LOCUS       NM_025436               1846 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus methylsterol monoxygenase 1 (Msmo1), mRNA.
ACCESSION   NM_025436
VERSION     NM_025436.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1846)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1846)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1846)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1846)
  AUTHORS   Xin,Y., Li,C., Guo,Y., Xiao,R., Zhang,H. and Zhou,G.
  TITLE     RNA-Seq analysis reveals a negative role of MSMO1 with a synergized
            NSDHL expression during adipogenesis of 3T3-L1
  JOURNAL   Biosci Biotechnol Biochem 83 (4), 641-652 (2019)
   PUBMED   30582412
  REMARK    GeneRIF: The findings indicate that MSMO1 and NSDHL are novel
            modulators of adipogenesis.
REFERENCE   5  (bases 1 to 1846)
  AUTHORS   Lowther,K.M., Favero,F., Yang,C.R., Taylor,H.S. and Seli,E.
  TITLE     Embryonic poly(A)-binding protein is required at the preantral
            stage of mouse folliculogenesis for oocyte-somatic communication
  JOURNAL   Biol Reprod 96 (2), 341-351 (2017)
   PUBMED   28203794
REFERENCE   6  (bases 1 to 1846)
  AUTHORS   Sisecioglu,M., Budak,H., Geffers,L., Cankaya,M., Ciftci,M.,
            Thaller,C., Eichele,G., Kufrevioglu,O.I. and Ozdemir,H.
  TITLE     A compendium of expression patterns of cholesterol biosynthetic
            enzymes in the mouse embryo
  JOURNAL   J Lipid Res 56 (8), 1551-1559 (2015)
   PUBMED   26108225
REFERENCE   7  (bases 1 to 1846)
  AUTHORS   Patra,D., DeLassus,E., Liang,G. and Sandell,L.J.
  TITLE     Cartilage-specific ablation of site-1 protease in mice results in
            the endoplasmic reticulum entrapment of type IIb procollagen and
            down-regulation of cholesterol and lipid homeostasis
  JOURNAL   PLoS One 9 (8), e105674 (2014)
   PUBMED   25147951
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1846)
  AUTHORS   Sukhanova,A., Gorin,A., Serebriiskii,I.G., Gabitova,L., Zheng,H.,
            Restifo,D., Egleston,B.L., Cunningham,D., Bagnyukova,T., Liu,H.,
            Nikonova,A., Adams,G.P., Zhou,Y., Yang,D.H., Mehra,R., Burtness,B.,
            Cai,K.Q., Klein-Szanto,A., Kratz,L.E., Kelley,R.I., Weiner,L.M.,
            Herman,G.E., Golemis,E.A. and Astsaturov,I.
  TITLE     Targeting C4-demethylating genes in the cholesterol pathway
            sensitizes cancer cells to EGF receptor inhibitors via increased
            EGF receptor degradation
  JOURNAL   Cancer Discov 3 (1), 96-111 (2013)
   PUBMED   23125191
  REMARK    GeneRIF: This work identifies a critical role for SC4MOL and NSDHL
            in the regulation of EGFR signaling and endocytic trafficking and
            suggests novel strategies to increase the potency of EGFR
            antagonists in tumors
REFERENCE   9  (bases 1 to 1846)
  AUTHORS   Pfister,S., Jones,V.J., Power,M., Truisi,G.L., Khoo,P.L.,
            Steiner,K.A., Kanai-Azuma,M., Kanai,Y., Tam,P.P. and Loebel,D.A.
  TITLE     Sox17-dependent gene expression and early heart and gut development
            in Sox17-deficient mouse embryos
  JOURNAL   Int J Dev Biol 55 (1), 45-58 (2011)
   PUBMED   21305474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005090.1 and AC152168.2.
            
            On Jun 14, 2018 this sequence version replaced NM_025436.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005090.1, AK151135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1824              AK005090.1         2-1825
            1825-1846           AC152168.2         59752-59773
FEATURES             Location/Qualifiers
     source          1..1846
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 32.3 cM"
     gene            1..1846
                     /gene="Msmo1"
                     /gene_synonym="1500001G16Rik; DESP4; ERG25; Sc4mol"
                     /note="methylsterol monoxygenase 1"
                     /db_xref="GeneID:66234"
                     /db_xref="MGI:MGI:1913484"
     exon            1..71
                     /gene="Msmo1"
                     /gene_synonym="1500001G16Rik; DESP4; ERG25; Sc4mol"
                     /inference="alignment:Splign:2.1.0"
     exon            72..356
                     /gene="Msmo1"
                     /gene_synonym="1500001G16Rik; DESP4; ERG25; Sc4mol"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..983
                     /gene="Msmo1"
                     /gene_synonym="1500001G16Rik; DESP4; ERG25; Sc4mol"
                     /EC_number="1.14.18.9"
                     /note="C-4 methylsterol oxidase; sterol-C4-methyl
