LOCUS       NM_001099314             743 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus microseminoprotein, prostate associated (Msmp), mRNA.
ACCESSION   NM_001099314 XM_001473471
VERSION     NM_001099314.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 743)
  AUTHORS   Song,Z., Yao,W., Wang,X., Mo,Y., Liu,Z., Li,Q., Jiang,L., Wang,H.,
            He,H., Li,N., Zhang,Z., Lv,P., Zhang,Y., Yang,L. and Wang,Y.
  TITLE     The novel potential therapeutic target PSMP/MSMP promotes acute
            kidney injury via CCR2
  JOURNAL   Mol Ther 32 (7), 2248-2263 (2024)
   PUBMED   38796708
  REMARK    GeneRIF: The novel potential therapeutic target PSMP/MSMP promotes
            acute kidney injury via CCR2.
REFERENCE   2  (bases 1 to 743)
  AUTHORS   She,S., Wu,X., Zheng,D., Pei,X., Ma,J., Sun,Y., Zhou,J., Nong,L.,
            Guo,C., Lv,P., Song,Q., Zheng,C., Liang,W., Huang,S., Li,Q.,
            Liu,Z., Song,Z., Li,Y., Zhang,Y., Kong,W., You,H., Xi,J. and
            Wang,Y.
  TITLE     PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a
            novel therapeutic target
  JOURNAL   J Hepatol 72 (3), 506-518 (2020)
   PUBMED   31813573
  REMARK    GeneRIF: PSMP/MSMP promotes hepatic fibrosis through CCR2 and
            represents a novel therapeutic target.
REFERENCE   3  (bases 1 to 743)
  AUTHORS   Mitamura,T., Pradeep,S., McGuire,M., Wu,S.Y., Ma,S., Hatakeyama,H.,
            Lyons,Y.A., Hisamatsu,T., Noh,K., Villar-Prados,A., Chen,X.,
            Ivan,C., Rodriguez-Aguayo,C., Hu,W., Lopez-Berestein,G.,
            Coleman,R.L. and Sood,A.K.
  TITLE     Induction of anti-VEGF therapy resistance by upregulated expression
            of microseminoprotein (MSMP)
  JOURNAL   Oncogene 37 (6), 722-731 (2018)
   PUBMED   29059175
  REMARK    GeneRIF: High MSMP expression is associated with drug-resistant
            prostate cancer.
REFERENCE   4  (bases 1 to 743)
  AUTHORS   Rauch,F., Geng,Y., Lamplugh,L., Hekmatnejad,B., Gaumond,M.H.,
            Penney,J., Yamanaka,Y. and Moffatt,P.
  TITLE     Crispr-Cas9 engineered osteogenesis imperfecta type V leads to
            severe skeletal deformities and perinatal lethality in mice
  JOURNAL   Bone 107, 131-142 (2018)
   PUBMED   29174564
REFERENCE   5  (bases 1 to 743)
  AUTHORS   Pei,X., Zheng,D., She,S., Ma,J., Guo,C., Mo,X., Zhang,Y., Song,Q.,
            Zhang,Y., Ma,D. and Wang,Y.
  TITLE     The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent
            colitis
  JOURNAL   Sci Rep 7 (1), 5107 (2017)
   PUBMED   28698550
  REMARK    GeneRIF: Study shows that PSMP plays a vital role in promoting
            dextran sodium sulfate (DSS)-colitis. PSMP is significantly
            up-regulated DSS-induced mouse colitis. PSMP is up-regulated in the
            initial stage prior to IL-6, TNF-alpha and CCL2 up-regulated
            expression in DSS colitis and promote the M1 macrophages to produce
            CCL2. PMSP affects the monocytes and macrophages through CCR2.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732626.8.
            
            On Jul 25, 2007 this sequence version replaced XM_001473471.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA481548.1, SRR7345562.4744863.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               AL732626.8         21708-22063         c
            357-465             AL732626.8         21382-21490         c
            466-743             AL732626.8         20785-21062         c
FEATURES             Location/Qualifiers
     source          1..743
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.05 cM"
     gene            1..743
                     /gene="Msmp"
                     /gene_synonym="Psmp"
                     /note="microseminoprotein, prostate associated"
                     /db_xref="GeneID:100039672"
                     /db_xref="MGI:MGI:3652339"
     exon            1..356
                     /gene="Msmp"
                     /gene_synonym="Psmp"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..646
                     /gene="Msmp"
                     /gene_synonym="Psmp"
                     /note="prostate-associated microseminoprotein;
                     PC3-secreted microprotein homolog; Vmicroseminoprotein,
                     prostate associated"
                     /codon_start=1
                     /product="prostate-associated microseminoprotein
                     precursor"
                     /protein_id="NP_001092784.1"
                     /db_xref="CCDS:CCDS51167.1"
                     /db_xref="GeneID:100039672"
                     /db_xref="MGI:MGI:3652339"
                     /translation="MALRMLWAGQAKGILGGWRTICLVVSLFLQHPGVSSKCYFQAQA
                     PCHYEGKYFTLGESWLRKDCFHCTCLHPVGVGCCDTAQHPIDFPAECEVLQEAGTCQF
                     SLVQKADPRLPCKGGGPDLEWGSANTPAPGASAPHSS"
     exon            357..465
                     /gene="Msmp"
                     /gene_synonym="Psmp"
                     /inference="alignment:Splign:2.1.0"
     exon            466..743
                     /gene="Msmp"
                     /gene_synonym="Psmp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttcatgcc ctcacctcag gaaacagagt tccagcctgt ccagctctcc tcagcagggg
       61 gccagggtcc tcactttata aacattccca gccatggtat gagacgggag cccaaggaga
      121 gagaaactca ggagtcaagg agcaaggcaa gaagagcaag ggggtaagaa gaccagagga
      181 gtctgagccg aagccaggaa gggtctgaga gcgctgagca gcaggaatgg ccctaaggat
      241 gctctgggct ggccaagcca aggggatcct cggaggctgg aggaccatct gcttggtggt
      301 gtctctgttc ctacagcacc cgggagttag cagcaagtgt tacttccaag ctcaagctcc
      361 ctgccactac gagggtaaat acttcactct gggtgaatct tggctccgca aggactgttt
      421 ccattgtacc tgtctgcatc ctgttggtgt gggctgctgt gacacggctc agcatcctat
      481 tgacttccct gctgagtgtg aagtgctaca ggaggcagga acctgtcaat tttccctggt
      541 gcagaaagct gaccctcggc tgccctgcaa agggggaggg cccgacttag aatggggctc
      601 ggctaacacc cctgctcctg gggcttctgc cccccactcc agctaaaggc ttgcccatct
      661 gctgattgct cactgctgct gccactttca gggaaaccac tagcagctgc caacttcctc
      721 caaagaaata aattaatgct aca
//
