatgagtacc ctcaaaccta gccagttgca
     2821 tctaaacttg ttgccacaaa ggaagaaact tttttgtacc tggctttagt atttttcctg
     2881 ccaggacttc taaactactt cccccagagc taatttgacc actgttcctg tttcacagat
     2941 acaaaatatg atgagtaaga gtagcccttg tctgtcagtc acccagcaat cctccctcat
     3001 cttacccagt gcaaagtggt gagtaggccc tgcttctgac aaatctctaa ctcaggcctc
     3061 atcactcatt gtgctgtccc ttggagatac agaaagctgc tgggtattct ggccttgtcc
     3121 cttcacaccc ccacaccctt ttctccactt tggagcagct gctccccctt ttttgtcaca
     3181 tgtgtgctct tttaattttt accagtatta tatattctag tgatatctaa caatattggt
     3241 ttctaccttt tttgctaatg cactattaga gatattagtc ttgggaaagg atcattttag
     3301 cttcattatt ttttactact gtcaccccac atctgagaag aatatactat attaaaaatg
     3361 atattttgcc aaaaacatta tgtaagaaga tttcagtatt agcgacttac ctgtcactat
     3421 aggtcataca atacatttaa aatgtactta gtatttggtt ttattgttcc tgtttgcttt
     3481 ttccccaggg ttcagtcccc aaaaggctgt cttgtccctc tatgcagtat ccttagtcca
     3541 gagcatccct cagcccatgc cccttttact taatcttggg gaatcttata tgcattgctg
     3601 tgaattatat tgacagttgg tgagctgtct tatattggct aaattcaaac ctggaattgt
     3661 gggggcaatc tagctgcatt aagggcaata acccaccccc ccatagaggc tggggagaag
     3721 ggtaggattt atattgaggt tttttttttg tgtatttttg ttttttaaat aattgttttg
     3781 gaggggttta tgctcaatct gtgttctatt tcagtgccaa taaaatttag gaagacttca
//