                     oxidase-like"
                     /codon_start=1
                     /product="methylsterol monooxygenase 1"
                     /protein_id="NP_079712.1"
                     /db_xref="CCDS:CCDS22328.1"
                     /db_xref="GeneID:66234"
                     /db_xref="MGI:MGI:1913484"
                     /translation="MATNKSVGVFSSASLAVEYVDSLLPENPLQEPFKNAWVYMLDNY
                     TKFQIATWGSLIVHEAIYFLFSLPGFLFQFIPYMRKYKIQKDKPETFEGQWKCLKKIL
                     FNHFFIQLPLICGTYYFTEFFNIPYDWERMPRWYLTLARCLGCAVIEDTWHYFLHRLL
                     HHKRIYKYIHKVHHEFQAPFGIEAEYAHPLETLILGTGFFIGIVLLCDHVILLWAWVT
                     IRLLETIDVHSGYDIPLNPLNLVPFYTGARHHDFHHMNFIGNYASTFTWWDKLFGTDA
                     QYHAYIEKSKKLGKKSD"
     exon            357..505
                     /gene="Msmo1"
                     /gene_synonym="1500001G16Rik; DESP4; ERG25; Sc4mol"
                     /inference="alignment:Splign:2.1.0"
     exon            506..632
                     /gene="Msmo1"
                     /gene_synonym="1500001G16Rik; DESP4; ERG25; Sc4mol"
                     /inference="alignment:Splign:2.1.0"
     exon            633..787
                     /gene="Msmo1"
                     /gene_synonym="1500001G16Rik; DESP4; ERG25; Sc4mol"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1846
                     /gene="Msmo1"
                     /gene_synonym="1500001G16Rik; DESP4; ERG25; Sc4mol"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1722..1727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msmo1"
                     /gene_synonym="1500001G16Rik; DESP4; ERG25; Sc4mol"
                     /note="hexamer: AATAAA"
     polyA_site      1743
                     /gene="Msmo1"
                     /gene_synonym="1500001G16Rik; DESP4; ERG25; Sc4mol"
                     /note="major polyA site"
     regulatory      1825..1830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msmo1"
                     /gene_synonym="1500001G16Rik; DESP4; ERG25; Sc4mol"
                     /note="hexamer: AATAAA"
     polyA_site      1830
                     /gene="Msmo1"
                     /gene_synonym="1500001G16Rik; DESP4; ERG25; Sc4mol"
                     /note="major polyA site"
ORIGIN      
        1 agaggtagtg aggaggccgc tgcacctgcc aggacttgcg cttagaccgc tgtctgtcgc
       61 ggggacgcca ggaataaaag gtccctcgca gagatttgaa aatggccaca aacaaaagtg
      121 ttggcgtgtt cagctctgca tccctggctg tggagtatgt ggactcactg ttgccggaga
      181 atcctctgca ggagcccttt aagaatgctt gggtctacat gttggacaac tatacaaagt
      241 tccagatcgc aacctggggc tccctgatag ttcacgaagc catctatttc ttgttctctt
      301 tacctggatt cctattccag tttatacctt acatgagaaa gtacaagatt caaaaggata
      361 aaccagaaac cttcgaaggc cagtggaagt gtttgaaaaa aattctattt aatcattttt
      421 ttatccagtt gcctctgatt tgtggaacat actattttac agagtttttc aatattcctt
      481 atgattggga aagaatgcca agatggtact taactttggc aaggtgtttg ggctgtgcag
      541 tcattgagga cacctggcat tatttcctgc acagactcct tcaccacaag agaatttata
      601 aatacattca taaagtccat cacgagtttc aggctccatt tggaatcgaa gcagaatacg
      661 cacatccctt ggaaaccctg attcttggga caggattttt catcggaatt gtgcttttgt
      721 gtgatcacgt aattctcctg tgggcatggg tgaccatacg tttgctggaa accatcgatg
      781 tgcacagcgg ttatgatatt cctctcaacc cgctgaactt ggttcctttt tatacgggcg
      841 ctcggcacca tgatttccac cacatgaact tcattgggaa ttatgcctcc accttcacgt
      901 ggtgggataa actctttggg acagatgccc agtatcatgc ctacattgaa aaatcgaaga
      961 agcttgggaa aaagtctgat tgagcacccc cactcgacgc cttcctcaac tgcagctggc
     1021 cactaacact gcttctgggg acttggctgc caagtgataa aaacgttaac gacctttaag
     1081 tactcttcca gatgagagct cttctacctt acgtccaaga tctgtatatg tgggaacaaa
     1141 taagtaaata tatatacata tatatatatt taagtacagt tttcatcagg aggttttaaa
     1201 ggccatattg ctaacctcac caaaaggttt cgggaactgg aggaagtatt aatgtacaac
     1261 tcaccacttc atgccatagg aggctgaagt tgacgttgcc ttttaagcct tttacataca
     1321 ctggtcagtt cggaaaattc tcaacaataa tgtttgcctt ctagtttaag acatggtgta
     1381 ttttagaaat tacctgaagt gaagctatca cgaagtgagt gtatcacctg gtgagcgagt
     1441 gactgaaacc tgctctggtc tgggtttgac caggttagga ctattctttc tgtgaaggat
     1501 tgtttgattg tagtaactct attggcatct tgtaaattgg ctcatttcct acgtgatgta
     1561 catagaatat tatagcctaa agattttcca gttacttgcg gtctttttaa attgaggagc
     1621 cccacttcca ctgtccaccc cttgtctttg tgtgtcaggt gatcattgaa atcgtatctt
     1681 gagcttgaat tcacttctct gtctgtttcc ggagctggtg aaataaatgt gatttttgtc
     1741 cgatccttct ggttttcatg aagattagct gccatgtttt attcttataa ggaaaagcac
     1801 agagatcatt aaagtaagtt ttacaataaa ggaatggttc tgtttt
//
